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31. 发明授权

US06419692B1 Surface protection method for stents and balloon catheters for drug delivery 有权
标题翻译：用于药物输送的支架和球囊导管的表面保护方法
公开(公告)号：US06419692B1
公开(公告)日：2002-07-16
申请号：US09243580
申请日：1999-02-03
申请人： Duchuan Yang , Joel Stanslaski , Lixiao Wang
发明人： Duchuan Yang , Joel Stanslaski , Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61L31/16 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91541 , A61F2002/91558 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： A medical device, such as a stent or balloon of a balloon catheter which includes a body portion which has an exterior surface which contacts, at least in part, a vessel wall during treatment. The body portion is expandable from a first position, wherein the body portion is sized for insertion into the vessel lumen, to a second position, wherein at least a portion of the exterior surface is in contact with the lumen wall. The medical device includes a first coating disposed over at least a portion of the exterior surface of the body portion with the first coating including a drug or therapeutic substance which is intended for controlled release from the surface. The medical device further includes a second coating overlying at least a substantial portion of the first coating. The second coating includes a material that is generally impervious to elution of the drug or therapeutic substance therethrough when the body portion is in a first position when inserted into the vessel lumen. The material of the second coating is relatively inelastic so that the second coating fractures during expansion of the body portion to the second position to allow elution of therapeutic substance through a multiplicity of fissures formed through the second coating.
摘要翻译：一种医疗装置，例如球囊导管的支架或球囊，其包括主体部分，该主体部分具有在治疗期间至少部分地与血管壁接触的外表面。主体部分从第一位置可膨胀，其中主体部分的尺寸适于插入血管腔，到达第二位置，其中外表面的至少一部分与内腔壁接触。医疗装置包括设置在主体部分的外表面的至少一部分上的第一涂层，第一涂层包括用于从表面受控释放的药物或治疗物质。医疗装置还包括覆盖第一涂层的至少大部分的第二涂层。第二涂层包括当插入血管内腔时主体部分处于第一位置时通常不透过药物或治疗物质的洗脱的材料。第二涂层的材料相对无弹性，使得第二涂层在主体部分膨胀到第二位置期间断裂，以允许通过穿过第二涂层形成的多个裂缝洗脱治疗物质。

32. 发明授权

US06387124B1 Biodegradable drug delivery vascular stent 失效
标题翻译：生物降解药物输送血管支架
公开(公告)号：US06387124B1
公开(公告)日：2002-05-14
申请号：US09420079
申请日：1999-10-18
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
摘要翻译：支架包括用于插入活体血管内腔的大体管状形状的主体。管状主体包括基本上可生物降解的基质，其具有包围基质内的空隙的胶原IV和层粘连蛋白。管状主体还包括与基质接触以增强基质的可生物降解的强化材料。管状主体基本上被药物饱和。

33. 发明授权

US06328710B1 Process improvements for preparing catheter balloons 失效
标题翻译：制备导管球囊的工艺改进
公开(公告)号：US06328710B1
公开(公告)日：2001-12-11
申请号：US08955984
申请日：1997-10-22
申请人： Lixiao Wang , Paul J. Miller , Daniel J. Horn , Deborah A. Frank
发明人： Lixiao Wang , Paul J. Miller , Daniel J. Horn , Deborah A. Frank
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M25/0045 , A61M25/1002 , A61M25/104 , A61M2025/1075 , A61M2025/1088 , B29C35/041 , B29C49/04 , B29C49/18 , B29C49/783 , B29C2049/0089 , B29K2067/00 , B29K2105/258 , B29K2905/12 , B29L2031/7542 , Y10T428/1331 , Y10T428/1352 , Y10T428/139
摘要： A method for forming a balloon for a dilatation catheter may utilize the steps of extruding a tubing preform of a polyester resin and then blowing the tubing into an oriented balloon, wherein the tubing preform is dried prior to blowing into the balloon form. Other process steps by which balloon cone and waist thicknesses may be reduced involve varying the axial tension and blowing pressure at several stages as a mold containing the balloon preform is dipped into a heating medium. Specifically, tubing of a thermoplastic material is placed in a mold and blown by pressurizing and tensioning the tubing and gradually dipping the mold into a heated heat transfer media so as to sequentially blow a first waist, a body and a second waist portion. The tubing is subjected to a relatively lower pressure while the body portion is blown than while the first and second waist portions are blown.
摘要翻译：用于形成用于扩张导管的球囊的方法可以采用以下步骤：挤出聚酯树脂的管坯预成型件，然后将管道吹入定向气囊中，其中将管坯预先吹入气囊形式之前进行干燥。球囊和腰部厚度可能减小的其他工艺步骤包括在将包含球囊预制件的模具浸入加热介质中时，在几个阶段改变轴向张力和吹塑压力。具体地说，将热塑性材料的管材放置在模具中，并通过加压和张紧管子并将模具逐渐浸入加热的传热介质中，以便顺序地吹动第一腰部，身体和第二腰部部分而吹塑。当吹塑本体部分时，管道相对于第一和第二腰部部分被吹送而受到相对较低的压力。

