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1. 发明授权

US4072687A Process for producing 2-amino-(2)-thiazoline-4-carboxylic acid 失效
标题翻译： 2-氨基 - （2） - 噻唑啉-4-羧酸的制备方法
公开(公告)号：US4072687A
公开(公告)日：1978-02-07
申请号：US737781
申请日：1976-11-01
申请人： Kazushi Togo , Fumihide Tamura , Naohiko Yasuda , Takehiko Ichikawa , Konosuke Sano , Keizo Matsuda , Koji Mitsugi
发明人： Kazushi Togo , Fumihide Tamura , Naohiko Yasuda , Takehiko Ichikawa , Konosuke Sano , Keizo Matsuda , Koji Mitsugi
IPC分类号： C07D277/18 , C12P13/12
CPC分类号： C12P13/12 , C07D277/18
摘要： 2-Amino-(2)-thiazoline-4-carboxylic acid is prepared by dehydrochlorinating S-(.beta.-carboxy-.beta.-chloroethyl) isothiourea by adding it to an aqueous medium maintained at a pH ranging from 5.5 to 7.5 with an alkali.
摘要翻译：通过将S-（β-羧基-β-氯乙基）异硫脲通过用碱保持在5.5至7.5的pH范围的水性介质中脱氯化氢来制备2-氨基 - （2） - 噻唑啉-4-羧酸。

2. 发明授权

US4006057A Method of producing L-cysteine and L-cystine 失效
标题翻译：生产L-半胱氨酸和L-胱氨酸的方法
公开(公告)号：US4006057A
公开(公告)日：1977-02-01
申请号：US628840
申请日：1975-11-04
申请人： Konosuke Sano , Keizo Matsuda , Koji Mitsugi , Kazuhiko Yamada , Fumihide Tamura , Naohiko Yasuda , Ichiro Noda
发明人： Konosuke Sano , Keizo Matsuda , Koji Mitsugi , Kazuhiko Yamada , Fumihide Tamura , Naohiko Yasuda , Ichiro Noda
IPC分类号： C12P13/12 , C12D13/06
CPC分类号： C12P13/12 , Y10S435/824 , Y10S435/829 , Y10S435/833 , Y10S435/84 , Y10S435/847 , Y10S435/859 , Y10S435/874 , Y10S435/881
摘要： A method for producing L-cysteine and/or L-cystine which comprises:A. holding 2-amino-thiazoline-4-carboxylic acid in an aqueous solution at a pH of 5 to 11 in the presence of an effective amount of enzyme produced by a microorganism; said enzyme being capable of converting the 2-amino-thiazoline-4-carboxylic acid to L-cysteine and/or L-cystine, and said microorganism being capable of growing in a medium containing 2-amino-thiazoline-4-carboxylic acid as a nitrogen source; andB. recovering the L-cysteine and/or L-cystine formed from said aqueous solution.
摘要翻译：一种L-半胱氨酸和/或L-胱氨酸的制造方法，其特征在于：

3. 发明授权

US6083728A Production of glutamate using wild type Bacillus methanolicus 失效
标题翻译：使用野生型甲醇芽孢杆菌生产谷氨酸
公开(公告)号：US6083728A
公开(公告)日：2000-07-04
申请号：US953265
申请日：1997-10-17
申请人： Frederick J. Schendel , Richard Dillingham , Richard S. Hanson , Konosuke Sano , Kazuhiko Matsui
发明人： Frederick J. Schendel , Richard Dillingham , Richard S. Hanson , Konosuke Sano , Kazuhiko Matsui
IPC分类号： C12P13/14 , C12P13/18 , C12N1/20
CPC分类号： C12P13/18 , C12P13/14 , Y10S435/832
摘要： A method of producing glutamic acid by culturing a biologically pure wild type Bacillus methanolicus which exhibits sustained growth at 50.degree. C. using methanol as a carbon and energy source and requiring vitamin B.sub.12 and biotin is provided.
摘要翻译：通过培养生物纯的野生型甲醇甲醇生产谷氨酸的方法，其在50℃下使用甲醇作为碳和能量源并需要维生素B12和生物素显示出持续的生长。

