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1. 发明授权

US06475239B1 Method for making polymer heart valves with leaflets having uncut free edges 有权
标题翻译：制造聚合物心脏瓣膜的方法，其具有具有未切割边缘的小叶
公开(公告)号：US06475239B1
公开(公告)日：2002-11-05
申请号：US09170925
申请日：1998-10-13
申请人： Louis A. Campbell , Riyad Moe , Edward J. Sarnowski
发明人： Louis A. Campbell , Riyad Moe , Edward J. Sarnowski
IPC分类号： A61F224
CPC分类号： A61F2/2412 , A61F2/2415 , Y10S623/901
摘要： A method for manufacturing a prosthetic heart valve. An elastic valve body and at least one leaflet are formed on a mold. The leaflet has a free edge which is formed by the mold without cutting the leaflet at the free edge.
摘要翻译：一种制造假体心脏瓣膜的方法。弹性阀体和至少一个叶片形成在模具上。该小叶具有由模具形成的自由边缘，而不在自由边缘处切割小叶。

2. 发明授权

US06270527B1 Elastic valve with partially exposed stent 有权
标题翻译：具有部分暴露的支架的弹性瓣膜
公开(公告)号：US06270527B1
公开(公告)日：2001-08-07
申请号：US09174387
申请日：1998-10-16
申请人： Louis A. Campbell , Riyad Moe
发明人： Louis A. Campbell , Riyad Moe
IPC分类号： A61F224
CPC分类号： A61F2/2412 , A61F2/2409 , A61F2/2415 , A61F2220/0075 , Y10S623/90
摘要： A valve includes an elastic valve body and a stent. A first portion of the stent is embedded in the elastic valve body and a second portion of the stent is outside the valve body. A method of manufacturing such a valve is also claimed.
摘要翻译：阀包括弹性阀体和支架。支架的第一部分嵌入在弹性阀体中，并且支架的第二部分在阀体的外部。还要求一种制造这种阀的方法。

3. 发明授权

US08449625B2 Methods of measuring heart valve annuluses for valve replacement 有权
标题翻译：测量瓣膜置换瓣膜瓣的方法
公开(公告)号：US08449625B2
公开(公告)日：2013-05-28
申请号：US12606945
申请日：2009-10-27
申请人： Louis A. Campbell , Travis Z. Oba , Rafael Pintor
发明人： Louis A. Campbell , Travis Z. Oba , Rafael Pintor
IPC分类号： A61B17/00 , A61B18/00
CPC分类号： A61B5/1076 , A61B5/6853 , A61B5/6858 , A61B5/6885 , A61B90/08 , A61B2090/061 , A61B2090/064 , A61B2090/0811 , A61F2/2496
摘要： A device for measuring an expanded internal orifice of a patient includes an orifice-expanding device, a pressure measuring device, and a size-measuring device. The size-measuring device measures a dimension of the orifice after it has been expanded by the orifice-expanding device.
摘要翻译：用于测量患者的扩张的内部孔的装置包括孔扩张装置，压力测量装置和尺寸测量装置。尺寸测量装置在通过孔扩展装置膨胀后测量孔口的尺寸。

4. 发明授权

US08349003B2 Suture locking assembly and method of use 失效
标题翻译：缝合线组装及使用方法
公开(公告)号：US08349003B2
公开(公告)日：2013-01-08
申请号：US13085183
申请日：2011-04-12
申请人： Mark Shu , Chris Coppin , Louis A. Campbell
发明人： Mark Shu , Chris Coppin , Louis A. Campbell
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2445 , A61F2220/0016 , A61F2220/0075 , A61F2250/001 , A61F2250/006
摘要： A suture locking assembly for use with a heart valve repair device. The suture locking assembly including a rim and a suture band. The rim defines a first flange and a second flange spaced from the first flange. The rim is configured to extend at least partially around a periphery of the heart valve repair device. The suture band is maintained between the first flange and the second flange. The suture locking assembly is configured to securely maintain a suture segment that is pulled from a first position to a second position relative the suture locking assembly, the second position being at least partially defined near an outer periphery of the rim.
摘要翻译：一种用于心脏瓣膜修复装置的缝合线锁定组件。缝合线锁定组件包括边缘和缝合带。边缘限定第一凸缘和与第一凸缘间隔开的第二凸缘。轮缘被构造成至少部分地围绕心脏瓣膜修复装置的周边延伸。缝合带保持在第一凸缘和第二凸缘之间。缝合线锁定组件构造成可靠地保持缝合线段，该缝合线段相对于缝合线锁定组件从第一位置被拉到第二位置，第二位置至少部分地限定在轮缘的外周附近。

5. 发明授权

US06638303B1 Heart valve prosthesis 失效
标题翻译：心脏瓣膜假体
公开(公告)号：US06638303B1
公开(公告)日：2003-10-28
申请号：US09665306
申请日：2000-09-19
申请人： Louis A. Campbell
发明人： Louis A. Campbell
IPC分类号： A61F224
CPC分类号： A61F2/2403
摘要： A heart valve prosthesis includes an annular body that has a fluid passageway and at least one rigid leaflet that is pivotally mounted in the passageway of the body. The leaflet is movable between a closed position wherein the fluid passageway is substantially closed and an open position wherein the fluid passageway is not substantially closed. The heart valve prosthesis has a biasing mechanism that is connected to the body and leaflet and is configured to exert a force on the leaflet to move the leaflet to the closed position before a second fluid pressure exerted on an outflow surface of the leaflet exceeds a first fluid pressure exerted on an inflow surface of the leaflet.
摘要翻译：心脏瓣膜假体包括具有流体通道的环形主体和枢转地安装在身体的通道中的至少一个刚性小叶。小叶可在关闭位置之间移动，其中流体通道基本上封闭，而打开位置，其中流体通道基本上不关闭。心脏瓣膜假体具有连接到身体和小叶上的偏置机构，并且构造成在小叶上施加力以将小叶移动到关闭位置，同时施加在小叶的流出表面上的第二流体压力超过第一施加在小叶流入表面上的流体压力。