34. 发明授权

US6117168A Multilayer liquid absorption and deformation devices 失效
公开(公告)号：US6117168A
公开(公告)日：2000-09-12
申请号：US775741
申请日：1996-12-31
申请人： Dachuan Yang , Lixiao Wang
发明人： Dachuan Yang , Lixiao Wang
IPC分类号： A61L31/00 , A61F2/82 , A61F2/88 , A61F2/92 , A61L31/10 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/92 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61F2210/0061 , A61F2210/0076 , A61L2300/00
摘要： A multilayer device comprised of at least one layer of material which is capable of absorbing liquid to thereby increase the volume of the layer, i.e., liquid swellable, and when bound to at least one non-absorbing or lesser absorbing layer of material causes deformation of the device upon liquid absorption.

35. 发明授权

US5980532A Stent installation method using balloon catheter having stepped compliance curve 失效
公开(公告)号：US5980532A
公开(公告)日：1999-11-09
申请号：US931190
申请日：1997-09-16
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/10 , A61M29/00 , A61F11/00
CPC分类号： A61M25/104 , A61F2/958 , A61M25/10 , A61M25/1002 , A61M25/1029 , A61F2250/0039 , A61M2025/1059 , A61M2025/1075
摘要： A method for installing a stent in a vessel utilizes a single balloon catheter for both low pressure predilation at a relatively small diameter to open the lesion sufficiently to allow insertion and deployment of the stent across the lesion and for subsequent high pressure embedding of the stent in the vessel wall. The same balloon catheter may also be employed to insert and deploy the stent. The balloons utilized in the method have a stepped compliance curve which allows for predilation at a low pressure and predetermined diameter and for high pressure embedding at a substantially larger diameter. The balloons may be provided with a configuration in which only a portion of the balloon has a stepped compliance curve while a further portion has a generally linear compliance profile. With such balloons high pressure treatment of the vessel wall areas not reinforced by the stent can be avoided despite the occurence of longitudinal shrinkage of the stent during expansion thereof.

36. 发明授权

US5738901A Catheter balloon with retraction coating 失效
公开(公告)号：US5738901A
公开(公告)日：1998-04-14
申请号：US551669
申请日：1995-11-01
申请人： Lixiao Wang , Linda J. Vickerman
发明人： Lixiao Wang , Linda J. Vickerman
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , B29C35/04 , B29C49/04 , B05D3/02 , A61L29/00 , A61L31/00
CPC分类号： A61M25/104 , A61M25/0045 , A61M25/1002 , A61M25/1038 , A61M2025/1031 , A61M2025/1075 , A61M2025/1088 , B29C2049/0089 , B29C35/041 , B29C49/04 , B29K2067/00 , B29K2105/258 , B29L2031/7542
摘要： An inflatable balloon (14) for a catheter (10) includes a coating (15) which causes the balloon to prefer a predetermined, low profile configuration, such as a trifold configuration (40), when deflated. The balloon has a wall (13) which has an exterior polymeric coating (15). The coating (15) is set while the balloon is in the predetermined low-profile deflated configuration so that after inflation, the coating acts to urge the balloon to return to the low profile configuration as the balloon is deflated.

