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31. 发明授权

US5174872A Metal-free buffer for ion selective electrode-based assays 失效
标题翻译：用于离子选择性电极测定的无金属缓冲液
公开(公告)号：US5174872A
公开(公告)日：1992-12-29
申请号：US535631
申请日：1990-06-08
申请人： William J. Scott
发明人： William J. Scott
IPC分类号： G01N27/26 , G01N27/28 , G01N27/416 , G01N33/84
CPC分类号： G01N33/84 , Y10T436/108331 , Y10T436/193333
摘要： A heavy metal-free composition and its method of use in an ion selective electrode-based assay are disclosed. The heavy metal-free composition includes a borate compound and an alkalinity adjusting compound, and is used to dilute a test sample; buffer the test sample; and substantially reduce the effects of interferents present in the test sample on the ion selective electrode-based assay. The heavy metal-free composition and its method of use are especially useful in an ion selective electrode-based assay for carbonate ion concentration in a test sample, like blood serum, blood plasma, urine or cerebrospinal fluid.

32. 发明授权

US4220811A Screw-on electrical connector 失效
标题翻译：螺丝电连接器
公开(公告)号：US4220811A
公开(公告)日：1980-09-02
申请号：US936587
申请日：1978-08-24
申请人： William J. Scott
发明人： William J. Scott
IPC分类号： H01R4/22 , H01R5/12
CPC分类号： H01R4/22
摘要： This is a screw-on electrical connector of the type in which an insulating cap has a generally open central bore and a wire coil is positioned in the bore to engage the stripped ends of the wires. The interior of the bore is provided with a formation to engage the rear end of the coil for positioning and interlocking the two to provide the torque necessary to turn the connector down on the stripped ends of the wires. The forward portion of the bore is also provided with a dam structure or barrier to prevent the coil from coming out of the bore. The subject matter includes a method of making such a connector.
摘要翻译：这是一种螺旋式电连接器，其中绝缘帽具有大体上敞开的中心孔，并且线圈位于孔中以与电线的剥离端接合。孔的内部设置有接合线圈的后端的结构，用于定位和互锁两者，以提供将连接器向下转动到电线剥离端所需的力矩。孔的前部还设置有坝结构或阻挡层，以防止线圈从孔中脱出。主题包括制造这种连接器的方法。

33. 发明授权

US4152821A Pipe joining connection process 失效
标题翻译：管道连接过程
公开(公告)号：US4152821A
公开(公告)日：1979-05-08
申请号：US804885
申请日：1977-06-09
申请人： William J. Scott
发明人： William J. Scott
IPC分类号： B21D39/04 , F16L27/12 , F16L33/20 , B23P17/00
CPC分类号： B21D39/04 , B21D39/206 , F16L27/12 , F16L33/20 , Y10T29/49805 , Y10T29/49911 , Y10T29/5367
摘要： The following specification discloses a pipe joining and connection process and apparatus for utilization with all forms of plastic pipes and metal and plastic pipe couplings. The joint comprises a plastic or metal adapter fixture which has been swaged in circumferential relationship to the pipe by expansion of the pipe into the fixture through a process and apparatus which serves to expand and hold the two elements together. The apparatus comprises a metal sleeve on the interior of the pipe and an exterior metal retainer overlying the fixture to provide the necessary hoop strength surrounding the joint. The process is effectuated by means of expanding a resilient elastomer within the bore of the pipe against the sleeve that is concomitantly expanded outwardly against the pipe. The plastic of the pipe is simultaneously caused to flow into grooves within the fixture. A metal retainer ring around the fixture provides for the hoop stress accompanying the expansion so that a retention of the entire fitting is effectuated. In other words, the inner expanded sleeve is expanded outwardly to hold the pipe within the fixture, while the outer metallic retainer ring provides hoop stress for maintenance of the members in juxtaposition with each other. An alternative coupling attachment is provided having O ring seals that are received within a collar, providing for both axial and lateral displacement of the coupled pipes.
摘要翻译：以下说明书公开了用于所有形式的塑料管和金属和塑料管接头的管接合和连接方法和装置。该接头包括塑料或金属适配器固定装置，其通过用于将两个元件膨胀和保持在一起的工艺和装置将管道膨胀到固定装置中而与管道成圆周关系。该装置包括在管内部的金属套管和覆盖固定装置的外部金属保持器，以提供围绕接头的必要的箍筋强度。该过程通过在管的孔内将弹性弹性体膨胀抵靠套筒来实现，该弹性弹性体相对于管子向外膨胀。同时使管道的塑料流入夹具内的槽内。夹具周围的金属保持环提供伴随膨胀的环向应力，从而实现整个配件的保持。换句话说，内部膨胀的套筒向外扩张以将管子保持在固定装置内，而外部金属保持环提供环向应力以维持构件彼此并置。提供了替代的联接附件，其具有容纳在轴环内的O形环密封件，用于提供耦合的管的轴向和横向位移。

