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1. 发明授权

US07656523B2 Multiplexed raman detection with filter set 有权
标题翻译：多路复用拉曼检测与滤波器组
公开(公告)号：US07656523B2
公开(公告)日：2010-02-02
申请号：US11477379
申请日：2006-06-30
申请人： Lei Sun , Tae-Woong Koo , Liming Wang
发明人： Lei Sun , Tae-Woong Koo , Liming Wang
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01J3/36 , G01J3/44
摘要： A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.
摘要翻译：利用多个光电倍增管（PMT）或与一组滤波器耦合的光电二极管以从样品收集拉曼信号的装置（以及使用和制造该装置的方法）。检测拉曼信号的方法还包括利用多个光电倍增管（PMT）或光电二极管从样品接收拉曼信号，其中至少一个PMT或光电二极管提供与至少一个其它PMT或光电二极管不同的拉曼信号。

2. 发明申请

US20080002198A1 Multiplexed Raman detection with filter set 有权
标题翻译：滤波器组复用拉曼检测
公开(公告)号：US20080002198A1
公开(公告)日：2008-01-03
申请号：US11477379
申请日：2006-06-30
申请人： Lei Sun , Tae Woong Koo , Liming Wang
发明人： Lei Sun , Tae Woong Koo , Liming Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01J3/36 , G01J3/44
摘要： A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.
摘要翻译：利用多个光电倍增管（PMT）或与一组滤波器耦合的光电二极管以从样品收集拉曼信号的装置（以及使用和制造该装置的方法）。检测拉曼信号的方法还包括利用多个光电倍增管（PMT）或光电二极管从样品接收拉曼信号，其中至少一个PMT或光电二极管提供与至少一个其它PMT或光电二极管不同的拉曼信号。

3. 发明授权

US07776547B2 Cellular analysis using Raman surface scanning 有权
标题翻译：使用拉曼表面扫描的细胞分析
公开(公告)号：US07776547B2
公开(公告)日：2010-08-17
申请号：US11027470
申请日：2004-12-30
申请人： Mark Roth , Andrew Berlin , Selena Chan , Tae-Woong Koo , Xing Su , Lei Sun
发明人： Mark Roth , Andrew Berlin , Selena Chan , Tae-Woong Koo , Xing Su , Lei Sun
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , G01N33/54373 , G01N33/58 , Y10T436/10
摘要： Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.
摘要翻译：提供了用于使用用复合有机 - 无机纳米颗粒（COIN）标记的探针和嵌入探针部分所连接的聚合物基质内的COIN的微球来测定可能为活细胞的细胞样品的方法和装置。 COIN在激光照射下固有地产生SERS信号，使得COIN标记的探针特别适用于多种测定细胞的方法，包括可能包含在细胞内或细胞内的生物分子，其中大部分不是固有的拉曼活性的。本发明提供使用特异性和简并结合的夹心免疫测定的变体，组织样品和细胞微结构的反相测定方法，溶液置换和竞争测定等。还提供了用于实施本发明测定的系统和芯片。

4. 发明授权

US07432113B2 Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 失效
公开(公告)号：US07432113B2
公开(公告)日：2008-10-07
申请号：US11134749
申请日：2005-05-19
申请人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
发明人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC分类号： G01N33/553
CPC分类号： G01N21/658
摘要： The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.

