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31. 发明授权

US09260422B2 Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof 有权
公开(公告)号：US09260422B2
公开(公告)日：2016-02-16
申请号：US14235253
申请日：2012-07-26
申请人： Celia Dominguez , Leticia M. Toledo-Sherman , Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson
发明人： Celia Dominguez , Leticia M. Toledo-Sherman , Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson
IPC分类号： A61K31/506 , C07D417/04 , C07D239/42 , C07D401/04 , C07D403/04 , C07D239/26 , C07D413/04 , C07D239/28 , C07D413/14 , C07D491/044 , C07D491/048 , C07D491/052
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/5377 , C07D239/26 , C07D239/28 , C07D239/42 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

32. 发明申请

US20140329795A1 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 有权
标题翻译：吉非烯-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：US20140329795A1
公开(公告)日：2014-11-06
申请号：US14241699
申请日：2012-08-28
申请人： Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson , Celia Dominguez , Leticia M. Toledo-Sherman , Ignacio Munoz
发明人： Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson , Celia Dominguez , Leticia M. Toledo-Sherman , Ignacio Munoz
IPC分类号： C07D239/28 , C07D401/12 , C07D403/06 , C07D417/12 , C07D239/42 , C07D403/12 , C07D471/04 , C07D405/12 , C07D487/04 , C07D401/04 , C07D413/12
CPC分类号： C07D239/28 , A61K31/506 , C07D239/42 , C07D239/52 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , Y02A50/401 , Y02A50/411 , Y02A50/465
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

33. 发明授权

US08822266B2 Integrated circuit micro-module 有权
标题翻译：集成电路微模块
公开(公告)号：US08822266B2
公开(公告)日：2014-09-02
申请号：US13013563
申请日：2011-01-25
申请人： Peter Smeys , Peter Johnson , Peter Deane , Reda R. Razouk
发明人： Peter Smeys , Peter Johnson , Peter Deane , Reda R. Razouk
IPC分类号： H01L21/50 , H01L21/48 , H01L21/44 , H01L23/00 , H01L21/56 , H01L21/683 , H01L23/538 , H01L23/498 , H01L23/31
CPC分类号： H01L23/5389 , H01L21/4853 , H01L21/486 , H01L21/568 , H01L21/6835 , H01L23/3114 , H01L23/3121 , H01L23/49822 , H01L23/49827 , H01L23/5385 , H01L24/24 , H01L24/82 , H01L24/97 , H01L2221/68377 , H01L2224/24137 , H01L2224/24145 , H01L2224/24227 , H01L2224/32145 , H01L2224/32225 , H01L2224/32245 , H01L2224/73267 , H01L2224/92244 , H01L2224/97 , H01L2924/01003 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01024 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01074 , H01L2924/01082 , H01L2924/01087 , H01L2924/014 , H01L2924/07802 , H01L2924/14 , H01L2924/1461 , H01L2924/15153 , H01L2924/15165 , H01L2924/1517 , H01L2924/15311 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/3025 , H01L2224/82 , H01L2924/00
摘要： Various apparatuses and methods for forming integrated circuit packages are described. One aspect of the invention pertains to an integrated circuit package in which one or more integrated circuits are embedded in a substrate and covered with a layer of photo-imageable epoxy. The substrate can be made of various materials, including silicon, quartz and glass. An integrated circuit is positioned within a cavity in the top surface of the substrate. The epoxy layer is formed over the top surface of the substrate and the active face of the integrated circuit. An interconnect layer is formed over the epoxy layer and is electrically coupled with the integrated circuit.
摘要翻译：描述了用于形成集成电路封装的各种装置和方法。本发明的一个方面涉及一种集成电路封装，其中一个或多个集成电路嵌入在基片中并被一层可光成像的环氧树脂覆盖。基板可以由各种材料制成，包括硅，石英和玻璃。集成电路位于衬底的顶表面中的空腔内。环氧树脂层形成在衬底的顶表面和集成电路的有源面上。在环氧树脂层上形成互连层并与集成电路电耦合。

