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31. 发明申请

US20100279402A1 Expression Construct for Digesting Aggregating Protein and Method of Inhibiting the Aggregation of Aggregating Protein 审中-公开
标题翻译：用于消化聚集蛋白的表达构建体和抑制聚集蛋白聚集的方法
公开(公告)号：US20100279402A1
公开(公告)日：2010-11-04
申请号：US12225311
申请日：2007-03-19
申请人： Shin-ichi Yamada , Jyun-ichi Niwa , Gen Sobue
发明人： Shin-ichi Yamada , Jyun-ichi Niwa , Gen Sobue
IPC分类号： C12N5/071 , C12N15/79 , C12N5/07
CPC分类号： C12N9/52 , C12N15/85
摘要： It is intended to provide a means which is efficacious in digesting a protein forming aggregates in a eukaryotic cell such as mutant superoxide dismutase 1 or an androgen receptor having an abnormally extended polyglutamine chain. Namely, an expression construct for digesting an aggregating protein which has a nucleic acid encoding an archaeal proteasome and being connected in an operable manner to a promoter for eukaryotic cells. By transferring this expression construct into a eukaryotic cell, the aggregating protein is digested owing to the action of the archaeal proteasome.
摘要翻译：旨在提供一种在真核细胞如突变型超氧化物歧化酶1或具有异常延长的聚谷氨酰胺链的雄激素受体中消化形成聚集体的蛋白质有效的方法。即，用于消化具有编码古细菌蛋白酶体的核酸并以可操作的方式连接到真核细胞的启动子的聚集蛋白的表达构建体。通过将该表达构建体转移到真核细胞中，由于古细菌蛋白酶体的作用，聚集蛋白被消化。

32. 发明授权

US07463563B2 Deficiency detecting apparatus for optical disk 有权
标题翻译：光盘缺陷检测装置
公开(公告)号：US07463563B2
公开(公告)日：2008-12-09
申请号：US10521630
申请日：2003-09-17
申请人： Eiji Ueda , Takashi Kishimoto , Shin-ichi Yamada
发明人： Eiji Ueda , Takashi Kishimoto , Shin-ichi Yamada
IPC分类号： G11B5/09
CPC分类号： G11B7/126 , G01N21/9506 , G11B7/00375
摘要： The present invention provides a deficiency detecting apparatus that can accurately detect dusts and deficiencies on an optical disk even when an emitting power of a laser light source changes. The deficiency detecting apparatus is provided with a deficiency detecting section for detecting deficiencies or the like on an optical disk by reflected light, and a power adjusting section for adjusting an emitting power of a laser light source to be an optimum value. The deficiency detecting section can accurately detect the deficiencies on the optical disk even when the laser power changes by comparing a threshold value, which is determined in accordance with the adjustment result of the power adjusting section, with a value in accordance with the reflected light.
摘要翻译：本发明提供一种即使在激光源的发光功率变化的情况下也能够准确地检测光盘上的灰尘和缺陷的缺陷检测装置。缺陷检测装置设置有用于通过反射光检测光盘上的不足等的缺陷检测部分和用于将激光源的发射功率调节为最佳值的功率调节部分。缺陷检测部分即使当通过将根据功率调节部分的调节结果确定的阈值与根据反射光的值进行比较而激光功率改变时，也可以准确地检测光盘上的不足。

