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31. 发明申请

US20090246835A1 L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING AN L-AMINO ACID 有权
标题翻译： L-氨基酸生产细菌和一种生产L-氨基酸的方法
公开(公告)号：US20090246835A1
公开(公告)日：2009-10-01
申请号：US12055438
申请日：2008-03-26
申请人： Shintaro Iwatani , Akira Imaizumi , Yoshihiro Usuda , Kazuhiko Matsui
发明人： Shintaro Iwatani , Akira Imaizumi , Yoshihiro Usuda , Kazuhiko Matsui
IPC分类号： C12P13/22 , C12P13/04 , C12P13/08
CPC分类号： C07K14/245 , C12P13/04 , C12P13/08 , C12P13/22
摘要： An L-amino acid is produced by culturing a microorganism of the family Enterobacteriaceae which has the ability to produce an L-amino acid and which has been modified so as to increase the expression of the evgA gene, the gadE gene, and/or the ydeO gene. These genes encode a transcription factor involved in the EvgAS two-component system regulon. The culture takes place in a medium, and the L-amino acid is collected from the medium or cells.
摘要翻译： L-氨基酸是通过培养具有产生L-氨基酸的能力的肠杆菌科的微生物而产生的，该微生物被修饰以增加evgA基因，gadE基因和/或 ydeO基因。这些基因编码参与EvgAS双组分系统调节子的转录因子。培养物在培养基中进行，从培养基或细胞收集L-氨基酸。

32. 发明申请

US20060234357A1 NOVEL POLYNUCLEOTIDES ENCODING USEFUL POLYPEPTIDES IN CORYNEBACTERIUM GLUTAMICUM SSP. LACTOFERMENTUM 失效
公开(公告)号：US20060234357A1
公开(公告)日：2006-10-19
申请号：US11422969
申请日：2006-06-08
申请人： Yoshihiro Usuda , Yousuke Nishio , Kazuhiko Matsui , Shinichi Sugimoto , Chie Koseki
发明人： Yoshihiro Usuda , Yousuke Nishio , Kazuhiko Matsui , Shinichi Sugimoto , Chie Koseki
IPC分类号： C12P13/04 , C07H21/04 , C12N15/74 , C12N1/21
CPC分类号： C12N9/0016 , C07H21/04 , C07K14/34 , C12N9/1007 , C12N9/22 , C12P13/04 , C12P21/00 , C12P21/02
摘要： The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. lactofermentum and methods of producing substances in organisms having enhanced or attenuated expression of these polypeptides and/or polynucleotides.

33. 发明授权

US07090998B2 Method for producing target substance by fermentation 有权
标题翻译：通过发酵生产目标物质的方法
公开(公告)号：US07090998B2
公开(公告)日：2006-08-15
申请号：US10613990
申请日：2003-07-08
申请人： Yukiko Ishikawa , Akira Imaizumi , Kazuhiko Matsui , Hiroyuki Kojima
发明人： Yukiko Ishikawa , Akira Imaizumi , Kazuhiko Matsui , Hiroyuki Kojima
IPC分类号： C12P1/04 , C12N1/20
CPC分类号： C07K14/245
摘要： In a method for producing a target substance utilizing a microorganism, which comprises culturing a γ-proteobacterium in a medium to produce and accumulate the target substance in the medium or cells and collecting the target substance, there is used a strain in which the ArcA protein does not normally function in the cell by means of, for example, disruption of the arcA gene on the chromosome.
摘要翻译：在利用微生物生产目标物质的方法中，其包括在培养基中培养γ-谷氨酸杆菌，以在培养基或细胞中产生并积累目标物质并收集目标物质，使用其中的ArcA蛋白通常不会通过例如染色体上arcA基因的破坏在细胞中起作用。

34. 发明授权

US07468262B2 Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum 有权
标题翻译：编码谷氨酸棒杆菌中有用多肽的多核苷酸乳发酵
公开(公告)号：US07468262B2
公开(公告)日：2008-12-23
申请号：US10439247
申请日：2003-05-16
申请人： Yoshihiro Usuda , Yousuke Nishio , Kazuhiko Matsui , Shinichi Sugimoto , Chie Koseki
发明人： Yoshihiro Usuda , Yousuke Nishio , Kazuhiko Matsui , Shinichi Sugimoto , Chie Koseki
IPC分类号： C12P13/04 , C12N1/21 , C12N15/63
CPC分类号： C12N9/0016 , C07H21/04 , C07K14/34 , C12N9/1007 , C12N9/22 , C12P13/04 , C12P21/00 , C12P21/02
摘要： The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. lactofermentum and methods of producing substances in organisms having enhanced or attenuated expression of these polypeptides and/or polynucleotides.
摘要翻译：本发明提供了用作生物技术工具的新型多肽和多核苷酸，其特异性在棒状杆菌型谷氨酸棒杆菌（Corynebacterium glutamicum）乳发酵和在这些多肽和/或多核苷酸具有增强或减弱的表达的生物体中产生物质的方法。