4. 发明授权

US4601983A Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine 失效
标题翻译：携带重组质粒的棒状细菌及其在L-苏氨酸和L-异亮氨酸发酵生产中的应用
公开(公告)号：US4601983A
公开(公告)日：1986-07-22
申请号：US504471
申请日：1983-06-15
申请人： Shigeru Nakamori , Masaaki Ishida , Hiroshi Takagi , Kiyoshi Miwa , Koichi Ito , Konosuke Sano
发明人： Shigeru Nakamori , Masaaki Ishida , Hiroshi Takagi , Kiyoshi Miwa , Koichi Ito , Konosuke Sano
IPC分类号： C12N9/04 , C12N15/00 , C12N15/09 , C12N15/77 , C12P13/06 , C12P13/08 , C12R1/13 , C12R1/15 , C12R1/125
CPC分类号： C12N9/0006 , C12N15/77 , C12P13/06 , C12P13/08 , Y10S435/84 , Y10S435/843
摘要： A genetic sequence coding for the production of a protein having the activity of homoserine dehydrogenase and having two Pst I cleavage sites in its DNA chain and a molecular weight of 2.24 Md, is incorporated into a vehicle capable of replication in Coryneform bacteria and used to produce L-threonine and L-isoleucine by fermentation.
摘要翻译：编码生产具有高丝氨酸脱氢酶活性并且在其DNA链中具有两个Pst I切割位点并且分子量为2.24Md的蛋白质的遗传序列被并入能够在棒状细菌中复制的载体中，并用于产生 L-苏氨酸和L-异亮氨酸通过发酵。

5. 发明授权

US5989875A Method of process for producing L-lysine by fermentation 失效
标题翻译：通过发酵生产L-赖氨酸的方法
公开(公告)号：US5989875A
公开(公告)日：1999-11-23
申请号：US973461
申请日：1998-04-20
申请人： Hiroyuki Kojima , Yuri Ogawa , Kazue Kawamura , Konosuke Sano
发明人： Hiroyuki Kojima , Yuri Ogawa , Kazue Kawamura , Konosuke Sano
IPC分类号： C12N9/12 , C12N9/88 , C12P13/08 , C12N15/00
CPC分类号： C12N9/1217 , C12N9/88 , C12P13/08
摘要： A bacterium belonging to the genus Serratia, which is transformed by introducing into its cells, a DNA coding for a dihydrodipicolinate synthase originating from a bacterium belonging to the genus Escherichia or Serratia having mutation to desensitize feedback inhibition by L-lysine and a DNA coding for an aspartokinase originating from a bacterium belonging to the genus Escherichia or Serratia having mutation to desensitize feedback inhibition by L-lysine is cultivated in an appropriate medium, L-lysine is produced and accumulated in a culture thereof, and L-lysine is collected from the culture.
摘要翻译： PCT No.PCT / JP96 / 00648 Sec。 371日期：1998年4月20日 102（e）1998年4月20日PCT 1996年3月14日PCT PCT。公开号WO96 / 41871 日期：1996年12月27日属于沙雷氏菌属的细菌，其通过向其细胞中引入编码源自属于埃希氏杆菌属或沙雷氏菌属的细菌的二氢吡啶二酸合成酶的DNA而被转化，其具有使L-赖氨酸反馈抑制脱敏的突变并且在合适的培养基中培养编码源自属于埃希氏杆菌属或沙雷氏菌属的属于具有L-赖氨酸的反馈抑制突变突变的天冬氨酸的DNA的DNA，并在其培养物中产生L-赖氨酸并积累，从培养物中收集赖氨酸。

