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31. 发明授权

US07879887B2 α-amino acid derivatives and medicaments containing the same as an active ingredient 有权
标题翻译： α-氨基酸衍生物和含有活性成分的药物
公开(公告)号：US07879887B2
公开(公告)日：2011-02-01
申请号：US12306901
申请日：2007-06-29
申请人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
发明人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
IPC分类号： C07D513/04 , A61K31/429
CPC分类号： C07D513/04
摘要： The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
摘要翻译：本发明提供新的式（1）的α-氨基酸衍生物：其中R1，R2，R3，R4，X和Y如权利要求中所定义）或其药学上可接受的盐，前药或溶剂合物。式（1）的衍生物具有ARK1抑制活性，可用于预防或治疗心力衰竭。此外，式（1）的衍生物还具有抗肿瘤活性，特别是对极光激酶和CDK的双重抑制活性，并且可用于细胞增殖性疾病如癌症。

32. 发明授权

US07271188B2 Imidazolidine derivatives 失效
标题翻译：咪唑烷衍生物
公开(公告)号：US07271188B2
公开(公告)日：2007-09-18
申请号：US10560281
申请日：2004-06-11
申请人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
发明人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
IPC分类号： A61K31/4166 , C07D233/86 , C07C311/03
CPC分类号： C07D233/86
摘要： The present invention provides a compound represented by formula (I):[Formula 1] wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom, or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof, as well as a drug, a pharmaceutical composition containing the compound, and the like.
摘要翻译：本发明提供由式（I）表示的化合物：[式1]其中n是选自1至20，R 1和R 2的整数，其中可以相同或不同，各自表示氢原子或直链或支链C 1 -C 6烷基，或其盐，前药或溶剂合物，以及药物，含有该化合物的药物组合物等。

33. 发明申请

US20060135583A1 Imidazolidine derivatives 失效
标题翻译：咪唑烷衍生物
公开(公告)号：US20060135583A1
公开(公告)日：2006-06-22
申请号：US10560281
申请日：2004-06-11
申请人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
发明人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
IPC分类号： A61K31/4166 , C07D233/76
CPC分类号： C07D233/86
摘要： The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom, or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof, as well as a drug, a pharmaceutical composition containing the compound, and the like.
摘要翻译：本发明提供由式（I）表示的化合物：其中n是选自1至20的整数，R 1和R 2可以相同或不同的，各自表示氢原子或直链或支链C 1 -C 6烷基，或其盐，前药或溶剂合物，以及药物，含有该化合物的药物组合物等。

34. 发明授权

US06313221B1 Powder coating of epoxy-acrylic resin, polycarboxylic acid, crosslinked particles and liquid resin 有权
标题翻译：环氧丙烯酸树脂，多元羧酸，交联颗粒和液体树脂的粉末涂料
公开(公告)号：US06313221B1
公开(公告)日：2001-11-06
申请号：US09579892
申请日：2000-05-26
申请人： Masami Yabuta , Yutaka Harada , Atsushi Yamada , Yasuhiko Nakae , Kazuhiko Nishimura , Haruhiko Sato
发明人： Masami Yabuta , Yutaka Harada , Atsushi Yamada , Yasuhiko Nakae , Kazuhiko Nishimura , Haruhiko Sato
IPC分类号： C08L3314
CPC分类号： C08G59/4207 , B05D7/582 , C08G59/4292 , C09D5/033 , C09D133/068 , C08L2666/02 , C08L2666/28
摘要： A thermosetting powder coating composition prepared by a wet process, which contains a mixture comprising (a) an epoxy-containing acrylic resin, (b) a polycarboxylic acid compound curing agent, (c) fine crosslinked resin particles and/or (d) a resin that exists in the liquid form at room temperature.
摘要翻译：通过湿法制备的热固性粉末涂料组合物，其含有（a）含环氧丙烯酸树脂，（b）多元羧酸化合物固化剂，（c）细交联树脂颗粒和/或（d）在室温下以液体形式存在的树脂。

