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31. 发明授权

US5465713A Energy-assisted transdermal collection patch for accelerated analyte collection and method of use 失效
标题翻译：用于加速分析物收集的能量辅助透皮收集贴片和使用方法
公开(公告)号：US5465713A
公开(公告)日：1995-11-14
申请号：US94787
申请日：1993-07-20
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61B5/00 , A61B10/00 , A61F7/03 , A61F13/00 , A61F13/15 , B01L3/00 , G01N1/10 , G01N33/15 , G01N33/483 , G01N33/487 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61F2013/00195 , A61F2013/00434 , A61F2013/00608 , A61F2013/00642 , A61F2013/00646 , A61F2013/00655 , A61F2013/00731 , A61F2013/00863 , A61F2013/00902 , A61F2013/8411 , A61F2013/842 , A61F2013/8473 , A61F2013/8491 , A61F7/032
摘要： A dermal patch including a means for generating heat on the surface of the skin of a subject wearing the patch. The temperature of the surface of the skin under the patch is raised to about 115.degree. F., and perspiration is collected in the patch over the course of about an hour. The patch is then analyzed to determine the presence of an analyte in the patch.
摘要翻译：皮肤贴片，其包括在穿着贴片的受试者的皮肤表面上产生热量的装置。贴片下皮肤表面的温度升高至约115°F，并在大约1小时的过程中将汗液收集在贴片中。然后分析贴片以确定贴片中分析物的存在。

32. 发明授权

US5403272A Apparatus and methods for generating leukocyte free platelet concentrate 失效
标题翻译：用于产生无白血球的血小板浓缩物的装置和方法
公开(公告)号：US5403272A
公开(公告)日：1995-04-04
申请号：US890980
申请日：1992-05-29
申请人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
发明人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
IPC分类号： A61M1/02 , A61K35/14 , A61M1/26 , A61M1/30 , A61M1/36 , A61M37/00
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M2202/0427 , A61M2202/0439
摘要： Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.
摘要翻译：通过使用旋转的膜过滤装置从白细胞污染的血液分数中分离白细胞的方法和装置。本发明包括用于制备基本上无白血球的血小板浓缩物用于治疗用途的方法/装置。本发明的装置包括用于白细胞分离的旋转膜过滤装置以及可用于与自动取样仪器相关联的管线束/部件系统（图2a，2b，2c）。

33. 发明授权

US5194145A Method and apparatus for separation of matter from suspension 失效
标题翻译：从悬浮液中分离物质的方法和装置
公开(公告)号：US5194145A
公开(公告)日：1993-03-16
申请号：US73378
申请日：1987-07-13
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61M1/00 , A61K35/14 , A61M1/02 , A61M1/26 , A61M1/34 , B01D61/14 , B01D61/22 , B01D63/16 , B01D65/02 , B04B5/00 , G01N33/48
CPC分类号： A61M1/3496 , A61M1/265 , B01D61/025 , B01D63/062 , B01D63/16 , B01D65/02 , B01D2313/48 , B01D2313/90 , B01D2315/02 , B01D2321/02
摘要： A system for filtration of matter from a liquid suspension through a membrane uses a rotor within a concentric shell rotating with a surface velocity which, together with the rotor-shell gap and suspension viscosity, establishes vigorous vortex cells about the rotor. At least one of the rotor and shell surfaces include a filter membrane. Tangential velocity components at the membrane surface constantly sweep the membrane surface to limit cell deposition tendencies while constantly replenishing the medium to be filtered. The vortex cells are established along the length of the membrane despite the constant extraction of filtrate and the resultant change in physical characteristics of the suspension.
摘要翻译：通过膜从液体悬浮液过滤物质的系统使用以表面速度旋转的同心壳内的转子，其与转子 - 壳隙和悬浮液粘度一起在转子周围建立剧烈的涡流细胞。转子和壳表面中的至少一个包括过滤膜。膜表面的切向速度分量不断地扫描膜表面，以限制细胞沉积倾向，同时不断补充待过滤的介质。不管滤液的不断提取和悬浮液的物理特性的变化，沿着膜的长度建立涡旋细胞。

