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31. 发明授权

US07410763B2 Multiplex data collection and analysis in bioanalyte detection 有权
标题翻译：生物分析仪检测中的多重数据收集和分析
公开(公告)号：US07410763B2
公开(公告)日：2008-08-12
申请号：US11216112
申请日：2005-09-01
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a green spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（各自由唯一报道分子标记）与样品接触，并采用绿色光谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

32. 发明申请

US20090005260A1 MULTIPLEX DATA COLLECTION AND ANALYSIS IN BIOANALYTE DETECTION 有权
标题翻译：多元数据收集与分析在生物检测中的应用
公开(公告)号：US20090005260A1
公开(公告)日：2009-01-01
申请号：US12147440
申请日：2008-06-26
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： C40B30/04
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a single spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（每个由唯一报道分子标记）与样品接触，并采用单个谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

33. 发明授权

US08062841B2 Multiplex data collection and analysis in bioanalyte detection 有权
标题翻译：生物分析仪检测中的多重数据收集和分析
公开(公告)号：US08062841B2
公开(公告)日：2011-11-22
申请号：US12147440
申请日：2008-06-26
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/02 , C07H21/04 , C07K14/00
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a single spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（每个由唯一报道分子标记）与样品接触，并采用单个谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

34. 发明申请

US20050151126A1 Methods of producing carbon nanotubes using peptide or nucleic acid micropatterning 审中-公开
标题翻译：使用肽或核酸微图案生产碳纳米管的方法
公开(公告)号：US20050151126A1
公开(公告)日：2005-07-14
申请号：US10750141
申请日：2003-12-31
申请人： Mineo Yamakawa , Yeugang Zhang , Xing Su , Lei Sun , Andrew Berlin , Narayanan Sundararajan
发明人： Mineo Yamakawa , Yeugang Zhang , Xing Su , Lei Sun , Andrew Berlin , Narayanan Sundararajan
IPC分类号： C01B31/02 , D01F9/127 , H01L51/00 , H01L51/30 , D01F9/12 , H01L29/06
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles 140, 230 to polymer 120, 210 molecules, attaching the polymer 120, 210 molecules to a substrate, removing the polymer 120, 210 molecules and producing carbon nanotubes on the catalyst nanoparticles 140, 230. The polymer 120, 210 molecules can be attached to the substrate in ordered patterns, using self-assembly or molecular alignment techniques. The nanotube arrays can be attached to selected areas 110, 310 of the substrate. Within the selected areas 110, 310, the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒140,230连接到聚合物120,210分子，将聚合物120,210分子连接到基底上的方法形成，除去聚合物120,210分子并产生碳催化剂纳米颗粒140,230上的纳米管。聚合物120,210分子可以使用自组装或分子对准技术以有序图案附着到基底上。纳米管阵列可以附着到基板的选定区域110,310。在所选择的区域110,310内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

35. 发明申请

US20100240870A1 Composite organic-inorganic nanoclusters 审中-公开
标题翻译：复合有机 - 无机纳米团簇
公开(公告)号：US20100240870A1
公开(公告)日：2010-09-23
申请号：US12658414
申请日：2010-02-10
申请人： Xing Su , Jingwu Zhang , Lei Sun , Andrew A. Berlin
发明人： Xing Su , Jingwu Zhang , Lei Sun , Andrew A. Berlin
IPC分类号： C07K14/765 , C07F1/10 , C07F15/00 , C07F5/06 , C07F1/12 , C07F1/08 , C07K16/00 , C07K14/00 , C07H21/00 , C07H23/00
CPC分类号： G01N33/54346 , G01N21/658
摘要： Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.
摘要翻译：提供了复合有机 - 无机纳米团簇（COINs），当激光激发时产生表面增强拉曼信号（SERS）。纳米团簇包括金属颗粒和拉曼活性有机化合物。实现合适的SERS信号所需的金属在纳米簇中是固有的，并且可以将多种拉曼活性有机化合物及其组合掺入纳米团簇中。此外，还提供了含有纳米簇的聚合物微球及其制备方法。纳米团簇和微球可用于例如用于多重检测生物分子的测定中。

36. 发明授权

US07656523B2 Multiplexed raman detection with filter set 有权
标题翻译：多路复用拉曼检测与滤波器组
公开(公告)号：US07656523B2
公开(公告)日：2010-02-02
申请号：US11477379
申请日：2006-06-30
申请人： Lei Sun , Tae-Woong Koo , Liming Wang
发明人： Lei Sun , Tae-Woong Koo , Liming Wang
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01J3/36 , G01J3/44
摘要： A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.
摘要翻译：利用多个光电倍增管（PMT）或与一组滤波器耦合的光电二极管以从样品收集拉曼信号的装置（以及使用和制造该装置的方法）。检测拉曼信号的方法还包括利用多个光电倍增管（PMT）或光电二极管从样品接收拉曼信号，其中至少一个PMT或光电二极管提供与至少一个其它PMT或光电二极管不同的拉曼信号。

