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1. 发明授权

US06582353B1 Intravascular radiation delivery system 失效
标题翻译：血管内辐射输送系统
公开(公告)号：US06582353B1
公开(公告)日：2003-06-24
申请号：US09618253
申请日：2000-07-18
申请人： Roger N. Hastings , Thomas R. Hektner , Stewart M. Kume
发明人： Roger N. Hastings , Thomas R. Hektner , Stewart M. Kume
IPC分类号： A61N500
CPC分类号： A61M25/0127 , A61M25/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N5/1002 , A61N2005/1003
摘要： An intravascular radiation delivery system including a catheter, a radiation source disposed in an open-ended lumen in the catheter and a closed-ended sheath surrounding the radiation source so as to prevent blood and other fluids from coming into contact with the radiation source. Preferably, the open-ended lumen is centered in the balloon for uniform radiation delivery. The catheter may include a blood perfusion lumen under the balloon or around the balloon. The open-ended lumen in the catheter may have a reduced diameter adjacent the distal end of the catheter to prevent the radiation source from exiting the lumen. Methods of using the radiation delivery system are also disclosed. An alternative method of delivering radiation to a treatment site inside the vasculature of a patient using a gas-filled balloon catheter and a radiation source disposed in the balloon catheter. The treatment site is exposed to radiation, preferably beta radiation, through the gas-filled balloon.
摘要翻译：一种血管内辐射传播系统，包括导管，设置在导管内的开放式腔内的辐射源和围绕辐射源的封闭护套，以防止血液和其它流体与辐射源接触。优选地，开口腔在球囊中居中以使辐射均匀。导管可以包括气囊下方或气球周围的血液灌注腔。导管中的开口腔可以具有邻近导管远端的减小的直径，以防止辐射源离开内腔。还公开了使用辐射递送系统的方法。使用设置在球囊导管中的充气球囊导管和辐射源将辐射递送到患者脉管系统内部的治疗部位的替代方法。通过充气球囊将治疗部位暴露于辐射，优选β辐射。

2. 发明授权

US06599230B2 Intravascular radiation delivery system 失效
公开(公告)号：US06599230B2
公开(公告)日：2003-07-29
申请号：US09808315
申请日：2001-03-14
申请人： Roger N. Hastings , Thomas R. Hektner , Stewart M. Kume
发明人： Roger N. Hastings , Thomas R. Hektner , Stewart M. Kume
IPC分类号： A61N500
CPC分类号： A61M25/0127 , A61M25/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N5/1002 , A61N2005/1003
摘要： An intravascular radiation delivery system including a catheter, a radiation source disposed in an open-ended lumen in the catheter and a closed-ended sheath surrounding the radiation source so as to prevent blood and other fluids from coming into contact with the radiation source. Preferably, the open-ended lumen is centered in the balloon for uniform radiation delivery. The catheter may include a blood perfusion lumen under the balloon or around the balloon. The open-ended lumen in the catheter may have a reduced diameter adjacent the distal end of the catheter to prevent the radiation source from exiting the lumen. Methods of using the radiation delivery system are also disclosed. An alternative method of delivering radiation to a treatment site inside the vasculature of a patient using a gas-filled balloon catheter and a radiation source disposed in the balloon catheter. The treatment site is exposed to radiation, preferably beta radiation, through the gas-filled balloon.

