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1. 发明申请

US20090093526A1 INHIBITION OF P38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS 审中-公开
标题翻译：使用对称和非对称二苯醚类尿素抑制P38激酶
公开(公告)号：US20090093526A1
公开(公告)日：2009-04-09
申请号：US11932397
申请日：2007-10-31
申请人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
发明人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号： A61K31/40 , A61K31/44 , C07D207/36 , C07D213/04 , A61P19/02
CPC分类号： A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4035 , A61K31/44 , A61K31/5375 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译：本发明涉及一组芳基脲在治疗细胞因子介导的疾病和蛋白水解酶介导的疾病中的用途，以及用于这种治疗的药物组合物。

2. 发明授权

US07517880B2 Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas 失效
标题翻译：使用对称和不对称二苯脲抑制p38激酶
公开(公告)号：US07517880B2
公开(公告)日：2009-04-14
申请号：US10060396
申请日：2002-02-01
申请人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
发明人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号： A61K31/40 , A61K31/44 , A61K31/535 , C07D333/22 , C07D233/61
CPC分类号： A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4035 , A61K31/44 , A61K31/5375 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译：本发明涉及一组芳基脲在治疗细胞因子介导的疾病和蛋白水解酶介导的疾病中的用途，以及用于这种治疗的药物组合物。

3. 发明申请

US20080269265A1 Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas 审中-公开
标题翻译：使用对称和非对称取代的二苯基脲对Raf激酶的抑制
公开(公告)号：US20080269265A1
公开(公告)日：2008-10-30
申请号：US12145679
申请日：2008-06-25
申请人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , David Gunn , Martha Rodriguez , Ming Wang , Tiffany Turner , Catherine Brennan
发明人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , David Gunn , Martha Rodriguez , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号： A61K31/17 , C07D213/70 , C07D213/63 , C07D409/12 , C07D401/12 , C07D277/68 , C07D215/20 , C07D239/38 , A61P35/00 , A61K31/505 , A61K31/47 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/428
CPC分类号： C07D409/12 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/40 , C07D213/40 , C07D213/50 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/81 , C07D213/89 , C07D215/20 , C07D239/38 , C07D277/68 , C07D317/64 , C07D401/04 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译：本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。

4. 发明授权

US06911443B2 Imidazopyrimidine derivatives and triazolopyrimidine derivatives 失效
标题翻译：咪唑并嘧啶衍生物和三唑并嘧啶衍生物
公开(公告)号：US06911443B2
公开(公告)日：2005-06-28
申请号：US10258628
申请日：2001-04-17
申请人： Takeshi Yura , Arnel B. Concepcion , Gyoonhee Han , Makiko Marumo , Hiroko Yoshino , Norihiro Kawamura , Toshio Kokubo , Hiroshi Komura , Yingfu Li , Timothy B. Lowinger , Muneto Mogi , Noriyuki Yamamoto , Nagahiro Yoshida , Scott Miller , Margaret A. Popp , Aniko M. Redmann , Martha E. Rodriguez , William J. Scott , Ming Wang
发明人： Takeshi Yura , Arnel B. Concepcion , Gyoonhee Han , Makiko Marumo , Hiroko Yoshino , Norihiro Kawamura , Toshio Kokubo , Hiroshi Komura , Yingfu Li , Timothy B. Lowinger , Muneto Mogi , Noriyuki Yamamoto , Nagahiro Yoshida , Scott Miller , Margaret A. Popp , Aniko M. Redmann , Martha E. Rodriguez , William J. Scott , Ming Wang
IPC分类号： A61K31/505 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/04 , A61P7/02 , A61P7/06 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/28 , A61P27/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D487/04 , C07D519/00 , C07D417/10
CPC分类号： C07D487/04
摘要： A compound of the formula (I) in which R1 is —OR11, —SR11, —SOR11, —SO2R11, —NHR11, or —NR12R13 , and R11, R12, and R13 are as defined broadly in the text. R2 is H, C1-C6alkyl, carbamoyl, or an ester group. R3 is thienyl, pyridyl optionally substituted by halogen or C1-C6alkoxy; naphthyl optionally substituted by C1-C6alkoxy; dioxane fused phenyl; dioxacyclopentane fused phenyl; or optionally substituted phenyl. Y is CH or N. A process for preparing such compounds, pharmaceutical compositions containing such compounds, and a method of treating asthma using them are also disclosed and claimed.
摘要翻译：其中R 1为-OR 11，-SR 11，-SOR 11的式（I）化合物， SO 2，-SO 2，R 11，-NHR 11或-NR 12 R 13 ＆lt; / SUP＆gt;和R 11，R 12和R 13如在文中广义地定义的。 R 2是H，C 1 -C 6烷基，氨基甲酰基或酯基。 R 3是噻吩基，任选被卤素或C 1 -C 6烷氧基取代的吡啶基; 任选被C 1 -C 6烷氧基取代的萘基; 二恶烷稠合苯基; 二氧杂环戊烷稠合苯基; 或任选取代的苯基。 Y是CH或N.一种制备这种化合物的方法，含有这些化合物的药物组合物和使用它们治疗哮喘的方法也被公开和要求保护。

