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31. 发明申请

US20060011548A1 Mobile phase gradient generation microfluidic device 有权
公开(公告)号：US20060011548A1
公开(公告)日：2006-01-19
申请号：US11224904
申请日：2005-09-12
申请人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
发明人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
IPC分类号： B01D15/08
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/285
摘要： The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

32. 发明申请

US20100193702A1 TANDEM IONIZER ION SOURCE FOR MASS SPECTROMETER AND METHOD OF USE 有权
标题翻译：用于质谱仪的串联离子源和使用方法
公开(公告)号：US20100193702A1
公开(公告)日：2010-08-05
申请号：US12363685
申请日：2009-01-30
申请人： Gangqiang Li , Hongfeng Yin
发明人： Gangqiang Li , Hongfeng Yin
IPC分类号： H01J27/02 , H01J49/04 , H01J49/10 , H01J49/14 , H01J27/20
CPC分类号： H01J49/107 , H01J49/165
摘要： An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.
摘要翻译：离子源，第一离子发生器，包括：电喷针，包括尖端; 以及围绕所述针环设置的导管，其被配置成使所述尖端附近的惰性气体通过，以使从所述尖端出来的流体雾化，所述雾化流体包含分析物和流动相。离子源包括与第一离子发生器串联的毛细管并且构造成接收液滴; 加热器，被配置为将毛细管加热至流动相蒸发的温度; 以及第二离子发生器，其与所述毛细管串联并且被配置为接收蒸发的流动相和所述分析物。还描述了一种方法。

33. 发明申请

US20070260624A1 Incremental update of long-term and short-term user profile scores in a behavioral targeting system 有权
标题翻译：在行为定位系统中增加长期和短期用户配置文件分数
公开(公告)号：US20070260624A1
公开(公告)日：2007-11-08
申请号：US11394358
申请日：2006-03-29
申请人： Christina Chung , Abhinav Gupta , Joshua Koran , Long-Ji Lin , Hongfeng Yin
发明人： Christina Chung , Abhinav Gupta , Joshua Koran , Long-Ji Lin , Hongfeng Yin
IPC分类号： G06F7/00
CPC分类号： G06Q30/02
摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.
摘要翻译：行为定位系统从在线活动确定用户个人资料。该系统包括多个模型，其定义用于确定用户简档分数的参数。事件信息，包括用户的在线活动，在一个实体被接收。要生成用户配置文件分数，选择一个模型。该模型包括近似度，强度和频率尺寸参数。行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。应用来自模型的参数以在类别中生成用户简档分数。行为定位系统具有在在线用户的广告投放中使用的应用。

34. 发明申请

US20070239535A1 Behavioral targeting system that generates user profiles for target objectives 有权
标题翻译：为目标目标生成用户配置文件的行为定位系统
公开(公告)号：US20070239535A1
公开(公告)日：2007-10-11
申请号：US11394332
申请日：2006-03-29
申请人： Joshua Koran , Christina Chung , Long-Ji Lin , Hongfeng Yin
发明人： Joshua Koran , Christina Chung , Long-Ji Lin , Hongfeng Yin
IPC分类号： G06Q30/00
CPC分类号： G06F17/30528 , G06F17/30294 , G06F17/30587 , G06F17/30876 , G06Q30/02 , G06Q30/0224 , G06Q30/0251
摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.
摘要翻译：行为定位系统从在线活动确定用户个人资料。该系统包括多个模型，其定义用于确定用户简档分数的参数。事件信息，包括用户的在线活动，在一个实体被接收。要生成用户配置文件分数，选择一个模型。该模型包括近似度，强度和频率尺寸参数。行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。应用来自模型的参数以在类别中生成用户简档分数。行为定位系统具有在在线用户的广告投放中使用的应用。

35. 发明授权

US07060975B2 Electrospray devices for mass spectrometry 有权
标题翻译：用于质谱的电喷雾装置
公开(公告)号：US07060975B2
公开(公告)日：2006-06-13
申请号：US10982189
申请日：2004-11-05
申请人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
发明人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
IPC分类号： H01J49/10
CPC分类号： H01J49/165
摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion. The hydrophobic coating is electrically nonconductive.
摘要翻译：描述了用于质谱系统的电喷雾装置。电喷雾装置包括主体部分和从主体部分延伸的尖端部分。尖端部分包括聚合材料。电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。疏水涂层是不导电的。

36. 发明授权

US06610978B2 Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry 有权
公开(公告)号：US06610978B2
公开(公告)日：2003-08-26
申请号：US09820321
申请日：2001-03-27
申请人： Hongfeng Yin , Thomas P. Doherty , Sally A Swedberg
发明人： Hongfeng Yin , Thomas P. Doherty , Sally A Swedberg
IPC分类号： H01J4900
CPC分类号： H01J49/045 , H01J49/0018 , H01J49/105
摘要： The present invention relates to microdevices for introducing a small volume of a fluid sample into an ionization chamber. The microdevices are constructed from a substrate having a first and second opposing surfaces, the substrate having a microchannel formed in the first surface, and a cover plate arranged over the first surface, the cover plate in combination with the microchannel defining a conduit for conveying the sample. A sample inlet port is provided in fluid communication with the microchannel, wherein the sample inlet port allows the fluid sample from an external source to be conveyed in a defined sample flow path that travels, in order, through the sample inlet port, the conduit and a sample outlet port and into the ionization chamber. Optionally, the fluid sample undergoes a chemical or biochemical reaction within an integrated portion of the microdevice before reaching the ionization chamber. A nebulizing means nebulizes the fluid sample in a nebulizing region adjacent to the sample outlet port. The invention also relates to a method for introducing a fluid sample using the microdevice.