5. 发明申请

US20070054288A1 Programmable molecular barcodes 审中-公开
标题翻译：可编程分子条形码
公开(公告)号：US20070054288A1
公开(公告)日：2007-03-08
申请号：US11430612
申请日：2006-05-08
申请人： Xing Su , Tae-Woong Koo , Andrew Berlin , Lei Sun , Narayanan Sundararajan , Mineo Yamakawa
发明人： Xing Su , Tae-Woong Koo , Andrew Berlin , Lei Sun , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： C12Q1/68 , C12M1/34 , G06K7/10
CPC分类号： B82Y10/00 , B82Y5/00 , C12Q1/6816 , G06K19/06028 , C12Q2525/161 , C12Q2537/143 , C12Q2565/1025
摘要： The present disclosure concerns methods for producing and/or using molecular barcodes. In certain embodiments of the invention, the barcodes comprise polymer backbones that may contain one or more branch structures. Tags may be attached to the backbone and/or branch structures. The barcode may also comprise a probe that can bind to a target, such as proteins, nucleic acids and other biomolecules or aggregates. Different barcodes may be distinguished by the type and location of the tags. In other embodiments, barcodes may be produced by hybridization of one or more tagged oligonucleotides to a template, comprising a container section and a probe section. The tagged oligonucleotides may be designed as modular code sections, to form different barcodes specific for different targets. In alternative embodiments, barcodes may be prepared by polymerization of monomeric units. Bound barcodes may be detected by various imaging modalities, such as, surface plasmon resonance, fluorescent or Raman spectroscopy.
摘要翻译：本公开涉及用于生产和/或使用分子条形码的方法。在本发明的某些实施方案中，条形码包含可包含一个或多个分支结构的聚合物主链。标签可以附加到骨干和/或分支结构。条形码还可以包含可以与靶标结合的探针，例如蛋白质，核酸和其他生物分子或聚集体。可以通过标签的类型和位置区分不同的条形码。在其它实施方案中，条形码可以通过将一个或多个标记的寡核苷酸与包含容器部分和探针部分的模板杂交来产生。标记的寡核苷酸可以被设计为模块代码部分，以形成针对不同靶标的不同条形码。在替代实施例中，条形码可以通过单体单元的聚合来制备。可以通过各种成像方式，例如表面等离子体共振，荧光或拉曼光谱来检测结合条形码。

6. 发明申请

US20070048746A1 Multiplex data collection and analysis in bioanalyte detection 有权
标题翻译：生物分析仪检测中的多重数据收集和分析
公开(公告)号：US20070048746A1
公开(公告)日：2007-03-01
申请号：US11216112
申请日：2005-09-01
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a green spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（各自由唯一报道分子标记）与样品接触，并采用绿色光谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

7. 发明申请

US20060009914A1 Detection and identification of nucleic acid, peptide, and protein modifications 审中-公开
标题翻译：检测和鉴定核酸，肽和蛋白质修饰
公开(公告)号：US20060009914A1
公开(公告)日：2006-01-12
申请号：US10919699
申请日：2004-08-16
申请人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
发明人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6818 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modifications to nucleic acids, proteins, and peptides using SERS and Raman spectroscopy. Applications of embodiments of the present invention include proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.
摘要翻译：本发明的实施方案提供用于使用SERS和拉曼光谱检测，鉴定，区分和定量对核酸，蛋白质和肽的修饰的装置和方法。本发明实施方案的应用包括在疾病诊断，预后和药物功效研究，酶活性分析和测定中的应用的蛋白质组广泛修饰分析和分析。

8. 发明申请

US20050221506A1 Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 有权
公开(公告)号：US20050221506A1
公开(公告)日：2005-10-06
申请号：US10814695
申请日：2004-03-30
申请人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
发明人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC分类号： G01N21/65 , G01N33/553
CPC分类号： G01N21/658
摘要： The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.

9. 发明申请

US20080262989A1 MULTIPLEX DATA COLLECTION AND ANALYSIS IN BIOANALYTE DETECTION 审中-公开
标题翻译：多元数据收集与分析在生物检测中的应用
公开(公告)号：US20080262989A1
公开(公告)日：2008-10-23
申请号：US12147243
申请日：2008-06-26
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： G06F17/50
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a single spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（每个由唯一报道分子标记）与样品接触，并采用单个谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

10. 发明授权

US07410763B2 Multiplex data collection and analysis in bioanalyte detection 有权
标题翻译：生物分析仪检测中的多重数据收集和分析
公开(公告)号：US07410763B2
公开(公告)日：2008-08-12
申请号：US11216112
申请日：2005-09-01
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a green spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（各自由唯一报道分子标记）与样品接触，并采用绿色光谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

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