5. 发明申请

US20100291485A1 NANOSCALE MOLECULE SYNTHESIS 审中-公开
公开(公告)号：US20100291485A1
公开(公告)日：2010-11-18
申请号：US12713148
申请日：2010-02-25
申请人： Troy Lapsys , Viswanath Krishnamoorthy , Paul Bentley , Uday Khire , Scott Miller , Peter Mikochik
发明人： Troy Lapsys , Viswanath Krishnamoorthy , Paul Bentley , Uday Khire , Scott Miller , Peter Mikochik
IPC分类号： G03F7/20 , C07H21/04
CPC分类号： C07H19/073 , C12P19/34
摘要： This invention relates to nanoscale molecule synthesis, including three-dimensional addressable arrays of biopolymeric nucleic acids and processes for manufacturing such arrays. Such arrays can be functionalized with complementary chemical reactive probes to provide catalytic enzymes.
摘要翻译：本发明涉及纳米尺度分子合成，包括生物聚合物核酸的三维可寻址阵列和用于制造这种阵列的方法。这样的阵列可以用互补的化学反应性探针进行功能化以提供催化酶。

6. 发明申请

US20190049714A1 OPTICAL COUPLER FOR OPTICAL IMAGING VISUALIZATION DEVICE 审中-公开
公开(公告)号：US20190049714A1
公开(公告)日：2019-02-14
申请号：US16161312
申请日：2018-10-16
申请人： Scott Miller
发明人： Scott Miller
IPC分类号： G02B23/24 , A61B1/00 , G02B23/26 , F21V8/00 , G02B6/32 , G02B6/26
摘要： An optical coupler for mounting at a distal end of an optical imaging device includes a visualization section and an attachment section. At least one surface of the visualization section has a roughness that does not interfere with a video capture system of an optical imaging device.

7. 发明申请

US20160085063A1 OPTICAL COUPLER FOR OPTICAL IMAGING VISUALIZATION DEVICE 审中-公开
公开(公告)号：US20160085063A1
公开(公告)日：2016-03-24
申请号：US14494090
申请日：2014-09-23
申请人： Scott Miller
发明人： Scott Miller
IPC分类号： G02B23/24 , G02B6/26
CPC分类号： G02B23/2423 , A61B1/00096 , A61B1/00101 , A61B1/00137 , G02B6/0008 , G02B6/262 , G02B6/322 , G02B23/2469 , G02B23/26
摘要： An optical coupler for mounting at a distal end of an optical imaging device includes a visualization section and an attachment section. At least one surface of the visualization section has a roughness that does not interfere with a video capture system of an optical imaging device.

8. 发明申请

US20150083728A1 RECEPTACLE WITH A SPRING HINGE 有权
标题翻译：与弹簧铰链接合
公开(公告)号：US20150083728A1
公开(公告)日：2015-03-26
申请号：US14036400
申请日：2013-09-25
申请人： Bradley Hooley , Scott Miller , William Croft
发明人： Bradley Hooley , Scott Miller , William Croft
IPC分类号： B65F1/06 , B65F1/14
CPC分类号： B65F1/06 , B65F1/02 , B65F1/1615 , B65F1/1623 , B65F1/1646
摘要： A receptacle includes a container having a bottom wall and a side wall extending from the bottom wall. The side wall defines an opening and is comprised of a front wall portion and a back wall portion. A lid is secured to the container along the back wall portion at a spring hinge where the lid covers the opening. The front wall portion diverges as it extends away from the base at a first angle and the back wall portion diverges as it extends away from the base at a second angle where the first angle is greater than the second angle. The spring hinge defines an axis of rotation of the lid where the axis of rotation of the lid is outside of the rim of the opening. The lid is shaped and dimensioned such that the lid contacts the rim for substantially the entire periphery thereof.
摘要翻译：容器包括具有底壁和从底壁延伸的侧壁的容器。侧壁限定开口并且包括前壁部分和后壁部分。在盖子覆盖开口的弹簧铰链处，盖子沿着后壁部分固定到容器上。前壁部分以第一角度从基部延伸离开而发散，并且后壁部分以第一角度大于第二角度的第二角度从基部延伸离开。弹簧铰链限定盖的旋转轴线，其中盖的旋转轴线在开口的边缘之外。盖的形状和尺寸使得盖基本上在其整个周边接触边缘。

