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31. 发明申请

US20060217413A1 4-Oxoquinoline compound and use thereof as HIV integrase inhibitor 有权
标题翻译： 4-氧喹啉化合物及其作为HIV整合酶抑制剂的用途
公开(公告)号：US20060217413A1
公开(公告)日：2006-09-28
申请号：US11446128
申请日：2006-06-05
申请人： Motohide Satoh , Hiroshi Kawakami , Yoshiharu Itoh , Hisashi Shinkai , Takahisa Motomura , Hisateru Aramaki , Yuji Matsuzaki , Wataru Watanabe , Shuichi Wamaki
发明人： Motohide Satoh , Hiroshi Kawakami , Yoshiharu Itoh , Hisashi Shinkai , Takahisa Motomura , Hisateru Aramaki , Yuji Matsuzaki , Wataru Watanabe , Shuichi Wamaki
IPC分类号： C07D471/02 , A61K31/4745 , A61K31/4709 , A61K31/4704 , C07D401/02
CPC分类号： A61K31/47 , A61K31/4375 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D215/58 , C07D401/06 , C07D409/06 , C07D417/06 , C07D471/04
摘要： An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.
摘要翻译：作为活性成分的含有下式[I]表示的4-氧代喹啉化合物的抗HIV剂，其中各符号如说明书中所述，或其药学上可接受的盐。本发明的化合物具有HIV整合酶抑制作用，可用作预防或治疗AIDS的抗HIV剂。此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，化合物可以成为更有效的抗HIV剂。由于该化合物对整合酶具有高的抑制活性，因此可提供对人体副作用较小的安全药剂。

32. 发明申请

US20060019906A1 Novel 4-oxoquinoline compound and use thereof as HIV integrase inhibitor 有权
标题翻译：新型4-氧代喹啉化合物及其作为HIV整合酶抑制剂的用途
公开(公告)号：US20060019906A1
公开(公告)日：2006-01-26
申请号：US11133470
申请日：2005-05-20
申请人： Motohide Satoh , Takashi Matsuda , Satoshi Okuda , Hiroshi Kawakami , Hisateru Aramaki , Hisashi Shinkai , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki , Mitsuru Takahashi , Naohito Yamada , Akemi Nagao
发明人： Motohide Satoh , Takashi Matsuda , Satoshi Okuda , Hiroshi Kawakami , Hisateru Aramaki , Hisashi Shinkai , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki , Mitsuru Takahashi , Naohito Yamada , Akemi Nagao
IPC分类号： A61K31/4704 , C07H17/02 , C07D215/36
CPC分类号： C07D215/56 , C07D401/04 , C07D401/06 , C07D405/06 , C07D491/04
摘要： Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity. A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification. The present invention also relates to a pharmaceutical composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; an integrase inhibitor, an antiviral agent, anti-HIV agent, and the like, which contains the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient; an anti-HIV composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and one or more other kinds of anti-HIV activity substances as active ingredients; an anti-HIV agent containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient, which is used for a multiple drug therapy with other anti-HIV agent(s), and the like.
摘要翻译：提供具有抗HIV活性的化合物，特别是整合酶抑制活性。由下式[I]表示的4-氧代喹啉化合物或其药学上可接受的盐：其中每个符号如说明书中所定义。本发明还涉及含有4-氧代喹啉化合物或其药学上可接受的盐和药学上可接受的载体的药物组合物; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的整合酶抑制剂，抗病毒剂，抗HIV剂等; 含有4-氧代喹啉化合物或其药学上可接受的盐的抗HIV组合物和一种或多种其它类型的抗HIV活性物质作为活性成分; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的抗HIV剂，其用于与其它抗HIV剂的多重药物治疗等。

33. 发明授权

US06202440B1 Process and apparatus for separation of stable isotope compound 有权
标题翻译：用于分离稳定同位素化合物的方法和装置
公开(公告)号：US06202440B1
公开(公告)日：2001-03-20
申请号：US09169955
申请日：1998-10-13
申请人： Shigeru Hayashida , Katsuyoshi Kuwata , Hiroshi Kawakami , Ushio Maeda
发明人： Shigeru Hayashida , Katsuyoshi Kuwata , Hiroshi Kawakami , Ushio Maeda
IPC分类号： F25J100
CPC分类号： F25J3/08 , B01D59/04 , F25J2200/90 , F25J2215/14 , F25J2220/90 , Y10S62/919
摘要： Stable isotope atoms present in the form of stable isotope compounds, for example, 13C present in the form of 13CO, are separated by distillation using a distillation column packed orderly with a formed packing, and preferably by distillation using a distillation column packed with a “promoting-fluid-dispersion type” structured packing.
摘要翻译：以稳定同位素化合物形式存在的稳定同位素原子，例如以13CO形式存在的13C，通过使用填充有成形填料的蒸馏塔进行蒸馏分离，优选通过使用填充有“ 促进流体分散型“结构填料。

