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1. 发明授权

US5197298A Sensor and control system for an automotive air conditioning system 失效
标题翻译：用于汽车空调系统的传感器和控制系统
公开(公告)号：US5197298A
公开(公告)日：1993-03-30
申请号：US789991
申请日：1991-11-12
申请人： Kazumitsu Kobayashi , Masaru Kuribara , Toru Takeshita
发明人： Kazumitsu Kobayashi , Masaru Kuribara , Toru Takeshita
IPC分类号： B60H1/00 , B60H1/32 , F24F11/08 , F25B49/00 , F25B49/02
CPC分类号： B60H1/3225 , F24F11/085 , F25B49/005 , F25B2500/222 , F25B2700/1331 , F25B2700/1332 , F25B2700/195
摘要： An air conditioning system including a refrigerant circulation route, a compressor, a condenser, an expansion valve, an evaporator and a pressure sensor for detecting pressure in the circulation route comprises a refrigerant phase detector provided on the circulation route between the condenser and the evaporator where the refrigerant should be in a liquid phase for detecting whether the refrigerant is in a liquid phase or in a vapor phase and a control for determining whether the compressor is in a locked state in accordance with the signals from the refrigerant phase detector and the pressure sensor. The air conditioning system can precisely determine and detect both compressor lock up and refrigerant leakage without providing a rotation detecting sensor for the compressor.

2. 发明授权

US4402975A Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical uses thereof 失效
公开(公告)号：US4402975A
公开(公告)日：1983-09-06
申请号：US284562
申请日：1981-07-17
申请人： Toru Takeshita , Kenji Hoshina , Akira Ohtsu , Tatsuyuki Naruchi
发明人： Toru Takeshita , Kenji Hoshina , Akira Ohtsu , Tatsuyuki Naruchi
IPC分类号： A61K31/135 , A61K31/195 , A61K31/24 , C07D295/18 , C07C101/34
CPC分类号： C07C229/34 , A61K31/135 , C07C225/18 , C07C233/51 , C07C2101/14 , Y10S514/927 , Y10S514/928
摘要： A compound represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom, an acyl group or an alkoxycarbonyl group; X.sup.1 represents an alkylene group having 3 to 6 carbon atoms, a 1,4-cyclohexylene group, or a 1,4-phenylene group, the alkylene group may be substituted by an alkyl group having 1 to 6 carbon atoms, and the 1,4-phenylene group may be substituted by 1 or 2 substituents selected from halogen atoms and alkoxy groups having 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom or a hydroxyl group and R.sup.3 represents hydrogen atom, or R.sup.2 and R.sup.3 together may form an oxo group (.dbd.O), and when X.sup.1 is other than the 1,4-phenylene group, R.sup.2 represents a hydrogen atom and R.sup.3 represents a bond between the carbon atoms to which R.sup.3 is bonded and that carbon atom of X.sup.1 which is adjacent to said carbon atom; X.sup.2 represents an alkylene group having 1 to 5 carbon atoms which may be substituted by an alkyl group having 1 to 6 carbon atoms or an amino group; and R.sup.4 represents the group --COOR.sup.5, --CH.sub.2 OR.sup.6 or --CONR.sup.7 R.sup.8 in which R.sup.5 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R.sup.6 represents a hydrogen atom or an acyl group having 1 to 6 carbon atoms, and R.sup.7 and R are identical or different and represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or taken together may form a 5- or 6-membered ring; or an acid addition salts of said compound wherein R.sup.1 represents a hydrogen atom or X.sup.2 represents an alkylene group having an amino group, or salts of said compound wherein R.sup.5 represents a hydrogen atom.The compounds represented by the above formula or their pharmaceutically acceptable salts are useful as anti-ulcer agents.The present invention also provides a process for producing the compounds or their pharmaceutically acceptable salts, which comprises acylating a protected derivative at the amino group of a corresponding acid halide with a corresponding substituted benzene in the presence of a Lewis acid; or reducing a corresponding compound in the presence of an inert solvent under conditions which induce reduction of the carbonyl group of said corresponding compound without substantially reducing the phenylene group of said corresponding compound; or dehydrating a corresponding compound.

