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31. 发明授权

US08060184B2 Method of navigating medical devices in the presence of radiopaque material 有权
标题翻译：在不透射线材料存在下导航医疗器械的方法
公开(公告)号：US08060184B2
公开(公告)日：2011-11-15
申请号：US11781236
申请日：2007-07-20
申请人： Roger N. Hastings , Steven J. Ferry , Demetrius K. Lopes
发明人： Roger N. Hastings , Steven J. Ferry , Demetrius K. Lopes
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/062 , A61B6/12
摘要： A method of navigating the distal end of a medical device through an operating region in a subject's body includes displaying an x-ray image of the operating region, including the distal end of the medical device; determining the location of the distal end of the medical device in a reference frame translatable to the displayed x-ray image; and displaying an enhanced indication of the distal end of the medical device on the x-ray image to facilitate the navigation of the distal end of the device in the operating region.
摘要翻译：通过主体的操作区域导航医疗装置的远端的方法包括显示包括医疗装置的远端的操作区域的X射线图像; 确定所述医疗装置的远端在参考框架中的位置，所述参考框架可转换成所显示的X射线图像; 以及在x射线图像上显示医疗装置的远端的增强指示，以便于在操作区域中设备的远端的导航。

32. 发明申请

US20100249599A1 SYSTEMS AND METHODS FOR MAKING AND USING AN IMAGING CORE OF AN INTRAVASCULAR ULTRASOUND IMAGING SYSTEM 有权
标题翻译：用于制造和使用静脉超声成像系统的成像核心的系统和方法
公开(公告)号：US20100249599A1
公开(公告)日：2010-09-30
申请号：US12415768
申请日：2009-03-31
申请人： Roger N. Hastings , Michael J. Pikus , Kevin D. Edmunds , Tat-Jin Teo
发明人： Roger N. Hastings , Michael J. Pikus , Kevin D. Edmunds , Tat-Jin Teo
IPC分类号： A61B8/14
CPC分类号： A61B8/4461 , A61B5/02007 , A61B8/12 , A61B8/4281 , A61B8/445
摘要： An imaging assembly for an intravascular ultrasound system includes a catheter, an imaging core, and at least one transducer conductor. The imaging core is insertable into the catheter and extendable from a distal end of the catheter. The imaging core includes a rotatable magnet, a tilted reflective surface, and at least one fixed transducer all disposed in a body. The rotatable magnet is configured and arranged to rotate by a magnetic field generated external to the catheter. The tilted reflective surface rotates with the magnet. The at least one transducer is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. The at least one transducer conductor is electrically coupled to the at least one transducer and is configured and arranged to extend into the catheter when the imaging core is extended from the catheter.
摘要翻译：用于血管内超声系统的成像组件包括导管，成像芯和至少一个换能器导体。成像芯可插入导管中并且可从导管的远端延伸。成像芯包括可旋转的磁体，倾斜的反射表面以及全部设置在主体中的至少一个固定换能器。可旋转磁体被构造和布置成通过导管外部产生的磁场旋转。倾斜的反射表面与磁体一起旋转。所述至少一个换能器被配置和布置成用于将所施加的电信号变换成声信号，并且还用于将接收的回波信号变换为电信号。所述至少一个换能器导体电耦合到所述至少一个换能器并且被配置和布置成当所述成像芯从所述导管延伸时延伸到所述导管中。

33. 发明授权

US07650186B2 Leadless cardiac stimulation systems 有权
公开(公告)号：US07650186B2
公开(公告)日：2010-01-19
申请号：US11075375
申请日：2005-03-07
申请人： Roger N. Hastings , Anupama Sadasiva , Mike Pikus , Kevin D. Edmunds
发明人： Roger N. Hastings , Anupama Sadasiva , Mike Pikus , Kevin D. Edmunds
IPC分类号： A61N1/372 , A61N1/05
CPC分类号： A61N1/37223 , A61N1/0587 , A61N1/08 , A61N1/3627 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