34. 发明授权

US5775998A Analyzer for developing attractions in a shooting game system 失效
标题翻译：用于在射击游戏系统中开发景点的分析器
公开(公告)号：US5775998A
公开(公告)日：1998-07-07
申请号：US681513
申请日：1996-07-23
申请人： Shinichi Ikematsu , Hiroshi Kawakami , Satoshi Nakano , Tatsuya Kouno , Keisuke Hiromi , Masakazu Yoshimoto
发明人： Shinichi Ikematsu , Hiroshi Kawakami , Satoshi Nakano , Tatsuya Kouno , Keisuke Hiromi , Masakazu Yoshimoto
IPC分类号： F41G3/26 , A63F9/02 , A63F13/00 , F41J7/06 , F41J11/00 , A63F9/22
CPC分类号： A63F9/0291 , F41H7/005 , F41J7/04 , A63F2300/8076
摘要： In a method for developing attractions in a shooting game system with which players can experience gun fights between the targets and players themselves, the present invention provides a method for developing attractions in a shooting game system with which the shooting game system can be easily installed in a short period anywhere and game quality can be always adjusted in the most suitable state. Namely, the method for developing attractions comprises the steps of producing various types of targets by combining fundamental mechanisms, each of which is used for a unit operation; incorporating unified control equipment and peripherals in the produced target to make them a target unit; embedding the above-described target unit in a target unit case so as to serve also as an indoor partition and posts; arranging the embedded target units in the designated rooms of the attraction hall.
摘要翻译：本发明提供了一种用于在射击游戏系统中开发景物的方法，玩家可以在目标和玩家本身之间体验枪战，本发明提供了一种用于在射击游戏系统中开发景点的方法，射击游戏系统可以通过该方法轻松地安装射击游戏系统短时间内任何地方，游戏质量可以随时调整到最合适的状态。也就是说，用于开发景点的方法包括通过组合基本机构来生产各种类型的目标的步骤，每个基本机制用于单位操作; 将统一的控制设备和外围设备结合在一起，使其成为目标单位; 将上述目标单元嵌入到目标单元壳体中，以用作室内分区和柱; 将嵌入的目标单位安排在吸引馆的指定房间内。

35. 发明授权

US5322955A Method of manufacturing 3-DPA-lactone 失效
标题翻译：制备3-DPA-内酯的方法
公开(公告)号：US5322955A
公开(公告)日：1994-06-21
申请号：US938238
申请日：1992-10-22
申请人： Katsuya Matsumoto , Takashi Ebata , Hiroshi Kawakami , Koshi Koseki , Hajime Matsushita
发明人： Katsuya Matsumoto , Takashi Ebata , Hiroshi Kawakami , Koshi Koseki , Hajime Matsushita
IPC分类号： C07D307/33 , C07D233/00
CPC分类号： C07D307/33 , Y02P20/55
摘要： In the method of the present invention for manufacturing 3-DPA-lactone, a protective group is introduced in the first step into the hydroxyl group at 4-position of .gamma.-ribonolactone by an ordinary method. Then, an acid anhydride or an acid chloride is added in the presence of a tertiary amine compound so as to conduct a .beta.-elimination of the hydroxyl group at the 3-position. As a result, a double bond is formed between the 2- and 3-positions and, at the same time, the hydroxyl group at the 2-position is acylated. The double bond between the 2- and 3-positions is reduced in the next step by means of a catalytic hydrogenation. Finally, the protective group of the hydroxyl group is eliminated by an ordinary method. The particular method permits using readily available raw materials, decreasing the number of manufacturing steps, and easily and selectively synthesizing the desired 3-DPA-lactone, which is hardly obtained from nature in a large amount, in high yield, compared with the conventional method.
摘要翻译： PCT No.PCT / JP92 / 00186 Sec。 371日期：1992年10月22日 102（e）日期1992年10月22日PCT提交1992年2月21日PCT公布。第WO92 / 14721号公报日本9月3日。在本发明的制备3-DPA-内酯的方法中，通过常规方法，将第一步中的保护基引入γ-内酯的4-位的羟基。然后，在叔胺化合物的存在下加入酸酐或酰氯，以在3-位进行羟基的β-烯丙基化。结果，在2-位和3-位之间形成双键，并且同时将2-位的羟基酰化。通过催化氢化，在下一步骤中2-和3-位之间的双键被还原。最后，通过常规方法除去羟基的保护基。该特定方法与常规方法相比，允许使用容易获得的原料，减少制造步骤的数量，并且容易且有选择地合成从大量难以获得的大量难以获得的所需3-DPA-内酯。