35. 发明授权

US07357879B2 Etching solution, method of etching and printed wiring board 有权
标题翻译：蚀刻溶液，蚀刻方法和印刷线路板
公开(公告)号：US07357879B2
公开(公告)日：2008-04-15
申请号：US10560421
申请日：2005-03-01
申请人： Tsunehisa Takahashi , Shigeki Sawa , Kazuhiko Matsui
发明人： Tsunehisa Takahashi , Shigeki Sawa , Kazuhiko Matsui
IPC分类号： B44C1/22 , C03C15/00 , C03C25/68 , C23F1/00 , C25F3/00
CPC分类号： C23F1/18 , C09K13/00 , C23F1/02 , C23F1/34 , H01L21/32134 , H05K3/064 , H05K3/067 , H05K3/383 , H05K2203/0597 , H05K2203/124
摘要： There is provided an etching solution comprised of a cupric chloride solution and a high-concentration triazole type compound added to the cupric chloride solution and capable of forming an etching-inhibiting coating. In a process of forming a circuit pattern by etching with the etching solution, an etching-inhibiting coating is selected formed on parts of a copper foil laid under the edge of an etching resist to effectively inhibit horizontal side-etching of the copper foil from the edge of the etching resist. Also, nonuniform irregularities formed on the side wall of the circuit pattern by the etching improves the adhesion between the circuit pattern and an insulating resin layer covering the circuit pattern.
摘要翻译：提供了由氯化铜溶液和加入到氯化铜溶液中的能够形成蚀刻抑制涂层的高浓度三唑型化合物组成的蚀刻溶液。在通过用蚀刻溶液蚀刻形成电路图案的过程中，在布置在抗蚀剂边缘的铜箔的部分上形成蚀刻抑制涂层，以有效地抑制铜箔的水平侧蚀边缘的抗蚀剂。此外，通过蚀刻形成在电路图案的侧壁上的不均匀的凹凸改善了电路图案和覆盖电路图案的绝缘树脂层之间的粘附。

36. 发明授权

US06989961B2 Magnetic head with medium sliding surface having varied curvature and recording/reproducing apparatus 失效
标题翻译：具有中等滑动面的磁头具有不同的曲率和记录/重放装置
公开(公告)号：US06989961B2
公开(公告)日：2006-01-24
申请号：US10601169
申请日：2003-06-20
申请人： Kazuhiko Matsui , Akihiro Sato , Kyoichi Kawase
发明人： Kazuhiko Matsui , Akihiro Sato , Kyoichi Kawase
IPC分类号： G11B5/187
CPC分类号： G11B5/1878 , G11B5/0086
摘要： A magnetic head includes core blocks having a medium sliding surface formed on one surface of the core blocks, the medium sliding surface having a slender convex curved shape formed along a sliding direction of a recording medium from the upstream side of the sliding direction to the downstream side, and the medium sliding surface having a magnetic gap formed thereon, wherein the medium sliding surface is shaped along a longitudinal direction thereof like a circular arc with a radius of curvature R while being shaped along a width direction like a circular arc with a radius of curvature r, which is smaller than the radius of curvature R, so that the radius of curvature r is continuously reduced with closer distance to the downstream end of the recording medium sliding direction from a vicinity of the magnetic gap, so that by employing the above magnetic head, a long life magnetic head with small damage due to foreign material adhesion as well as small abrasion can be provided.
摘要翻译：磁头包括具有形成在芯块的一个表面上的介质滑动表面的芯块，介质滑动表面具有从滑动方向的上游侧到下游的沿着记录介质的滑动方向形成的细长的凸形弯曲形状并且介质滑动面具有形成在其上的磁隙，其中介质滑动表面沿着其纵向方向成像为具有曲率半径R的圆弧，同时沿着具有半径的圆弧的宽度方向成形的曲率半径r比曲率半径R短，从而使距离磁记录介质滑动方向的下游端更靠近距离的曲率半径r连续地减小，从而通过采用磁头以上，可以提供由于异物附着而造成的损伤小且磨损小的长寿命磁头。

37. 发明授权

US4980285A Method for producing L-amino acids 失效
标题翻译：生产L-氨基酸的方法
公开(公告)号：US4980285A
公开(公告)日：1990-12-25
申请号：US412562
申请日：1989-09-25
申请人： Konosuke Sano , Chieko Osumi , Kazuhiko Matsui , Kiyoshi Miwa
发明人： Konosuke Sano , Chieko Osumi , Kazuhiko Matsui , Kiyoshi Miwa
IPC分类号： C12N15/09 , C12N1/21 , C12N15/00 , C12N15/52 , C12N15/77 , C12P13/04 , C12P13/08 , C12P13/22 , C12R1/13 , C12R1/15
CPC分类号： C12N15/52 , C12N15/77 , C12P13/08 , C12P13/22 , Y10S435/84
摘要： A method for producing an L-amino acid, which comprises inserting a gene which codes for an enzyme which is utilized on the route of biosynthesis of an L-amino acid product into one of at least two plasmid vectors which have compatible replicating origins different from each other, inserting a second gene which codes for an enzyme different from the first enzyme on the route of biosynthesis of the L-amino acid into a second of the plasmid vectors; introducing the thus obtained recombinant plasmids into a strain of Coryneform bacteria; and culturing the thus transformed strain which is capable of producing the L-amino acid, said two enzymes being highly rate determining enzymes for the biosynthesis of L-amino acid.
摘要翻译：一种L-氨基酸的制造方法，其特征在于，将在L-氨基酸产物的生物合成途径中使用的酶编码的基因插入至少两个具有不同于其的复制起点的质粒载体之一将在L-氨基酸生物合成途径上编码不同于第一酶的酶的第二基因插入第二质粒载体; 将如此获得的重组质粒导入棒状细菌菌株; 并培养能够产生L-氨基酸的如此转化的菌株，所述两种酶是用于生物合成L-氨基酸的高速率决定酶。