33. 发明授权

US5878007A Anti-wobble optical medium and tracking method and apparatus 失效
标题翻译：抗摆动光学介质及跟踪方法及装置
公开(公告)号：US5878007A
公开(公告)日：1999-03-02
申请号：US57172
申请日：1998-04-08
申请人： Yasuki Matsumoto , Mitsuro Moriya , Hiroyuki Yamaguchi , Shin-ichi Yamada
发明人： Yasuki Matsumoto , Mitsuro Moriya , Hiroyuki Yamaguchi , Shin-ichi Yamada
IPC分类号： G11B7/007 , G11B7/09 , G11B7/095
CPC分类号： G11B7/00718 , G11B7/094 , G11B7/00745 , G11B7/0901 , G11B7/0938
摘要： In the optical recording medium of the invention, land and groove tracks are arranged in a spiral manner, and a completion information region having identification reading completion information indicative of a rear end of an identification region is disposed between data regions. A pair of wobble pits are disposed immediately behind the identification reading completion information region, and therefore the wobble pits can accurately be detected by reading out the wobble pits on the basis of the identification reading completion information.
摘要翻译：在本发明的光记录介质中，以脊线和凹槽轨迹布置螺旋状，并且在数据区域之间设置具有表示识别区域的后端的识别读取完成信息的完成信息区域。在识别读取完成信息区域之后立即设置一对摆动凹坑，因此可以通过基于识别读取完成信息读出摆动坑来精确地检测摆动坑。

34. 发明授权

US5705638A Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor 失效
标题翻译：光学活性3-羟基-1,5-苯并硫氮杂衍生物及其中间体的制备方法
公开(公告)号：US5705638A
公开(公告)日：1998-01-06
申请号：US744817
申请日：1996-11-06
申请人： Ryuzo Yoshioka , Shin-ichi Yamada , Takeji Shibatani
发明人： Ryuzo Yoshioka , Shin-ichi Yamada , Takeji Shibatani
IPC分类号： C07D281/10
CPC分类号： C07D281/10
摘要： An optical resolution process of the compound of the formula (1): ##STR1## wherein Ring A and Ring B are a substituted or unsubstituted benzene ring and R.sup.1 and R.sup.2 are the same or different and a lower alkyl group, by utilizing difference in solubility between the two diastereoisomeric salts prepared by treating the racemic compound (1) with an acidic resolution agent. The present process is industrially advantageous with compared to conventional processes for preparing an optically active 3-hydroxy-1,5-benzothiazepine derivative which are useful as an intermediate for preparing medicines.
摘要翻译：式（1）化合物的光学拆分方法：其中环A和环B为取代或未取代的苯环，且R 1和R 2相同或不同，低级烷基通过利用通过用酸性分解剂处理外消旋化合物（1）制备的两种非对映异构体盐之间的溶解度差异。与用于制备药物的中间体有用的光学活性3-羟基-1,5-苯并硫氮杂衍生物的制备方法相比，本方法在工业上是有利的。

35. 发明授权

US5117037A Cis-bicyclo[4,3.0]non-2-end derivatives 失效
标题翻译： CIS-BICYCLO（4,3.0）非2-D衍生物
公开(公告)号：US5117037A
公开(公告)日：1992-05-26
申请号：US622471
申请日：1990-12-05
申请人： Masakatsu Shibasaki , Takahashi Atsuo , Tuyoshi Aoki , Hiroyasu Sato , Shin-ichi Yamada , Michiko Kudo , Takaji Yamaguchi , Kentaro Kogi , Sen-ichi Narita
发明人： Masakatsu Shibasaki , Takahashi Atsuo , Tuyoshi Aoki , Hiroyasu Sato , Shin-ichi Yamada , Michiko Kudo , Takaji Yamaguchi , Kentaro Kogi , Sen-ichi Narita
IPC分类号： C07C59/46 , C07C59/62 , C07C69/712 , C07C69/732 , C07C69/738 , C07C405/00
CPC分类号： C07C69/738 , C07C405/0083 , C07C59/46 , C07C59/62 , C07C69/712 , C07C69/732 , Y02P20/55
摘要： A cis-bicyclo[4.3.0]non-2-ene derivative of the formula: ##STR1## wherein R is a hydrogen atom, or a protecting group for a hydroxyl group, R.sup.1 is a hydrogen atom, A C.sub.1 -C.sub.12 straight or branched chain alkyl group, a substituted or unsubstituted phenyl group, a C.sub.6 -C.sub.12 aralkyl group containing a condensed aromatic ring or an aromatic hetero ring, or 1 equivalent of a cation, A is --CH.dbd.CH--CH.sub.2 --, or --CH.sub.2 --CH.sub.2 --O--, R.sup.2 is a C.sub.3 -C.sub.10 straight or branched chain alkyl group, a C.sub.1 -C.sub.3 alkyl group substituted by an aryloxy group which may be substituted, a C.sub.3 -C.sub.12 straight or branched chain alkenyl group, a C.sub.3 -C.sub.8 straight or branched chain alkynyl group, a C.sub.1 -C.sub.3 alkyl group substituted by a phenyl or phenoxy group which may be substituted, by a C.sub.1 -C.sub.6 alkoxy group or by a C.sub.5 -C.sub.8 cycloalkyl group, R.sup.3 is a hydrogen atom, a methyl group, or a vinyl group, and X is a halogen atom.