34. 发明授权

US07647109B2 Leadless cardiac stimulation systems 有权
标题翻译：无铅心脏刺激系统
公开(公告)号：US07647109B2
公开(公告)日：2010-01-12
申请号：US11075376
申请日：2005-03-07
申请人： Roger N. Hastings , Anupama Sadasiva , Michael J. Pikus , Graig Kveen
发明人： Roger N. Hastings , Anupama Sadasiva , Michael J. Pikus , Graig Kveen
IPC分类号： A61N1/372 , A61N1/05
CPC分类号： A61N1/37223 , A61N1/0587 , A61N1/08 , A61N1/3627 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.
摘要翻译：提供了使用无引线电极来提供起搏治疗的各种构造的系统。在一个示例中，提供用于心脏心肌的多个部位的系统包括使用经皮，经腔，导管递送系统可植入位于心肌附近的位置的无线起搏电极组件。还公开了用于递送和植入电极组件的这种系统，无线电极组件和输送导管的各种配置。

35. 发明授权

US06662034B2 Magnetically guidable electrophysiology catheter 有权
标题翻译：磁导引电生理导管
公开(公告)号：US06662034B2
公开(公告)日：2003-12-09
申请号：US09840311
申请日：2001-04-23
申请人： Garland L. Segner , Roger N. Hastings , Michael Eng
发明人： Garland L. Segner , Roger N. Hastings , Michael Eng
IPC分类号： A61B504
CPC分类号： A61M25/0127 , A61B5/042 , A61B5/06 , A61B5/062 , A61B18/1492 , A61B34/20 , A61B2017/00053 , A61B2017/00084 , A61B2218/002 , A61M25/0054 , A61M25/01 , A61M25/0108 , A61M2025/0004 , A61M2025/0166 , A61M2230/50
摘要： An electrophysiology catheter includes a tube having a proximal end, a distal end, and a lumen therebetween. The tube is preferably comprised of multiple sections of different flexibility, arranged so that the flexibility of the catheter increases from the proximal end to the distal end. There is a first generally hollow electrode member at the distal end. A magnetically responsive element is disposed at least partially in the hollow end electrode, for aligning the distal end of the catheter with an externally applied magnetic field. The hollow end electrode can have openings for delivering irrigating fluid, and/or a sleeve can be provided around the tube to create an annular space for the delivering of irrigating fluid. A temperature sensor can be provided to control the operation of the catheter. A localization coil can also be provided to sense the position and orientation of the catheter.
摘要翻译：电生理导管包括具有近端，远端和其间的内腔的管。管优选地由具有不同柔性的多个部分组成，其布置成使得导管的柔性从近端增加到远端。在远端处有第一大致中空的电极部件。磁响应元件至少部分地设置在中空端电极中，用于使导管的远端与外部施加的磁场对准。中空端电极可以具有用于输送冲洗流体的开口，和/或可以在管周围设置套筒，以产生用于输送冲洗流体的环形空间。可以提供温度传感器来控制导管的操作。还可以提供定位线圈以感测导管的位置和取向。