34. 发明授权

US5171456A Automated blood component separation procedure and apparatus promoting different functional characteristics in multiple blood components 失效
标题翻译：自动血液成分分离程序和装置促进多种血液成分中的不同功能特征
公开(公告)号：US5171456A
公开(公告)日：1992-12-15
申请号：US538301
申请日：1990-06-14
申请人： Yean Yow Hwang , Brian Ritchey , Donald W. Schoendorfer
发明人： Yean Yow Hwang , Brian Ritchey , Donald W. Schoendorfer
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3646 , A61M1/3672 , A61M1/3693 , A61M2202/0427
摘要： Method and apparatus are provided for machine separation of blood into blood components, wherein a preselected fluid such as anticoagulant is added to at least two different locations through the fluid flow path of the set, in order to promote the different functional characteristics in different blood components. The method results in reduced incidence of citrate reaction in the blood donor and increased platelet yield in platelet rich plasma collected during the procedure.
摘要翻译：提供了用于将血液机械分离成血液成分的方法和装置，其中预先选定的流体例如抗凝血剂通过组的流体流动路径被添加到至少两个不同位置，以促进不同血液成分中的不同功能特征。该方法导致血液供体中柠檬酸盐反应的发生率降低，并且在手术期间收集的富血小板血浆中的血小板产生增加。

35. 发明授权

US5053127A Continuous centrifugation system and method for directly deriving intermediate density material from a suspension 失效
标题翻译：连续离心系统和从悬浮液中直接得到中密度材料的方法
公开(公告)号：US5053127A
公开(公告)日：1991-10-01
申请号：US526568
申请日：1990-05-21
申请人： Donald W. Schoendorfer , Claude E. Berthe
发明人： Donald W. Schoendorfer , Claude E. Berthe
IPC分类号： A61M1/26 , A61M1/30 , A61M1/36 , B04B5/04
CPC分类号： B04B5/0442 , A61M1/262 , A61M1/265 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/3696 , B04B2005/0464
摘要： A system for continuously esparating lighter and intermediate density matter, such as plasma rich in platelets from whole blood moves blood through a diverging centrifugation gap between inner and outer walls of a rotor rotating about a central axis within an outer housing. The centrifugation action creates layered flow along an intermediate section. However by crating trailing wakes in the gap between the rotor and housing, localized remixing patterns tending to move in the opposite direction are induced in the layered matter. Platelet rich plasma may then be extracted through adjacent platelet concentrate ports on the inner wall of the rotor. An interior passageway system passes the platelet rich plasma to a platelet concentrate reservoir. Recirculation of blood in the rotor-housing gap between the output and input, and pumping action provided by the diverging centrifugation gap, aid in enhancing throughput and concentration levels. Prior to the centrifugation gap an initial narrow gap section is employed to limit backward propagation of the induced circulatory patterns.
摘要翻译：用于连续地包含较轻和中等密度物质的系统，例如富血小板从全血中移出的血液通过在外壳内围绕中心轴旋转的转子的内壁和外壁之间的发散的离心间隙移动血液。离心作用沿着中间部分产生分层流。然而，通过在转子和壳体之间的间隙中装配尾部的擦拭物，在分层物质中引起倾向于在相反方向移动的局部再混合模式。然后可以通过转子内壁上的相邻血小板浓缩物端口提取富血小板血浆。内部通道系统将富含血小板的血浆传递到血小板浓缩物储存器。在输出和输入之间的转子 - 壳体间隙中的血液再循环以及由分散离心间隙提供的泵送作用有助于提高产量和浓度水平。在离心间隙之前，采用初始窄间隙部分来限制诱导循环图案的反向传播。

