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31. 发明授权

US06607889B1 Methods, kits and compositions pertaining to detection complexes 有权
标题翻译：与检测复合物相关的方法，试剂盒和组合物
公开(公告)号：US06607889B1
公开(公告)日：2003-08-19
申请号：US09867345
申请日：2001-05-29
申请人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
发明人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
IPC分类号： C12Q168
CPC分类号： C12Q1/6851 , C07K14/003 , C12Q1/6818 , C12Q1/686 , C12Q2565/101 , C12Q2561/113 , C12Q2525/107
摘要： This invention is directed to methods, kits and compositions which utilize Detection Complexes to detect or identify the presence, absence or quantity of a target molecule in a sample of interest. A Detection Complex comprises at least two component polymers and at least one set of donor and acceptor moieties. To each of at least two component polymers is linked at least one moiety of a set of donor and acceptor moieties, such that formation of the complex facilitates transfer of energy between donor and acceptor moieties of each set in a manner which, in an assay, produces changes in detectable signal which can be correlated with the presence absence of quantity of target sequence and/or target molecule of interest in the sample.
摘要翻译：本发明涉及利用检测复合物检测或鉴定感兴趣样品中目标分子的存在，不存在或数量的方法，试剂盒和组合物。检测复合物包含至少两种组分聚合物和至少一组供体和受体部分。至少两种组分聚合物中的每一种连接一组供体和受体部分的至少一个部分，使得复合物的形成促进了每组的供体和受体部分之间的能量转移，产生可检测信号的变化，其可以与样品中靶序列和/或目标分子的量的存在不相关。

32. 发明授权

US06361942B1 Method, kits and compositions pertaining to detection complexes 有权
标题翻译：与检测复合物相关的方法，试剂盒和组合物
公开(公告)号：US06361942B1
公开(公告)日：2002-03-26
申请号：US09275848
申请日：1999-03-24
申请人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
发明人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
IPC分类号： C12Q168
CPC分类号： C12Q1/6851 , C07K14/003 , C12Q1/6818 , C12Q1/686 , C12Q2565/101 , C12Q2561/113 , C12Q2525/107
摘要： This invention is directed to methods, kits and compositions which utilize Detection Complexes to detect or identify the presence, absence or quantity of a target molecule in a sample of interest. A Detection Complex comprises at least two component polymers and at least one set of donor and accepter moieties. To each of at least two component polymers is linked at least one moiety of a set of donor and accepter moieties, such that formation of the complex facilitates transfer of energy between donor and acceptor moieties of each set in a manner which, in an assay, produces changes in detectable signal which can be correlated with the presence absence of quantity of target sequence and/or target molecule of interest in the sample.
摘要翻译：本发明涉及利用检测复合物检测或鉴定感兴趣样品中目标分子的存在，不存在或数量的方法，试剂盒和组合物。检测复合物包含至少两种组分聚合物和至少一组供体和受体部分。至少两种组分聚合物中的每一种连接一组供体和受体部分的至少一个部分，使得复合物的形成促进每组的供体和受体部分之间的能量转移，其方式是在测定中，产生可检测信号的变化，其可以与样品中靶序列和/或目标分子的量的存在不相关。

33. 发明授权

US07135563B2 Compositions for detecting target sequences 有权
标题翻译：用于检测靶序列的组合物
公开(公告)号：US07135563B2
公开(公告)日：2006-11-14
申请号：US09950255
申请日：2001-09-10
申请人： Kyriaki Stefano , James M. Coull , Henrik Stender , Jens J. Hyldig-Nielsen , Kenneth H. Peterson
发明人： Kyriaki Stefano , James M. Coull , Henrik Stender , Jens J. Hyldig-Nielsen , Kenneth H. Peterson
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/682 , C12Q1/6839 , Y10T436/143333 , C12Q2537/119 , C12Q2525/107 , C12Q2521/337 , C12Q2563/131
摘要： The present invention relates to methods, kits and compositions suitable for the improved detection, quantitation and analysis of nucleic acid target sequences using probe-based hybridization assays.
摘要翻译：本发明涉及适用于使用基于探针的杂交测定来改进核酸靶序列的检测，定量和分析的方法，试剂盒和组合物。