37. 发明申请

US20080002198A1 Multiplexed Raman detection with filter set 有权
标题翻译：滤波器组复用拉曼检测
公开(公告)号：US20080002198A1
公开(公告)日：2008-01-03
申请号：US11477379
申请日：2006-06-30
申请人： Lei Sun , Tae Woong Koo , Liming Wang
发明人： Lei Sun , Tae Woong Koo , Liming Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01J3/36 , G01J3/44
摘要： A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.
摘要翻译：利用多个光电倍增管（PMT）或与一组滤波器耦合的光电二极管以从样品收集拉曼信号的装置（以及使用和制造该装置的方法）。检测拉曼信号的方法还包括利用多个光电倍增管（PMT）或光电二极管从样品接收拉曼信号，其中至少一个PMT或光电二极管提供与至少一个其它PMT或光电二极管不同的拉曼信号。

38. 发明申请

US20080241569A1 ENCAPSULATION OF RAMAN ACTIVE NANOPARTICLES 审中-公开
标题翻译：拉曼活性纳米颗粒的包封
公开(公告)号：US20080241569A1
公开(公告)日：2008-10-02
申请号：US11694293
申请日：2007-03-30
申请人： Haoyu Qin , Jingwu Zhang , Claire E. Dentinger , Lei Sun , Xing Su
发明人： Haoyu Qin , Jingwu Zhang , Claire E. Dentinger , Lei Sun , Xing Su
IPC分类号： B32B5/16
CPC分类号： G01N21/658 , B82Y15/00 , B82Y30/00 , Y10T428/12028 , Y10T428/2991
摘要： Embodiments of the present invention provide methods for coating nanoparticles with polymeric coatings and nanoparticles that are coated with polymeric coatings. The polymeric coatings typically comprise two or more layers wherein the first layer has a charge that is opposite to that of the second layer. In further embodiments, the nanoparticles that can act as labels or reporters are coated with polymeric coatings. Optionally, these reporter or label nanoparticles may be Raman-active, such that they provide a distinctive Raman signature upon excitation with electromagnetic radiation.
摘要翻译：本发明的实施方案提供了用聚合物涂层和纳米颗粒涂覆聚合物涂层的方法。聚合物涂层通常包含两层或更多层，其中第一层具有与第二层相反的电荷。在另外的实施方案中，可以用作标记或报告物的纳米颗粒涂覆有聚合物涂层。任选地，这些报告物或标记纳米颗粒可以是拉曼活性的，使得它们在用电磁辐射激发时提供独特的拉曼特征。

39. 发明申请

US20090303461A1 DETECTION OF ENHANCED MULTIPLEX SIGNALS BY SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) 审中-公开
标题翻译：通过表面增强拉曼光谱法检测增强多重信号（SERS）
公开(公告)号：US20090303461A1
公开(公告)日：2009-12-10
申请号：US12359503
申请日：2009-01-26
申请人： Lei Sun , Xing Su
发明人： Lei Sun , Xing Su
IPC分类号： G01N1/44 , G01N21/65 , C07H21/02 , C07H21/04 , C07K14/00 , C07K16/00 , C07H1/00
CPC分类号： G01N21/658 , G01N33/54306
摘要： Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the nucleic acid and/or protein-containing analytes in a body fluid are provided.
摘要翻译：提供了使用拉曼活性或SERS-活性探针构建体检测生物样品中的分析物的各种方法，例如体液中的核酸和/或蛋白质分析物。

40. 发明申请

US20090023135A1 DETECTION OF ENHANCED MULTIPLEX SIGNALS BY SURFACE ENHANCED RAMAN SPECTROSCOPY 有权
标题翻译：通过表面增强拉曼光谱检测增强多重信号
公开(公告)号：US20090023135A1
公开(公告)日：2009-01-22
申请号：US11016613
申请日：2004-12-17
申请人： Lei Sun , Xing Su
发明人： Lei Sun , Xing Su
IPC分类号： C12Q1/68 , G01N33/573 , G01N33/551
CPC分类号： G01N21/658 , G01N33/54306
摘要： Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the nucleic acid and/or protein-containing analytes in a body fluid are provided.
摘要翻译：提供了使用拉曼活性或SERS-活性探针构建体检测生物样品中的分析物的各种方法，例如体液中的核酸和/或蛋白质分析物。

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