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    • 32. 发明授权
    • Digital scan converter
    • 数字扫描转换器
    • US4668974A
    • 1987-05-26
    • US804152
    • 1985-12-03
    • Hiroyuki KitaMasaharu TokuharaHiroyuki Kawashima
    • Hiroyuki KitaMasaharu TokuharaHiroyuki Kawashima
    • H04N11/20H04N5/12H04N7/01H04N9/64
    • H04N7/012H04N5/126
    • A digital scan converter having an oscillator providing a clock signal used to scan-convert an input video signal to thereby produce a scan-converted output video signal, an automatic frequency control for controlling the oscillator in synchronism with a synchronizing signal separated from the input video signal and a counter for frequency-dividing the clock signal from the oscillator to thereby form a control signal used for controlling blanking of the input video signal. The counter also provides an address signal for a memory in which the video signal is temporarily stored during the scan converting operation. Since a composite blanking pulse for the input video signal is formed in synchronism with the address signal for the memory, it is possible to prevent appearance of a jitter of the composite blanking pulse on a display screen.
    • 一种数字扫描转换器,具有提供用于对输入视频信号进行扫描转换以产生扫描转换的输出视频信号的时钟信号的振荡器,用于与从输入视频分离的同步信号同步地控制振荡器的自动频率控制 信号和用于对来自振荡器的时钟信号进行分频的计数器,从而形成用于控制输入视频信号的消​​隐的控制信号。 计数器还为扫描转换操作期间临时存储视频信号的存储器提供地址信号。 由于与存储器的地址信号同步地形成用于输入视频信号的复合消隐脉冲,因此可以防止在显示屏幕上出现复合消隐脉冲的抖动。
    • 33. 发明授权
    • Novel 1.alpha.,24-dihydroxycholecalciferol compositions, novel
precursors thereof, and processes for preparing them
    • 新型1 {60,24-二羟基胆钙化甾醇组合物,其新型前体及其制备方法
    • US4022891A
    • 1977-05-10
    • US583115
    • 1975-06-02
    • Toru TakeshitaYoshinobu HashimotoHiroyuki KawashimaSachio IshimotoNobuo IkekawaMasuo Morisaki
    • Toru TakeshitaYoshinobu HashimotoHiroyuki KawashimaSachio IshimotoNobuo IkekawaMasuo Morisaki
    • A23K1/16C07J9/00C07J71/00A61K31/59
    • C07J9/00A23K20/174C07J71/001Y02P20/55
    • Novel 1.alpha., 24-dihydroxycholecalciferol and derivatives thereof which are useful with reduced side-effects for the treatment of abnormal metabolism of calcium and phosphorus caused by liver failure, renal failure, gastrointestinal tract failure and parathyroid failure, and related bone diseases. Preparation of the novel 1.alpha., 24-dihydroxycholecalciferol and their derivatives starts from 1.alpha., 24-dihydroxycholesterol prepared by reacting 1.alpha., 2.alpha.-epoxy-24-keto-cholesta-4,6-dien-3-one with an alkali metal and a proton donor in the presence of liquid ammonia or a liquid amine. Reaction of the 1.alpha., 24-dihydroxycholesterol with an allylic brominating agent, followed by contacting with a dehydrobrominating agent, affords 1.alpha.,3.beta., 24-trihydroxycholesta-5,7-diene derivative, which can then be converted to 1.alpha., 24-dihydroxycholocalciferol by ultraviolet irradiation in a organic solvent, followed by isomerization. Processes are also provided for separating 1.alpha., 24-dihydroxycholesterol into an (S)-epimer and an (R)-epimer, and also for separating at least one of 1.alpha., 3.beta., 24(S)-and 1.alpha., 3.beta., 24(R)-trihydroxycholesta-5,7-dienes from trihydroxycholesta-4,6-diene.
    • 用于治疗由肝衰竭,肾衰竭,胃肠道衰竭和甲状旁腺功能衰竭引起的钙和磷的异常代谢的副作用的新型1α,24-二羟基胆钙化甾醇及其衍生物以及相关的骨疾病。 1α,24-二羟基胆钙化甾醇及其衍生物的制备从1α,24-二羟基胆固醇开始,其通过使1α,2α-环氧-24-酮 - 胆甾烯-4,6-二烯-3-酮与碱 金属和质子供体在液态氨或液态胺存在下进行。 1α,24-二羟基胆固醇与烯丙基溴化剂的反应,然后与脱氢溴化剂接触,得到1α,3β,24-三羟基胆甾-5,7-二烯衍生物,然后将其转化为1α, 通过紫外线照射在有机溶剂中进行异构化,得到24-二羟基胆钙化甾醇。 还提供了用于将1α,24-二羟基胆固醇分离成(S) - 对映体和(R) - 对映体的方法,还用于分离1α,3β,24(S) - 和1α, 3β,24(R) - 三羟基胆甾-5,7-二烯的三羟基胆甾-4,6-二烯。
    • 39. 发明授权
    • Ophthalmologic apparatus
    • 眼科仪器
    • US07540614B2
    • 2009-06-02
    • US12005275
    • 2007-12-27
    • Hiroyuki KawashimaGaku TakeuchiTakao TanabeNoriyasu Kiryu
    • Hiroyuki KawashimaGaku TakeuchiTakao TanabeNoriyasu Kiryu
    • A61B3/14A61B3/10
    • A61B3/14
    • An ophthalmologic apparatus includes an imaging system that illuminates a retina of an eye, and images the retina of the eye based on reflective luminous flux from the retina, an aberration measurement part that measures optical aberration of the eye, an aberration compensation device disposed in the imaging system to compensate the optical aberration of the eye based on a signal from the aberration measurement part, a first focusing device disposed in an optical path of the imaging system to perform focusing of the image of the retina of the eye according to a refractive property of the eye, and a second focusing device disposed in the optical path of the imaging system to compensate infinitesimal spherical aberration generated by the aberration compensation device after adjustment by the first focusing device.
    • 眼科装置包括:照射眼睛的视网膜的成像系统,并且基于来自视网膜的反射光束对眼睛的视网膜进行成像,测量眼睛的光学像差的像差测量部,设置在眼睛中的像差补偿装置 成像系统,用于基于来自像差测量部分的信号补偿眼睛的光学像差;第一聚焦装置,其设置在成像系统的光路中,以根据折射特性进行眼睛的视网膜的图像的聚焦; 以及设置在成像系统的光路中的第二聚焦装置,以补偿由第​​一聚焦装置调节之后由像差补偿装置产生的无穷小的球面像差。