3. 发明授权

US5876426A System and method of providing a blood-free interface for intravascular light delivery 失效
标题翻译：为血管内光输送提供无血界面的系统和方法
公开(公告)号：US5876426A
公开(公告)日：1999-03-02
申请号：US662585
申请日：1996-06-13
申请人： Stewart M. Kume , Thomas R. Hektner
发明人： Stewart M. Kume , Thomas R. Hektner
IPC分类号： A61B18/00 , A61B18/24 , A61M3/02 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61B18/245 , A61B2018/0097 , A61M2025/105 , A61M2025/1072 , A61M3/0279
摘要： A system and method of providing a blood-free interface for intravascular light delivery is disclosed. The method includes the steps of inserting a balloon catheter into the vasculature of a patient wherein the balloon catheter includes an infusion layer disposed about the balloon; inserting a light delivery catheter into the working lumen of the balloon catheter; inflating the balloon to displace blood inside the vasculature; infusing a liquid to displace blood between the inflated balloon and the inside wall of the vasculature so as to provide a relatively blood-free interface; and delivering light through the blood-free interface to the vasculature from the light delivery catheter. Fluid may be infused into the working lumen of the balloon catheter and around the light delivery catheter in order to displace any blood in the lumen. The system includes a light delivery catheter and a balloon catheter where the balloon catheter includes a long shaft having an inflation lumen, an infusion lumen and a working lumen. A balloon is connected to the distal end of the shaft and an infusion layer is disposed about the balloon. The catheter may include one or more radial restraints disposed about the balloon to center the working lumen and to limit the expandable diameter of the balloon. The radial restraint imparts flexibility and allows the balloon and the working lumen to be centered in vasculature that is curved (i.e., non-linear).
摘要翻译：公开了提供用于血管内光输送的无血界面的系统和方法。该方法包括以下步骤：将气囊导管插入患者的脉管系统中，其中气囊导管包括围绕气囊设置的输注层; 将光输送导管插入到气囊导管的工作腔中; 充气气球以置换血管内的血液; 输注液体以置换充气气囊和脉管系统内壁之间的血液，以提供相对无血液的界面; 并将光通过无血清界面从光输送导管输送到脉管系统。可以将流体输入气囊导管的工作腔和光输送导管周围，以便置换内腔中的任何血液。该系统包括光输送导管和球囊导管，其中气囊导管包括具有充气腔，输液腔和工作腔的长轴。气球连接到轴的远端，并且输注层围绕气球设置。导管可以包括围绕气囊设置的一个或多个径向限制器，以使工作腔体居中并限制气囊的可扩张直径。径向约束提供了灵活性，并允许气球和工作腔在弯曲（即非线性）的脉管系统中居中。

4. 发明授权

US6092526A Percutaneous chamber-to-artery bypass 失效
标题翻译：经皮腔至动脉旁路
公开(公告)号：US6092526A
公开(公告)日：2000-07-25
申请号：US878804
申请日：1997-06-19
申请人： Daniel M. LaFontaine , Roger N. Hastings , Thomas R. Hektner , Chad J. Kugler
发明人： Daniel M. LaFontaine , Roger N. Hastings , Thomas R. Hektner , Chad J. Kugler
IPC分类号： A61B17/00 , A61B17/11 , A61F2/02 , A61B19/00
CPC分类号： A61B17/11 , A61F2/2493 , A61B2017/00243 , A61B2017/00247 , A61B2017/1107 , A61B2017/1135 , A61B2018/00392
摘要： A vessel lies adjacent heart tissue, and a restriction in the vessel is bypassed. A chamber in the heart is accessed and a lumen is formed through the heart tissue which communicates with the vessel and a region distal to the restriction. Blood flows from the heart chamber into the vessel distal the restriction, thus bypassing the restriction.
摘要翻译：血管位于心脏组织附近，并绕过血管中的限制。进入心脏中的腔室，通过与容器连通的心脏组织和远离限制区域的区域形成管腔。血液从心脏腔室流入远离限制的血管，从而绕过限制。

5. 发明申请

US20090227934A1 Methods and Apparatus for Treating Glaucoma 有权
标题翻译：治疗青光眼的方法和装置
公开(公告)号：US20090227934A1
公开(公告)日：2009-09-10
申请号：US12398847
申请日：2009-03-05
申请人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
发明人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
IPC分类号： A61F9/007 , A61B17/32
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00885 , A61F2009/00891 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905 , Y10S623/906
摘要： An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.
摘要翻译：提供了用于治疗青光眼的眼部植入物，其可以包括任何数量的特征。更具体地说，本发明涉及有利于将流体从眼睛的一个区域转移到眼睛的另一区域的植入物。植入物的一个特点是它包括适于插入眼睛前房的近端入口部分和远侧入口部分，以及适于插入施莱姆氏管的中间部分。植入物的另一个特征是它可被偏置以呈现预定的形状以帮助放置在眼睛内。

6. 发明授权

US5247942A Guide wire with swivel 失效
标题翻译：导丝与旋转
公开(公告)号：US5247942A
公开(公告)日：1993-09-28
申请号：US864443
申请日：1992-04-06
申请人： Richard R. Prather , Thomas R. Hektner
发明人： Richard R. Prather , Thomas R. Hektner
IPC分类号： A61B17/22 , A61M25/01
CPC分类号： A61M25/0905 , A61B2017/22072
摘要： A guide wire, and methods of use thereof, comprising a main part, an extension part, and a connector. The connector connects the main part to the extension part such that the main part and the extension part can be rotated relative to each other.
摘要翻译：导丝及其使用方法，包括主要部分，延伸部分和连接器。连接器将主要部分连接到延伸部分，使得主要部分和延伸部分可相对于彼此旋转。

7. 发明授权

US08529494B2 Methods and apparatus for treating glaucoma 有权
公开(公告)号：US08529494B2
公开(公告)日：2013-09-10
申请号：US13610769
申请日：2012-09-11
申请人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
发明人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
IPC分类号： A61F9/007 , A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00885 , A61F2009/00891 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905 , Y10S623/906
摘要： An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