9. 发明授权

US08881881B2 Viscous clutch valve assembly 有权
标题翻译：粘性离合器阀门总成
公开(公告)号：US08881881B2
公开(公告)日：2014-11-11
申请号：US13809988
申请日：2011-08-18
申请人： William Frances Gevers , Derek Savela , Scott Miller
发明人： William Frances Gevers , Derek Savela , Scott Miller
IPC分类号： F16D35/02
CPC分类号： F16D35/028 , F16D35/024
摘要： A valve assembly for a viscous clutch includes an orifice plate defining a bore to allow the passage of a fluid through the orifice plate, a reed valve secured relative to the orifice plate, an armature comprising a magnetic flux-conducting material, an anchor spring secured to the armature, and a stiffening plate. The reed valve includes a tongue configured to selectively cover the bore of the orifice plate, and a first pivot location along the tongue. A second pivot location is defined along the anchor spring at an edge of the stiffening plate. The first and second pivot locations are spaced from each other. The armature is configured to selectively apply a force to the reed valve to pivot at least a portion of the tongue about the first pivot location.
摘要翻译：一种用于粘性离合器的阀门组件包括孔板，该孔板限定一个孔，以允许流体通过孔板，相对于孔板固定的簧片阀，包括磁性导电材料的电枢，固定弹簧固定到电枢，和加强板。簧片阀包括构造成选择性地覆盖孔板的孔的舌部和沿着舌部的第一枢转位置。在加强板的边缘处沿着锚固弹簧限定第二枢转位置。第一和第二枢转位置彼此间隔开。电枢被构造成选择性地将力施加到簧片阀以使得舌头的至少一部分围绕第一枢转位置枢转。

10. 发明申请

US20120279820A1 INTEGRATED VISCOUS CLUTCH 有权
标题翻译：集成VISCOUS离合器
公开(公告)号：US20120279820A1
公开(公告)日：2012-11-08
申请号：US13509856
申请日：2010-11-15
申请人： David R. Hennessy , Thomas Schmidt , Scott Miller
发明人： David R. Hennessy , Thomas Schmidt , Scott Miller
IPC分类号： F16D29/00 , F16D33/02
CPC分类号： F16D35/024 , F16D2300/18
摘要： A viscous clutch (30; 30′) includes a stationary journal bracket (32; 32′) defining a mounting shaft (32-1; 32-1′), an output member (34; 34′) rotatably supported on the mounting shaft about an axis (A), an input member (34; 34′) rotatably supported on the mounting shaft about the axis, and a working chamber (50; 50′) defined between the input member and the output member to selectively transmit torque there between when a shear fluid is present. The mounting shaft extends axially through the viscous clutch from a front face (62; 62′) of the viscous clutch to a rear face (56; 56′) of the viscous clutch, with the rear face defining a mounting surface for mounting the viscous clutch at a mounting location. The front and rear faces are located at opposite sides of the viscous clutch and face in opposite directions.
摘要翻译：粘性离合器（30; 30'）包括限定安装轴（32-1; 32-1'）的固定轴颈支架（32; 32'），可旋转地支撑在安装轴上的输出构件（34; 34'）围绕轴线（A），围绕所述轴线可旋转地支撑在所述安装轴上的输入构件（34; 34'）以及限定在所述输入构件和所述输出构件之间的选择性地传递扭矩的工作室（50; 50'）当存在剪切流体时。安装轴从粘性离合器的前表面（62; 62'）轴向延伸穿过粘性离合器到粘性离合器的后表面（56; 56'），后表面限定了用于安装粘性的安装表面离合器在安装位置。前表面和后表面位于粘性离合器的相对侧并且面向相反方向。

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