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31. 发明申请

US20130028930A1 Albumin Derivatives and Variants 审中-公开
标题翻译：白蛋白衍生物和变体
公开(公告)号：US20130028930A1
公开(公告)日：2013-01-31
申请号：US13640235
申请日：2011-04-08
申请人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
发明人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
IPC分类号： C07K19/00 , A61K38/38 , C12N1/19 , A61K39/385 , A61P31/14 , A61P31/20 , C12N15/63 , C12N9/96
CPC分类号： C07K14/765 , C07K2319/00
摘要： The application discloses albumin derivatives comprising or consisting of domain III and at least one further domain wherein the derivative or variant is not a naturally occurring albumin derivative or variant. The derivatives may be used in conjugates and fusion polypeptides.
摘要翻译：本申请公开了包含或由结构域III和至少一个其它结构域组成的白蛋白衍生物，其中该衍生物或变体不是天然存在的白蛋白衍生物或变体。衍生物可用于缀合物和融合多肽。

32. 发明申请

US20120220530A1 ALBUMIN VARIANTS 有权
公开(公告)号：US20120220530A1
公开(公告)日：2012-08-30
申请号：US13504326
申请日：2010-11-01
申请人： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
发明人： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
IPC分类号： A61K38/38 , C07H21/04 , C12P21/02 , C07K14/76
CPC分类号： C07K14/765 , A61K45/06 , C07K14/54 , C07K2319/20 , C07K2319/31
摘要： The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
摘要翻译：本发明涉及与母体白蛋白相比具有改变的血浆半衰期的亲本白蛋白的变体。本发明还涉及包含所述变体白蛋白的融合多肽和缀合物。

33. 发明授权

US07871806B2 Asparaginases 有权
标题翻译：天冬酰胺酶
公开(公告)号：US07871806B2
公开(公告)日：2011-01-18
申请号：US12782150
申请日：2010-05-18
申请人： Tomoko Matsui , Esben Peter Friis , Akihiko Yamagishi
发明人： Tomoko Matsui , Esben Peter Friis , Akihiko Yamagishi
IPC分类号： C12N9/82 , C12N1/20 , C12N1/00 , C12N15/00 , C07H21/04
CPC分类号： C12N9/82 , A23L5/25 , A23L19/18 , C12Y305/01001
摘要： The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The invention also relates to DNA sequences encoding such improved asparaginases, their production in a recombinant host cell, as well as methods of using the asparaginases, in particular for reduction of acrylamide in foods. The invention furthermore relates to methods of generating and preparing asparaginase variants having improved properties.
摘要翻译：本发明涉及具有改进性能的新型天冬酰胺酶，优选改进的耐热性，例如在高温下改善的活性和/或改善的热稳定性。本发明还涉及编码这种改良天冬酰胺酶的DNA序列，其在重组宿主细胞中的产生，以及使用天冬酰胺酶，特别是用于还原食品中丙烯酰胺的方法。本发明还涉及产生和制备具有改进性质的天冬酰胺酶变体的方法。

34. 发明申请

US20130000055A1 CLEANING COMPOSITIONS COMPRISING AMYLASE VARIANTS REFERENCE TO A SEQUENCE LISTING 有权
标题翻译：包含氨基酸变体的清洁组合物参考序列表
公开(公告)号：US20130000055A1
公开(公告)日：2013-01-03
申请号：US13537606
申请日：2012-06-29
申请人： Michelle Jackson , Philip Frank Souter , Lindsay Suzanne Bewick , Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaangner Christiansen
发明人： Michelle Jackson , Philip Frank Souter , Lindsay Suzanne Bewick , Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaangner Christiansen
IPC分类号： C11D7/42 , D06L1/12 , C12S11/00 , C11D7/60
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417 , C12Y302/01001
摘要： The present invention relates to cleaning compositions comprising variants of an alpha-amylase and methods of treating surfaces such as textiles with aqueous liquor comprising such compositions, especially at low temperatures.
摘要翻译：本发明涉及包含α-淀粉酶的变体的清洁组合物以及包含这种组合物的含水液体的表面如纺织品的处理方法，特别是在低温下。

35. 发明申请

US20120288585A1 Methods of Producing GH8 Xylanase Variants 有权
标题翻译：生产GH8木聚糖酶变体的方法
公开(公告)号：US20120288585A1
公开(公告)日：2012-11-15
申请号：US13511546
申请日：2010-12-09
申请人： Lars Beier , Miguel Duarte Toscano , Esben Peter Friis , Merete Moeller Engelsen , Henrik Lundkvist , Sune Sauer Lobedanz
发明人： Lars Beier , Miguel Duarte Toscano , Esben Peter Friis , Merete Moeller Engelsen , Henrik Lundkvist , Sune Sauer Lobedanz
IPC分类号： C12N1/15 , C12N15/56 , A21D8/04 , C12N1/21 , C12N1/19 , A23L1/28 , C12N9/24 , C12N15/63
CPC分类号： A21D8/042 , C12N9/248
摘要： The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有木聚糖酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

36. 发明授权

US08202831B2 Detergent composition comprising a variant of a family 44 xyloglucanase 有权
标题翻译：包含家族44木葡聚糖酶的变体的洗涤剂组合物
公开(公告)号：US08202831B2
公开(公告)日：2012-06-19
申请号：US12478793
申请日：2009-06-05
申请人： Neil Joseph Lant , Werner Besenmatter , Esben Peter Friis , Keith Gibson , Frank Winther Rasmussen , Michael Skjøt
发明人： Neil Joseph Lant , Werner Besenmatter , Esben Peter Friis , Keith Gibson , Frank Winther Rasmussen , Michael Skjøt
IPC分类号： C11D3/00 , C11D3/22 , C11D3/386 , C12N9/24 , C07H21/04
CPC分类号： C11D3/38681 , C11D3/38636 , C12N9/2434
摘要： The present invention relates to detergent compositions comprising a variant of a parent xyloglucanase.
摘要翻译：本发明涉及包含亲本木葡聚糖酶的变体的洗涤剂组合物。