6. 发明授权

US5661012A Method for the production of L-threonine by fermentation, using mutated DNA encoding aspartokinase III 失效
标题翻译：通过发酵生产L-苏氨酸的方法，使用编码天冬氨酸激酶III的突变型DNA
公开(公告)号：US5661012A
公开(公告)日：1997-08-26
申请号：US256136
申请日：1994-07-01
申请人： Konosuke Sano , Hiroyuki Kojima , Yuri Ogawa
发明人： Konosuke Sano , Hiroyuki Kojima , Yuri Ogawa
IPC分类号： C12N1/21 , C12N9/12 , C12N15/54 , C12N15/63 , C12P13/08 , C12R1/19
CPC分类号： C12N9/1217 , C12N9/12 , C12P13/08
摘要： A DNA containing a gene which codes for aspartokinase III originating in Escherichia bacteria and which has in the coding region a mutation which releases the feedback inhibition by lysine on the aspartokinase III, a recombinant DNA wherein the DNA is linked to a vector DNA capable of autonomous replication in Escherichia bacteria, a microorganism belonging to the genus Escherichia which has been transformed by the introduction of the above mentioned recombinant DNA into the cells thereof, and a method for the production of L-threonine which comprises culturing the microorganism in a fermentation medium, producing and accumulating L-threonine in the culture medium, and collecting the L-threonine from said-culture medium. Escherichia bacteria-derived AK III genes are obtained which sufficiently release the feedback inhibition due to lysine. Introduction of these genes into threonine-producing bacteria results in new threonine-producing bacteria which are much improved in their threonine production over those of the prior art. Use of these threonine-producing bacteria provides a much more excellent method for the production of L-threonine by fermentation than the conventional methods.
摘要翻译： PCT No.PCT / JP93 / 01640 Sec。 371日期：1994年7月1日 102（e）日期1994年7月1日PCT 1993年11月10日PCT公布。出版物WO94 / 11517 日期1994年5月26日包含编码源自大肠杆菌细菌的天冬氨酸激酶III的基因的DNA，其编码区具有在天冬氨酸激酶III上释放赖氨酸的反馈抑制的突变，其是DNA与载体连接的重组DNA 能够在大肠杆菌中自主复制的DNA，通过将上述重组DNA导入其细胞而转化的埃希氏杆菌属的微生物，以及L-苏氨酸的制备方法，其特征在于，发酵培养基，在培养基中产生和积累L-苏氨酸，并从所述培养基中收集L-苏氨酸。获得大肠杆菌细菌来源的AK III基因，其充分释放由赖氨酸引起的反馈抑制。将这些基因引入产生苏氨酸的细菌导致新的苏氨酸生产细菌，其苏氨酸生产比现有技术的产生大大改善。使用这些苏氨酸生产菌比传统方法提供了通过发酵生产L-苏氨酸的更优异的方法。

7. 发明授权

US4514502A Composite plasmid 失效
标题翻译：复合质粒
公开(公告)号：US4514502A
公开(公告)日：1985-04-30
申请号：US386980
申请日：1982-06-10
申请人： Kiyoshi Miwa , Mahito Terabe , Koichi Ito , Masaaki Ishida , Kazuhiko Matsui , Shigeru Makamori , Konosuke Sano
发明人： Kiyoshi Miwa , Mahito Terabe , Koichi Ito , Masaaki Ishida , Kazuhiko Matsui , Shigeru Makamori , Konosuke Sano
IPC分类号： C12N15/09 , C07H21/04 , C12N15/52 , C12N15/75 , C12N15/77 , C12P13/22 , C12N1/20 , C12N1/00 , C12N15/00 , C12R1/15
CPC分类号： C12N15/52 , C12N15/75 , C12N15/77 , C12P13/222 , Y10S435/843
摘要： A composite plasmid which comprises (A) a drive-unit region derived from a plasmid a capable of propagating in a Coryneform glutamic acid-producing bacterium, and (B) a gene fragment derived from a plasmid b capable of propagating in Escherichia coli or Bacillus subtilis and having at least a region expressing drug resistance.
摘要翻译：一种复合质粒，其包含（A）衍生自能够在棒杆菌型谷氨酸生产细菌中繁殖的质粒的驱动单位区域，和（B）源自能够在大肠杆菌或芽孢杆菌中扩散的质粒b的基因片段并且至少具有表达耐药性的区域。

