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1. 发明申请

US20070048818A1 Human secreted proteins 审中-公开
标题翻译：人体分泌的蛋白质
公开(公告)号：US20070048818A1
公开(公告)日：2007-03-01
申请号：US10868184
申请日：2004-06-16
申请人： Craig Rosen , Steven Ruben , George Komatsoulis
发明人： Craig Rosen , Steven Ruben , George Komatsoulis
IPC分类号： C07K14/47 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

2. 发明申请

US20070015162A1 99 human secreted proteins 审中-公开
标题翻译： 99人分泌蛋白
公开(公告)号：US20070015162A1
公开(公告)日：2007-01-18
申请号：US10670185
申请日：2003-09-25
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C12Q1/68 , C07H21/04 , C12N5/06
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2800/24
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗过敏性和哮喘性疾病。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

3. 发明申请

US20060246483A1 337 human secreted proteins 审中-公开
标题翻译： 337人分泌蛋白
公开(公告)号：US20060246483A1
公开(公告)日：2006-11-02
申请号：US11366486
申请日：2006-03-03
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00 , C07K14/47 , C07K16/18
CPC分类号： C07K14/47
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

4. 发明申请

US20060166327A1 Human G-protein receptor HGBER32 审中-公开
公开(公告)号：US20060166327A1
公开(公告)日：2006-07-27
申请号：US11389101
申请日：2006-03-27
申请人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
发明人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
IPC分类号： C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/7158 , A61K38/00 , C07K14/723
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

5. 发明申请

US20060099575A9 67 human secreted proteins 审中-公开
标题翻译： 67人分泌蛋白
公开(公告)号：US20060099575A9
公开(公告)日：2006-05-11
申请号：US09949925
申请日：2001-09-12
申请人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
发明人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/47
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

6. 发明申请

US20060003378A1 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US20060003378A1
公开(公告)日：2006-01-05
申请号：US11214796
申请日：2005-08-31
申请人： Paul Young , Steven Ruben , Craig Rosen , Henrik Olsen
发明人： Paul Young , Steven Ruben , Craig Rosen , Henrik Olsen
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

7. 发明申请

US20050239059A1 67 human secreted proteins 审中-公开
标题翻译： 67人分泌蛋白
公开(公告)号：US20050239059A1
公开(公告)日：2005-10-27
申请号：US09949925
申请日：2001-09-12
申请人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
发明人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

8. 发明申请

US20050214844A1 86 human secreted proteins 审中-公开
标题翻译： 86人分泌蛋白
公开(公告)号：US20050214844A1
公开(公告)日：2005-09-29
申请号：US11111953
申请日：2005-04-22
申请人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P43/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/04 , C12N5/06 , C12N5/10 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/11 , C12N15/12 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

9. 发明申请

US20050214786A1 26 human secreted proteins 审中-公开
标题翻译： 26人分泌蛋白
公开(公告)号：US20050214786A1
公开(公告)日：2005-09-29
申请号：US10921235
申请日：2004-08-19
申请人： Charles Birse , George Komatsoulis , Gil Choi , Henrik Olsen , Jian Ni , Kevin Baker , Craig Rosen , Steven Ruben , Michele Fiscella , Paul Moore , Ping Wei
发明人： Charles Birse , George Komatsoulis , Gil Choi , Henrik Olsen , Jian Ni , Kevin Baker , Craig Rosen , Steven Ruben , Michele Fiscella , Paul Moore , Ping Wei
IPC分类号： C07H21/04 , C07K14/47 , C12N9/00 , C12Q1/68
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

10. 发明申请

US20050214209A1 Antibodies that immunospecifically bind to TRAIL receptors 审中-公开
公开(公告)号：US20050214209A1
公开(公告)日：2005-09-29
申请号：US10986349
申请日：2004-11-12
申请人： Theodora Salcedo , Steven Ruben , Craig Rosen , Vivian Albert
发明人： Theodora Salcedo , Steven Ruben , Craig Rosen , Vivian Albert
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30 , A61K51/00 , C07K16/46
CPC分类号： A61K39/395 , A61K31/00 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

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