35. 发明授权

US5977167A Benzopyran and benzoxazine derivatives 失效
标题翻译：苯并吡喃和苯并恶嗪衍生物
公开(公告)号：US5977167A
公开(公告)日：1999-11-02
申请号：US26127
申请日：1998-02-19
申请人： Hiroshi Koga , Haruhiko Sato , Takenori Ishizawa , Hiroyuki Nabata
发明人： Hiroshi Koga , Haruhiko Sato , Takenori Ishizawa , Hiroyuki Nabata
IPC分类号： C07D311/22 , C07D311/68 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , A61K31/35
CPC分类号： C07D405/04 , C07D311/22 , C07D311/68 , C07D405/12 , C07D413/04 , C07D417/04
摘要： Novel benzopyran and benzoxazine derivatives represented by the general formula: wherein R.sub.1 and R.sub.2 represent a lower haloalkyl group, R.sub.3 represents a hydrogen atom, etc., R.sub.4 represents a heterocyclic group or A--O-- wherein A represents a cyclic structure, etc., R.sub.5 and R.sub.6 represent a lower haloalkyl, X represents .dbd.N--, N.fwdarw.O, etc, are disclosed. These compounds exhibit K.sup.+ channel opening activating and can be widely used as an anti-asthma drug, an anti-epilepsy drug, etc.
摘要翻译：新的苯并吡喃和苯并恶嗪衍生物由以下通式表示：其中R1和R2代表低级卤代烷基，R3代表氢原子等，R4代表杂环基或AO-，其中A代表环状结构等，R5和 R6表示低级卤代烷基，X表示= N-，N-→O等。这些化合物显示K +通道开启活化，可广泛用作抗哮喘药，抗癫痫药等。

36. 发明授权

US5898064A Process for manufacturing resin particles having narrow particle size distribution 失效
标题翻译：具有窄粒度分布的树脂颗粒的制造方法
公开(公告)号：US5898064A
公开(公告)日：1999-04-27
申请号：US725676
申请日：1996-10-02
申请人： Yutaka Harada , Takehiro Ojima , Haruhiko Sato
发明人： Yutaka Harada , Takehiro Ojima , Haruhiko Sato
IPC分类号： C08F2/20 , C08G18/08 , C08J3/00 , C08J3/16 , C09D5/03 , G03G9/08 , C08F6/24
CPC分类号： G03G9/0804 , C08F2/20 , C08G18/0866 , C08J3/005 , C08J3/16 , C09D5/031 , C08G2150/20
摘要： Thermoplastic or thermosetting resin particles having a narrow particle size distribution are produced by suspending a liquid resinous composition in an aqueous solution of an anionic or cationic polyelectrolyte as primary particles of oil droplets, adjustion the suspension at a pH at which the polyelectrolyte is insolubilized to agglomerate into secondary particles of larger particle size, and allowing the secondary particles in the suspension to solidify.
摘要翻译：通过将液体树脂组合物悬浮在阴离子或阳离子聚电解质的水溶液中作为油滴的主要颗粒来制备具有窄粒度分布的热塑性或热固性树脂颗粒，在悬浮液的pH下调节悬浮液，其中聚电解质不溶于聚集体成为较大粒度的二次粒子，并允许悬浮液中的二次粒子固化。

37. 发明授权

US5610269A Process for manufacturing thermosetting resin particles 失效
标题翻译：制备热固性树脂颗粒的方法
公开(公告)号：US5610269A
公开(公告)日：1997-03-11
申请号：US574130
申请日：1995-12-18
申请人： Haruhiko Sato , Yutaka Harada
发明人： Haruhiko Sato , Yutaka Harada
IPC分类号： C08J3/16 , C08F6/18 , C08J3/14 , C08L1/00 , C08L29/04 , C08L71/00 , C08L71/02 , C08L101/00 , C08L101/14 , C09D5/03
CPC分类号： C08F6/18 , C08J3/14 , C09D5/03
摘要： Thermosetting resin particles having a narrow particle size distribution useful for powder coating application are produced by the steps of (a) providing a first water-soluble polymer having a cloud point within the range between 30.degree. C. and 90.degree. C. and a second water-soluble polymer not having any cloud point; (b) preparing an aqueous suspension in which an organic solvent-containing, liquid thermosetting resin composition is suspended as primary particles of oil droplets in an aqueous suspension medium containing the first and second water-soluble polymers, (c) heating the suspension to a temperature higher than the cloudy point to allow the oil droplets to agglomerate into secondary particles of larger particle sizes, (d) removing the organic solvent contained in the particles during or after step (c) and optionally (e) recovering the particles.
摘要翻译：通过以下步骤制备具有用于粉末涂料应用的窄粒度分布的热固性树脂颗粒：（a）提供具有30℃至90℃范围内的浊点的第一水溶性聚合物，不具有任何浊点的水溶性聚合物; （b）制备水性悬浮液，其中将含有机溶剂的液态热固性树脂组合物悬浮在含有第一和第二水溶性聚合物的水性悬浮介质中的油滴的初级颗粒，（c）将悬浮液加热至温度高于混浊点以允许油滴聚集成较大颗粒尺寸的二次颗粒，（d）在步骤（c）期间或之后除去颗粒中包含的有机溶剂，任选地（e）回收颗粒。