37. 发明授权

US5658446A Preparative capillary electrophoresis with wide-bore capillary 失效
标题翻译：具有宽孔毛细管的制备性毛细管电泳
公开(公告)号：US5658446A
公开(公告)日：1997-08-19
申请号：US688351
申请日：1996-07-30
申请人： Hongfeng Yin , Douglass McManigill , Catherine A. Keely-Templin , Robert R. Holloway
发明人： Hongfeng Yin , Douglass McManigill , Catherine A. Keely-Templin , Robert R. Holloway
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44704
摘要： A wide-bore capillary electrophoresis apparatus for the analysis of analyte ions is provided. The apparatus has a wide-bore capillary that has a restriction zone at one or more ends. The capillary has an inlet end and an outlet end and an opening at each of said ends. The restriction zone is capable of providing fluid communication between the wide bore and the opening at said end. The restriction zone includes a narrow bore extending to the opening and a transition zone providing gradual change of bore diameter from the wide bore to the narrow bore. The apparatus further has a buffer source to supply buffer to the inlet end of the capillary and a power supply for supplying power to drive buffer and analyte ions through the capillary. During CE, electrodes provide electrical communication between the power supply and the inlet end and the outlet end and apply a voltage differential between said ends.
摘要翻译：提供了一种用于分析离子的分析的宽孔毛细管电泳装置。该装置具有在一个或多个端部处具有限制区的宽孔毛细管。毛细管具有入口端和出口端以及在每个端部处的开口。限制区域能够在所述端部的宽孔和开口之间提供流体连通。限制区域包括延伸到开口的窄孔和过渡区，其提供从宽孔到窄孔的孔直径的逐渐变化。该装置还具有缓冲源，以向毛细管的入口端供应缓冲器，以及用于通过毛细管向驱动缓冲器和分析物离子供电的电源。在CE期间，电极在电源与入口端和出口端之间提供电气连通，并在所述端部之间施加电压差。

38. 发明授权

US08438170B2 Behavioral targeting system that generates user profiles for target objectives 有权
公开(公告)号：US08438170B2
公开(公告)日：2013-05-07
申请号：US11394332
申请日：2006-03-29
申请人： Joshua M. Koran , Christina Yip Chung , Long-Ji Lin , Hongfeng Yin
发明人： Joshua M. Koran , Christina Yip Chung , Long-Ji Lin , Hongfeng Yin
IPC分类号： G06F17/30
CPC分类号： G06F17/30528 , G06F17/30294 , G06F17/30587 , G06F17/30876 , G06Q30/02 , G06Q30/0224 , G06Q30/0251
摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.

39. 发明授权

US07483891B2 Content presentation and management system associating base content and relevant additional content 有权
标题翻译：内容演示和管理系统将基础内容和相关附加内容相关联
公开(公告)号：US07483891B2
公开(公告)日：2009-01-27
申请号：US10829814
申请日：2004-04-21
申请人： Hongche Liu , Anand Madhavan , Majid Mohazzab , Hongfeng Yin , Eric Leu
发明人： Hongche Liu , Anand Madhavan , Majid Mohazzab , Hongfeng Yin , Eric Leu
IPC分类号： G06F17/30
CPC分类号： G06F17/30648 , G06F17/30864 , Y10S707/99935 , Y10S707/99936 , Y10S707/99937
摘要： A system for determining associations between base content and relevant content and for publishing the base content and relevant content on a client browser. The system includes a parsing module configured to parse the base content to form parsed base content; a unit-dictionary module including a plurality of query units; a unit-extraction module configured to extract query units included in the unit dictionary from the parsed base content, wherein the query units extracted from the base content are referred to as the extracted-query units; a unit-ranking module configured to rank the extracted-query units based on at least one of relevance scores and revenue-generation amounts for the query units; and a unit-matching module configured to generate at least one association between the base content and the relevant content based on whether the extracted-query units and at least one of query units and keywords associated with the relevant content are the same.
摘要翻译：一种用于确定基础内容和相关内容之间的关联以及用于在客户端浏览器上发布基础内容和相关内容的系统。所述系统包括解析模块，所述解析模块被配置为解析所述基本内容以形成解析的基本内容; 包括多个查询单元的单位字典模块; 单元提取模块，被配置为从解析的基本内容中提取包含在单元字典中的查询单元，其中从基本内容中提取的查询单元被称为提取查询单元; 单元分级模块，被配置为基于所述查询单元的相关性分数和收入生成量中的至少一个来对提取的查询单元进行排名; 以及单元匹配模块，被配置为基于所提取的查询单元以及与相关内容相关联的查询单元和关键字中的至少一个是相同的，来生成基本内容和相关内容之间的至少一个关联。

40. 发明申请

US20080142479A1 MICROMACHINED TITANIUM FOR HIGH PRESSURE MICROFLUIDIC APPLICATIONS 有权
标题翻译：用于高压微流控应用的微孔板
公开(公告)号：US20080142479A1
公开(公告)日：2008-06-19
申请号：US11554537
申请日：2006-10-30
申请人： Timothy Beerling , Hongfeng Yin
发明人： Timothy Beerling , Hongfeng Yin
IPC分类号： C03C25/68 , C23F1/00 , B44C1/22
CPC分类号： B81C1/00063 , B01L3/5027 , B81B2201/058 , B81C2201/0132 , G01N30/6095
摘要： In accordance with the invention, a method for making microfluidic structures in bulk titanium is disclosed. Specific microfluidic structures include HPLC structures.
摘要翻译：根据本发明，公开了一种在体积钛中制造微流体结构的方法。特定的微流体结构包括HPLC结构。

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