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31. 发明申请

US20050250117A1 Isolation of single polymeric molecules 审中-公开
标题翻译：分离单个聚合物分子
公开(公告)号：US20050250117A1
公开(公告)日：2005-11-10
申请号：US10959237
申请日：2004-10-05
申请人： Xing Su , Narayan Sundararajan
发明人： Xing Su , Narayan Sundararajan
IPC分类号： B01L3/00 , C12Q1/68 , G01N27/447 , C07H21/04
CPC分类号： C12Q1/68 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/0415 , C07H1/06 , C07H21/04 , G01N27/447
摘要： Methods and devices for immobilizing and isolating single polymeric molecules are disclosed. In some aspects, controllable dispensing of target polymeric molecules is provided. In additional aspects of the invention, methods for creating and manipulating microbeads having a single target nucleic acid molecule attached are provided. Aspects of the disclosed devices and methods are exemplified using microfluidics.
摘要翻译：公开了用于固定和分离单一聚合物分子的方法和装置。在一些方面，提供目标聚合物分子的可控分配。在本发明的另外的方面，提供了用于产生和操作具有连接的单个靶核酸分子的微珠的方法。所公开的装置和方法的方面使用微流体示例。

32. 发明申请

US20180272221A1 SENSOR-DERIVED OBJECT FLIGHT PERFORMANCE TRACKING 有权
公开(公告)号：US20180272221A1
公开(公告)日：2018-09-27
申请号：US15470530
申请日：2017-03-27
申请人： Narayan Sundararajan , Xue Yang , Suresh V. Golwalkar , Mahanth Gowda , Romit Roy Choudhury
发明人： Narayan Sundararajan , Xue Yang , Suresh V. Golwalkar , Mahanth Gowda , Romit Roy Choudhury
IPC分类号： A63B69/36 , G01P15/08 , A63B24/00 , A63B69/00 , A63B43/00
摘要： Systems and techniques for sensor-derived object flight performance tracking are described herein. A set of magnetometer readings may be obtained from a magnetometer included with an object. A local rotation axis of the object may be determined at a time using the set of magnetometer readings. The local rotation axis may describe rotation of the object around a local magnetic target. A global rotation axis may be calculated based on an initial orientation of the object. The global rotation axis may describe a fixed rotation axis of the object during flight in a global coordinate frame, wherein an angle between the global rotation axis and magnetic north remains constant during the flight. An orientation of the object may be determined for the time using the global rotation axis and the local rotation axis of the object at the time.

33. 发明申请

US20170187253A1 Activity accessory with energy harvesting 审中-公开
公开(公告)号：US20170187253A1
公开(公告)日：2017-06-29
申请号：US14757873
申请日：2015-12-23
申请人： Stephanie Moyerman , Narayan Sundararajan
发明人： Stephanie Moyerman , Narayan Sundararajan
IPC分类号： H02K1/22 , H02K5/04
CPC分类号： H02K1/22 , A63B37/00 , A63B41/00 , A63B43/004 , A63B60/46 , A63B67/14 , A63B2209/00 , A63B2209/08 , A63B2220/00 , A63B2220/40 , A63B2220/80 , A63B2220/803 , A63B2220/833 , A63B2225/50 , H02K5/04 , H02K7/1876 , H02K35/02 , H02K99/10
摘要： Apparatus and methods are provided for activity accessory including an energy harvester or generator. In an example, an activity accessory can include a first enclosure and an energy generator enclosed within the first enclosure. The energy generator can include a second enclosure. The energy generator can include a spherical magnet housed within the second enclosure and windings surrounding the second enclosure. Movement of the spherical magnet within the second enclosure can induce charge movement in the windings.

34. 发明申请

US20100171950A1 METHODS FOR UNIFORM METAL IMPREGNATION INTO A NANOPOROUS MATERIAL 有权
标题翻译：将金属均匀地纳入纳米材料的方法
公开(公告)号：US20100171950A1
公开(公告)日：2010-07-08
申请号：US12575369
申请日：2009-10-07
申请人： Selena CHAN , Sunghoon Kwon , Narayan Sundararajan
发明人： Selena CHAN , Sunghoon Kwon , Narayan Sundararajan
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B01D67/0062 , B01D67/0086 , B01D67/0088 , B01D71/02 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01J3/44 , G01N21/65 , G01N2021/6439 , G01N2021/655 , G01N2021/656 , C12Q2565/632 , C12Q2563/155
摘要： The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.
摘要翻译：本文公开的方法，系统400和装置涉及金属150浸渍的多孔基材110,210。本发明的某些实施方案涉及用于制造金属涂覆的多孔硅基板110,210的方法，其显示出显着改善金属150沉积物的均匀性和深度的渗透。增加的均匀性和深度允许分析物的改进和更可重复的拉曼检测。在本发明的示例性实施例中，所述方法可以包括多孔硅110的氧化，浸入金属盐溶液130中，干燥和热分解金属盐140以形成金属沉积物150.在本发明的其它示例性实施方案中，方法可以包括多孔硅衬底210与一种或多种金属盐溶液130的微流体浸渍。本发明的其它实施方案涉及用于分析物的拉曼检测的装置和/或系统400，包括金属涂覆的多孔硅衬底110,210，由公开的方法。