37. 发明申请

US20110092409A1 VARIANTS OF A FAMILY 44 XYLOGLUCANASE 有权
标题翻译：家族44 XYLOGLUCANASE的变体
公开(公告)号：US20110092409A1
公开(公告)日：2011-04-21
申请号：US12995706
申请日：2009-06-04
申请人： Werner Besenmatter , Esben Peter Friis , Keith Gibson , Frank Winther Rasmussen , Michael Skjoet
发明人： Werner Besenmatter , Esben Peter Friis , Keith Gibson , Frank Winther Rasmussen , Michael Skjoet
IPC分类号： C11D3/386 , C12N9/24 , C07H21/00 , C12N5/10
CPC分类号： C12N9/2437 , C11D3/38636 , C12N9/2408 , C12N9/2434 , C12Y302/01151
摘要： The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide.
摘要翻译：本发明涉及亲本木葡聚糖酶的变体。本发明还涉及编码变体木葡聚糖酶的多核苷酸以及包含多核苷酸的核酸构建体，载体和宿主细胞。

38. 发明申请

US20110045572A1 PROTEIN VARIANTS HAVING MODIFIED IMMUNOGENICITY 审中-公开
标题翻译：具有改良免疫原性的蛋白质变体
公开(公告)号：US20110045572A1
公开(公告)日：2011-02-24
申请号：US12699979
申请日：2010-02-04
申请人： Erwin Ludo Roggen , Steffen Ernst , Allan Svendsen , Esben Peter Friis , Claus Von Der Osten
发明人： Erwin Ludo Roggen , Steffen Ernst , Allan Svendsen , Esben Peter Friis , Claus Von Der Osten
IPC分类号： C12N9/56 , C12N9/48 , C12N15/63 , C12N5/10 , C12N1/15
CPC分类号： C12N9/54 , A21D2/267 , A21D8/042 , A61K39/00 , C07K1/047 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K14/001 , C07K16/40 , C07K16/4283 , C11D3/38627 , C11D3/38645 , C12N9/0061 , C12N9/20 , C12Y110/03002 , C12Y304/21062 , Y10S435/911
摘要： The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids situated within 5 Å from the epitope amino acids constituting the epitope sequence, changing one or more of the amino acids defining the epitope area of the parent protein by genetical engineering mutations of a DNA sequence encoding the parent protein, introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and use thereof, as well as to a method for producing said protein variant.
摘要翻译：本发明涉及选择与亲本蛋白相比具有改良的免疫原性的蛋白质变体的方法，其包括获得抗体结合肽序列的步骤，使用该序列来定位母体蛋白的3维结构上的表位序列，限定表位包括位于构成表位序列的表位氨基酸5埃范围内的氨基酸，通过编码母体蛋白质的DNA序列的遗传工程突变改变限定母体蛋白表位区域的一个或多个氨基酸，引入突变的 DNA序列转化为合适的宿主，培养所述宿主并表达蛋白质变体，并使用亲本蛋白作为参考来评估蛋白质变体的免疫原性。本发明还涉及蛋白质变体及其用途，以及生产所述蛋白质变体的方法。

39. 发明授权

US06398940B1 Method for fabricating nanoscale patterns on a surface 失效
标题翻译：在表面上制造纳米尺度图案的方法
公开(公告)号：US06398940B1
公开(公告)日：2002-06-04
申请号：US09497881
申请日：2000-02-04
申请人： Quijin Chi , Jingdong Zhang , Jens Enevold Thaulov Andersen , Jens Ulstrup , Esben Peter Friis
发明人： Quijin Chi , Jingdong Zhang , Jens Enevold Thaulov Andersen , Jens Ulstrup , Esben Peter Friis
IPC分类号： C25F302
CPC分类号： B23H3/00 , B82Y10/00 , B82Y30/00 , G01Q80/00 , G11B9/14 , G11B9/1463 , Y10S977/856
摘要： A novel method to fabricate nanoscale pits on Au(111) surfaces in contact with aqueous solution is claimed. The method uses in situ electrochemical scanning tunnelling microscopy with independent electrochemical substrate and tip potential control and very small bias voltages. This is significantly different from other documented methods, which mostly apply high and short voltage pulses. The most important advantages of the present method are that the dimensions and positions of the pits can be controlled with high precision in aqueous environment so that nanopatterns of the pits can be designed, and that the operations are simple and require no instrumental accessories. Parameters, which control the pit formation and size, have been systematically characterized and show that the primary controlling parameter is the bias voltage. A mechanism based on local surface reconstruction induced by electronic contact between tip and substrate is in keeping with the overall patterns for pit formation. A range of potential applications is proposed.
摘要翻译：要求在与水溶液接触的Au（111）表面上制造纳米级凹坑的新方法。该方法使用原位电化学扫描隧道显微镜，具有独立的电化学底物和尖端电位控制和非常小的偏置电压。这与其他文献记载的方法有很大的不同，它们主要应用高压和短压脉冲。本方法的最重要的优点是可以在水性环境中以高精度控制凹坑的尺寸和位置，从而可以设计凹坑的纳米图案，操作简单，不需要仪器附件。控制坑形成和尺寸的参数已经被系统地表征，并且表明主要控制参数是偏置电压。基于尖端和衬底之间的电子接触引起的局部表面重建的机理与凹坑形成的整体图案保持一致。提出了一系列潜在的应用。

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