3. 发明授权

US4199577A Novel 1.alpha.-hydroxy-24-oxovitamin D.sub.3, its preparing process and the novel precursors thereof 失效
标题翻译：新型1α-羟基-24-氧维生素D3，其制备方法及其新型前体
公开(公告)号：US4199577A
公开(公告)日：1980-04-22
申请号：US939043
申请日：1978-09-01
申请人： Toru Takeshita , Takao Niki , Hiroyuki Kawashima , Kiyoshi Bannai
发明人： Toru Takeshita , Takao Niki , Hiroyuki Kawashima , Kiyoshi Bannai
IPC分类号： A61K31/59 , A61P3/02 , C07C67/00 , C07C401/00 , C07J9/00 , C07J17/00 , C07J51/00
CPC分类号： C07J17/00 , C07J51/00 , C07J9/00 , Y02P20/55
摘要： Novel 1.alpha.,3.beta.-dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof.Said novel 1.alpha.-hydroxy-24-oxovitamin D.sub.3 and said novel intermediates are also useful as the intermediates of 1.alpha.,24-dihydroxyvitamin D.sub.3.1.alpha.,3.beta.-Dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof are prepared from fucosterol via 1.alpha.,3.beta.-diprotected hydroxy-24(24)-ethylenedioxycholest-5-ene. 1.alpha.-hydroxy-24-oxovitamin D.sub.3 is prepared by irradiation with ultraviolet rays to 1.alpha.,3.beta.-dihydroxy-24-oxocholesta-5,7-diene or a hydroxyl group-protected derivatives thereof, isomerization using heat energy, and, when necessary, elimination of the protecting groups.
摘要翻译：新的1α，3β-二羟基-24-氧代胆甾-5,7-二烯及其羟基保护的衍生物。所述新型1α-羟基-24-氧维生素D3和所述新型中间体也可用作1α，24-二羟基维生素D3的中间体。 1α，3β-二羟基-24-氧代胆甾烯-5,7-二烯及其羟基保护的衍生物通过1α，3β-双保护的羟基-24（24） - 亚乙基二氧胆甾-5-烯由岩藻甾醇制备。 1α-羟基-24-氧代维生素D3通过用1α，3β-二羟基-24-氧代胆甾烯-5,7-二烯或其羟基受保护的衍生物用紫外线照射制备，使用热能异构化，必要时消除保护基团。

4. 发明授权

US4456553A Vitamin D.sub.3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom 失效
标题翻译：维生素D3衍生物，其制备方法和包含用于制备用于免疫化学测定的抗体的所述衍生物的抗原和由其制备的抗体
公开(公告)号：US4456553A
公开(公告)日：1984-06-26
申请号：US495877
申请日：1983-05-18
申请人： Jun-ichi Oshida , Osamu Nishikawa , Hideki Tsuruta , Toru Takeshita , Itaru Yamamoto , Kenji Ishimaru
发明人： Jun-ichi Oshida , Osamu Nishikawa , Hideki Tsuruta , Toru Takeshita , Itaru Yamamoto , Kenji Ishimaru
IPC分类号： C07J9/00
CPC分类号： C07J9/00 , Y10S530/807
摘要： The present invention relates to novel vitamin D.sub.3 derivatives which have a carboxyl group or its ester group at the 22-position, processes for the preparation thereof, and antigens, which comprise said vitamin D.sub.3 derivative and an immunogenic carrier material, to be used for the preparation of antibodies for enzymeimmunoassay or radioimmunoassay and antibodies obtained therefrom.The determination of such activated vitamin D.sub.3 compounds as 25-hydroxy vitamin D.sub.3, 24, 25-dihydroxy vitamin D.sub.3, etc. can be made satisfactorily according to the present invention.
摘要翻译：本发明涉及在22位具有羧基或其酯基的新型维生素D3衍生物，其制备方法，以及包含所述维生素D3衍生物和免疫原性载体材料的抗原，其用于制备用于酶免疫测定或放射免疫测定的抗体及其获得的抗体。根据本发明，可以令人满意地确定这种活化的维生素D3化合物作为25-羟基维生素D3,24,25-二羟基维生素D3等。