35. 发明申请

US20080108149A1 Solid-phase mediated synthesis of molecular microarrays 审中-公开
标题翻译：固相介导的分子微阵列合成
公开(公告)号：US20080108149A1
公开(公告)日：2008-05-08
申请号：US11585413
申请日：2006-10-23
申请人： Narayan Sundararajan , John J. Rajasekaran , Guangyu Xu
发明人： Narayan Sundararajan , John J. Rajasekaran , Guangyu Xu
IPC分类号： C12Q1/68 , A61K38/00 , G01N33/543 , C07K1/00
CPC分类号： C07H21/00 , C40B50/14
摘要： Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived methods and electrochemically generated reagents. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides, polymers joined by peptide bonds, nucleic acids, and polymers joined by phosphodiester bonds may be fabricated in a highly multiplexed manner.
摘要翻译：使用半导体加工衍生的方法和电化学产生的试剂提供以高度复用的方式制备聚合物分子的致密阵列的方法。有利地，该方法适用于各种聚合物的合成。例如，通过肽键连接的肽的阵列，通过磷酸二酯键连接的核酸和聚合物可以以高度复用的方式制造。

36. 发明授权

US07361313B2 Methods for uniform metal impregnation into a nanoporous material 有权
标题翻译：均匀金属浸渍到纳米多孔材料中的方法
公开(公告)号：US07361313B2
公开(公告)日：2008-04-22
申请号：US10368976
申请日：2003-02-18
申请人： Selena Chan , Sunghoon Kwon , Narayan Sundararajan
发明人： Selena Chan , Sunghoon Kwon , Narayan Sundararajan
IPC分类号： G01N21/65 , G01J3/44
CPC分类号： G01N21/658 , B01D67/0062 , B01D67/0086 , B01D67/0088 , B01D71/02 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01J3/44 , G01N21/65 , G01N2021/6439 , G01N2021/655 , G01N2021/656 , C12Q2565/632 , C12Q2563/155
摘要： The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.
摘要翻译：本文公开的方法，系统400和装置涉及金属150浸渍的多孔基材110,210。本发明的某些实施方案涉及用于制造金属涂覆的多孔硅基板110,210的方法，其显示出显着改善金属150沉积物的均匀性和深度的渗透。增加的均匀性和深度允许分析物的改进和更可重复的拉曼检测。在本发明的示例性实施例中，所述方法可以包括多孔硅110的氧化，浸入金属盐溶液130中，干燥和热分解金属盐140以形成金属沉积物150.在本发明的其它示例性实施方案中，方法可以包括多孔硅衬底210与一种或多种金属盐溶液130的微流体浸渍。本发明的其它实施方案涉及用于分析物的拉曼检测的装置和/或系统400，包括金属涂覆的多孔硅衬底110,210，由公开的方法。