36. 发明申请

US20090046549A1 OPTICAL DISC DEVICE, CROSSTALK CORRECTION METHOD, AND INTEGRATED CIRCUIT 有权
标题翻译：光盘设备，CROSSTALK校正方法和集成电路
公开(公告)号：US20090046549A1
公开(公告)日：2009-02-19
申请号：US12097739
申请日：2006-12-13
申请人： Minoru Takazawa , Shin-ichi Yamada , Takeharu Yamamoto , Yasuo Ooishi
发明人： Minoru Takazawa , Shin-ichi Yamada , Takeharu Yamamoto , Yasuo Ooishi
IPC分类号： G11B7/00
CPC分类号： G11B7/0917 , G11B7/094 , G11B7/0941 , G11B7/0948 , G11B7/0956
摘要： When a focus error signal (FE signal) is detected with an astigmatic method, a track crossing component leaks into the FE signal. Another detection method for the FE signal would reduce the leaking signal, but is not applicable when the light use efficiency decreases. An optical crosstalk correction amount determination unit (1000) determines a correction amount to correct an output of a tracking error detection unit (120) based on optical crosstalk from a TE signal to an FE signal occurring in reflection light from an optical disc (102) when a spot crosses a track. An output of the tracking error detection unit (120) is multiplied by the determined correction amount, and added to an output of the focus error detection unit (118). A focus control unit (138) executes focus control based on the addition result. This effectively reduces a TE signal component that leaks into the FE signal due to optical crosstalk.
摘要翻译：当利用散光法检测到聚焦误差信号（FE信号）时，轨迹交叉分量泄漏到FE信号中。 FE信号的另一种检测方法将减少泄漏信号，但是当光使用效率降低时不适用。光串扰校正量确定单元（1000）基于从TE信号到来自光盘（102）的反射光中发生的FE信号的光串扰确定校正跟踪误差检测单元（120）的输出的校正量，当一个点穿过一条轨道。将跟踪误差检测单元（120）的输出乘以所确定的校正量，并将其相加到聚焦误差检测单元（118）的输出。聚焦控制单元（138）基于相加结果执行聚焦控制。这有效地减少了由于光串扰而泄漏到FE信号中的TE信号分量。

37. 发明授权

US5508995A Optical disk capable of recording information on both groove and land tracks 失效
标题翻译：能够在凹槽和纹路轨迹上记录信息的光盘
公开(公告)号：US5508995A
公开(公告)日：1996-04-16
申请号：US275984
申请日：1994-07-15
申请人： Mitsurou Moriya , Yasuhiro Sugihara , Shunji Oohara , Yasuki Matsumoto , Shin-ichi Yamada
发明人： Mitsurou Moriya , Yasuhiro Sugihara , Shunji Oohara , Yasuki Matsumoto , Shin-ichi Yamada
IPC分类号： G11B7/007 , G11B7/013 , G11B7/09 , G11B7/26 , G11B11/105 , G11B7/24
CPC分类号： G11B7/00745 , G11B7/00718 , G11B7/0938 , G11B7/24085 , G11B11/10578 , G11B7/26
摘要： An optical recording medium includes a groove track and a land track provided on a resin substrate. Each of the tracks is divided into a plurality of sectors for every turn. Each sector has an ID region, a servo region, and an information region. A pit in the ID region is formed so as to span across both the groove track and the land track. The first wobble pit and the second wobble pit are provided on both sides of the center line of each track, and they are spaced with each other in the direction of the track. Thus, since a larger width of the pit can be provided, production of the optical recording medium can be facilitated. Moreover, since the center of the track can be detected accurately by the first and second wobble pits, accurate tracking control can be performed.
摘要翻译：光记录介质包括设置在树脂基板上的槽轨道和槽脊轨道。每个轨道每转一圈分成多个扇区。每个扇区具有ID区域，伺服区域和信息区域。 ID区域中的凹坑形成为跨越凹槽轨道和槽脊轨道跨过。第一摆动凹坑和第二摆动凹坑设置在每个轨道的中心线的两侧，并且它们在轨道的方向上彼此间隔开。因此，由于可以提供更大的凹坑宽度，所以可以方便生产光学记录介质。此外，由于可以通过第一和第二摆动坑精确地检测轨道的中心，因此可以进行精确的跟踪控制。