5. 发明授权

US07560236B2 Microbial community analysis 失效
标题翻译：微生物群落分析
公开(公告)号：US07560236B2
公开(公告)日：2009-07-14
申请号：US11759692
申请日：2007-06-07
申请人： Yoshihisa Yamashita , Yoshio Nakano , Toru Takeshita
发明人： Yoshihisa Yamashita , Yoshio Nakano , Toru Takeshita
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/683 , C12Q2545/113
摘要： The present invention provides a method which can enhance the precision of identification of bacterial species using a T-RFLP method and achieve, by itself, the identification of bacteria constituting a bacterial flora and the tracing of distribution changes thereof. The present invention provides a method for analyzing a bacterial community including: amplifying DNAs extracted from a bacterial community by PCR using 16S rRNA genes as templates and fluorescently labeled primers; cleaving the amplification products with a restriction enzyme to thereby obtain sample PCR fragments; electrophoresing the sample PCR fragments together with size standard PCR fragments; and comparing the mobilities thereof to thereby determine the sizes of the sample PCR fragments, wherein PCR fragments amplified by using, as a template, a 16S rRNA gene derived from a bacterium contained in the bacterial community to be analyzed are used as the size standards.
摘要翻译：本发明提供了一种使用T-RFLP方法提高细菌物种鉴定精度的方法，并且本身实现了构成细菌菌群的细菌的鉴定和其分布变化的追踪。本发明提供一种分析细菌群落的方法，包括：使用16S rRNA基因作为模板和荧光标记的引物通过PCR扩增从细菌群落提取的DNA; 用限制酶切割扩增产物，从而获得样品PCR片段; 将样品PCR片段与大小标准PCR片段一起进行电泳; 并比较其迁移率，从而确定样品PCR片段的大小，其中使用通过使用来源于待分析的细菌群落中的细菌的16S rRNA基因作为模板扩增的PCR片段作为大小标准。

6. 发明申请

US20080305475A1 MICROBIAL COMMUNITY ANALYSIS 失效
标题翻译：微生物社区分析
公开(公告)号：US20080305475A1
公开(公告)日：2008-12-11
申请号：US11759692
申请日：2007-06-07
申请人： Yoshihisa YAMASHITA , Yoshio Nakano , Toru Takeshita
发明人： Yoshihisa YAMASHITA , Yoshio Nakano , Toru Takeshita
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/683 , C12Q2545/113
摘要： The present invention provides a method which can enhance the precision of identification of bacterial species using a T-RFLP method and achieve, by itself, the identification of bacteria constituting a bacterial flora and the tracing of distribution changes thereof. The present invention provides a method for analyzing a bacterial community including: amplifying DNAs extracted from a bacterial community by PCR using 16S rRNA genes as templates and fluorescently labeled primers; cleaving the amplification products with a restriction enzyme to thereby obtain sample PCR fragments; electrophoresing the sample PCR fragments together with size standard PCR fragments; and comparing the mobilities thereof to thereby determine the sizes of the sample PCR fragments, wherein PCR fragments amplified by using, as a template, a 16S rRNA gene derived from a bacterium contained in the bacterial community to be analyzed are used as the size standards.
摘要翻译：本发明提供了一种使用T-RFLP方法提高细菌物种鉴定精度的方法，并且本身实现了构成细菌菌群的细菌的鉴定和其分布变化的追踪。本发明提供一种分析细菌群落的方法，包括：使用16S rRNA基因作为模板和荧光标记的引物通过PCR扩增从细菌群落提取的DNA; 用限制酶切割扩增产物，从而获得样品PCR片段; 将样品PCR片段与大小标准PCR片段一起进行电泳; 并比较其迁移率，从而确定样品PCR片段的大小，其中使用通过使用来源于待分析的细菌群落中的细菌的16S rRNA基因作为模板扩增的PCR片段作为大小标准。

