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31. 发明申请

US20090143852A1 STORAGE AND LOADING SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：可植入医疗器械的储存和装载系统
公开(公告)号：US20090143852A1
公开(公告)日：2009-06-04
申请号：US12328273
申请日：2008-12-04
申请人： Sean D. Chambers , Ram H. Paul
发明人： Sean D. Chambers , Ram H. Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/0095 , A61F2/2427 , A61F2/95 , A61F2002/9522 , A61F2002/9528
摘要： Storage and loading systems for expandable intraluminal medical devices are described. The systems include a container that defines an opening that tapers from a relatively large first diameter to a relatively small second diameter. A neck region includes structure adapted to engage an outer sheath of a delivery system such that an intraluminal medical device within the chamber of the container can be advanced through the tapered opening to effect compression of the intraluminal medical device and, ultimately, loading of the device into the delivery system. Methods of preparing and intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了可扩展管腔内医疗器械的储存和装载系统。该系统包括限定从相对大的第一直径逐渐变细到相对小的第二直径的开口的容器。颈部区域包括适于接合输送系统的外鞘的结构，使得容器腔室内的管腔内医疗装置可以推进通过锥形开口以实现腔内医疗装置的压缩，并且最终装载装置进入送货系统。还描述了用于植入患者的制备方法和管腔内医疗装置以及在这些方法中有用的试剂盒。

32. 发明申请

US20090138078A1 Remodelable Prosthetic Valve 有权
标题翻译：可重塑假肢瓣膜
公开(公告)号：US20090138078A1
公开(公告)日：2009-05-28
申请号：US12273284
申请日：2008-11-18
申请人： Ram H. Paul, JR. , Sean D. Chambers , Chad E. Johnson
发明人： Ram H. Paul, JR. , Sean D. Chambers , Chad E. Johnson
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2230/0026 , A61F2230/0095 , A61F2250/0031
摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.
摘要翻译：提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医疗装置的方法和使用医疗装置的治疗方法。医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料液体接触可重塑材料。医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

33. 发明公开

US20230248241A1 Medical Systems, Devices, and Kits Useful in Performing Treatment under Magnetic Resonance Imaging and Related Methods 审中-公开
公开(公告)号：US20230248241A1
公开(公告)日：2023-08-10
申请号：US18106601
申请日：2023-02-07
申请人： Eric D. Anttila , Grant M. Baker , Eric Brandner , Sean D. Chambers , Neal Fearnot , David C. Gross , Joshua F. Krieger , Ram H. Paul, JR. , Andrew J. Robison , Jesse Roll
发明人： Eric D. Anttila , Grant M. Baker , Eric Brandner , Sean D. Chambers , Neal Fearnot , David C. Gross , Joshua F. Krieger , Ram H. Paul, JR. , Andrew J. Robison , Jesse Roll
IPC分类号： A61B5/00 , A61B90/00 , A61B5/055 , A61B10/02
CPC分类号： A61B5/0036 , A61B5/055 , A61B10/0233 , A61B90/39 , A61B2090/3954
摘要： Example medical systems for performing treatment under magnetic resonance imaging and related devices, kits, and methods are described. An example medical system includes a first medical device, a second medical device, and a marker. The first medical device is formed of a first material. The first material has a first magnetic susceptibility. The second medical device is formed of a second material. The second material has a second magnetic susceptibility. The marker is disposed on the second medical device and is formed of a third material. The third material has a third magnetic susceptibility that is different than the first magnetic susceptibility and the second magnetic susceptibility.

