专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US6147196A Process for producing esters of fatty substances and the high purity esters produced 有权
标题翻译：生产脂肪物质酯和高纯度酯的方法
公开(公告)号：US6147196A
公开(公告)日：2000-11-14
申请号：US213286
申请日：1998-12-17
申请人： Robert Stern , Gerard Hillion , Jean-Jacques Rouxel
发明人： Robert Stern , Gerard Hillion , Jean-Jacques Rouxel
IPC分类号： C07C67/03 , C11C1/00
CPC分类号： C11C3/003 , C07C67/03
摘要： In order to produce a composition of esters of linear monocarboxylic acids containing 6 to 26 carbon atoms and glycerine simultaneously with high degrees of purity, the following is carried out:a step a) in which a plant or animal oil, which may or may not be acidic, is reacted with an excess of at least one aliphatic mono-alcohol containing 1 to 4 carbon atoms in the presence of a heterogeneous catalyst, eliminating the excess mono-alcohol and separating out glycerine, this step producing a crude ester containing residual mono-glycerides;a step b) in which the crude ester obtained undergoes transesterification or esterification of the residual mono-glycerides to di- and tri-glycerides, in the presence of a heterogeneous catalyst; anda step c) in which the ester composition is evaporated under reduced pressure, recycling the evaporation residue to the starting oil of step a). The ester compositions obtained, which are of high purity, are of particular use as gas oil substitutes.
摘要翻译：为了以高纯度同时生产含有6至26个碳原子的直链单羧酸酯和甘油的组合物，进行以下操作：步骤a）其中植物或动物油可以或不可以在多相催化剂存在下与过量的至少一种含有1至4个碳原子的脂肪族一元醇反应，除去过量的单醇并分离出甘油，该步骤产生含有残留单体的粗酯甘油酯步骤b）其中所得粗酯在多相催化剂存在下进行酯交换反应或将残留的单甘油酯酯化为二 - 和三 - 甘油酯; 和步骤c），其中酯组合物在减压下蒸发，将蒸发残余物再循环到步骤a）的起始油中。获得的具有高纯度的酯组合物特别用作瓦斯油替代物。

32. 发明授权

US6123938A Human urinary hyaluronidase 失效
标题翻译：人尿透明质酸酶
公开(公告)号：US6123938A
公开(公告)日：2000-09-26
申请号：US987743
申请日：1997-12-09
申请人： Robert Stern , Anthony Csoka , Gregory I. Frost , Tim M. Wong
发明人： Robert Stern , Anthony Csoka , Gregory I. Frost , Tim M. Wong
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61P9/10 , A61P27/06 , A61P35/00 , C07K14/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12Q1/68 , C12R1/93 , G01N33/573 , C07K1/00
CPC分类号： C07K16/40 , C12N9/16 , C12N9/2474 , C12Y302/01035 , C12Y302/01036 , G01N33/573 , A61K38/00 , Y10S530/828 , Y10S530/834
摘要： The present invention is based on the purification and sequencing of isozymes of plasma hyaluronidase (pHAse) found in urine. Specifically, urine contains two hyaluronidases (HAses): 1) a 57 kDa HAse that is apparently the same as the 57 kDa HAse found in plasma; and 2) a 45 kDa HAse, which is found in urine but not plasma. The smaller urine isozyme is composed of two disulfide-linked polypeptides produced by endoproteolytic cleavage of the 57 kDa isoform. The present invention thus features a urinary hyaluronidase (uHAse) polypeptide and nucleotide sequences encoding a Chain A polypeptide and a Chain B polypeptide, the two polypeptides of which uHAse is composed. In a particular aspect, the uHAse is a human uHAse (huHAse), preferably a huHAse composed of the Chain A and B polypeptides having SEQ ID NOS: 2 and 4, respectively. In related aspects the invention features polynucleotide sequence encoding Chain A and Chain B polypeptides, preferably having the sequences of SEQ ID NOS: 1 and 3, respectively. In addition, the invention features polynucleotide sequences that hybridize under stringent conditions to SEQ ID NOS: 1 and 3. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode uHAse polypeptide Chains A and B. The present invention also features antibodies that bind specifically to uHAse, and methods for producing uHAse.
摘要翻译：本发明基于在尿中发现的血浆透明质酸酶（pHAse）的同功酶的纯化和测序。具体来说，尿液含有两种透明质酸酶（HAses）：1）57kDa的HAse与血浆中57kDa的HAse显然相同; 和2）45kDa的HAse，其存在于尿中而不是血浆中。较小的尿同功酶由通过57kDa同种型的内切蛋白切割产生的两个二硫键连接的多肽组成。因此，本发明的特征在于尿液透明质酸酶（uHA））多肽和编码链A多肽和链B多肽的核苷酸序列，其中uHAse组成的两个多肽。在一个特定方面，uHA是人uHAse（huHAse），优选分别由具有SEQ ID NO：2和4的链A和B多肽组成的huHAse。在相关方面，本发明具有分别编码链A和链B多肽的多核苷酸序列，优选分别具有SEQ ID NO：1和3的序列。此外，本发明还提供了在严格条件下与SEQ ID NO：1和3杂交的多核苷酸序列。在相关方面，本发明涉及包含编码uHAse多肽链A和B的多核苷酸的表达载体和宿主细胞。本发明还具有抗体它们专门用于uHAse，以及生产uHA的方法。