7. 发明授权

US5551502A Pressurizing control method and pressurizing control system for low-pressure casting 失效
标题翻译：低压铸造加压控制方法及加压控制系统
公开(公告)号：US5551502A
公开(公告)日：1996-09-03
申请号：US439939
申请日：1995-05-12
申请人： Nobuyuki Matsubayashi , Toru Takeshita
发明人： Nobuyuki Matsubayashi , Toru Takeshita
IPC分类号： B22D18/04 , B22D18/08 , B22D46/00 , B22D17/06 , B22D17/32 , B22D27/13
CPC分类号： B22D18/08
摘要： In a low-pressure casting in which molten metal is introduced into a cavity of a casting mold under a pressure applied to the surface of the molten metal according to a preset reference pressurizing pattern, the reference pressurizing pattern is corrected when that the cavity has been filled with molten metal is detected and the pressure applied to the molten metal surface is controlled according to the reference pressurizing pattern after the correction. The pressure difference between a set pressure at a predetermined time in the reference pressurizing pattern after the correction and a set pressure at the corresponding time in the reference pressurizing pattern before the correction, is calculated and a set pressure for the period up to the time the cavity is filled with molten metal in the reference pressurizing pattern for the next casting cycle is corrected on the basis of the calculated pressure difference.
摘要翻译：在根据预设的参考加压模式在熔融金属表面施加的压力下将熔融金属引入铸模的腔中的低压铸造中，当空腔已经被加热时，参考加压模式被校正检测到熔融金属，并且在校正后根据参考加压模式控制施加到熔融金属表面的压力。在校正之后的参考加压模式中的预定时间的设定压力与校正前的参考加压模式中的相应时间的设定压力之间的压力差被计算，并且直到该时间段的设定压力基于计算出的压力差校正下一个铸造循环的基准加压模式中的熔融金属的空腔。

8. 发明授权

US4388243A Process for the preparation of active-type vitamin D.sub.3 compounds 失效
标题翻译：活性型维生素D3化合物的制备方法
公开(公告)号：US4388243A
公开(公告)日：1983-06-14
申请号：US371870
申请日：1982-04-26
申请人： Osamu Nishikawa , Kenji Ishimaru , Toru Takeshita , Hideki Tsuruta
发明人： Osamu Nishikawa , Kenji Ishimaru , Toru Takeshita , Hideki Tsuruta
IPC分类号： C07J9/00
CPC分类号： C07J9/00 , Y02P20/55 , Y02P20/582
摘要： The present invention relates to a novel process for the preparation of active-type vitamin D.sub.3 compounds and their intermediates. In accordance with the present invention, a large amount of an active-type vitamin D.sub.3 compounds, for example 1.alpha.-hydroxycholecalciferol, 1.alpha.,25-dihydroxycholecalciferol and the like, is efficiently prepared with high industrial advantages by a novel processes, which comprises (i) reacting hydroxycholesta-5-enes having the hydroxyl groups protected with lower alkoxycarbonyl group as a starting material with allylic brominating agent and dehydrobrominating agent to prepare the corresponding hydroxycholesta-5,7-dienes, (ii) exposing the hydroxycholesta-5,7-dienes to ultraviolet irradiation or to a combination of the irradiation with thermal isomerization to obtain a mixture of the unreacted hydroxycholesta-5,7-dienes and previtamin D.sub.3 compounds or a mixture of the unreacted hydroxycholesta-5,7-dienes and the protected active-type vitamin D.sub.3 compounds, (iii) separating the mixture into the unreacted hydroxycholesta-5,7-dienes and previtamin D.sub.3 compounds or the protected active-type vitamin D.sub.3 compounds, (iv) recycling the unreacted hydroxycholesta-5,7-dienes as reuse and (v) thermally isomerizing the remaining compounds and/or splitting off the protective groups. The process for the preparation of active-type vitamin D.sub.3 compounds, in the present invention, is of very high industrial value, capable of carrying out by simple operation and adaptable to large scale commercial production.
摘要翻译：本发明涉及一种制备活性型维生素D3化合物及其中间体的新方法。根据本发明，通过新工艺有效地制备了大量活性型维生素D3化合物，例如1α-羟基胆钙化甾醇，1α，25-二羟基胆钙化甾醇等，具有高工业优势，其包括（i）使具有被低级烷氧基羰基保护的羟基作为起始原料的羟基胆甾-5-烯与烯丙基溴化剂和脱溴溴化剂反应以制备相应的羟基胆甾-5,7-二烯，（ii）将羟基胆甾-5， 7-二烯对紫外线照射或通过热异构化的照射的组合，得到未反应的羟基胆甾-5,7-二烯和维生素D3化合物的混合物或未反应的羟基胆甾-5,7-二烯与受保护的活性型维生素D3化合物，（iii）将混合物分离成未反应的羟基胆甾-5,7-二烯和维生素D3化合物或受保护的活性（iv）将未反应的羟基胆甾-5,7-二烯再循环使用，和（v）使其余化合物热异构化和/或分离保护基团。在本发明中制备活性型维生素D3化合物的方法具有非常高的工业价值，能够通过简单的操作进行并适应于大规模的商业生产。