34. 发明授权

US4112251A Screw-on wire connector and method of making it 失效
标题翻译：螺丝连接器及其制作方法
公开(公告)号：US4112251A
公开(公告)日：1978-09-05
申请号：US602440
申请日：1975-08-06
申请人： William J. Scott
发明人： William J. Scott
IPC分类号： H01R4/22 , H01R5/12
CPC分类号： H01R4/22 , Y10T29/49208 , Y10T29/49881
摘要： A method of joining the stripped ends of electrical wires and screw-on connectors for performing the method. The method includes bunching the stripped ends of wire, inserting the bunched wires into a distortable relatively nonexpandable wire retainer having an inwardly tapered thread, rotating the wires and wire retainer relative to one another to feed the bunched wires into the wire retainer, applying torque to the bunched wires and the wire retainer to cause the wire retainer to compress the wires into contact with one another and form a thread thereon, supporting the wire retainer during application of the torque in a manner which permits the wire retainer to freely distort without substantial expansion to thereby accommodate the wires as the wires are forced into the small end of the tapered thread, and covering the wire retainer and retained wire with an insulator. A screw-on wire connector which includes an insulating cap with a bore open at one end for the reception of the stripped ends of the wires. A distortable relatively non-expandable wire retainer which receives the wires is located in the cap. The wire retainer is of various forms each of which has a tapered thread which engages the inserted wires. The wire retainer is spaced circumferentially from the inside of the wall between its ends to provide for circumferential distortion of the retainer by the wires without placing an outward load on the cap due to substantial contact between the retainer and the cap.
摘要翻译：一种连接用于执行该方法的电线和螺纹连接器的剥离末端的方法。该方法包括聚集线的剥离端，将聚束线插入具有向内锥形螺纹的可变形相对不可调的线保持器中，使线和线保持器相对于彼此旋转，以将成束的线馈送到线保持器中，将扭矩施加到聚束电线和电线保持器，以使电线保持器压缩电线彼此接触并在其上形成线，在施加扭矩期间以允许电线保持器自由变形而不显着膨胀的方式支撑电线保持器从而当电线被迫进入锥形螺纹的小端部并且用绝缘体覆盖电线保持器和保持电线时容纳电线。一种螺旋式电线连接器，其包括绝缘帽，孔的一端开口，用于接收电线的剥离末端。容纳电线的可变形相对不可扩展的电线保持器位于盖中。电线保持器具有各种形式，每个形式具有接合插入的电线的锥形螺纹。电线保持器在其端部之间的壁的内部周向间隔开，以通过导线使保持器周向变形，而不会由于保持器和盖子之间的实质接触而将向外的负载放置在盖上。

35. 发明申请

US20120040986A1 OMEGA CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS 审中-公开
标题翻译： OMEGA CARBOXYARYL替代二苯醚作为RAF激酶抑制剂
公开(公告)号：US20120040986A1
公开(公告)日：2012-02-16
申请号：US13208010
申请日：2011-08-11
申请人： Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , Mary-Katherine MONAHAN , Reina NATERO , Joel RENICK , Robert N. SIBLEY
发明人： Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , Mary-Katherine MONAHAN , Reina NATERO , Joel RENICK , Robert N. SIBLEY
IPC分类号： A61K31/5377 , A61K31/17 , C07D209/44 , A61K31/4035 , C07D211/70 , A61P35/00 , C07D213/63 , C07D413/12 , C07D403/04 , A61K31/497 , C07D241/04 , A61K31/4965 , C07C275/28 , A61K31/44
CPC分类号： C07C275/40 , C07C275/30 , C07C275/34 , C07D213/81 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译：本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。

36. 发明授权

US07557129B2 Cyanopyridine derivatives useful in the treatment of cancer and other disorders 有权
标题翻译：可用于治疗癌症和其他疾病的氰基吡啶衍生物
公开(公告)号：US07557129B2
公开(公告)日：2009-07-07
申请号：US10788029
申请日：2004-02-27
申请人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
发明人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
IPC分类号： A61K31/4433 , C07D405/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

37. 发明申请

US20090093526A1 INHIBITION OF P38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS 审中-公开
标题翻译：使用对称和非对称二苯醚类尿素抑制P38激酶
公开(公告)号：US20090093526A1
公开(公告)日：2009-04-09
申请号：US11932397
申请日：2007-10-31
申请人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
发明人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号： A61K31/40 , A61K31/44 , C07D207/36 , C07D213/04 , A61P19/02
CPC分类号： A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4035 , A61K31/44 , A61K31/5375 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译：本发明涉及一组芳基脲在治疗细胞因子介导的疾病和蛋白水解酶介导的疾病中的用途，以及用于这种治疗的药物组合物。