34. 发明授权

US06528267B1 Methods, kits and compositions pertaining to PNA molecular beacons 有权
公开(公告)号：US06528267B1
公开(公告)日：2003-03-04
申请号：US09888341
申请日：2001-06-22
申请人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
发明人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
IPC分类号： C12Q168
CPC分类号： C12Q1/6818
摘要： This invention is directed to methods, kits and compositions pertaining to PNA Molecular Beacons. PNA Molecular Beacons comprise self-complementary arm segments and flexible linkages which promote intramolecular or intermolecular interactions. In the absence of a target sequence, PNA Molecular Beacons facilitate efficient energy transfer between the linked donor and acceptor moieties of the probe. Upon hybridization of the probe to a target sequence, there is a measurable change in at least one property of at least one donor or acceptor moiety of the probe which can be used to detect, identify or quantitate the target sequence in a sample.

35. 发明授权

US5612458A Antibody to PNA/nucleic acid complexes 失效
标题翻译： PNA /核酸复合物的抗体
公开(公告)号：US5612458A
公开(公告)日：1997-03-18
申请号：US361643
申请日：1994-12-22
申请人： Jens J. Hyldig-Nielsen , Karl-Johan Pluzek
发明人： Jens J. Hyldig-Nielsen , Karl-Johan Pluzek
IPC分类号： G01N33/53 , C07K16/44 , C12N15/09 , A61K39/00 , A61K51/10
CPC分类号： C07K16/44
摘要： This invention relates to antibodies to complexes formed between PNA (Peptide Nucleic Acid) and nucleic acids, particularly antibodies to PNA/DNA or PNA/RNA complexes. The preferred antibodies are polyclonal, monoclonal and recombinant antibodies that binds to PNA/DNA or PNA/RNA complexes, but not to single-stranded PNA, double-stranded nucleic acid or single-stranded nucleic acid. Peptide Nucleic Acids (PNA) are newly developed, not naturally occurring compounds comprising a polyamide backbone bearing a plurality of ligands such as naturally occuring nucleobases attached to a polyamide backbone through a suitable linker. PNA oligomers with a backbone of N-(2-aminoethyl)glycin units have a surprising high affinity for complementary nucleic acid forming very stable and specific complexes. This property makes PNA oligomers suitable as hybridization probes for detection of nucleic acids. The usability of PNA as hybridization probes is greatly increased by the present antibodies. The antibodies according to the invention are useful in the capture, recognition, detection, identification or quantitation of nucleic acids in biological samples, via their ability to react with PNA-nucleic acid complexes.
摘要翻译：本发明涉及在PNA（肽核酸）和核酸之间形成的复合物的抗体，特别是针对PNA / DNA或PNA / RNA复合物的抗体。优选的抗体是结合PNA / DNA或PNA / RNA复合物但不与单链PNA，双链核酸或单链核酸结合的多克隆，单克隆和重组抗体。肽核酸（PNA）是新开发的，而不是天然存在的化合物，其包含具有多个配体的聚酰胺主链，例如通过合适的接头天然存在连接到聚酰胺主链的核碱基。具有N-（2-氨基乙基）甘氨酸单元骨架的PNA寡聚体对形成非常稳定和特异性复合物的互补核酸具有惊人的高亲和力。该性质使得PNA低聚物适合作为检测核酸的杂交探针。通过本发明的抗体，PNA作为杂交探针的可用性大大提高。根据本发明的抗体可用于通过其与PNA-核酸复合物反应的能力捕获，识别，鉴定或定量生物样品中的核酸。

