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31. 发明申请

US20050249671A9 Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof 审中-公开
标题翻译：中性粒细胞α偶联物，中性粒细胞α复合物及其应用
公开(公告)号：US20050249671A9
公开(公告)日：2005-11-10
申请号：US10742634
申请日：2003-12-22
申请人： David Parmelee , Ren-Hwa Yeh , Olga Galperina , David Hilbert , Craig Rosen
发明人： David Parmelee , Ren-Hwa Yeh , Olga Galperina , David Hilbert , Craig Rosen
IPC分类号： A61K47/48 , C07K14/52 , A61K49/00 , C07K14/525
CPC分类号： C07K14/52 , A61K47/66 , A61K47/6903 , B82Y5/00
摘要： The present invention is directed to a Neutrokine-alpha conjugate, wherein said Neutrokine-alpha conjugate comprises a Neutrokine-alpha protein and a chelator. The present invention is also directed to a Neutrokine-alpha complex, wherein said Neutrokine-alpha complex comprises a Neutrokine-alpha conjugate and a metal ion wherein said metal ion is noncovalently associated with the chelator of said conjugate. The present invention is further directed to compositions, specifically pharmaceutical and diagnostic compositions, comprising a Neutrokine-alpha conjugate or complex as described herein. Therapeutic and diagnostic uses of said conjugate, complex, and compositions are described.
摘要翻译：本发明涉及一种Neutrokine-α缀合物，其中所述Neutrokine-α缀合物包含Neutrokine-α蛋白和螯合剂。本发明还涉及一种中枢神经素α复合物，其中所述中枢神经素α复合物包含中枢神经素α偶联物和金属离子，其中所述金属离子与所述缀合物的螯合剂非共价结合。本发明进一步涉及包含如本文所述的中和型α结合物或复合物的组合物，特别是药物和诊断组合物。描述了所述缀合物，复合物和组合物的治疗和诊断用途。

32. 发明申请

US20050239059A1 67 human secreted proteins 审中-公开
标题翻译： 67人分泌蛋白
公开(公告)号：US20050239059A1
公开(公告)日：2005-10-27
申请号：US09949925
申请日：2001-09-12
申请人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
发明人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

33. 发明申请

US20050214844A1 86 human secreted proteins 审中-公开
标题翻译： 86人分泌蛋白
公开(公告)号：US20050214844A1
公开(公告)日：2005-09-29
申请号：US11111953
申请日：2005-04-22
申请人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P43/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/04 , C12N5/06 , C12N5/10 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/11 , C12N15/12 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

34. 发明申请

US20050214289A1 Antibodies against Nogo receptor 审中-公开
标题翻译：抗Nogo受体的抗体
公开(公告)号：US20050214289A1
公开(公告)日：2005-09-29
申请号：US11090846
申请日：2005-03-25
申请人： Adam Bell , Craig Rosen
发明人： Adam Bell , Craig Rosen
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505
摘要： The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.
摘要翻译：本发明涉及特异性结合Nogo受体（NogoR）的抗体和相关分子。这样的抗体具有例如用于治疗脊髓损伤，脑损伤，麻痹，退行性神经系统疾病和中风的用途。本发明还涉及编码抗NogoR抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。

35. 发明申请

US20050214209A1 Antibodies that immunospecifically bind to TRAIL receptors 审中-公开
公开(公告)号：US20050214209A1
公开(公告)日：2005-09-29
申请号：US10986349
申请日：2004-11-12
申请人： Theodora Salcedo , Steven Ruben , Craig Rosen , Vivian Albert
发明人： Theodora Salcedo , Steven Ruben , Craig Rosen , Vivian Albert
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30 , A61K51/00 , C07K16/46
CPC分类号： A61K39/395 , A61K31/00 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

36. 发明申请

US20050214206A1 Antibodies that immunospecifically bind to TRAIL receptors 审中-公开
公开(公告)号：US20050214206A1
公开(公告)日：2005-09-29
申请号：US10981621
申请日：2004-11-05
申请人： Theodora Salcedo , Craig Rosen , Vivian Albert , Robin Humphreys , Tristan Vaughan
发明人： Theodora Salcedo , Craig Rosen , Vivian Albert , Robin Humphreys , Tristan Vaughan
IPC分类号： A61K39/395 , A61K51/00 , C07K16/28 , C07K16/30 , C07K16/46
CPC分类号： C07K16/2878 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.

37. 发明申请

US20050197285A1 Human secreted proteins 审中-公开
标题翻译：人体分泌的蛋白质
公开(公告)号：US20050197285A1
公开(公告)日：2005-09-08
申请号：US10472533
申请日：2002-03-19
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： A61K35/76 , A61K38/00 , C07K14/47 , G01N33/68 , A61K38/17
CPC分类号： G01N33/5005 , A61K38/00 , C07K14/47 , G01N33/5091 , G01N33/68 , A61K35/76 , A61K2300/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating gastrointestinal diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides and also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antogonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与其有关的胃肠道疾病，病症和/或病症。结合这些多肽并且也包括在本发明中的抗体。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明进一步包括用于鉴定本发明的多核苷酸和多肽的激动剂和亲和体的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

38. 发明申请

US20050176103A1 Vascular endothelial growth factor 2 失效
标题翻译：血管内皮生长因子2
公开(公告)号：US20050176103A1
公开(公告)日：2005-08-11
申请号：US11067015
申请日：2005-02-28
申请人： Jing-Shan Hu , Craig Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig Rosen , Liang Cao
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C12N1/21 , C12N15/18 , C07K14/515 , C07H21/04
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译：公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

39. 发明申请

US20050158313A1 Antibodies that specifically bind to Reg IV 审中-公开
标题翻译：特异性结合Reg IV的抗体
公开(公告)号：US20050158313A1
公开(公告)日：2005-07-21
申请号：US11017030
申请日：2004-12-21
申请人： Craig Rosen
发明人： Craig Rosen
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV.
摘要翻译：本发明涉及特异性结合Reg IV的抗体和相关分子。这样的抗体具有例如用于预防和治疗胃肠道癌症，炎症性肠病和糖尿病的用途。本发明还涉及编码抗Reg IV抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是胃肠道癌症，炎症性肠病和糖尿病的方法和组合物，包括向动物，优选人类施用有效量的一种或更多的与Reg IV特异性结合的抗体或其片段或变体，或相关分子。

40. 发明申请

US20050129614A1 Antibodies that specifically bind to TL5 失效
标题翻译：特异性结合TL5的抗体
公开(公告)号：US20050129614A1
公开(公告)日：2005-06-16
申请号：US10943197
申请日：2004-09-17
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C07K16/28 , C12N5/24 , A61K51/00 , A61K39/395 , C07K16/30 , C07K16/46
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding anti-TL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.
摘要翻译：本发明涉及特异性结合TL5的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及包括自身免疫疾病，类风湿性关节炎，移植物排斥，移植物抗宿主病和淋巴结病的免疫系统疾病和病症。本发明还涉及编码抗TL5抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及包括自身免疫性疾病，类风湿性关节炎，移植排斥反应，移植物抗宿主病和免疫系统疾病和病症的方法和组合物。淋巴腺病，包括向动物，优选人类施用有效量的特异性结合TL5的一种或多种抗体或其片段或变体或相关分子。

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