8. 发明申请

US20130006165A1 Methods and Apparatus for Treating Glaucoma 有权
公开(公告)号：US20130006165A1
公开(公告)日：2013-01-03
申请号：US13610769
申请日：2012-09-11
申请人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
发明人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
IPC分类号： A61F9/007 , A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00885 , A61F2009/00891 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905 , Y10S623/906
摘要： An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

9. 发明授权

US08088165B2 Spinal disc annulus reconstruction method and deformable spinal disc annulus stent 有权
标题翻译：脊椎椎间盘瓣环重建方法及可变形椎间盘环状支架
公开(公告)号：US08088165B2
公开(公告)日：2012-01-03
申请号：US11386642
申请日：2006-03-23
申请人： Joseph C. Cauthen, III , Matthew M. Burns , Thomas R. Hektner , Paul Burmeister , Lawrence W. Wales , Daniel O. Adams , Rodney L. Houfburg
发明人： Joseph C. Cauthen, III , Matthew M. Burns , Thomas R. Hektner , Paul Burmeister , Lawrence W. Wales , Daniel O. Adams , Rodney L. Houfburg
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61B17/04 , A61B17/06166 , A61B17/0642 , A61B17/86 , A61B2017/00004 , A61B2017/06176 , A61B2017/0641 , A61B2017/0647 , A61B2017/0648 , A61F2/0063 , A61F2/30907 , A61F2/442 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/30062 , A61F2002/30093 , A61F2002/30158 , A61F2002/30299 , A61F2002/30579 , A61F2002/30777 , A61F2002/30784 , A61F2002/30841 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2210/0004 , A61F2210/0019 , A61F2230/0026 , A61F2230/0093 , A61F2310/00011 , Y10S623/902
摘要： A spinal disc annulus repair stent for repair and reconstruction of the spinal disc wall (annulus) after surgical invasion or pathologic rupture, which may incorporate suture closure or other means of stent insertion and fixation, designed to reduce the failure rate of conventional surgical procedures on the spinal discs. In an illustrative embodiment, the design of the spinal disc annulus stent advantageously allows ingrowth of normal cells of healing in an enhanced fashion strengthening the normal reparative process.
摘要翻译：用于修复和重建手术入侵或病理性破裂后的脊椎椎间盘壁（环）的脊椎椎间盘瓣环修复支架，其可以包括缝合闭合或其他支架插入和固定手段，旨在降低常规外科手术的失败率脊椎盘。在说明性的实施例中，椎间盘环状支架的设计有利地允许正常的愈合细胞以增强的方式向内生长，从而加强正常的修复过程。

10. 发明授权

US08034112B2 Spinal disc annulus reconstruction method and spinal disc annulus stent 失效
标题翻译：脊柱环重建方法和椎间盘环状支架
公开(公告)号：US08034112B2
公开(公告)日：2011-10-11
申请号：US11557997
申请日：2006-11-09
申请人： Joseph C. Cauthen, III , Matthew M. Burns , Thomas R. Hektner , Paul Burmeister , Lawrence W. Wales , Daniel O. Adams , Rodney L. Houfburg
发明人： Joseph C. Cauthen, III , Matthew M. Burns , Thomas R. Hektner , Paul Burmeister , Lawrence W. Wales , Daniel O. Adams , Rodney L. Houfburg
IPC分类号： A61F2/44 , A61F2/46
CPC分类号： A61F2/441 , A61B17/04 , A61B17/06166 , A61B17/0642 , A61B17/86 , A61B2017/00004 , A61B2017/06176 , A61B2017/0641 , A61B2017/0647 , A61B2017/0648 , A61F2/0063 , A61F2/30907 , A61F2/442 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/30062 , A61F2002/30093 , A61F2002/30158 , A61F2002/30299 , A61F2002/30579 , A61F2002/30777 , A61F2002/30784 , A61F2002/30841 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2210/0004 , A61F2210/0019 , A61F2230/0026 , A61F2230/0093 , A61F2310/00011 , Y10S623/902
摘要： A spinal disc annulus repair device for repair and reconstruction of the spinal disc wall (annulus) after surgical invasion or pathologic rupture, which may incorporate suture closure or other means of stent insertion and fixation, designed to reduce the failure rate of conventional surgical procedures on the spinal discs.
摘要翻译：用于修复和重建手术入侵或病理性破裂后的脊椎盘壁（环）的脊椎椎间盘环修复装置，其可以包括缝合封闭件或其他支架插入和固定装置，以减少常规外科手术的失败率脊椎盘。

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