36. 发明授权

US5260253A Heat-sensitive recording material 失效
公开(公告)号：US5260253A
公开(公告)日：1993-11-09
申请号：US906474
申请日：1992-06-30
申请人： Hiroshi Kawakami , Ken Iwakura
发明人： Hiroshi Kawakami , Ken Iwakura
IPC分类号： B41M5/333 , B41M5/28
CPC分类号： B41M5/3333
摘要： A heat-sensitive recording material comprising a support having thereon a heat-sensitive color forming layer comprising an electron-donating colorless dye and an electron-accepting compound, wherein said electron-accepting compound is a bisthiourea compound.

37. 发明授权

US5181125A Apparatus for muting noise resulting from reproducing of a PCM audio signal recorded in an extension of a slant track containing a recorded video signal 失效
标题翻译：用于使记录在包含记录的视频信号的倾斜轨道的扩展中的PCM音频信号的再现产生的噪声静噪的装置
公开(公告)号：US5181125A
公开(公告)日：1993-01-19
申请号：US757232
申请日：1991-09-10
申请人： Hiroshi Kawakami
发明人： Hiroshi Kawakami
IPC分类号： H02P1/18 , H04N5/911 , H04N5/928 , H04N5/93 , H04N5/94
CPC分类号： H04N5/911 , H04N5/928 , H04N5/93 , H04N5/94
摘要： An apparatus for reproducing video signals recorded in slant tracks on a magnetic tape also having respective pulse code modulated audio signals recorded in extensions of the slant tracks with gaps therebetween: comprises a rotary head drum having magnetic heads mounted thereon with an angular spacing of 180 degrees therebetween for scanning the slant tracks and extensions thereof and thereby providing reproduced head outputs containing video and audio signals reproduced from the magnetic tape with dropouts in said reproduced head outputs corresponding to the gaps between the respective recorded video and audio signals; and a signal extracting circuit including a head changeover switch receiving the reproduced head outputs and responsive to a head switching signal synchronized with rotation of the head drum to provide a switched output which, in a normal reproducing mode employing a tape speed equal to that for recording, consists of the reproduced video signals and, in another reproducing mode employing a different tape speed, also includes the dropouts and noises corresponding to at least portions of the reproduced audio signals. Dropouts in the switched output are detected to provide dropout detected pulses, and the switched output is muted in response to muting signals each initiated by a respecitve dropout detected pulse and continuing for a period corresponding to the duration of the respective dropout and the following noise so as to eliminate from the switched output in the other reproducing mode noises due to audio signals that may be contained therein.
摘要翻译：一种用于再现记录在磁带上的倾斜磁道中的视频信号的装置，还具有记录在其间具有间隙的倾斜磁道的延伸部分中的相应的脉冲编码调制音频信号：包括安装有角度间隔为180度的磁头的旋转磁头鼓用于扫描倾斜轨道及其延伸部分，从而提供再现的头部输出，其中包含从磁带再现的视频和音频信号，在与所记录的视频和音频信号之间的间隙对应的所述再现的头部输出中具有出口; 以及信号提取电路，包括接收再现磁头输出的磁头切换开关，并且响应与磁头磁鼓转动同步的磁头切换信号，以提供切换输出，该切换输出在采用等于记录速度的磁带速度的正常再现模式下由再现的视频信号组成，并且在采用不同磁带速度的另一种再现模式中，还包括对应于再现的音频信号的至少一部分的丢失和噪声。检测到切换输出中的丢失以提供检测到的丢失的脉冲，并且响应于由分别丢失检测到的脉冲启动的静噪信号并且连续相应于相应丢失的持续时间和随后的噪声的周期，开关输出被静音为了从另一再现模式中的切换输出消除由于可能包含在其中的音频信号引起的噪声。