34. 发明授权

US08732276B2 Data gathering using a mobile computing device 有权
标题翻译：使用移动计算设备进行数据采集
公开(公告)号：US08732276B2
公开(公告)日：2014-05-20
申请号：US13250108
申请日：2011-09-30
申请人： James St. Clair , Jon Watts , Karl Schulze , Peter Johnson
发明人： James St. Clair , Jon Watts , Karl Schulze , Peter Johnson
IPC分类号： G06F15/16 , H04W4/00 , H04L12/18 , H04L29/08
CPC分类号： H04W4/00 , G06Q10/00 , G06Q10/06 , H04L12/189 , H04L67/04 , H04L67/22
摘要： Systems and methods for field data gathering and which provide flexible configuration options for a central office. The system, run from, mobile computing devices, provides a free-flowing data gathering experience while only requiring what the central office needs from the field. The central office can configure the system to accept different types of data by way of different data input means available to the mobile computing device. Only the data needed by the central office need be collected by the mobile device operator. The data format is defined by the central office and is uploaded to each of the relevant mobile computing devices for use by the operators. Once each data set has been collected by an operator, the data package with the data set is scheduled for transmission to the central office once a connection with the central office can be made.
摘要翻译：用于现场数据采集的系统和方法，并为中心局提供灵活的配置选项。该系统从移动计算设备运行，提供了一个自由流动的数据收集体验，同时只需要中心局从现场需要的。中央办公室可以通过移动计算设备可用的不同数据输入手段，将系统配置为接受不同类型的数据。只有中央办公室需要的数据需要由移动设备运营商收集。数据格式由中心局定义，并被上传到每个相关的移动计算设备供操作者使用。一旦每个数据集已被操作员收集，与数据集的数据包一起可以一旦与中心局建立连接就被安排传送到中心局。

35. 发明申请

US20130174124A1 VERSION NUMBERING IN SINGLE DEVELOPMENT AND TEST ENVIRONMENT 审中-公开
标题翻译：单一开发和测试环境中的版本编号
公开(公告)号：US20130174124A1
公开(公告)日：2013-07-04
申请号：US13339906
申请日：2011-12-29
申请人： Christina Watters , Peter Johnson
发明人： Christina Watters , Peter Johnson
IPC分类号： G06F9/44
CPC分类号： G06F8/71
摘要： System and method for version string generation for artifacts in a repository is disclosed. A first source code management server manages first source code versions in a first repository and assigns a first source code version string to each first source code version. A first artifact repository comprises a first artifact built based on one of the first source code versions. A product manager generates a first artifact version string for the first artifact based on the first source code version string of the first source code version used to build the first artifact.
摘要翻译：公开了用于存储库中的工件的版本字符串生成的系统和方法。第一个源代码管理服务器管理第一个存储库中的第一个源代码版本，并将第一个源代码版本字符串分配给每个第一个源代码版本。第一工件存储库包括基于第一源代码版本之一构建的第一伪像。产品管理器基于用于构建第一个工件的第一个源代码版本的第一个源代码版本字符串为第一个工件生成第一个工件版本字符串。

36. 发明申请

US20130174122A1 META-DATA FOR SINGLE DEVELOPMENT TEST ENVIRONMENT 有权
标题翻译：用于单一开发测试环境的元数据
公开(公告)号：US20130174122A1
公开(公告)日：2013-07-04
申请号：US13339892
申请日：2011-12-29
申请人： Christina Watters , Peter Johnson , Robert S. Baker
发明人： Christina Watters , Peter Johnson , Robert S. Baker
IPC分类号： G06F9/44
CPC分类号： G06F8/36
摘要： System and method for generating meta-data for a product is disclosed. An artifact repository stores first artifacts for building the product. The artifact repository stores first meta-data for one or more of the artifacts in the repository. A build manager builds second artifacts for the product from source code and one or more of the first artifacts based on information in a project script. The build manager is adapted to combine the first meta-data for each of the one or more of the first artifacts used to build the second artifact to form second meta-data for each of the second artifacts.
摘要翻译：公开了用于产生产品元数据的系统和方法。工件存储库存储用于构建产品的第一个工件。工件存储库存储存储库中一个或多个工件的第一个元数据。构建管理器根据项目脚本中的信息，从源代码和一个或多个第一个工件构建产品的第二个工件。构建管理器适于组合用于构建第二工件的一个或多个第一工件中的每一个的第一元数据以形成第二工件中的每一个的第二元数据。

37. 发明授权

US08378766B2 MEMS relay and method of forming the MEMS relay 有权
标题翻译： MEMS继电器和形成MEMS继电器的方法
公开(公告)号：US08378766B2
公开(公告)日：2013-02-19
申请号：US13020052
申请日：2011-02-03
申请人： Dok Won Lee , Peter Johnson , Aditi Dutt Chaudhuri
发明人： Dok Won Lee , Peter Johnson , Aditi Dutt Chaudhuri
IPC分类号： H01H51/22
CPC分类号： H01L29/84 , H01H1/0036 , H01H49/00 , H01H50/005 , H01H50/36 , H01H50/44 , Y10T29/49073
摘要： A micro-electromechanical systems (MEMS) relay includes a switch with a first contact region and a second contact region that are vertically separated from each other by a gap. The MEMS relay requires a small vertical movement to close the gap and therefore is mechanically robust. In addition, the MEMS relay has a small footprint and, therefore, can be formed on top of small integrated circuits.
摘要翻译：微机电系统（MEMS）继电器包括具有通过间隙彼此垂直分离的第一接触区域和第二接触区域的开关。 MEMS继电器需要小的垂直运动来封闭间隙，因此机械稳健。此外，MEMS继电器占地面积小，因此可以形成在小型集成电路之上。