36. 发明授权

US08912312B2 PNA probes, probe sets, methods and kits pertaining to the detection of Candida 有权
标题翻译： PNA探针，探针组，与念珠菌检测有关的方法和试剂盒
公开(公告)号：US08912312B2
公开(公告)日：2014-12-16
申请号：US13207283
申请日：2011-08-10
申请人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
发明人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
IPC分类号： C12Q1/68 , C07K14/00
CPC分类号： C12Q1/6895 , C07K14/003 , C12Q1/689 , C12Q2525/107
摘要： This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be selected from the group consisting of: AGA-GAG-CAG-CAT-GCA (Seq. Id. No. 1), AGA-GAG-CAA-CAT-GCA (Seq. Id. No. 2), ACA-GCA-GAA-GCC-GTG (Seq. Id. No. 3), CAT-AAA-TGG-CTA-CCA-GA (Seq. Id. No. 4), CAT-AAA-TGG-CTA-CCC-AG (Seq. Id. No. 5), ACT-TGG-AGT-CGA-TAG (Seq. Id. No. 6), CCA-AGG-CTT-ATA-CTC-GC (Seq. Id. No. 7), CCC-CTG-AAT-CGG-GAT (Seq. Id. No. 8), GAC-GCC-AAA-GAC-GCC (Seq. Id. No. 9), ATC-GTC-AGA-GGC-TAT-AA (Seq. Id. No. 10), TAG-CCA-GAA-GAA-AGG (Seq. Id. No. 11), CAT-AAA-TGG-CTA-GCC-AG (Seq. Id. No. 12), CTC-CGA-TGT-GAC-TGC-G (Seq. Id. No. 13), TCC-CAG-ACT-GCT-CGG (Seq. Id. No. 14), TCC-AAG-AGG-TCG-AGA (Seq. Id. No. 15), GCC-AAG-CCA-CAA-GGA (Seq. Id. No. 16), GCC-GCC-AAG-CCA-CA (Seq. Id. No. 17), GGA-CTT-GGG-GTT-AG (Seq. Id. No. 18), CCG-GGT-GCA-TTC-CA (Seq. Id. No. 19), ATG-TAG-AAC-GGA-ACT-A (Seq. Id. No. 20), GAT-TCT-CGG-CCC-CAT-G (Seq. Id. No. 21), CTG-GTT-CGC-CAA-AAA-G (Seq. Id. No. 22) and AGT-ACG-CAT-CAG-AAA (Seq. Id. No. 23).
摘要翻译：本发明涉及与一种或多种念珠菌酵母的检测有关的新型PNA探针，探针组，方法和试剂盒。可用于本发明探针的探测核碱基序列的非限制性实例可以选自：AGA-GAG-CAG-CAT-GCA（Seq.Id。No.1），AGA-GAG- CAA-CAT-GCA（序列号2），ACA-GCA-GAA-GCC-GTG（序列号3），CAT-AAA-TGG-CTA-CCA-GA（Seq.Id。第4号），CAT-AAA-TGG-CTA-CCC-AG（Seq.Id。No.5），ACT-TGG-AGT-CGA-TAG（Seq.Id。No.6），CCA-AGG-CTT -ATA-CTC-GC（Seq.Id。No.7），CCC-CTG-AAT-CGG-GAT（Seq.Id。No.8），GAC-GCC-AAA-GAC-GCC（Seq.Id.No ATC-GTC-AGA-GGC-TAT-AA（序列号10），TAG-CCA-GAA-GAA-AGG（序列号11），CAT-AAA-TGG- CTA-GCC-AG（序列号12），CTC-CGA-TGT-GAC-TGC-G（序列号13），TCC-CAG-ACT-GCT-CGG（Seq.Id。第14号），TCC-AAG-AGG-TCG-AGA（序列号15），GCC-AAG-CCA-CAA-GGA（序列号16），GCC-GCC-AAG-CCA -CA（Seq.Id。No.17），GGA-CTT-GGG-GTT-AG（Seq.Id.18），CCG-GGT-GCA-TTC-CA（Seq.Id.No.19） ATG-TAG-AAC-GGA-ACT-A（序列号20），GAT-TCT-CGG-CCC-CAT-G（序列号21），CTG-GTT-CGC-CAA- AAA-G （Seq。 ID。 No.22）和AGT-ACG-CAT-CAG-AAA（Seq.Id。No.23）。