38. 发明授权

US5395880A Manufacturing method of resin granules 失效
标题翻译：树脂颗粒的制造方法
公开(公告)号：US5395880A
公开(公告)日：1995-03-07
申请号：US967740
申请日：1992-10-28
申请人： Haruhiko Sato , Naoya Yabuuchi , Shinji Seo , Takehiro Ojima
发明人： Haruhiko Sato , Naoya Yabuuchi , Shinji Seo , Takehiro Ojima
IPC分类号： G03G9/08 , C08L29/04 , C08F2/20 , C08F2/24 , C08F1/00
CPC分类号： G03G9/0806 , G03G9/0819
摘要： The present invention provides a method which makes it possible to manufacture substantially spherical resin granules with a narrow grain size distribution by a simple operation. According to the present invention, there is provided a method of manufacturing resin granules with a grain diameter of 1.about.100 .mu.m and narrow grain size distribution by controlling the cloud point of polyvinyl alcohol and other water soluble polymers.
摘要翻译：本发明提供一种可以通过简单的操作制造具有窄的粒度分布的基本上球形的树脂颗粒的方法。根据本发明，通过控制聚乙烯醇和其它水溶性聚合物的浊点，提供了通过控制聚乙烯醇和其它水溶性聚合物的浊点来制造晶粒直径为1微米，粒径分布窄的树脂颗粒的方法。

39. 发明授权

US5264841A Paging apparatus equipped with a clock function 失效
标题翻译：分路设备配有时钟功能
公开(公告)号：US5264841A
公开(公告)日：1993-11-23
申请号：US761663
申请日：1991-09-18
申请人： Kiyoshi Wagai , Tatsuaki Sekigawa , Mitsuji Shiono , Haruhiko Sato
发明人： Kiyoshi Wagai , Tatsuaki Sekigawa , Mitsuji Shiono , Haruhiko Sato
IPC分类号： G08B3/10 , G04G5/04 , G04G9/00 , G04G99/00 , G08B5/22 , H04W84/02 , H04W88/02
CPC分类号： G08B5/228
摘要： A paging apparatus with a time information generating circuit comprises a combination switch having multiple switch positions in different operation directions, so that a time setting mode is set when a predetermined first operation is performed by the combination switch, and a paging mode is set other operations are performed. When a predetermined second operation is performed with the time setting mode set, time information measured by the time information generating circuit is replaced with time information input by the second operation. Even in the time setting mode, it is checked if a call is made to the apparatus. When there is such a call, a user is informed of this event without ignoring the occurrence of the call.
摘要翻译：具有时间信息生成电路的寻呼装置包括具有不同操作方向上的多个开关位置的组合开关，从而当由组合开关执行预定的第一操作时设置时间设定模式，并且寻呼模式被设置为其他操作被执行。当在设置了时间设定模式的情况下执行预定的第二操作时，由时间信息产生电路测量的时间信息被用第二操作输入的时间信息代替。即使在时间设定模式下，检查是否对设备进行呼叫。当有这样的呼叫时，向用户通知该事件而不忽视呼叫的发生。

40. 发明授权

US4732906A Dioxolobenzizoxazole derivatives 失效
标题翻译：二氧代苯并恶唑衍生物
公开(公告)号：US4732906A
公开(公告)日：1988-03-22
申请号：US840680
申请日：1986-03-18
申请人： Hiroshi Koga , Takashi Dan , Haruhiko Sato , Etsuro Onuma
发明人： Hiroshi Koga , Takashi Dan , Haruhiko Sato , Etsuro Onuma
IPC分类号： A61K31/357 , A61K31/42 , A61P7/10 , C07D261/00 , C07D317/00 , C07D498/04 , C07D261/20
CPC分类号： C07D498/04
摘要： Dioxolobenzisoxazole derivatives of the formula ##STR1## wherein R.sub.1 is a phenyl group which may be substituted with a halogen atom, a lower alkyl group having 1-3 carbon atoms or a lower haloalkyl group, or a thienyl group; R.sub.2 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; and X and Y which may be the same or different represent a hydrogen atom or a halogen atom, as well as non-toxic salts thereof wherein R.sub.2 is a hydrogen atom, a process for preparing the same and a pharmaceutical composition containing the same are disclosed.The derivatives have diuretic and uricosuric activities and, therefore, are useful as a drug for treating hyperuricemia or hypertension.
摘要翻译：其中R 1是可以被卤素原子取代的苯基，具有1-3个碳原子的低级烷基或低级卤代烷基，或噻吩基的式Ⅱ的二氧代联苯并恶唑衍生物; R2是氢原子或具有1-4个碳原子的低级烷基; 和可以相同或不同的X和Y表示氢原子或卤素原子，以及其中R2是氢原子的无毒盐，其制备方法和含有它们的药物组合物。衍生物具有利尿和尿酸活性，因此可用作治疗高尿酸血症或高血压的药物。

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