36. 发明授权

US06582353B1 Intravascular radiation delivery system 失效
标题翻译：血管内辐射输送系统
公开(公告)号：US06582353B1
公开(公告)日：2003-06-24
申请号：US09618253
申请日：2000-07-18
申请人： Roger N. Hastings , Thomas R. Hektner , Stewart M. Kume
发明人： Roger N. Hastings , Thomas R. Hektner , Stewart M. Kume
IPC分类号： A61N500
CPC分类号： A61M25/0127 , A61M25/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N5/1002 , A61N2005/1003
摘要： An intravascular radiation delivery system including a catheter, a radiation source disposed in an open-ended lumen in the catheter and a closed-ended sheath surrounding the radiation source so as to prevent blood and other fluids from coming into contact with the radiation source. Preferably, the open-ended lumen is centered in the balloon for uniform radiation delivery. The catheter may include a blood perfusion lumen under the balloon or around the balloon. The open-ended lumen in the catheter may have a reduced diameter adjacent the distal end of the catheter to prevent the radiation source from exiting the lumen. Methods of using the radiation delivery system are also disclosed. An alternative method of delivering radiation to a treatment site inside the vasculature of a patient using a gas-filled balloon catheter and a radiation source disposed in the balloon catheter. The treatment site is exposed to radiation, preferably beta radiation, through the gas-filled balloon.
摘要翻译：一种血管内辐射传播系统，包括导管，设置在导管内的开放式腔内的辐射源和围绕辐射源的封闭护套，以防止血液和其它流体与辐射源接触。优选地，开口腔在球囊中居中以使辐射均匀。导管可以包括气囊下方或气球周围的血液灌注腔。导管中的开口腔可以具有邻近导管远端的减小的直径，以防止辐射源离开内腔。还公开了使用辐射递送系统的方法。使用设置在球囊导管中的充气球囊导管和辐射源将辐射递送到患者脉管系统内部的治疗部位的替代方法。通过充气球囊将治疗部位暴露于辐射，优选β辐射。

37. 发明授权

US06432062B1 Thermal and stress mapping of body lumens 有权
公开(公告)号：US06432062B1
公开(公告)日：2002-08-13
申请号：US09813064
申请日：2001-03-20
申请人： Brooke Q. Ren , Roger N. Hastings
发明人： Brooke Q. Ren , Roger N. Hastings
IPC分类号： A61B500
摘要： The inventive method requires advancing a three-dimensional imaging balloon catheter to the site of a lesion to be imaged, inflating or molding the balloon to image the lesion, deflating the balloon, withdrawing the catheter from the body lumen and re-inflating the balloon which reassumes its memorized shape. Stress and thermal mapping of the balloon is then done by direct observation or by numerical analysis of the material strain and color of the re-inflated 3D imaging balloon.

38. 发明授权

US06298257B1 Cardiac methods and system 有权
标题翻译：心脏方法和系统
公开(公告)号：US06298257B1
公开(公告)日：2001-10-02
申请号：US09405314
申请日：1999-09-22
申请人： Andrew F. Hall , Roger N. Hastings , Walter M. Blume
发明人： Andrew F. Hall , Roger N. Hastings , Walter M. Blume
IPC分类号： A61B505
CPC分类号： A61B5/06 , A61B5/042 , A61B5/061 , A61B5/062 , G06F19/3481 , G16H50/50
摘要： A method of applying a magnetic medical device to the surface of an internal body structure, the medical device having a magnetically responsive element associated with its distal end, the method comprising applying a magnetic field to the distal end of the magnetic medical device to apply a measured and controlled force between the medical device and tissue to facilitate cardiac sensing, mapping, pacing, ablation, biopsying and other procedures. Contact is confirmed by the angle between the direction of the magnetic medical device and the applied magnetic field, and the contact force is controlled by controlling at least one of the magnetic field direction and the magnetic field strength.
摘要翻译：一种将磁性医疗装置应用于内部身体结构的表面的方法，所述医疗装置具有与其远端相关的磁性应答元件，所述方法包括向所述磁性医疗装置的远端施加磁场，在医疗设备和组织之间测量和控制力，以促进心脏感测，映射，起搏，消融，活检和其他程序。通过磁性医疗装置的方向与施加的磁场之间的角度来确认接触，并且通过控制磁场方向和磁场强度中的至少一个来控制接触力。

