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31. 发明授权

US06475239B1 Method for making polymer heart valves with leaflets having uncut free edges 有权
标题翻译：制造聚合物心脏瓣膜的方法，其具有具有未切割边缘的小叶
公开(公告)号：US06475239B1
公开(公告)日：2002-11-05
申请号：US09170925
申请日：1998-10-13
申请人： Louis A. Campbell , Riyad Moe , Edward J. Sarnowski
发明人： Louis A. Campbell , Riyad Moe , Edward J. Sarnowski
IPC分类号： A61F224
CPC分类号： A61F2/2412 , A61F2/2415 , Y10S623/901
摘要： A method for manufacturing a prosthetic heart valve. An elastic valve body and at least one leaflet are formed on a mold. The leaflet has a free edge which is formed by the mold without cutting the leaflet at the free edge.
摘要翻译：一种制造假体心脏瓣膜的方法。弹性阀体和至少一个叶片形成在模具上。该小叶具有由模具形成的自由边缘，而不在自由边缘处切割小叶。

32. 发明授权

US06287339B1 Sutureless heart valve prosthesis 有权
标题翻译：无缝合心脏瓣膜假体
公开(公告)号：US06287339B1
公开(公告)日：2001-09-11
申请号：US09321079
申请日：1999-05-27
申请人： Demetrio J. Vazquez , Louis A. Campbell , Jeffrey M. Mabrey
发明人： Demetrio J. Vazquez , Louis A. Campbell , Jeffrey M. Mabrey
IPC分类号： A61F224
CPC分类号： A61F2/2403 , A61F2/2409 , A61F2250/0063
摘要： A heart valve prosthesis which incorporates a substantially permanently implantable abutment structure which is surgically attached to a native heart valve annulus through utilization of a resilient metal substructure having an attachment portion which moves into engagement with a native heart annulus upon being released from a retracted orientation. The system employs a positioning instrument which locates the abutment structure and associated heart valve prosthesis at the proper location for releasing the attachment components. Mechanical heart valve components including an occluder function are removably attached to the abutment structure using sutures, such that the valve function itself may be subsequently replaced.
摘要翻译：一种心脏瓣膜假体，其包括基本上永久性可植入的邻接结构，其通过利用具有附接部分的弹性金属子结构手术附接到天然心脏瓣膜环，所述附接部分在从缩回方向释放时移动到与天然心脏环的接合。该系统使用定位仪器，其将邻接结构和相关联的心脏瓣膜假体定位在适当的位置以释放附接部件。包括闭塞器功能的机械心脏瓣膜部件使用缝合线可拆卸地附接到邻接结构，使得阀功能本身可以随后被替换。

33. 发明授权

US06270527B1 Elastic valve with partially exposed stent 有权
标题翻译：具有部分暴露的支架的弹性瓣膜
公开(公告)号：US06270527B1
公开(公告)日：2001-08-07
申请号：US09174387
申请日：1998-10-16
申请人： Louis A. Campbell , Riyad Moe
发明人： Louis A. Campbell , Riyad Moe
IPC分类号： A61F224
CPC分类号： A61F2/2412 , A61F2/2409 , A61F2/2415 , A61F2220/0075 , Y10S623/90
摘要： A valve includes an elastic valve body and a stent. A first portion of the stent is embedded in the elastic valve body and a second portion of the stent is outside the valve body. A method of manufacturing such a valve is also claimed.
摘要翻译：阀包括弹性阀体和支架。支架的第一部分嵌入在弹性阀体中，并且支架的第二部分在阀体的外部。还要求一种制造这种阀的方法。

34. 发明授权

US6143024A Annuloplasty ring having flexible anterior portion 失效
标题翻译：瓣膜成形术环具有柔韧的前部
公开(公告)号：US6143024A
公开(公告)日：2000-11-07
申请号：US090192
申请日：1998-06-04
申请人： Louis A. Campbell , Robert M. Casanova
发明人： Louis A. Campbell , Robert M. Casanova
IPC分类号： A61F2/24
CPC分类号： A61F2/2448
摘要： An annuloplasty ring is provided for implanting about a mitral valve. The annuloplasty ring includes a first, generally rigid section and a second, generally flexible section. The rigid section is positioned adjacent the posterior portion of a mitral valve annulus and the flexible section is positioned adjacent the anterior portion of the mitral valve annulus.
摘要翻译：提供瓣环成形术环用于植入二尖瓣。瓣膜成形术环包括第一，大致刚性的部分和第二，通常是柔性部分。刚性部分邻近二尖瓣环的后部定位，并且柔性部分邻近二尖瓣环的前部分定位。

35. 发明授权

US6106550A Implantable attaching ring 失效
标题翻译：植入式安装环
公开(公告)号：US6106550A
公开(公告)日：2000-08-22
申请号：US114008
申请日：1998-07-10
申请人： James A. Magovern , Louis A. Campbell
发明人： James A. Magovern , Louis A. Campbell
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2403
摘要： An implantable attaching device includes an annular ring having an axial passageway and a plurality of channels extending radially through the ring. Tissue attaching pins are positioned in the channels and extend radially inward into the axial passageway during implantation. The pins are driven into the native annulus tissue after the ring is positioned. Once the pins are driven into the annulus, the axial passageway of the ring is unobstructed and is adapted to receive a heart valve or other implantable device.
摘要翻译：可植入附接装置包括具有轴向通道和径向延伸穿过环的多个通道的环形环。组织连接销定位在通道中并且在植入期间径向向内延伸到轴向通道中。在定位环之后，将引脚驱动到天然环带中。一旦销被引入环形空间中，环的轴向通道就不受阻碍，并且适于容纳心脏瓣膜或其他可植入装置。

