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31. 发明申请

US20060153921A1 Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions 有权
标题翻译：从超临界流体或压缩气体乳液制备颗粒的方法
公开(公告)号：US20060153921A1
公开(公告)日：2006-07-13
申请号：US10534665
申请日：2004-06-02
申请人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
发明人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
IPC分类号： A61K48/00 , A61K39/12 , A61K9/14 , A61K36/18 , B29B9/02
CPC分类号： A61K48/00 , A61K9/1605 , A61K9/19 , B01J2/04
摘要： The present invention provides a method of producing particles from solution-in-supercritical fluid or compressed gas emulsions. In accordance with the method of the invention, a solution that includes a solute dissolved in a solvent is contacted with supercritical fluid or compressed gas to form a solution-in-super critical fluid or compressed gas emulsion. The emulsion is sprayed through an orifice to create spray droplets. The supercritical fluid or compressed gas and the solvent are removed from the spray droplets resulting in the formation of particles that include the solute. In one embodiment of the invention, the solvent is removed from the spray droplets by lyophilization. In another embodiment of the invention, the solvent is removed from the spray droplets by evaporation.
摘要翻译：本发明提供了一种从超临界流体或压缩气体乳液中制备颗粒的方法。根据本发明的方法，将包含溶解在溶剂中的溶质的溶液与超临界流体或压缩气体接触以形成超临界流体或压缩气体乳液。通过孔喷雾乳液以产生喷雾液滴。从喷雾液滴中除去超临界流体或压缩气体和溶剂，导致形成包括溶质的颗粒。在本发明的一个实施方案中，通过冷冻干燥从喷雾液滴中除去溶剂。在本发明的另一个实施方案中，通过蒸发从喷雾液滴中除去溶剂。

32. 发明申请

US20060138687A1 Method of forming particles 有权
标题翻译：形成颗粒的方法
公开(公告)号：US20060138687A1
公开(公告)日：2006-06-29
申请号：US10536330
申请日：2004-10-15
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： B29B9/00 , A61K9/16
CPC分类号： A61K9/14 , A61K9/1688 , B01J2/04 , B01J2/06
摘要： The present invention provides a method of forming particles that involves contacting a solution, which includes a solute and/or other material to be precipitated dissolved or dispersed in a solvent, with a first compressed or liquefied gas at an initial temperature to form a mixture. The mixture is then expanded at a first temperature to form droplets. Depending upon the composition of the droplets and the first temperature, the droplets may be in a solid state or a liquid state. The droplets are then contacted with an extracting fluid at a second temperature to extract the solvent from the droplets. The method can be used to produce micro and nanoparticles suitable for various drug delivery systems.
摘要翻译：本发明提供一种形成颗粒的方法，该方法包括使初始温度下与第一压缩或液化气体接触的溶液（包括溶解或分散在溶剂中的溶质或其他物质）溶液形成混合物。然后将混合物在第一温度下膨胀以形成液滴。根据液滴的组成和第一温度，液滴可以是固体状态或液体状态。然后在第二温度下使液滴与萃取液接触以从液滴中提取溶剂。该方法可用于生产适用于各种药物递送系统的微型和纳米颗粒。

33. 发明申请

US20050082701A1 Method and apparatus for enhanced size reduction of particles using supercritical fluid liquefaction of materials 有权
标题翻译：使用超临界流体物质液化来增强颗粒尺寸减小的方法和装置
公开(公告)号：US20050082701A1
公开(公告)日：2005-04-21
申请号：US10932559
申请日：2004-09-02
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： B01D11/00 , B01D11/04 , B01F20060101 , B29B9/00 , B65D1/00 , B65D85/48 , H01L20060101 , H05B6/00
CPC分类号： B01J2/02 , A61K9/1647 , A61K9/1694 , B01D11/0411
摘要： The present invention provides a method and an apparatus for forming particles using supercritical fluid. The method includes the steps of mixing a load material with a first flow of a supercritical fluid in a first mixing chamber having a primary mixing device disposed therein to form a melt, transferring the melt from the first mixing chamber to a second mixing chamber having a secondary mixing device disposed therein, mixing the melt with a second flow of the supercritical fluid in the second mixing chamber to form a lower viscosity melt, expanding the lower viscosity melt across a pressure drop into an expansion chamber that is at a pressure below the critical pressure of the supercritical fluid to convert the supercritical fluid to a gas and thereby precipitate the load material in the form of particles.
摘要翻译：本发明提供使用超临界流体形成颗粒的方法和装置。该方法包括以下步骤：在第一混合室中混合负载材料与超临界流体的第一流，其中设置有初级混合装置以形成熔体，将熔体从第一混合室转移到具有二次混合装置设置在其中，将熔体与第二混合室中的超临界流体的第二流混合，以形成较低粘度的熔体，将较低粘度的熔体在压降范围内膨胀到膨胀室内，该膨胀室的压力低于临界值超临界流体的压力将超临界流体转化为气体，从而使负载材料以颗粒的形式沉淀。