38. 发明授权

US06849638B2 4-AMINO-5,6-SUBSTITUTED THIOPHENO [2,3-D] PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND THEIR USE IN THE TREATMENT OR PREVENTION OF PDE7B-MEDIATED DISEASES AND CONDITIONS 失效
标题翻译： 4-氨基-5,6-取代的噻吩并[2,3-D]嘧啶，含有它们的药物组合物及其在治疗或预防PDE7B介导的疾病和病症中的用途
公开(公告)号：US06849638B2
公开(公告)日：2005-02-01
申请号：US10136575
申请日：2002-04-29
申请人： Andreas Stolle , Donald E. Bierer , Yuanwei Chen , Dongping Fan , Barry Hart , Mary Katherine Monahan , William J. Scott
发明人： Andreas Stolle , Donald E. Bierer , Yuanwei Chen , Dongping Fan , Barry Hart , Mary Katherine Monahan , William J. Scott
IPC分类号： A61K31/4365 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P1/18 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/24 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D495/04 , C07D495/14 , C07D521/00
CPC分类号： C07D231/12 , A61K31/4365 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D233/56 , C07D249/08 , C07D495/04 , C07D495/14
摘要： The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B (PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma.
摘要翻译：本发明涉及4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶，含有它们的药物组合物及其用于治疗或预防由磷酸二酯酶7B（PDE7B）介导的疾病和病症的用途。 PDE7B介导的疾病和病症包括骨质疏松症，骨质减少和哮喘。

39. 发明授权

US5354625A Metal-air power supply and air-manager system, and metal-air cell for use therein 失效
标题翻译：金属空气电源和空气管理系统以及用于其中的金属空气电池
公开(公告)号：US5354625A
公开(公告)日：1994-10-11
申请号：US852001
申请日：1992-03-16
申请人： R. Dennis Bentz , Christopher S. Pedicini , William J. Scott, Jr.
发明人： R. Dennis Bentz , Christopher S. Pedicini , William J. Scott, Jr.
IPC分类号： H01M12/06 , H01M6/46 , H01M6/50 , H01M10/42 , H01M10/50 , H01M12/08 , H01M8/04
CPC分类号： H01M10/4257 , H01M12/08 , H01M6/46 , H01M6/5038 , H01M6/5044 , Y02E60/128
摘要： A metal-air power supply which provides improved control over air flow is provided. The reactant air and cooling air inlets are separate from one another and isolated from the exhausted reactant and cooling portions of the air flow. The reactant air flow is limited to a volumetric flow rate sufficient to provide from about 3 to about 10 times the stoichiometric amount of oxygen necessary to produce a predetermined level of current from the cell, and a total volumetric flow rate of air sufficient so that the cooling portion of the air flow has a volumetric flow rate from about 10 to about 1000 times the volumetric flow rate of the reactant portion of the air flow is provided. This limits the flow rate of the reactant air over the cathode, isolates the cooling air flow from the reactant air flow, and maintains the temperature of the metal-air cell at a low level without exposing the air cathode to an excessive air flow rate to reduce the likelihood of drying out the metal-air cells, reduce the exposure of the battery cell to contaminants, and minimize the effects of temperature on the vaporization of water within the cell. In a preferred embodiment, the power supply housing and the metal-air cell case form part of the air plenums. A substantially leak-proof metal-air cell is also disclosed.
摘要翻译：提供了一种提供改进的空气流控制的金属空气电源。反应物空气和冷却空气入口彼此分开，并与空气流的排出的反应物和冷却部分分离。反应物气流被限制为足以提供从电池产生预定水平的电流所需的化学计量量的约3至约10倍的体积流量，以及足够的总体积流量，使得空气流的冷却部分的体积流速为提供空气流的反应物部分的体积流量的约10至约1000倍。这限制了反应物空气在阴极上的流速，将冷却空气流与反应物气流隔离，并将金属 - 空气池的温度维持在低水平，而不会使空气阴极暴露于过大的空气流速减少干燥金属 - 空气细胞的可能性，减少电池对污染物的暴露，并尽量减少温度对电池内水蒸发的影响。在优选实施例中，电源壳体和金属空气电池壳体形成空气增压室的一部分。还公开了一种基本上防漏的金属空气电池。

40. 发明授权

US4227040A Screw-on electrical connector 失效
标题翻译：螺丝电连接器
公开(公告)号：US4227040A
公开(公告)日：1980-10-07
申请号：US28056
申请日：1979-04-09
申请人： William J. Scott
发明人： William J. Scott
IPC分类号： H01R4/22 , H01R5/12
CPC分类号： H01R4/22
摘要： This is concerned with a so-called screw-on electrical connector which contains or is made up of a plastic insulating cap with a coil spring on the inside which is constructed and arranged to be screwed down on the stripped ends of two or more electric wires. More specifically, the connector is constructed to provide a variable and controlled spring rate or compression load on the stripped ends of the largest number of wire combinations and in a less expensive form.
摘要翻译：这涉及所谓的螺旋式电连接器，其包含或由内侧具有螺旋弹簧的塑料绝缘盖组成，其被构造和布置成被拧到两根或多根电线的剥离端上。更具体地，连接器被构造成在最大数量的线组合的剥离端上以较便宜的形式提供可变和受控的弹簧刚度或压缩载荷。

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