34. 发明申请

US20120211120A1 IMPLANTABLE GRAFT DEVICE HAVING TREATED YARN AND METHOD FOR MAKING SAME 有权
标题翻译：具有处理纱线的可植入纱线装置及其制造方法
公开(公告)号：US20120211120A1
公开(公告)日：2012-08-23
申请号：US13457949
申请日：2012-04-27
申请人： Shyam SV Kuppurathanam , Sean D. Chambers , David P. Biggs , Scott E. Eells
发明人： Shyam SV Kuppurathanam , Sean D. Chambers , David P. Biggs , Scott E. Eells
IPC分类号： D03C13/00
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2250/0067 , Y10T29/49849
摘要： An implantable graft device having treated yarn is disclosed. The device comprises a graft body forming a lumen defining a longitudinal axis and comprising proximal and distal ends. The graft body comprises a woven fabric having warp yarns aligned in a first direction and a weft yarns aligned in a second direction. At least one of the weft yarns and the warp yarns has an agent applied thereto defining treated yarns of the graft body.
摘要翻译：公开了一种具有经处理的纱线的可植入移植装置。该装置包括形成限定纵向轴线并包括近端和远端的内腔的移植物主体。移植物主体包括具有沿第一方向排列的经纱和沿第二方向排列的纬纱的机织织物。纬纱和经纱中的至少一个具有施加到其上的试剂，其限定了移植物体的经处理的纱线。

35. 发明申请

US20120060348A1 TWO-STAGE METHOD OF COMPRESSING A STENT 有权
标题翻译：压缩方法的两阶段方法
公开(公告)号：US20120060348A1
公开(公告)日：2012-03-15
申请号：US13322091
申请日：2010-05-21
申请人： Sean D. Chambers , Mark A. Magnuson , Fred T. Parker
发明人： Sean D. Chambers , Mark A. Magnuson , Fred T. Parker
IPC分类号： B23P11/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9522 , Y10T29/49908
摘要： A two-stage method of compressing a stent entails providing an expandable stent (100,105) in a radially expanded state. An outward pressure is applied to an inner surface of the tubular framework to support the stent, and a diameter of the stent is reduced to a first compressed diameter (D1) while applying the outward pressure. The outward pressure is halted after reaching the first compressed diameter. According to an embodiment in which the stent is balloon-expandable, a delivery balloon catheter (130) comprising an uninflated balloon in a delivery configuration is inserted into the lumen after halting the outward pressure. The diameter of the stent is reduced to a second compressed diameter (D2) smaller than the first compressed diameter to crimp the stent onto the delivery balloon catheter.
摘要翻译：压缩支架的两级方法需要提供处于放大状态的可扩张支架（100,105）。向管状框架的内表面施加向外的压力以支撑支架，并且在施加向外的压力的同时将支架的直径减小到第一压缩直径（D1）。达到第一压缩直径后，向外的压力停止。根据其中支架是球囊可膨胀的实施例，包括具有输送构型的未膨胀气囊的输送气囊导管（130）在停止向外的压力之后插入腔内。支架的直径减小到小于第一压缩直径的第二压缩直径（D2），以将支架卷曲到输送球囊导管上。

36. 发明授权

US08109990B2 Low profile support frame and related intraluminal medical devices 有权
标题翻译：薄型支架和相关管腔内医疗器械
公开(公告)号：US08109990B2
公开(公告)日：2012-02-07
申请号：US12711915
申请日：2010-02-24
申请人： Ram H. Paul , Sean D. Chambers , Charles L. McIntosh , Charles W. Agnew
发明人： Ram H. Paul , Sean D. Chambers , Charles L. McIntosh , Charles W. Agnew
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/01 , A61F2/2412 , A61F2/2475 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2002/016 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0013 , A61F2230/0021 , A61F2230/0026
摘要： A low profile support frame for use as an or in an expandable intraluminal medical device includes first and second wire members that define arcuate paths having opposing curves. Connectors join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.
摘要翻译：用作可扩展管腔内医疗装置中的或在可扩展的管腔内医疗装置中的低调支撑框架包括限定具有相对曲线的弓形路径的第一和第二线构件。连接器连接线构件，倒钩可以设置在连接器上。支撑框架具有径向压缩和径向扩张的构造。当支撑框架处于径向展开构型时，支撑框架的基本上没有部分设置在与框架的一端相对的框架的第一横向轴线上，并且基本上没有框架的任何部分设置在框架的第二横向轴线上框架与框架的另一端相对。支撑框架可以作为管腔内医疗装置本身或作为包括其它部件（例如支架，假体瓣膜，封堵器或过滤器）的医疗装置中的部件使用。