36. 发明授权

US4957108A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US4957108A
公开(公告)日：1990-09-18
申请号：US241707
申请日：1988-09-08
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： G01N31/22 , A61B5/00 , A61B10/00 , A61F13/00 , B01L3/00 , G01N33/50 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B10/0064 , A61B2010/0009 , A61F2013/00608 , A61F2013/00646
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。

37. 发明授权

US4919817A Blood cell washing systems and methods 失效
标题翻译：血细胞清洗系统及方法
公开(公告)号：US4919817A
公开(公告)日：1990-04-24
申请号：US159446
申请日：1988-02-18
申请人： Donald W. Schoendorfer , Lee H. Williamson
发明人： Donald W. Schoendorfer , Lee H. Williamson
IPC分类号： B01D61/14 , A61M1/02 , A61M1/26 , A61M1/34 , A61M1/36 , B01D63/16
CPC分类号： A61M1/34 , A61M1/265 , A61M1/3692
摘要： A system and method for cleaning contaminants from shed blood to enable reinfusion of a cell concentrate in the patient employs successive rotary membrane filtering stages in which Taylor vortices are generated. Shed blood led into the first rotary membrane stage is filtered to a hematocrit in the range of 50-60 with some of the waste matter being removed. The intermediate cell concentrate is passed to the second filter stage where further waste matter is initially extracted. At any intermediate region, however, a major amount of wash solution is fed into the concentrate and effectively mixed by the Taylor vortices. In the remaining length of the second filter stage waste matter is entrained in wash solution and both waste and wash solution are filtered out to provide a cell concentrate from which the great majority of contaminants have been removed.
摘要翻译：用于从流出的血液清洁污染物以使患者能够再次输注细胞浓缩物的系统和方法采用生成泰勒涡流的连续旋转膜过滤阶段。导入第一个旋转膜阶段的血液过滤到50-60范围内的血细胞比容，其中一些废物被去除。将中间细胞浓缩物送至第二过滤器阶段，其中最初提取进一步的废物。然而，在任何中间区域，将主要量的洗涤溶液进料到浓缩物中并由泰勒涡流有效地混合。在第二过滤段的剩余长度中，废物被夹带在洗涤溶液中，并且废物和洗涤溶液都被过滤出来以提供细胞浓缩物，其中大部分污染物已被除去。

38. 发明授权

US4816151A Rotor drive for medical disposables 失效
标题翻译：转子驱动医疗一次性用品
公开(公告)号：US4816151A
公开(公告)日：1989-03-28
申请号：US079256
申请日：1987-07-29
申请人： Donald W. Schoendorfer , Warren P. Williamson, IV
发明人： Donald W. Schoendorfer , Warren P. Williamson, IV
IPC分类号： A61M1/34 , B01D17/038 , F16J15/34 , F16J15/50 , H02K5/128 , H02K49/10
CPC分类号： F16J15/50 , A61M1/265 , B01D61/08 , B01D63/062 , B01D63/16 , F16J15/34 , H02K49/106 , A61M1/3496 , B01D2313/04 , B01D2313/12 , B01D2315/02 , H02K5/128
摘要： A disposable biomedical rotating filtration system for processing fluids in a closed environment includes a rotor mounted for rotation on a pivot pin, a seal between the rotor and pivot pin, an external permanent magnet drive mechanism, and a star shaped drive element mounted on the rotor for rotating the rotor in response to a magnetic field induced by the permanent magnet of the drive mechanism. The drive element on the rotor is stamped from an inexpensive non-permanent ferromagnetic sheet metal and has a configuration and position in relation to the center of said magnetic field such that said drive element receives sufficient torque for driving said rotor and sufficient seal force is applied on the rotor to provide fluid tight seal between the rotating rotor and the seal. The pivot pin is molded from a hard plastic material such as a polyamide base resin having a low coefficient of friction and good lubriciousness. The pivot pin is irradiated by gamma radiation for sterilization and modifying of the plastic material without degradation or loss of lubricious properties.
摘要翻译：用于在封闭环境中处理流体的一次性生物医学旋转过滤系统包括安装在枢轴销上的转子，转子和枢转销之间的密封件，外部永磁体驱动机构和安装在转子上的星形驱动元件用于响应于由驱动机构的永磁体感应的磁场来旋转转子。转子上的驱动元件由便宜的非永久性铁磁金属板冲压而成，并且具有相对于所述磁场中心的构造和位置，使得所述驱动元件接收足够的转矩来驱动所述转子并施加足够的密封力在转子上提供旋转转子和密封件之间的流体密封。枢轴销由诸如具有低摩擦系数和良好光滑性的聚酰胺基础树脂的硬塑料材料模制而成。枢轴销被γ射线照射，用于塑料材料的灭菌和改性，而不降解或丧失润滑性能。