9. 发明授权

US4298537A Process for producing steroid compounds having an oxo group in the side chain 失效
标题翻译：在侧链中具有氧代基的类固醇化合物的制备方法
公开(公告)号：US4298537A
公开(公告)日：1981-11-03
申请号：US97980
申请日：1979-11-28
申请人： Osamu Nishikawa , Kenji Ishimaru , Toru Takeshita , Hideki Tsuruta
发明人： Osamu Nishikawa , Kenji Ishimaru , Toru Takeshita , Hideki Tsuruta
IPC分类号： C07J9/00 , C07J53/00
CPC分类号： C07J9/005 , C07J9/00 , Y02P20/55
摘要： A process for producing a steroid compound having an oxo group in the side chain, which comprises condensing an acid halide having a steroid skeleton with an organozinc compound at the halocarbonyl group of the acid halide in an inert organic medium in the presence of a catalytic amount of an ether capable of forming a complex with the organozinc compound, and if desired, hydrolyzing the product. The process produces the steroid compound at a high yield, and often at an almost quantitative yield. The steroid compound is an important intermediate for the production of vitamin D.sub.3 analogs such as active forms of vitamin D.sub.3. In one preferred embodiment, an industrially advantageous process from the standpoint of operation is provided.
摘要翻译：一种制备侧链中具有氧代基的类固醇化合物的方法，该方法包括在惰性有机介质中，在催化量存在下将具有类固醇骨架的酰卤与有机锌化合物在酰卤的卤代羰基的能够与有机锌化合物形成络合物的醚，如果需要，水解产物。该方法以高产率产生类固醇化合物，并且通常以几乎定量的产率。类固醇化合物是生产维生素D3类似物（如活性形式的维生素D3）的重要中间体。在一个优选实施例中，提供了从工作角度出发的工业上有利的工艺。

10. 发明授权

US3936478A Process for the preparation of desmosterol derivatives 失效
标题翻译：去极化衍生物的制备方法
公开(公告)号：US3936478A
公开(公告)日：1976-02-03
申请号：US480823
申请日：1974-06-19
申请人： Toru Takeshita , Sachio Ishimoto
发明人： Toru Takeshita , Sachio Ishimoto
IPC分类号： C07J9/00
CPC分类号： Y02P20/55
摘要： A process for the preparation of desmosterol of which the hydroxyl group at the 3-position is protected, or bis-form derivatives thereof in high purity and with high yields, which comprises reacting 24-hydroxycholesterol of which the hydroxyl group at the 3-position is protected, or bis-form derivatives thereof, withA. phosphorus pentoxide or acid potassium sulfate, orB. phosphorus oxychloride, thionyl chloride, or sulfonyl chlorides, in the presence of tertiary amine.
摘要翻译：一种制备其3-羟基被保护的去极化剂的方法，或其高纯度和高收率的双键衍生物，其包括使4-羟基胆固醇在3-位上的羟基反应在叔胺存在下，与五氧化二磷或硫酸钾，或三氧化磷三乙酰氯，亚硫酰氯或磺酰氯保护或双键衍生物。

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