33. 发明授权

US5908946A Process for the production of esters from vegetable oils or animal oils alcohols 失效
标题翻译：从植物油或动物油醇制造酯的方法
公开(公告)号：US5908946A
公开(公告)日：1999-06-01
申请号：US908983
申请日：1997-08-08
申请人： Robert Stern , Gerard Hillion , Jean-Jacques Rouxel , Serge Leporq
发明人： Robert Stern , Gerard Hillion , Jean-Jacques Rouxel , Serge Leporq
IPC分类号： C07C67/03 , C10L1/02 , C11C3/10 , C07C51/00
CPC分类号： C11C3/003 , C07C67/03 , C10L1/02
摘要： For the production of linear monocarboxylic acid esters with 6 to 26 carbon atoms vegetable oils or animal oils, which may or may not be neutral, are reacted with monoalcohols having a low molecular weight, for example 1 to 5 carbon atoms, in the presence of a catalyst that is selected from among zinc oxide, mixtures of zinc oxide and aluminum oxide, and the zinc aluminates that correspond to the formula:ZnAl.sub.2 O.sub.4, x ZnO, y Al.sub.2 O.sub.3(with x and y each being in the range of 0-2) and having more particularly a spinel type structure, thereby enabling the direct production in one or more stages, of an ester that can be used as a fuel or combustible and a pure glycerine.
摘要翻译：对于具有6至26个碳原子的线性单羧酸酯的生产，可以是或可以不是中性的植物油或动物油与具有低分子量，例如1-5个碳原子的一元醇在存在选自氧化锌，氧化锌和氧化铝的混合物的催化剂和对应于下式的ZnAl 2 O 4，x ZnO，y Al 2 O 3（x和y各自在0-2范围内）的铝酸锌，并且更具体地具有尖晶石型结构，从而能够在一个或多个阶段直接生产可用作燃料或可燃物的酯和纯甘油。

34. 发明授权

US5880298A Process for oligomerization of polyunsaturated acids and esters, products obtained and use thereof 失效
标题翻译：多不饱和酸和酯的低聚方法，获得的产品及其用途
公开(公告)号：US5880298A
公开(公告)日：1999-03-09
申请号：US186483
申请日：1994-01-14
申请人： Gerard Hillion , Robert Stern , Odile Le Borgne
发明人： Gerard Hillion , Robert Stern , Odile Le Borgne
IPC分类号： C07C67/465 , C09F7/00 , C07B35/08
CPC分类号： C07C67/465
摘要： For the oligomerization of a fatty ester or fatty acid containing conjugated double bonds, the reaction uses a catalyst consisting of an activated earth, e.g., montmorillonite, at a temperature of from 100.degree.-180.degree. C., preferably from 130.degree.-160.degree. C. The process can be carried out continuously or in a batch process on a fixed bed and is particularly applicable to conjugated methyl esters obtained by conjugating and transesterifying sunflower seed oil. The oligomerized products obtained are particularly useful as lubricants or polycondensation reactants.
摘要翻译：对于含有共轭双键的脂肪酸酯或脂肪酸的低聚反应，使用由活化土如蒙脱石组成的催化剂，温度为100-180℃，优选130-160℃。 C.该方法可以在固定床上连续进行或以间歇方式进行，特别适用于通过将向日葵籽油接合和酯交换得到的共轭甲酯。获得的低聚产物特别可用作润滑剂或缩聚反应物。

