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    • 2. 发明申请
    • 99 human secreted proteins
    • 99人分泌蛋白
    • US20070015162A1
    • 2007-01-18
    • US10670185
    • 2003-09-25
    • Craig RosenSteven Ruben
    • Craig RosenSteven Ruben
    • C12Q1/68C07H21/04C12N5/06
    • C12Q1/6883C07K14/47C12Q2600/156C12Q2600/158G01N33/6893G01N2500/04G01N2800/24
    • The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
    • 本发明涉及人分泌多肽,以及编码所述多肽的分离的核酸分子,其可用于诊断和治疗过敏性和哮喘性疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体,宿主细胞以及用于产生所述多核苷酸,多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
    • 3. 发明申请
    • 337 human secreted proteins
    • 337人分泌蛋白
    • US20060246483A1
    • 2006-11-02
    • US11366486
    • 2006-03-03
    • Craig RosenSteven Ruben
    • Craig RosenSteven Ruben
    • C12Q1/68C07H21/04C12P21/06C12N9/00C07K14/47C07K16/18
    • C07K14/47
    • The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
    • 本发明涉及人分泌的多肽,以及编码所述多肽的分离的核酸分子,其可用于诊断和治疗与之有关的心血管疾病,病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体,宿主细胞,以及用于产生所述多核苷酸,多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
    • 6. 发明申请
    • Peptidoglycan recognition proteins
    • 肽聚糖识别蛋白
    • US20060003378A1
    • 2006-01-05
    • US11214796
    • 2005-08-31
    • Paul YoungSteven RubenCraig RosenHenrik Olsen
    • Paul YoungSteven RubenCraig RosenHenrik Olsen
    • C12Q1/68C07H21/04C12P21/06C07K14/705C07K16/28
    • C07K14/47A61K38/00
    • The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
    • 本发明涉及由角质形成细胞,伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。 更具体地,提供分离的核酸分子,其编码人胶原聚糖识别蛋白相关蛋白(本文称为PGRP-K(角质形成细胞),PGRP-W(伤口愈合)和PGRP-C(软骨肉瘤))。 图1A-B, 图2A-C, 3,分别与人肽聚糖识别蛋白(PGRP)以及鼠Tag-7都具有同源性。 还提供了PGRP-K,PGRP-W和PGRP-C多肽。 进一步提供载体,宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K,PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K,PGRP-W和PGRP-C基因表达的诊断方法。