37. 发明授权

US5348538A Shrinking balloon catheter having nonlinear or hybrid compliance curve 失效
标题翻译：具有非线性或混合顺应性曲线的收缩球囊导管
公开(公告)号：US5348538A
公开(公告)日：1994-09-20
申请号：US953677
申请日：1992-09-29
申请人： Lixiao Wang , The Thomas T. Tran
发明人： Lixiao Wang , The Thomas T. Tran
IPC分类号： A61M25/00 , A61M29/02
CPC分类号： A61M25/1029 , A61M25/104 , B29L2022/022 , B29L2031/7542 , Y10S264/909
摘要： A balloon catheter, having a non-linear compliance curve, made up of a single layered balloon, that was molded from a polymeric material to have a specific nominal diameter and then shrunk to a diameter that is less than the specific nominal diameter. When the shrunk balloon is expanded it has the characteristics of a compliant balloon until its diameter has been expanded to its original specific nominal diameter after which it follows the non compliant compliance curve that it would have had it not been shrunk.
摘要翻译：具有非线性顺应性曲线的球囊导管由单层气囊构成，其由聚合物材料模制成具有特定公称直径，然后收缩至小于特定公称直径的直径。当缩小的气球膨胀时，它具有适应气囊的特征，直到其直径已经扩展到其原始的特定公称直径，然后遵循不符合的顺应曲线，它将不会收缩。

38. 发明授权

US08620406B2 Medical devices visible by magnetic resonance imaging 有权
标题翻译：磁共振成像可见的医疗器械
公开(公告)号：US08620406B2
公开(公告)日：2013-12-31
申请号：US10763690
申请日：2004-01-23
申请人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
发明人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
IPC分类号： A61B5/05
CPC分类号： G01R33/285 , A61B2090/3954 , A61M25/0043 , A61M25/0127 , G01R33/286
摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要翻译：描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。导电路径能够连接到电流源。医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

39. 发明授权

US08597276B2 Implant delivery system with interlocked RX port orientation 有权
标题翻译：植入物交付系统具有互锁的RX端口方向
公开(公告)号：US08597276B2
公开(公告)日：2013-12-03
申请号：US11433328
申请日：2006-05-12
申请人： Khamla Vongphakdy , Huisun Wang , Adel Hashw , Lixiao Wang
发明人： Khamla Vongphakdy , Huisun Wang , Adel Hashw , Lixiao Wang
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61F2/95 , A61F2/966 , A61F2002/9505 , A61F2002/9583 , A61F2002/9665 , Y10T29/49938
摘要： A medical implant delivery system maintains an orientation between a guidewire lumen of an inner member of the system and a rapid-exchange port in an outer member. The medical device is disposed intermediate the inner and outer members and in friction or pressure-fit contact with the outer member. Once the guidewire lumen of the inner member and the rapid exchange port of the outer member are oriented, the friction or pressure-fit operates to maintain the orientation until deployment of the medical implant. Orientation is further maintained by a telescoping coupling of the guide wire lumen with the rapid exchange port.
摘要翻译：医疗植入物递送系统保持系统的内部构件的导丝管腔和外部构件中的快速交换口之间的取向。医疗装置设置在内部构件和外部构件之间并且与外部构件摩擦或压配合接触。一旦内部构件的导丝腔和外部构件的快速交换口定向，则摩擦或压力配合操作以维持取向直到医疗植入物展开。通过导丝管腔与快速交换口的伸缩耦合来进一步保持定向。

40. 发明授权

US08337968B2 Radiation sterilized medical devices comprising radiation sensitive polymers 有权
标题翻译：包含辐射敏感聚合物的辐射灭菌医疗器械
公开(公告)号：US08337968B2
公开(公告)日：2012-12-25
申请号：US10241278
申请日：2002-09-11
申请人： Lixiao Wang , John Jianhua Chen
发明人： Lixiao Wang , John Jianhua Chen
IPC分类号： B32B23/00 , B32B1/02
CPC分类号： A61L29/14 , A61L29/041 , A61L29/049 , A61L29/085 , Y10T428/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/1359 , Y10T428/139 , C08L77/00
摘要： A medical device, for instance a device inserted into the body such as catheter or a balloon, at least a portion of which is made of a thermoplastic polymeric material. The thermoplastic polymeric material comprises a blend or laminate of an aromatic protectant polymer and a radiation sensitive polymer, and/or the polymeric material includes a stabilizer against radiation oxidative degradation. The device is sterilized by exposure to high energy radiation.
摘要翻译：医疗装置，例如插入体内的装置，例如导管或气囊，其至少一部分由热塑性聚合材料制成。热塑性聚合物材料包括芳族保护剂聚合物和辐射敏感聚合物的共混物或层压材料，和/或聚合物材料包括抗辐射氧化降解的稳定剂。该装置通过暴露于高能量辐射而灭菌。

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