34. 发明申请

US20070158266A1 Method And Apparatus For Producing Particles Via Supercritical Fluid Processing 审中-公开
标题翻译：通过超临界流体处理生产颗粒的方法和装置
公开(公告)号：US20070158266A1
公开(公告)日：2007-07-12
申请号：US11687266
申请日：2007-03-16
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： B01D11/04
CPC分类号： B01J2/04 , A61K9/1688 , B01D11/0411 , B01F7/008 , B01F7/00908 , B01F2003/0064
摘要： An apparatus and method for producing particles using supercritical fluid with enhanced mixing. The process includes a vessel having an inner surface defining a chamber. A high-speed shear or turbulent mixer is incorporated inside the vessel in order to create a region of enhanced mixing (mixing zone). A supercritical fluid pump communicates with the first inlet, and supplies supercritical fluid into the mixing zone through the first inlet. A solution pump communicates with the second inlet, and supplies solution into the mixing zone through the second inlet. A mixer assembly includes a motor drive and a rotor. The rotor is in the mixing zone and can mix the solution and the supercritical fluid. Particles are produced when the solution and the supercritical fluid are pumped into the mixing zone while the rotor is mixing. The design of the mixer and the direction of the flow of materials into the chamber creates a plug flow in the mixing zone. The plug flow allows the particles to be removed from the mixing zone as soon as they are precipitated. Because of the high intensity homogeneous mixing and plug flow configuration, the particle uniformity is enhanced and production of composite particles facilitated.
摘要翻译：一种使用超临界流体加强混合生产颗粒的装置和方法。该方法包括具有限定室的内表面的容器。将高速剪切或湍流混合器并入容器内，以产生增强混合区域（混合区）。超临界流体泵与第一入口连通，并通过第一入口将超临界流体供应到混合区。溶液泵与第二入口连通，并通过第二入口将溶液供入混合区。混合器组件包括马达驱动器和转子。转子处于混合区，可以混合溶液和超临界流体。当溶液和超临界流体在转子混合时泵送到混合区域时产生颗粒。混合器的设计和材料流入腔室的方向在混合区域中产生塞子流。插塞流允许颗粒在沉淀时立即从混合区移除。由于高强度均匀混合和活塞流动配置，颗粒均匀性得到提高，并且复合颗粒的生产有助于。

35. 发明申请

US20060145375A1 Method and apparatus for supercritical fluid assisted particle production 有权
标题翻译：用于超临界流体辅助颗粒生产的方法和装置
公开(公告)号：US20060145375A1
公开(公告)日：2006-07-06
申请号：US10541292
申请日：2004-01-30
申请人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
发明人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
IPC分类号： A61K9/14 , B29B9/00
CPC分类号： C08J3/16 , A61K9/145 , A61K9/1617 , A61K9/1694 , B01F3/0807 , B01F7/22 , B01F2003/0064 , B01J2/04 , C08J3/02 , C08J2391/00 , Y02P20/544
摘要： The present invention provides an apparatus and methods of producing particles that include a polymer, a wax and/or lipid and, optionally, a biologically active substance. In accordance with the methods of the invention, a load stock including a polymer, a wax and/or a lipid that is a solid at standard temperature and pressure and, optionally, a biologically active substance is provided. The load stock is contacted with a supercritical fluid to form a melt. The melt is contacted with a polar solvent under suitable conditions to form an emulsion. The emulsion is expanded across a pressure drop to form solid particles that include the load stock. The methods and apparatus facilitate the production of very small particles that have a narrow particle size distribution.
摘要翻译：本发明提供了一种生产包括聚合物，蜡和/或脂质以及任选的生物活性物质的颗粒的装置和方法。根据本发明的方法，提供了包含聚合物，蜡和/或在标准温度和压力下为固体的脂质和任选的生物活性物质的负载储备。负载原料与超临界流体接触以形成熔体。在合适的条件下使熔体与极性溶剂接触以形成乳液。乳液在压降下膨胀以形成包括负载原料的固体颗粒。该方法和装置有助于生产具有窄粒度分布的非常小的颗粒。

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