35. 发明授权

US5792103A Viscosurgical method and apparatus 失效
标题翻译：粘膜手术方法及装置
公开(公告)号：US5792103A
公开(公告)日：1998-08-11
申请号：US620384
申请日：1996-03-22
申请人： Daniel M. Schwartz , David G. Hwang , Robert Stern
发明人： Daniel M. Schwartz , David G. Hwang , Robert Stern
IPC分类号： A61B19/00 , A61F9/00 , A61F9/007 , A61M5/19 , A61M37/00
CPC分类号： A61F9/007 , A61F9/0017 , A61B2090/08021 , A61F9/00736 , A61M5/19
摘要： An improved viscosurgical method involving the administration of a viscoelastic and a corresponding degradative agent, such that the post-operative intraocular pressure spike often observed following the use of viscoelastics in ophthalmic surgery is minimized, and an apparatus and clinical kit useful in the method are provided.
摘要翻译：一种改进的粘膜手术方法，其包括施用粘弹性和相应的降解剂，使得在眼科手术中使用粘弹性体后经常观察到的手术后眼内压峰值被最小化，并且提供了可用于该方法的装置和临床试剂盒。

36. 发明授权

US5722098A Swimming pool cover with drainage and filter means 失效
标题翻译：游泳池盖有排水和过滤装置
公开(公告)号：US5722098A
公开(公告)日：1998-03-03
申请号：US745878
申请日：1996-11-08
申请人： Robert Stern
发明人： Robert Stern
IPC分类号： E04H4/10 , E04H4/00
CPC分类号： E04H4/10
摘要： A cover for a water pool comprised of flexible waterproof material having a drainage opening positioned therein and a sleeve defining a passageway secured on the cover and in alignment with and intersecting the drainage opening allowing a filter means to be slidably positionable therein for filtering of rain water and melting snow to remove particulate matter, the filter means repositionable or removable for cleaning without the need for removing the cover for the water pool.
摘要翻译：一种用于水池的盖子，包括具有定位在其中的排水开口的柔性防水材料，以及限定固定在盖上并与排水口对准并与之相交的通道的套筒，允许过滤器装置可滑动地定位在其中以过滤雨水并融化雪以去除颗粒物，过滤装置可重新定位或拆卸，无需拆除水池盖。

37. 发明授权

US4264515A Process for manufacturing a N-acyl .alpha.-amino acid 失效
标题翻译：制备N-酰基α-氨基酸的方法
公开(公告)号：US4264515A
公开(公告)日：1981-04-28
申请号：US103774
申请日：1979-12-14
申请人： Robert Stern , Andre Hirschauer , Dominique Commereuc , Yves Chauvin
发明人： Robert Stern , Andre Hirschauer , Dominique Commereuc , Yves Chauvin
IPC分类号： C07C233/45 , C07C102/00
CPC分类号： C07C233/45
摘要： A N-acyl .alpha.-amino acid is manufactured by reacting an unsaturated vegetable oil or a C.sub.8 -C.sub.30 mono-olefinic compound with an amide, carbon monoxide and hydrogen, in the presence of a cobalt catalyst. The process is operated in one step, providing for an increased selectivity as compared with a two-step process.
摘要翻译：通过使不饱和植物油或C 8 -C 30单烯烃化合物与酰胺，一氧化碳和氢气在钴催化剂存在下反应制备N-酰基α-氨基酸。该方法在一个步骤中操作，与两步法相比提供了增加的选择性。

38. 发明授权

US4230897A Process for selectively hydrogenating a hydrocarbon cut containing at least one diolefinic hydrocarbon and at least one acetylenic hydrocarbon using a palladium catalyst with crystallites of at least 50 angstroms 失效
标题翻译：使用具有至少50埃的微晶的钯催化剂选择性氢化含有至少一种二烯烃和至少一种炔烃的烃馏分
公开(公告)号：US4230897A
公开(公告)日：1980-10-28
申请号：US26984
申请日：1979-04-04
申请人： Jean Cosyns , Robert Stern , Jean-Francois Le Page
发明人： Jean Cosyns , Robert Stern , Jean-Francois Le Page
IPC分类号： C07C7/167 , B01J23/44 , C07C1/00 , C07C5/08 , C07C11/12 , C07C67/00 , C10G45/40 , C07C7/00
CPC分类号： C07C5/08 , B01J23/44 , C07C2521/04 , C07C2523/44
摘要： Process for selectively hydrogenating acetylenic hydrocarbons such as vinylacetylene contained in an unsaturated hydrocarbon fraction such as a C.sub.4 fraction also containing a diolefinic hydrocarbon such as butadiene, without substantially hydrogenating said diolefinic hydrocarbon, comprising the step of contacting said fraction, at least partially in the liquid phase, in the presence of hydrogen, with a catalyst of palladium on alumina whose palladium crystallites have an average size of at least 50 Angstroms, said step being optionally followed with a step of contacting the resultant fraction from the preceding step, in the presence of hydrogen, with a catalyst of palladium an alumina whose palladium crystallites have an average size of at most 45 Angstroms.
摘要翻译：用于选择性氢化不饱和烃馏分中的炔属烃如乙烯基乙炔的方法，所述不饱和烃馏分例如也含有二烯烃如丁二烯的C4馏分，而基本上不氢化所述二烯烃，包括使所述馏分至少部分地接触液体的步骤在氢气存在下与钯钯微晶的平均尺寸至少为50埃的氧化钯催化剂相接触，所述步骤任选地在下述步骤中使之与前述步骤的所得部分接触：在氢气，钯催化剂，其钯微晶具有至多45埃的平均尺寸的氧化铝。