37. 发明申请

US20110270177A1 Device for Treating Hardened Lesions 有权
标题翻译：治疗硬化病变的装置
公开(公告)号：US20110270177A1
公开(公告)日：2011-11-03
申请号：US13130420
申请日：2008-12-01
申请人： Sean D. Chambers , Steen Aggerholm , Joe Horn
发明人： Sean D. Chambers , Steen Aggerholm , Joe Horn
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61B17/320725 , A61B2017/00539 , A61B2017/00778 , A61B2017/22061 , A61M2025/0057 , A61M2025/1013 , A61M2025/105 , A61M2025/1061 , A61M2025/1086 , A61M2025/109
摘要： A balloon catheter is provided that may be used to dilate hardened regions of a stenosis on a vessel wall. The balloon catheter is provided with cutting elements that extend along a surface of a balloon. At least one bioactive is present, either on the cutting element, within the interior of the balloon, within the material of the balloon or on an outside surface of the balloon. The bioactive is delivered to the vessel wall upon dilation of the balloon.
摘要翻译：提供了可用于扩张血管壁上的狭窄硬化区域的球囊导管。气囊导管设置有沿气球表面延伸的切割元件。在切割元件上，在球囊的内部，气囊的材料内或气球的外表面上存在至少一种生物活性物质。气球膨胀后，生物活性物质被传送到血管壁。

38. 发明授权

US08034095B2 Intraluminal system for retrieving an implantable medical device 有权
标题翻译：用于检索可植入医疗器械的管腔内系统
公开(公告)号：US08034095B2
公开(公告)日：2011-10-11
申请号：US12201556
申请日：2008-08-29
申请人： James R. Randolph , Sean D. Chambers
发明人： James R. Randolph , Sean D. Chambers
IPC分类号： A61F2/06
CPC分类号： A61F2/962 , A61F2002/9528
摘要： An intraluminal system for retrieving an implantable medical device from a body vessel includes, according to one embodiment, a grasping component including at least one deployable arm, where a proximal end of the arm is configured to extend away from a longitudinal axis of the system when deployed, and a first sheath disposed adjacent to the grasping component, where the first sheath includes a radially expandable portion at a distal end thereof. A second sheath overlies the first sheath and the grasping component. Relative motion between the second sheath and the grasping component allows the proximal end of the deployable arm to be deployed for grasping a distal portion of an implantable medical device, and relative motion between the second sheath and the first sheath allows the expandable portion of the first sheath to radially expand to receive a proximal portion of the implantable medical device.
摘要翻译：根据一个实施例，一种用于从身体容器收回植入式医疗装置的管腔内系统包括：包括至少一个可展开臂的把持部件，其中臂的近端被构造为远离系统的纵向轴线延伸，以及与所述抓握部件相邻设置的第一护套，其中所述第一护套在其远端处包括径向可扩张部分。第二护套覆盖第一护套和抓握部件。第二护套和抓握部件之间的相对运动允许可展开臂的近端展开以夹持可植入医疗装置的远端部分，并且第二护套和第一护套之间的相对运动允许第一护套和第一护套的可扩张部分护套以径向扩张以接收可植入医疗装置的近端部分。

39. 发明授权

US07846199B2 Remodelable prosthetic valve 有权
标题翻译：可重塑假体瓣膜
公开(公告)号：US07846199B2
公开(公告)日：2010-12-07
申请号：US12273284
申请日：2008-11-18
申请人： Ram H. Paul, Jr. , Sean D. Chambers , Chad E. Johnson
发明人： Ram H. Paul, Jr. , Sean D. Chambers , Chad E. Johnson
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2230/0026 , A61F2230/0095 , A61F2250/0031
摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.
摘要翻译：提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医疗装置的方法和使用医疗装置的治疗方法。医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料液体接触可重塑材料。医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

40. 发明申请

US20100280586A1 MEDICAL DEVICE WITH TENSIONABLY ATTACHED REMODELABLE MATERIAL 有权
标题翻译：具有可张紧连接的可重复材料的医疗装置
公开(公告)号：US20100280586A1
公开(公告)日：2010-11-04
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, JR. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, JR. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodellable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当减弱的框架部分处于第一构造时，可重构材料限制框架从径向压缩构型到径向膨胀构型的膨胀。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

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