36. 发明授权

US5192313A Heart valve prosthesis with improved bi-leaflet pivot design 失效
标题翻译：心瓣膜假体具有改进的双瓣枢轴设计
公开(公告)号：US5192313A
公开(公告)日：1993-03-09
申请号：US896831
申请日：1992-06-11
申请人： John C. Budd , Louis A. Campbell
发明人： John C. Budd , Louis A. Campbell
IPC分类号： A61F2/24
CPC分类号： A61F2/2403
摘要： A bi-leaflet heart valve having an annular body and a pair of leaflets. The leaflets pivot around improved ears, whose motion is constrained by generally triangular recesses. The triangular recesses have a pivotal vertex in proximity to a centerline of the annular base and on the upstream side of the heart valve. Opposite the pivotal vertex is a slightly concave base. An upstream wall of the recess is convex.
摘要翻译：一种具有环形体和一对传单的双瓣心脏瓣膜。传单围绕改进的耳朵转动，其运动受到大致三角形凹陷的约束。三角形凹槽具有靠近环形基座的中心线和心脏瓣膜上游侧的枢转顶点。相对的枢轴顶点是一个稍凹的底座。凹槽的上游壁是凸的。

37. 发明授权

US5123919A Combined prosthetic aortic heart valve and vascular graft 失效
标题翻译：联合假体主动脉瓣膜和血管移植
公开(公告)号：US5123919A
公开(公告)日：1992-06-23
申请号：US795497
申请日：1991-11-21
申请人： Joseph A. Sauter , Louis A. Campbell
发明人： Joseph A. Sauter , Louis A. Campbell
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2403 , A61F2/06 , A61F2/2409
摘要： A combined mechanical heart valve and vascular graft having a shortened transition area between the valve and the graft. The mechanical valve comprises a rigid circular annulus supporting internal leaflets. A stiffening ring surrounds the annulus and provides support for a sewing ring to attach the valve to the heart. The stiffening ring also captures a proximal end of the vascular graft between the stiffening ring and the annulus.
摘要翻译：组合的机械心脏瓣膜和血管移植物在瓣膜和移植物之间具有缩短的过渡面积。机械阀包括支撑内部小叶的刚性圆形环。一个加强环围绕环形空间，并为缝合环提供支撑以将瓣膜附接到心脏。加强环还捕获加强环和环之间的血管移植物的近端。

38. 发明授权

US11213393B2 Compressible heart valve annulus sizing templates 有权
公开(公告)号：US11213393B2
公开(公告)日：2022-01-04
申请号：US13429123
申请日：2012-03-23
申请人： Matthew T. Winston , Da-Yu Chang , Louis A. Campbell , James A. Davidson
发明人： Matthew T. Winston , Da-Yu Chang , Louis A. Campbell , James A. Davidson
IPC分类号： A61F2/24
摘要： Compressible heart valve annulus sizing templates suitable for minimally-invasive or otherwise reduced accessibility surgeries. The sizing templates may be folded, rolled, or otherwise compressed into a reduced configuration for passage through an access tube or other such access channel. Once expelled from the access tube the sizing templates expand to their original shape for use in sizing the annulus. The templates may be formed of an elastomeric polymer material such as silicone, a highly elastic metal such as NITINOL, or both. Grasping tabs or connectors for handles permit manipulation from outside the body. A NITINOL wireform may be compressed for passage through an access tube and expelled from the distal end thereof into a cloth cover to assume a sizer shape.

39. 发明授权

US08869982B2 Prosthetic heart valve packaging and deployment system 有权
标题翻译：假心脏瓣膜包装和部署系统
公开(公告)号：US08869982B2
公开(公告)日：2014-10-28
申请号：US12969238
申请日：2010-12-15
申请人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
发明人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
IPC分类号： A61B17/06 , A61B19/02 , A61L15/00 , A61F2/00 , A61F2/24
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0075
摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly. The packaging system facilitates attachment of the valve delivery tube for use in a quick-connect valve implant procedure.
摘要翻译：用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。该包装系统便于安装用于快速连接阀注入过程的阀输送管。

40. 发明授权

US08348998B2 Unitary quick connect prosthetic heart valve and deployment system and methods 有权
标题翻译：单一快速连接假体心脏瓣膜和部署系统和方法
公开(公告)号：US08348998B2
公开(公告)日：2013-01-08
申请号：US12821628
申请日：2010-06-23
申请人： Rafael Pintor , Mark Chau , Travis Oba , August Yambao , Louis A. Campbell , Tammy Huntley , Qinggang Zeng , Carey Cristea , Faisal Kalam
发明人： Rafael Pintor , Mark Chau , Travis Oba , August Yambao , Louis A. Campbell , Tammy Huntley , Qinggang Zeng , Carey Cristea , Faisal Kalam
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2439 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/005 , A61F2250/006
摘要： A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.
摘要翻译：提供了一种快速连接的心脏瓣膜假体，可以在手术过程中快速方便地植入。心脏瓣膜包括基本上不可膨胀的不可压缩的人造瓣膜和塑性可扩张的联接支架，从而使得能够在不缝合的情况下连接到环形空间。可以提供少量的导向缝线用于主动脉瓣取向。假体瓣膜可以是具有连接有联接支架的缝合环的市售阀。联接支架可以从锥形展开形状扩展到圆锥形膨胀形状，并且可以包括连接在轴向延伸柱之间的腹板状支柱。用于展开的系统和方法包括气球导管通过的中空两件式手柄。与心脏瓣膜一起存储阀保持器，并且手柄容易地附接到其上以改善阀门准备步骤。

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