39. 发明授权

US4141100A Binding machine and cover for use therewith 失效
标题翻译：装订机和盖子一起使用
公开(公告)号：US4141100A
公开(公告)日：1979-02-27
申请号：US726613
申请日：1976-09-27
申请人： William E. Domroe , Thomas W. F. Lindquist , Robert Stern
发明人： William E. Domroe , Thomas W. F. Lindquist , Robert Stern
IPC分类号： B42C9/00 , B42C11/00 , B42C11/02 , B42C13/00 , B42D3/00 , B42C19/00
CPC分类号： B42C9/00 , B42C11/02 , B42D3/00 , Y10S412/90 , Y10S412/902
摘要： A machine for binding a plurality of loose sheets into bound pamphlet form is disclosed, together with a cover suitable to receive such sheets. The machine has a stationary base to which a main chassis is fixedly mounted. A movable carriage is mounted for slidable movement with respect to the chassis by means of rollers fixed to the carriage and which slide along the inner side edges of the upper plate of the chassis. When the carriage is in the open position, its upper rear wall is separated from the fixed rear wall of the base, thereby exposing an underlying heating channel and permitting the insertion therein of a cover containing pages to be bound thereto. The chassis is then moved to a relatively closed position, whereby its rear wall approaches the corresponding rear wall of the base, retaining the cover and its contained pages therebetween. A brief heating cycle, utilizing a printed circuit board in the heating channel, then causes the pages to adhere to a pre-glued strip along the inner spine of the cover, which has become somewhat viscous during the heating cycle. The cover is then removed and following a short cooling period, the bound pamphlet is completed.In one embodiment of the cover to be used with this invention, thin flexible strips running parallel to the spine of the cover are affixed to the inner surfaces of the front and rear cover portions to provide sufficient rigidity to retain the pages in a firm binding position in the cover when the carriage is moved to its closed position and the heating cycle is initiated. Other embodiments of the cover provide for adhering different binding members to the cover member to provide binding versatility.
摘要翻译：公开了一种用于将多个松散片材结合成绑定小册子形式的机器，以及适于接收这种片材的盖子。机器具有固定的基座，主机架固定在该基座上。安装有可移动的托架，用于通过固定到托架上的滚子相对于底盘滑动运动，并且沿着底盘的上板的内侧边缘滑动。当滑架处于打开位置时，其上后壁与基座的固定后壁分离，从而露出下面的加热通道并允许在其中插入包含页的盖子。然后将底盘移动到相对闭合的位置，由此其底壁接近基座的相应的后壁，将盖子及其包含的页面保持在其间。在加热通道中使用印刷电路板的简单的加热循环然后使得页面沿着盖的内部脊柱粘附到预先胶合的带上，其在加热循环期间变得有些粘性。然后取下盖子，经过短暂的冷却期，结束了小册子。

40. 发明授权

US3478370A Swimming pool step construction with integral vinyl liner 失效
标题翻译：游泳池步骤施工与整体乙烯内衬
公开(公告)号：US3478370A
公开(公告)日：1969-11-18
申请号：US3478370D
申请日：1968-01-19
申请人： ROBERT STERN , ROSARIO A PURPURI
发明人： STERN ROBERT , PURPURI ROSARIO A
IPC分类号： E04F11/16 , E04H4/14 , E04H3/16
CPC分类号： E04F11/16 , E04H4/144 , E04H2004/146

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式