37. 发明授权

US08754191B2 Methods, kits and compositions pertaining to the suppression of the detectable probe binding to randomly distributed repeat sequences genomic nucleic acid 有权
标题翻译：与抑制可检测探针结合随机分布的重复序列基因组核酸有关的方法，试剂盒和组合物
公开(公告)号：US08754191B2
公开(公告)日：2014-06-17
申请号：US13368732
申请日：2012-02-08
申请人： Kirsten Vang Nielsen , Jens J. Hyldig-Nielsen , Brett F. Williams
发明人： Kirsten Vang Nielsen , Jens J. Hyldig-Nielsen , Brett F. Williams
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6837 , C12Q1/6876 , C12Q2600/156 , C12Q2537/162 , C12Q2525/186 , C12Q2525/107 , C12Q2525/151
摘要： This invention is directed to methods, kits, non-nucleotide probes as well as other compositions pertaining to the suppression of binding of detectable nucleic acid probes to undesired nucleotide sequences of genomic nucleic acid in assays designed to determine target genomic nucleic acid.
摘要翻译：本发明涉及方法，试剂盒，非核苷酸探针以及其它有关抑制可检测的核酸探针与设计用于确定靶基因组核酸的测定中的基因组核酸的不需要的核苷酸序列结合有关的组合物。

38. 发明授权

US08026051B2 PNA probes, probe sets, methods and kits pertaining to the detection of Candida 有权
标题翻译： PNA探针，探针组，与念珠菌检测有关的方法和试剂盒
公开(公告)号：US08026051B2
公开(公告)日：2011-09-27
申请号：US10150045
申请日：2002-05-17
申请人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
发明人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6895 , C07K14/003 , C12Q1/689 , C12Q2525/107
摘要： This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be selected from the group consisting of: AGA-GAG-CAG-CAT-GCA (Seq. Id. No. 1), AGA-GAG-CAA-CAT-GCA (Seq. Id. No. 2), ACA-GCA-GAA-GCC-GTG (Seq. Id. No. 3), CAT-AAA-TGG-CTA-CCA-GA (Seq. Id. No. 4), CAT-AAA-TGG-CTA-CCC-AG (Seq. Id. No. 5), ACT-TGG-AGT-CGA-TAG (Seq. Id. No. 6), CCA-AGG-CTT-ATA-CTC-GC (Seq. Id. No. 7), CCC-CTG-AAT-CGG-GAT (Seq. Id. No. 8), GAC-GCC-AAA-GAC-GCC (Seq. Id. No. 9), ATC-GTC-AGA-GGC-TAT-AA (Seq. Id. No. 10), TAG-CCA-GAA-GAA-AGG (Seq. Id. No. 11), CAT-AAA-TGG-CTA-GCC-AG (Seq. Id. No. 12), CTC-CGA-TGT-GAC-TGC-G (Seq. Id. No. 13), TCC-CAG-ACT-GCT-CGG (Seq. Id. No. 14), TCC-AAG-AGG-TCG-AGA (Seq. Id. No. 15), GCC-AAG-CCA-CAA-GGA (Seq. Id. No. 16), GCC-GCC-AAG-CCA-CA (Seq. Id. No. 17), GGA-CTT-GGG-GTT-AG (Seq. Id. No. 18), CCG-GGT-GCA-TTC-CA (Seq. Id. No. 19), ATG-TAG-AAC-GGA-ACT-A (Seq. Id. No. 20), GAT-TCT-CGG-CCC-CAT-G (Seq. Id. No. 21), CTG-GTT-CGC-CAA-AAA-G (Seq. Id. No. 22) and AGT-ACG-CAT-CAG-AAA (Seq. Id. No. 23).
摘要翻译：本发明涉及与一种或多种念珠菌酵母的检测有关的新型PNA探针，探针组，方法和试剂盒。可用于本发明探针的探测核碱基序列的非限制性实例可以选自：AGA-GAG-CAG-CAT-GCA（Seq.Id。No.1），AGA-GAG- CAA-CAT-GCA（序列号2），ACA-GCA-GAA-GCC-GTG（序列号3），CAT-AAA-TGG-CTA-CCA-GA（Seq.Id。第4号），CAT-AAA-TGG-CTA-CCC-AG（Seq.Id。No.5），ACT-TGG-AGT-CGA-TAG（Seq.Id。No.6），CCA-AGG-CTT -ATA-CTC-GC（Seq.Id。No.7），CCC-CTG-AAT-CGG-GAT（Seq.Id。No.8），GAC-GCC-AAA-GAC-GCC（Seq.Id.No ATC-GTC-AGA-GGC-TAT-AA（序列号10），TAG-CCA-GAA-GAA-AGG（序列号11），CAT-AAA-TGG- CTA-GCC-AG（序列号12），CTC-CGA-TGT-GAC-TGC-G（序列号13），TCC-CAG-ACT-GCT-CGG（Seq.Id。第14号），TCC-AAG-AGG-TCG-AGA（序列号15），GCC-AAG-CCA-CAA-GGA（序列号16），GCC-GCC-AAG-CCA -CA（Seq.Id。No.17），GGA-CTT-GGG-GTT-AG（Seq.Id.18），CCG-GGT-GCA-TTC-CA（Seq.Id.No.19） ATG-TAG-AAC-GGA-ACT-A（序列号20），GAT-TCT-CGG-CCC-CAT-G（序列号21），CTG-GTT-CGC-CAA- AAA-G （Seq。 ID。 No.22）和AGT-ACG-CAT-CAG-AAA（Seq.Id。No.23）。