6. 发明授权

US06312465B1 Heart valve prosthesis with a resiliently deformable retaining member 有权
标题翻译：心脏瓣膜假体具有可弹性变形的保持构件
公开(公告)号：US06312465B1
公开(公告)日：2001-11-06
申请号：US09360093
申请日：1999-07-23
申请人： Charles Durward Griffin , Louis A. Campbell , Tammi Elizabethy Klostermeyer
发明人： Charles Durward Griffin , Louis A. Campbell , Tammi Elizabethy Klostermeyer
IPC分类号： A61F224
CPC分类号： A61F2/2409 , A61F2/2403
摘要： A valve body assembly for being mounted adjacent an annulus within a heart. A first retainer is attached to the valve body assembly for engaging a first side of the annulus. A second retainer is attached to the valve body assembly and includes a resiliently-deformable retaining member for resiliently engaging a second side of the annulus. The resiliently deformable retaining member is collapsed to a size permitting it to be inserted into through the annulus and positioned adjacent the second side of the annulus. The retaining member is then allowed to expand such that it resiliently engages the second side of the annulus.
摘要翻译：一种阀体组件，用于安装在心脏内的环形附近。第一保持器附接到阀体组件以接合环形空间的第一侧。第二保持器附接到阀体组件并且包括用于弹性地接合环形空间的第二侧的可弹性变形的保持构件。可弹性变形的保持构件被折叠成允许其插入通过环形物并且定位成邻近环形空间的第二侧的尺寸。然后允许保持构件膨胀使得其弹性地接合环形空间的第二侧。

7. 发明授权

US06200340B1 Tilting disk heart valve having cavitation reducing contact geometry 失效
标题翻译：具有气蚀减少接触几何形状的倾斜盘心瓣膜
公开(公告)号：US06200340B1
公开(公告)日：2001-03-13
申请号：US09284000
申请日：1999-04-01
申请人： Louis A. Campbell
发明人： Louis A. Campbell
IPC分类号： A61F224
CPC分类号： A61F2/2403
摘要： A heart valve prosthesis includes a valve housing having an opening formed therein having an inmost arcuate surface and a leaflet pivotally mounted in the opening for movement between an open position and a closed position with the inmost arcuate surface. The leaflet has an outmost edge providing multiple points of contact with the housing. The leaflet also forms a leakage gap adjacent the leaflet major radius and between the inmost and outmost surfaces such that the multiple points of contact are displaced from the leaflet major radius and are adjacent to and on opposite sides of the leakage gap. One or several such leaflets may be provided in the housing. Each leaflet respectively includes the leakage gap and the adjacent multiple points of contact.
摘要翻译：心脏瓣膜假体包括具有形成在其中的开口的阀壳体，其具有最前面的弧形表面，以及可旋转地安装在开口中的小叶，用于在打开位置和关闭位置之间与最前面的弓形表面一起运动。传单具有最外边缘，提供与壳体的多个接触点。小叶片还形成邻近小叶主半径和最外表面之间的泄漏间隙，使得多个接触点从小叶主半径移位并邻近泄漏间隙的相对侧。一个或几个这样的传单可以设置在壳体中。每个小叶分别包括泄漏间隙和相邻的多个接触点。

8. 发明授权

US08846390B2 Methods of conditioning sheet bioprosthetic tissue 有权
标题翻译：调节片材生物假体组织的方法
公开(公告)号：US08846390B2
公开(公告)日：2014-09-30
申请号：US13069827
申请日：2011-03-23
申请人： Jeffrey S. Dove , Bin Tian , Ralph Schneider , Jeffrey S. Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James M. Young , Louis A. Campbell
发明人： Jeffrey S. Dove , Bin Tian , Ralph Schneider , Jeffrey S. Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James M. Young , Louis A. Campbell
IPC分类号： C12N5/00 , A61F2/24 , A61L27/36 , A61L27/50 , A61B18/20
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。选择激光器的波长，功率和脉冲速率，这将使纤维表面平滑，并将表面烧蚀到合适的厚度。或者，使用皮肤表面从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。然后可以通过封闭钙化成核位点和硼氢化钠还原来处理最终变薄的膜。传单可以形成为具有多于一个均匀厚度的区域，例如较厚的外围缝合区域。

9. 发明申请

US20130116676A1 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 有权
公开(公告)号：US20130116676A1
公开(公告)日：2013-05-09
申请号：US13621685
申请日：2012-09-17
申请人： Bin Tian , Ralph Schneider , Jeffrey S. Dove , Jeff Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James Young , Louis A. Campbell
发明人： Bin Tian , Ralph Schneider , Jeffrey S. Dove , Jeff Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James Young , Louis A. Campbell
IPC分类号： A61B18/20
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.

10. 发明申请

US20130110097A1 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 有权
标题翻译：调节片生物组织的方法
公开(公告)号：US20130110097A1
公开(公告)日：2013-05-02
申请号：US13621680
申请日：2012-09-17
申请人： Ralph Schneider , Bin Tian , Jeffrey S. Dove , Jeff Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James Young , Louis A. Campbell
发明人： Ralph Schneider , Bin Tian , Jeffrey S. Dove , Jeff Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James Young , Louis A. Campbell
IPC分类号： A61B18/20
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。选择激光器的波长，功率和脉冲速率，这将使纤维表面平滑，并将表面烧蚀到合适的厚度。或者，使用皮肤表面从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。

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