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    • 37. 发明申请
    • Ultrasound-enhanced stenosis therapy
    • 超声增强狭窄治疗
    • US20110237982A1
    • 2011-09-29
    • US13134470
    • 2011-06-08
    • Michael P. Wallace
    • Michael P. Wallace
    • A61N7/00
    • A61B17/22012A61B17/2202A61B2017/22014A61B2017/22082A61B2017/22088A61B2018/00029
    • Apparatus and methods are disclosed for vein and arterial-venous fistulas stenosis and occlusion therapies, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the vessel wall. Ultrasound energy may be delivered at frequencies less than 10 MHz and power less than 20 watts using transcutaneous techniques and endovascular methods. Therapeutic agents may be delivered to the treatment area via intravenous and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices. In some other embodiments, a therapeutic agent may be removed from the body after exposure to the vessel wall to minimize a systemic effect of the therapeutic drug.
    • 公开了用于静脉和动脉 - 静脉瘘狭窄和闭塞治疗的装置和方法,包括使用超声能量增强血管壁的渗透性并将治疗剂递送到血管壁中。 超声能量可以使用经皮技术和血管内方法在小于10MHz的频率和功率小于20瓦的情况下递送。 治疗剂可通过静脉内和血管内途径递送至治疗区域。 在一些实施例中,超声能量和治疗剂应用可以与血管成形术技术和血液流动保护装置组合。 在一些其它实施方案中,治疗剂可以在暴露于血管壁之后从体内除去,以使治疗药物的全身效应最小化。