38. 发明授权

US4601026A Autochanger type disc player 失效
公开(公告)号：US4601026A
公开(公告)日：1986-07-15
申请号：US618937
申请日：1984-06-08
申请人： Hiroshi Kawakami
发明人： Hiroshi Kawakami
IPC分类号： G11B17/04 , G11B17/22 , G11B17/28
CPC分类号： G11B17/22 , G11B17/04 , G11B17/28
摘要： An autochanger type optical compact disc player includes a tray for holding a large number of discs in close proximity, a disc selection mechanism for selecting a disc from the tray, a disc port for entering a disc from the outside of the player, a disc playback mechanism for playing a disc, a first loading mechanism for transferring a selected disc from the tray to the disc playback mechanism, a second disc loading mechanism for transferring a disc from the port to the disc playback mechanism, an unloading mechanism for selectively returning a disc to the tray or to the port, and a control section for controlling operations of the player. A disc is returned from the tray by a roller for contacting the edge of the disc during movement through a limited arc to impart rotational force to the disc.

39. 发明授权

US4463473A Vacuum cleaner 失效
标题翻译：吸尘器
公开(公告)号：US4463473A
公开(公告)日：1984-08-07
申请号：US333787
申请日：1981-12-23
申请人： Seiichi Nakada , Hiromi Yoshikawa , Hiroshi Ohno , Tsuneo Nishijima , Hiroshi Kawakami
发明人： Seiichi Nakada , Hiromi Yoshikawa , Hiroshi Ohno , Tsuneo Nishijima , Hiroshi Kawakami
IPC分类号： A47L5/28 , A47L9/00 , A47L9/19
CPC分类号： A47L5/28 , A47L9/19
摘要： The present invention relates to a vacuum cleaner in which an alarm sound is generated by introducing air from the exterior in bypassing relation to a filter 8 when a suction load imposed on a fan motor 3 exceeds a predetermined value. The alarm sound can be emitted or stopped without adversely affecting the introduction of bypassing air toward the fan motor 3. With such an arrangement, the vacuum cleaner can be used conveniently, and the fan motor 3 is prevented from being burned out.
摘要翻译： PCT No.PCT / JP81 / 00090 Sec。 371日期：1981年12月23日 102（e）1981年12月23日日期PCT提交1981年4月17日PCT公布。公开号WO81 / 02971 日本1981年10月29日。一种真空吸尘器技术领域本发明涉及一种真空吸尘器，其中，当施加在风扇电动机3上的吸入负载超过预定值时，通过将来自外部的空气以旁路方式引入过滤器8而产生报警声。可以发出或停止报警声音，而不会不利地影响向风扇电动机3引入旁路空气。通过这样的布置，可以方便地使用真空吸尘器，并且防止风扇电动机3被烧毁。

40. 发明授权

US4446595A Upright vacuum cleaner 失效
标题翻译：直立吸尘器
公开(公告)号：US4446595A
公开(公告)日：1984-05-08
申请号：US328575
申请日：1981-12-02
申请人： Seiichi Nakada , Hiroshi Ohno , Tsuneo Nishijima , Hiroshi Kawakami
发明人： Seiichi Nakada , Hiroshi Ohno , Tsuneo Nishijima , Hiroshi Kawakami
IPC分类号： A47L5/30 , A47L9/04 , A47L9/06 , A47L5/34
CPC分类号： A47L9/0411 , A47L5/30
摘要： An upright vacuum cleaner includes a rotary brush 12 disposed at a suction port in a floor nozzle 4 and capable of being rotated or stopped by shifting a motor-driven belt toward a drive pulley 17 or an idle pulley 18. The upright vacuum cleaner can conveniently be used for cleaning flat noncarpeted floors as well as carpeted floors.
摘要翻译： PCT No.PCT / JP81 / 00069 Sec。 371日期：1981年12月2日 102（e）日期1981年12月2日PCT提交1981年4月30日PCT公布。公开号WO81 / 02830 日本10月15日，1981.直立式真空吸尘器包括设置在地板喷嘴4中的吸入口处的旋转刷12，并且能够通过将电动机驱动带朝向驱动滑轮17或空转滑轮18移动而旋转或停止立式真空吸尘器可以方便地用于清洁扁平的非地毯地板以及铺有地毯的地板。

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