38. 发明申请

US20120278102A1 Real-Time Automated Interpretation of Clinical Narratives 审中-公开
标题翻译：实时自动解释临床叙事
公开(公告)号：US20120278102A1
公开(公告)日：2012-11-01
申请号：US13425719
申请日：2012-03-21
申请人： Peter Johnson
发明人： Peter Johnson
IPC分类号： G06Q50/24
CPC分类号： G06Q50/22 , G06F17/2785 , G06F17/2872 , G06Q10/10 , G16H15/00
摘要： Techniques for enabling real-time automated interpretation of clinical narratives are disclosed. The automated interpretation can be achieved by translating narrative text into a clinical terminology-encoded structural representation such as the Systemized Nomenclature of Medicine-Clinical Terms (SNOMED-CT) example of such a clinical terminology. The translation process enables the generation of both pre-coordinated and post-coordinated SNOMED CT concept expressions.
摘要翻译：公开了实现临床叙述实时自动解释的技术。可以通过将叙事文本翻译成临床术语编码的结构表示来实现自动解释，例如这种临床术语的系统命名的医学术语 - 临床术语（SNOMED-CT）示例。翻译过程能够生成预协调和后协调的SNOMED CT概念表达式。

39. 发明申请

US20120216268A1 IDENTITY ASSERTION FRAMEWORK 有权
标题翻译：身份认证框架
公开(公告)号：US20120216268A1
公开(公告)日：2012-08-23
申请号：US13029871
申请日：2011-02-17
申请人： Farhang Kassaei , Neeti Deshmukh , Peter Johnson , Franco Travostino , Sachin Khanna , Anand Bahety , Benoy Antony
发明人： Farhang Kassaei , Neeti Deshmukh , Peter Johnson , Franco Travostino , Sachin Khanna , Anand Bahety , Benoy Antony
IPC分类号： H04L9/32
CPC分类号： H04L9/3234 , G06F21/335 , H04L63/20
摘要： Systems and methods for implementing an identity assertion framework to authenticate a user in a federation of security domains are provided. A first security token service (STS) is configured to receive a request for a first token from a consumer and to issue the first token to the consumer. The first STS is associated with a first security domain, and the first token is issued according to a first issuing policy of the first security domain. A service provider within a second security domain receives the first token and makes a determination whether the first token is invalid in the second security domain. A second STS receives the first token from the service provider, determines that the first token was issued by the first STS, and validates the first token according to a federation policy between the first security domain and the second security domain.
摘要翻译：提供了用于实现身份断言框架以验证安全域的联合中的用户的系统和方法。第一安全令牌服务（STS）被配置为从消费者接收对第一令牌的请求，并向消费者发出第一令牌。第一STS与第一安全域相关联，并且根据第一安全域的第一发布策略发出第一令牌。第二安全域内的服务提供商接收第一令牌并确定第二安全域中的第一令牌是否无效。第二个STS从服务提供商接收第一令牌，确定第一个令牌是由第一个STS发出的，并根据第一个安全域和第二个安全域之间的联盟策略来验证第一个令牌。

40. 发明授权

US08205324B2 Method of fabricating an inductor structure 有权
标题翻译：制造电感器结构的方法
公开(公告)号：US08205324B2
公开(公告)日：2012-06-26
申请号：US12275599
申请日：2008-11-21
申请人： Peter Smeys , Peter Johnson , Andrei Papou
发明人： Peter Smeys , Peter Johnson , Andrei Papou
IPC分类号： H01F3/00 , H01F41/02
CPC分类号： H01F17/0006 , H01F41/046 , H01F2017/0066 , H01L23/5227 , H01L2924/0002 , Y10T29/49005 , Y10T29/4902 , Y10T29/49069 , Y10T29/49071 , Y10T29/49073 , Y10T29/49144 , H01L2924/00
摘要： A damascene process is utilized to fabricate the segmented magnetic core elements of an integrated circuit inductor structure. The magnetic core is electroplated from a seed layer that is conformal with a permanent dielectric mold that results in sidewall plating defining an easy magnetic axis. The hard axis runs parallel to the longitudinal axis of the core and the inductor coils are orthogonal to the core's longitudinal axis. The magnetic field generated by the inductor coils is, therefore, parallel and self-aligned to the hard magnetic axis. The easy axis is enhanced by electroplating in an applied magnetic field parallel to the easy axis.
摘要翻译：利用镶嵌工艺来制造集成电路电感器结构的分段磁芯元件。磁芯从与保持永久介电模具的种子层电镀，导致侧壁镀层限定易磁轴。硬轴平行于芯的纵轴延伸，并且电感线圈与芯的纵向轴线正交。因此，由电感线圈产生的磁场与硬磁轴平行和自对准。通过在平行于容易轴的施加磁场中电镀来增强易轴。

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