39. 发明授权

US06253769B1 Method for percutaneous coronary artery bypass 失效
标题翻译：经皮冠状动脉搭桥方法
公开(公告)号：US06253769B1
公开(公告)日：2001-07-03
申请号：US09391112
申请日：1999-09-07
申请人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
发明人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
IPC分类号： A61B1900
CPC分类号： A61F2/82 , A61B17/32053 , A61B2017/00243 , A61B2017/00252 , A61B2017/1135 , A61B2017/306 , A61B2090/3929 , A61B2090/3945 , A61B2090/3958 , A61F2/06 , A61F2/064 , A61F2/90 , A61F2/958 , A61F2250/0098 , Y10S623/902
摘要： A percutaneous system for bypassing a restriction in an artery of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. First and second expandable stents are provided at the first and second ends of the graft, respectively. Apertures are formed in the artery, distal of the restriction, and in the aorta and the graft is inserted between the apertures. At least a portion of the first stent is inserted through the aperture in the artery and the stent is deployed to connect the first end of the graft within the artery. The second stent is positioned such that a first expandable portion is outside the aorta and a second expandable portion is within the aorta. The first and second expandable portions of the second stent are expanded to have outer diameters at least as large as the aperture in the aorta to anchor the first end of the graft in the aorta such that the lumen in the graft communicates with the aorta and the artery.
摘要翻译：用于绕过具有主动脉的哺乳动物的动脉中的限制的经皮系统包括提供具有主体部分的移植物，其具有第一端，第二端和内腔。第一和第二可扩张支架分别设置在移植物的第一和第二端。孔径形成在动脉的远端，在主动脉的远侧，移植物插入孔之间。第一支架的至少一部分插入通过动脉中的孔，并且支架被展开以将移植物的第一端连接在动脉内。第二支架定位成使得第一可膨胀部分在主动脉外侧，第二可膨胀部分在主动脉内。第二支架的第一和第二可膨胀部分被扩张以具有至少与主动脉中的孔相同的外径，以将移植物的第一端锚定在主动脉中，使得移植物中的内腔与主动脉连通，并且动脉。

40. 发明授权

US6059713A Catheter system having tubular radiation source with movable guide wire 失效
标题翻译：导管系统具有带可动导丝的管状辐射源
公开(公告)号：US6059713A
公开(公告)日：2000-05-09
申请号：US35705
申请日：1998-03-05
申请人： Michael J. Urick , Timothy G. J. Ehr , Roger N. Hastings
发明人： Michael J. Urick , Timothy G. J. Ehr , Roger N. Hastings
IPC分类号： A61F2/958 , A61M29/02 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61M2025/0063 , A61M2025/0656 , A61M2025/1061 , A61M25/0138 , A61M25/1002 , A61M25/104 , A61N2005/1003 , A61N2005/1004
摘要： A radiation source for inhibiting restenosis including a radiation delivery tube having a radioactive distal region, the tube being adapted to slide over a core wire within a radiation delivery catheter. The core wire is preferably in a slidable relation with the radiation delivery catheter. By withdrawing the core wire to a proximal position, the flexibility of a distal region of the radiation delivery catheter may be increased, thereby allowing the radiation delivery catheter to navigate more tortuous paths and reach more distal sites. Before the radiation delivery tube is advanced into the catheter distal region, the core wire is preferably slid distally to a distal position. With the core wire in the distal position, the core wire may provide a structure that can be used to rapidly advance the radiation source to the lesion site. The core wire may also help constrain lateral movement of the radiation delivery tube and help center the radiation delivery tube within the vessel to provide a more even radiation exposure to the vessel walls.
摘要翻译：一种用于抑制再狭窄的辐射源，包括具有放射性远侧区域的辐射递送管，所述管适于在辐射递送导管内的芯线上滑动。芯线优选地与辐射递送导管可滑动关系。通过将芯线抽出到近端位置，可以增加放射线输送导管的远端区域的柔性，从而允许放射线输送导管更多的曲折路径导航并到达更远侧的位置。在辐射输送管进入导管远端区域之前，芯线优选地向远侧滑动到远端位置。在芯线处于远端位置时，芯线可以提供可用于将辐射源快速推进到病变部位的结构。芯线还可以有助于限制辐射输送管的横向运动，并帮助辐射输送管在容器内居中以提供更均匀的辐射暴露于血管壁。

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