8. 发明授权

US4407952A Method for producing L-phenylalanine by fermentation 失效
标题翻译：通过发酵生产L-苯丙氨酸的方法
公开(公告)号：US4407952A
公开(公告)日：1983-10-04
申请号：US159477
申请日：1980-06-16
申请人： Takayasu Tsuchida , Konosuke Sano
发明人： Takayasu Tsuchida , Konosuke Sano
IPC分类号： C12N15/09 , C12N1/21 , C12N15/52 , C12P13/22 , C12R1/185 , C12N15/00 , C12R1/19
CPC分类号： C12N15/52 , C12P13/222 , Y10S435/849
摘要： L-phenylalanine is produced by fermentation by culturing in a culture medium an L-phenylalanine producing microorganism constructed by incorporating a hybrid plasmid in a recipient strain of the genus Escherichia and recovering the L-phenylalanine which accumulates in the culture medium, said hybrid plasmid containing a deoxyribonucleic acid fragment possessing genetic information related to L-phenylalanine production and obtained from a phenylalanine analogue resistant mutant of the genus Escherichia.
摘要翻译：通过在培养基中培养产生L-苯丙氨酸的微生物来产生L-苯丙氨酸，所述微生物通过在埃希氏杆菌属的受体菌株中掺入杂交质粒而构建，并回收积累在培养基中的L-苯丙氨酸，所述杂交质粒含有具有与L-苯丙氨酸生产相关的遗传信息的脱氧核糖核酸片段，其由埃希氏杆菌属的苯丙氨酸类似物抗性突变体获得。

9. 发明授权

US4980285A Method for producing L-amino acids 失效
标题翻译：生产L-氨基酸的方法
公开(公告)号：US4980285A
公开(公告)日：1990-12-25
申请号：US412562
申请日：1989-09-25
申请人： Konosuke Sano , Chieko Osumi , Kazuhiko Matsui , Kiyoshi Miwa
发明人： Konosuke Sano , Chieko Osumi , Kazuhiko Matsui , Kiyoshi Miwa
IPC分类号： C12N15/09 , C12N1/21 , C12N15/00 , C12N15/52 , C12N15/77 , C12P13/04 , C12P13/08 , C12P13/22 , C12R1/13 , C12R1/15
CPC分类号： C12N15/52 , C12N15/77 , C12P13/08 , C12P13/22 , Y10S435/84
摘要： A method for producing an L-amino acid, which comprises inserting a gene which codes for an enzyme which is utilized on the route of biosynthesis of an L-amino acid product into one of at least two plasmid vectors which have compatible replicating origins different from each other, inserting a second gene which codes for an enzyme different from the first enzyme on the route of biosynthesis of the L-amino acid into a second of the plasmid vectors; introducing the thus obtained recombinant plasmids into a strain of Coryneform bacteria; and culturing the thus transformed strain which is capable of producing the L-amino acid, said two enzymes being highly rate determining enzymes for the biosynthesis of L-amino acid.
摘要翻译：一种L-氨基酸的制造方法，其特征在于，将在L-氨基酸产物的生物合成途径中使用的酶编码的基因插入至少两个具有不同于其的复制起点的质粒载体之一将在L-氨基酸生物合成途径上编码不同于第一酶的酶的第二基因插入第二质粒载体; 将如此获得的重组质粒导入棒状细菌菌株; 并培养能够产生L-氨基酸的如此转化的菌株，所述两种酶是用于生物合成L-氨基酸的高速率决定酶。

10. 发明授权

US4885245A Process for producing L-tryptophan 失效
标题翻译：生产L-色氨酸的方法
公开(公告)号：US4885245A
公开(公告)日：1989-12-05
申请号：US760930
申请日：1985-07-31
申请人： Masaaki Ishida , Kiyoshi Miwa , Shigeru Nakamori , Konosuke Sano
发明人： Masaaki Ishida , Kiyoshi Miwa , Shigeru Nakamori , Konosuke Sano
IPC分类号： C12N15/09 , C12N1/21 , C12N9/88 , C12N15/00 , C12N15/77 , C12P13/22 , C12R1/13 , C12R1/15
CPC分类号： C12P13/227 , C12N15/77 , C12N9/88
摘要： A process for producing L-tryptophan in which a suitable substrate such as a carbohydrate, indole or anthranilic acid is contacted with Coryneform bacteria, where the Coryneform bacteria bear recombinant DNA constructed by connecting a gene coding for tryptophan synthetase with a plasmid vector capable of proliferating in Coryneform bacteria.
摘要翻译：一种生产L-色氨酸的方法，其中适当的底物如碳水化合物，吲哚或邻氨基苯甲酸与棒状细菌接触，其中棒状细菌携带通过将编码色氨酸合成酶的基因与能够增殖的质粒载体连接而构建的重组DNA 在棒状细菌。

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