38. 发明授权

US08510054B2 Intracellular metabolic flux analysis method using substrate labeled with isotope 失效
标题翻译：使用同位素标记的底物的细胞内代谢通量分析方法
公开(公告)号：US08510054B2
公开(公告)日：2013-08-13
申请号：US11048923
申请日：2005-02-03
申请人： Shintaro Iwatani , Yoshihiro Usuda , Kazuhiko Matsui
发明人： Shintaro Iwatani , Yoshihiro Usuda , Kazuhiko Matsui
IPC分类号： G01N33/48 , C12Q1/00
CPC分类号： G01N33/5091 , C12Q1/00 , G06F19/12
摘要： A method for intracellular metabolic flux analysis comprising (a) culturing cells in a medium not containing any isotope-labeled substrate to a target phase of the metabolic flux analysis, (b) adding an isotope-labeled substrate to the medium, and continuing culture and collecting samples from the medium in time course, (c) measuring isotope distribution in an intracellular metabolite contained in the samples collected in time course, (d) performing a regression analysis for measured data and calculating an isotope distribution ratio in a steady state, and (e) analyzing a metabolic flux of the cultured cells by using the calculated isotope distribution ratio.
摘要翻译：一种用于细胞内代谢通量分析的方法，包括（a）在不含任何同位素标记的底物的培养基中将细胞培养至代谢通量分析的目标阶段，（b）将同位素标记的底物加入到培养基中，在时间过程中从培养基中收集样品，（c）测量在时间过程中收集的样品中所含的细胞内代谢物中的同位素分布，（d）对稳定状态进行测量数据和计算同位素分布比的回归分析，以及（e）使用计算出的同位素分布比分析培养细胞的代谢通量。

39. 发明授权

US08076111B2 Method for producing an organic acid 有权
标题翻译：有机酸的制造方法
公开(公告)号：US08076111B2
公开(公告)日：2011-12-13
申请号：US12579594
申请日：2009-10-15
申请人： Keita Fukui , Yoshinori Tajima , Kazue Kawamura , Yoshihiro Usuda , Kazuhiko Matsui
发明人： Keita Fukui , Yoshinori Tajima , Kazue Kawamura , Yoshihiro Usuda , Kazuhiko Matsui
IPC分类号： C12P7/46 , C12P1/04 , C12P21/06 , C12P19/34 , C12N1/20 , C12N9/00 , C07H21/02 , C07H21/04 , C07K1/00
CPC分类号： C12P7/46
摘要： An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction mixture containing carbonate ions, bicarbonate ions, or carbon dioxide gas to produce the organic acid, and collecting the organic acid.
摘要翻译：有机酸是通过使具有生产有机酸的能力的细菌进行改性的，以使yidE基因的表达增强，或通过加工细菌获得的产物作用于反应中的有机原料含有碳酸根离子，碳酸氢根离子或二氧化碳气体的混合物以产生有机酸，并收集有机酸。

40. 发明授权

US07670822B2 Aldolase and production process of 4-hydroxy-L-isoleucine 失效
标题翻译：醛缩酶和4-羟基-L-异亮氨酸的生产过程
公开(公告)号：US07670822B2
公开(公告)日：2010-03-02
申请号：US12212767
申请日：2008-09-18
申请人： Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Tomohiro Kodera , Kazuhiko Matsui
发明人： Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Tomohiro Kodera , Kazuhiko Matsui
IPC分类号： C07H21/04 , C12N9/88
CPC分类号： C12N9/88 , C12P13/06
摘要： A novel aldolase is described. 4-hydroxy-3-methyl-2-keto-pentanoic acid, which is useful as an intermediate in the synthesis of 4-hydroxy-L-isoleucine, may be synthesized from acetaldehyde and α-ketobutyric acid using a novel aldolase, which is derived from the genus Arthrobacter.
摘要翻译：描述了一种新的醛缩酶。可用于合成4-羟基-L-异亮氨酸的中间体的4-羟基-3-甲基-2-酮戊酸可以使用新的醛缩酶由乙醛和α-酮丁酸合成，其是衍生自节杆菌属。

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