37. 发明授权

US07279134B2 Microfluidic devices with porous membranes for molecular sieving, metering, and separations 有权
标题翻译：具有用于分子筛，计量和分离的多孔膜的微流体装置
公开(公告)号：US07279134B2
公开(公告)日：2007-10-09
申请号：US10246049
申请日：2002-09-17
申请人： Selena Chan , Narayan Sundararajan , Andrew A. Berlin , Mineo Yamakawa
发明人： Selena Chan , Narayan Sundararajan , Andrew A. Berlin , Mineo Yamakawa
IPC分类号： B01L3/02 , B31D3/00
CPC分类号： B01D61/18 , B01D61/022 , B01D61/142 , B01D61/20 , B01D69/02 , B01D71/02 , B01D2325/02 , B01D2325/04 , B01L3/502753 , B01L2200/12 , B01L2300/0681 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Microfluidic devices with porous membranes for molecular sieving, metering, and separation of analyte fluids. In one aspect, a microfluidic device includes a substrate having input and output microfluidic channel sections separated by a porous membrane formed integral to the substrate. In another aspect, the porous membrane may comprise a thin membrane that is sandwiched between upper and lower substrate members. The microfluidic device may include one or a plurality of porous membranes. In one embodiment, a plurality of porous membranes having increasingly smaller pores are disposed along portions of a microfluidic channel. In another embodiment, a cascading series of upper and lower channels are employed, wherein each upper/lower channel interface is separated by a respective porous membrane. In another aspect, a porous membrane is rotatably coupled to a substrate within a microfluidic channel via a MEMS actuator to enable the porous membrane to be positioned in filtering and pass-through positions.
摘要翻译：具有多孔膜的微流体装置用于分析筛分，计量和分析分析液体。在一个方面，微流体装置包括具有输入和输出微流体通道部分的基底，所述输入和输出微流体通道部分由与所述基底一体形成的多孔膜隔开。在另一方面，多孔膜可以包括夹在上部和下部衬底构件之间的薄膜。微流体装置可以包括一个或多个多孔膜。在一个实施例中，具有越来越小的孔的多个多孔膜沿着微流体通道的部分设置。在另一个实施例中，采用了上下通道的级联系列，其中每个上/下通道界面由相应的多孔膜隔开。在另一方面，多孔膜通过MEMS致动器可旋转地联接到微流体通道内的衬底，以使得多孔膜能够位于过滤位置和穿过位置。

38. 发明申请

US20070122842A1 Massively parallel synthesis of proteinaceous biomolecules 审中-公开
公开(公告)号：US20070122842A1
公开(公告)日：2007-05-31
申请号：US11395899
申请日：2006-03-30
申请人： John Rajasekaran , Gunjan Tiwari , Edelmira Cabezas , Jacqueline Fidanza , Narayan Sundararajan
发明人： John Rajasekaran , Gunjan Tiwari , Edelmira Cabezas , Jacqueline Fidanza , Narayan Sundararajan
IPC分类号： G01N1/28 , G01N33/53 , C12M1/34
CPC分类号： C40B50/18 , B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00497 , B01J2219/00504 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C40B40/10
摘要： Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.

39. 发明申请

US20070116882A1 Methods for uniform metal impregnation into a nanoporous material 有权
标题翻译：均匀金属浸渍到纳米多孔材料中的方法
公开(公告)号：US20070116882A1
公开(公告)日：2007-05-24
申请号：US11436489
申请日：2006-05-18
申请人： Selena Chan , Sunghoon Kwon , Narayan Sundararajan
发明人： Selena Chan , Sunghoon Kwon , Narayan Sundararajan
IPC分类号： B05D1/18
CPC分类号： G01N21/658 , B01D67/0062 , B01D67/0086 , B01D67/0088 , B01D71/02 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01J3/44 , G01N21/65 , G01N2021/6439 , G01N2021/655 , G01N2021/656 , C12Q2565/632 , C12Q2563/155
摘要： The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.
摘要翻译：本文公开的方法，系统400和装置涉及金属150浸渍的多孔基材110,210。本发明的某些实施方案涉及用于制造金属涂覆的多孔硅基板110,210的方法，其显示出显着改善金属150沉积物的均匀性和深度的渗透。增加的均匀性和深度允许分析物的改进和更可重复的拉曼检测。在本发明的示例性实施例中，所述方法可以包括多孔硅110的氧化，浸入金属盐溶液130中，干燥和热分解金属盐140以形成金属沉积物150.在本发明的其它示例性实施方案中，方法可以包括多孔硅衬底210与一种或多种金属盐溶液130的微流体浸渍。本发明的其它实施方案涉及用于分析物的拉曼检测的装置和/或系统400，包括金属涂覆的多孔硅衬底110,210，由公开的方法。

40. 发明申请

US20060234248A1 Composite organic inorganic nanoclusters 审中-公开
标题翻译：复合有机无机纳米团簇
公开(公告)号：US20060234248A1
公开(公告)日：2006-10-19
申请号：US11081772
申请日：2005-03-15
申请人： Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Narayan Sundararajan
发明人： Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Narayan Sundararajan
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N21/658 , B82Y30/00 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters may be further functionalized, for example, with coatings and layers, such as adsorption layers, metal coatings, silica coatings, probes, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.
摘要翻译：提供能够从其中并入的有机拉曼活性分子提供增强的拉曼信号的金属纳米团簇。纳米团簇可以进一步官能化，例如具有涂层和层，例如吸附层，金属涂层，二氧化硅涂层，探针和有机层。纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

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