39. 发明授权

US4675106A Pivot pin bearing for biomedical systems 失效
标题翻译：枢轴轴承用于生物医学系统
公开(公告)号：US4675106A
公开(公告)日：1987-06-23
申请号：US722707
申请日：1985-04-12
申请人： Donald W. Schoendorfer , Warren P. Williamson, IV
发明人： Donald W. Schoendorfer , Warren P. Williamson, IV
IPC分类号： B01D63/16 , A61M1/00 , A61M1/34 , A61M1/36 , B01D21/26 , B01D35/00 , B01D61/18 , B04B5/00 , B04B9/12 , F16C17/08 , F16C33/20 , G01N33/48 , B01D45/14
CPC分类号： F16C33/20 , A61M1/265 , B01D61/08 , B01D63/062 , B01D63/16 , F16C17/08 , A61M1/3496 , B01D2315/02
摘要： In a disposable biomedical system for processing fluids in a closed environment such as a plasmapheresis system, comprising a plastic rotor mounted for rotation on a pivot pin bearing and a seal, particularly a silicone lubricated O-ring seal, between the rotor and pin, the improvement wherein said pivot pin is a molded pivot pin of a hard plastic material having a low coefficient of friction and lubriciousness, and which is capable of being irradiated by gamma radiation for sterilization and modification of the plastic material without degradation or loss of lubricious properties. The pivot pin bearing preferably comprises an injection molded polyamide based resin.
摘要翻译：在用于在诸如血浆置换术系统的封闭环境中处理流体的一次性生物医学系统中，包括在转子和销之间安装用于在枢轴销轴承和密封件（特别是硅橡胶润滑的O形密封圈）上旋转的塑料转子，改进之处在于，所述枢轴销是具有低摩擦系数和光滑性的硬塑料材料的模制枢轴销，并且能够被伽马辐射照射以消除和改变塑料材料，而不会降低或丧失润滑性能。枢轴销轴承优选地包括注塑聚酰胺基树脂。

40. 发明授权

US4464167A Pheresis apparatus 失效
标题翻译：排血装置
公开(公告)号：US4464167A
公开(公告)日：1984-08-07
申请号：US518956
申请日：1983-08-01
申请人： Donald W. Schoendorfer , Lee E. Hansen
发明人： Donald W. Schoendorfer , Lee E. Hansen
IPC分类号： A61M1/30 , A61M1/36 , B04B5/04 , A61M1/03
CPC分类号： B04B5/0442 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M1/3696
摘要： This invention relates to an improvement in two-port centrifuge bowls in which component yield is enhanced by utilizing the centrifuge bowl for eluttriation, as well as centrifugation. In a particular embodiment, platelet yield is improved by terminating flow of anticoagulated whole blood from the donor to the bowl and pumping low density fluid, preferably plasma, back into the bowl at a relatively high rate to elutriate centrifugally separated cells in the bowl.
摘要翻译：本发明涉及双端口离心机碗的改进，其中通过利用离心机碗来提高组分产率，以及离心。在一个具体的实施方案中，血小板产量通过终止来自供体到碗的抗凝血全血的流动并将低密度流体（优选血浆）以相对较高的速率返回到碗中来改善，以淘洗碗中离心分离的细胞。

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