38. 发明授权

US5149702A Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same 失效
标题翻译：环庚烯并吡啶衍生物，其制备方法和含有它们的抗溃疡剂
公开(公告)号：US5149702A
公开(公告)日：1992-09-22
申请号：US618943
申请日：1990-11-27
申请人： Shin-ichi Yamada , Takao Goto , Rie Yorita , Eizi Shimanuki , Takaji Yamaguchi , Kentaro Kogi , Senichi Narita
发明人： Shin-ichi Yamada , Takao Goto , Rie Yorita , Eizi Shimanuki , Takaji Yamaguchi , Kentaro Kogi , Senichi Narita
IPC分类号： C07D401/12 , C07D471/04
CPC分类号： C07D401/12 , C07D471/04 , Y02P20/55 , Y10S514/926 , Y10S514/927
摘要： Provided are cycloheptenopyridine derivatives represented by the general formula ##STR1## [wherein R represents a hydrogen atom or lower alkyl group; R.sup.1 represents a hydrogen atom, halogen atom, lower cycloalkoxy group, amido group, substituted phenoxy group, substituted benzyloxy group, lower alkoxy group optionally containing halogen atoms(s), nitro group, hydroxyl group, lower alkenyloxy group, lower alkylthio group, or a group--NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or lower alkyl group, or R.sup.4 and R.sup.5 mutually combine together with the nitrogen atom adjacent thereto to form a 5- or 6-membered heterocyclic group); R.sup.2 represents a hydrogen atom, halogen atom, lower alkyl group optionally containing a halogen atom, lower alkoxy group optionally containing a halogen atom, hydroxyl group, acyl group, lower alkoxycarbonyl group, nitro group or amino group; R.sup.3 represents a hydrogen atom, a lower alkyl group, lower alkoxymethyl group, lower alkylcarbonyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkylcarbamoyl group, lower alkylcarbonylmethyl group, lower alkoxycarbonyl group, lower acyloxymethyl group, lower alkylsulfonyl group, or physiologically acceptable protective group eliminatable in an acid medium or under a physiological condition; n represents 0 or 1; and A represents a methine carbon or nitrogen atom] or their salts. These derivatives and their salts are useful as antiulcer agents.
摘要翻译：提供由通式[IMAGE] [I]表示的环庚烯并吡啶衍生物[其中R表示氢原子或低级烷基; R1表示氢原子，卤素原子，低级环烷氧基，酰胺基，取代苯氧基，取代的苄氧基，任选含有卤原子的低级烷氧基，硝基，羟基，低级链烯氧基，低级烷硫基，或基团-NR 4 R 5（其中R 4和R 5可以相同或不同，各自表示氢原子或低级烷基，或者R 4和R 5与与其相邻的氮原子相互结合形成5-或6-元杂环基）; R2表示氢原子，卤素原子，任选含有卤原子的低级烷基，任选含有卤素原子的低级烷氧基，羟基，酰基，低级烷氧基羰基，硝基或氨基; R3表示氢原子，低级烷基，低级烷氧基甲基，低级烷基羰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，低级烷基羰基甲基，低级烷氧基羰基，低级酰氧基甲基，低级烷基磺酰基或生理上可接受的保护性组在酸性培养基中或在生理条件下可消除; n表示0或1; A表示次甲基碳或氮原子]或其盐。这些衍生物及其盐可用作抗溃疡剂。