39. 发明授权

US08017758B2 PNA oligomers, oligomer sets, methods and kits pertaining to the detection of Bacillus anthracis 有权
标题翻译： PNA寡聚体，低聚物组，与炭疽芽孢杆菌检测有关的方法和试剂盒
公开(公告)号：US08017758B2
公开(公告)日：2011-09-13
申请号：US10393855
申请日：2003-03-21
申请人： Henrik Stender , Jens J. Hyldig-Nielsen
发明人： Henrik Stender , Jens J. Hyldig-Nielsen
IPC分类号： C07H21/04 , A61K31/70 , C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q2525/107
摘要： This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the determination of Bacillus anthracis.
摘要翻译：本发明涉及新型PNA探针，探针组，与炭疽芽孢杆菌测定有关的方法和试剂盒。

40. 发明申请

US20110111393A1 PNA Probes, Mixtures, Methods And Kits Pertaining To The Determination Of Mycoplasma and related Mollicutes 审中-公开
标题翻译： PNA探针，混合物，方法和试剂盒有关测定支原体和相关的细胞
公开(公告)号：US20110111393A1
公开(公告)日：2011-05-12
申请号：US12421927
申请日：2009-04-10
申请人： Jens J. Hyldig-Nielsen , Susan Rigby , Byron F. Brehm-Stecher , Ditte S. Lee , Michael Tanner
发明人： Jens J. Hyldig-Nielsen , Susan Rigby , Byron F. Brehm-Stecher , Ditte S. Lee , Michael Tanner
IPC分类号： C12Q1/68 , C07K7/08 , G01N33/50
CPC分类号： C12Q1/6816 , C12Q2525/313 , C12Q2525/107
摘要： This invention is related to PNA probes, probe sets, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes.
摘要翻译：本发明涉及与确定支原体和相关的Mollicutes有关的PNA探针，探针组，混合物，方法和试剂盒。

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