39. 发明授权

US08815597B2 Baglike container for centrifugation and method of gene transfer using the same 有权
标题翻译：用于离心的袋状容器和使用其的基因转移方法
公开(公告)号：US08815597B2
公开(公告)日：2014-08-26
申请号：US12377234
申请日：2007-08-23
申请人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
发明人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
IPC分类号： C12N1/00 , C12M1/42 , C12N15/87 , A61J1/10 , C12M1/00 , C12M3/00 , C12N15/00 , C12P21/04 , C12P21/06 , B01L3/00
CPC分类号： A61J1/10 , B01L3/5021 , B01L3/505 , C12M23/14 , C12M35/04 , C12N15/87
摘要： The present invention provides a baglike container for centrifugation that is mounted in a centrifuge to thereby allow centrifugation of a dispersion liquid accommodated therein. The baglike container for centrifugation is less likely to tear or break as a result of centrifugation by disposing a container wall surface of the baglike container so as to apply centrifugal force perpendicular to the container wall surface.
摘要翻译：本发明提供一种用于离心的袋状容器，其安装在离心机中，从而允许其中容纳的分散液的离心。用于离心的袋状容器由于通过设置袋状容器的容器壁表面而离心而不易撕裂或破裂，从而施加垂直于容器壁表面的离心力。

40. 发明申请

US20100284258A1 INTERLAYER MOVEMENT APPARATUS, AND INTEGRATED CIRCUIT FOR INTERLAYER MOVEMENT APPARATUS 有权
标题翻译：中间层运动装置和中间层运动装置的集成电路
公开(公告)号：US20100284258A1
公开(公告)日：2010-11-11
申请号：US12810970
申请日：2008-12-25
申请人： Shin-ichi Yamada , Masaya Kuwahara , Yu Okada
发明人： Shin-ichi Yamada , Masaya Kuwahara , Yu Okada
IPC分类号： G11B27/36
CPC分类号： G11B7/08511 , G11B7/0941 , G11B7/0945 , G11B7/13925 , G11B2007/0013
摘要： To provide an interlayer movement apparatus of an optical disc apparatus which can perform the interlayer movement stably even when the interlayer distances of the multi-layer optical disc which are specified by the disc specification are different between the respective layers.In an interlayer movement apparatus for moving the focal point of the laser light to an arbitrary layer, there are provided an objective lens which collects the laser light from an optical source, a focus actuator which makes the objective lens move in its optical axis direction, a focus error detection means for detecting the convergent state of the laser light on the information layer of the optical disc, and an interlayer movement control system for making the focal point of the laser light move to an information layer two or more layers apart by controlling the focus actuator according to a relative speed between the information layer of the optical disc and the focal point which was calculated using the time required for the focal point of the laser light passing through the respective layers which was measured on the basis of the output signal of the focus error detection means and the respective interlayer distances which are specified by the optical disc specifications.
摘要翻译：为了提供即使当由盘规格指定的多层光盘的层间距离在各层之间不同时，也可以稳定地执行层间移动的光盘装置的层间移动装置。在将激光焦点移动到任意层的层间移动装置中，设置有从光源收集激光的物镜，使物镜沿其光轴方向移动的聚焦致动器，用于检测激光在光盘的信息层上的会聚状态的聚焦误差检测装置，以及通过控制使激光的焦点移动到两层或更多层的信息层的层间移动控制系统所述聚焦致动器根据所述光盘的信息层和所述焦点之间的相对速度，所述相对速度是使用根据所述输出信号测量的通过各个层的激光的焦点所需的时间计算的的焦点误差检测装置和由光盘规格指定的各层间距离。

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