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31. 发明授权

US06496715B1 System and method for non-invasive determination of optimal orientation of an implantable sensing device 有权
标题翻译：用于非侵入性确定可植入感测装置的最佳取向的系统和方法
公开(公告)号：US06496715B1
公开(公告)日：2002-12-17
申请号：US09718689
申请日：2000-11-22
申请人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
发明人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
IPC分类号： A61B504
CPC分类号： A61N1/375
摘要： A system and method for determining the optimal positioning of an implantable system for sensing physiologic signals within a body. According to a one embodiment of the system, electrodes are positioned on an external surface of a body, and an ECG monitoring device is used to measure cardiac signals between various pairs of the electrodes. One or more of the electrodes may be re-positioned until an electrode pair position and orientation is located that provides a maximum signal reading. This position and orientation may then be used as the position and orientation in which to implant a corresponding device.
摘要翻译：一种用于确定用于感测身体内的生理信号的可植入系统的最佳定位的系统和方法。根据系统的一个实施例，电极定位在身体的外表面上，并且使用ECG监测装置来测量各对电极之间的心脏信号。一个或多个电极可以被重新定位，直到位于提供最大信号读数的电极对位置和取向。然后可以将该位置和取向用作植入相应装置的位置和取向。

32. 发明授权

US5782888A Method of selecting an operating mode for an implantable medical device 失效
标题翻译：选择可植入医疗装置的操作模式的方法
公开(公告)号：US5782888A
公开(公告)日：1998-07-21
申请号：US823006
申请日：1997-03-21
申请人： Weimin Sun , Eric J. Panken , William J. Combs
发明人： Weimin Sun , Eric J. Panken , William J. Combs
IPC分类号： A61B5/042 , A61B5/0464 , A61N1/37
CPC分类号： A61B5/726 , A61B5/0422 , A61B5/0464 , A61B5/7203 , A61B5/7267 , A61B5/7225
摘要： This is a method and apparatus for the automated discrimination of cardiac events of interest, including P-waves, R-waves, T-waves and specific arrhythmic sequences, in EGM signals for data storage in an implantable monitor or to control operations of an implantable cardiac stimulator through the use of Hidden Markov Modeling techniques and a reduced set of observations.
摘要翻译：这是用于自动辨别感兴趣的心脏事件（包括P波，R波，T波和特定心律失常序列）的方法和装置，用于在可植入监测器中进行数据存储的EGM信号中，或用于控制可植入的心脏刺激器通过使用隐马尔可夫建模技术和一组减少的观察结果。

33. 发明授权

US5755739A Adaptive and morphological system for discriminating P-waves and R-waves inside the human body 失效
标题翻译：用于辨别人体内P波和R波的自适应和形态系统
公开(公告)号：US5755739A
公开(公告)日：1998-05-26
申请号：US759902
申请日：1996-12-04
申请人： Weimin Sun , Pamela A. Abshire , Eric J. Panken , William J. Combs
发明人： Weimin Sun , Pamela A. Abshire , Eric J. Panken , William J. Combs
IPC分类号： A61B5/0452 , A61N1/368 , A61N1/37 , A61N1/362 , A61B5/0464
CPC分类号： A61N1/3704 , A61B5/04525 , A61N1/368
摘要： The present invention is a method and apparatus for processing a sensed atrial electrogram in conjunction with a sensed ventricular electrogram. The present invention permits accurate discrimination of atrial P-waves from far field ventricular events such as far field R-waves and avoids oversensing such far field ventricular events as atrial sense events and undersensing atrial events occurring within a fusion beat masked by a far field ventricular event in the atrial electrogram. Atrial channel trigger signals are generated in response to sensed P-waves and far field R-waves in the atrial electrogram, and ventricular trigger signals are generated in response to sensed R-waves in the ventricular electrogram. In response to each ventricular channel trigger signal, the sensed atrial electrogram signal is adaptively filtered for an adaptive filter time window only to remove the far field R-wave signal from the sensed atrial electrogram signal while avoiding adaptive filtering of the sensed atrial electrogram signal at other times. In response to each atrial channel trigger signal, the adaptively filtered, sensed atrial electrogram signal is subjected to morphological analysis in respect of a morphological model of a P-wave only during a morphology time window. In this manner, P-waves in the sensed atrial electrogram signal are detected and far field R-waves in the sensed atrial electrogram signal are not mistakenly detected as P-waves, while morphological analysis of the sensed atrial electrogram at other times is avoided.
摘要翻译：本发明是一种结合感测的心室电描记图处理感测的心房电描记图的方法和装置。本发明允许从远场心室事件（例如远场R波）中准确地辨别心房P波，并避免过度监测诸如心房感觉事件的远场心室事件以及在由远场心室掩蔽的融合搏动内发生的低度心房事件心房电图中的事件。响应于心房电描记图中的感测到的P波和远场R波产生心房通道触发信号，并且响应于心室电图中的感测到的R波而产生心室触发信号。响应于每个心室通道触发信号，感测的心房电描记信号被自适应滤波以用于自适应滤波器时间窗口，仅从感测的心房电描记图信号中去除远场R波信号，同时避免对感测的心房电描记图信号的自适应滤波其他时候。响应于每个心房通道触发信号，仅在形态学时间窗口期间，自适应滤波感应的心房电描记信号就P波的形态学模型进行形态学分析。以这种方式，检测到感测的心房电描记信号中的P波，并且将感测到的心房电描记信号中的远场R波未被错误地检测为P波，同时避免了其他时间的感测的心房电描记图的形态学分析。

34. 发明授权

US5562711A Method and apparatus for rate-responsive cardiac pacing 失效
标题翻译：速率响应心脏起搏方法和装置
公开(公告)号：US5562711A
公开(公告)日：1996-10-08
申请号：US346813
申请日：1994-11-30
申请人： Charles G. Yerich , William J. Combs , Karen J. Kleckner , Eric J. Panken , Richard S. Schallhorn , John D. Wahlstrand
发明人： Charles G. Yerich , William J. Combs , Karen J. Kleckner , Eric J. Panken , Richard S. Schallhorn , John D. Wahlstrand
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： A body-implantable rate-responsive cardiac pacemaker is provided with circuitry for sensing a plurality of physiologic parameters known to be indicative of a patient's metabolic demand for increased cardiac output. In one embodiment, a rate-responsive pacemaker is provided with an activity sensor for detecting the patient's level of physical activity, and is further provided with an impedance sensing circuit for detecting the patient's level of minute ventilation by monitoring cardiac impedance. A rate-response transfer function, implemented by the pacemaker's control circuitry, periodically computes a rate-responsive pacing rate as a function of the outputs from both physiologic sensing circuits. The pacemaker's pacing rate is variable within a rate range defined by predetermined (programmable) upper and lower limits. In the preferred embodiment, the influence of activity sensing and minute ventilation parameters varies in accordance with the current pacing rate. In particular, the influence of activity sensing in rate determination in accordance with the rate-response function is greater than that of minute ventilation, for slower pacing rates, while the influence of minute ventilation sensing dominates over that of activity sensing for higher pacing rates. Rate response operation of the disclosed system is recorded in the form of histogram data stored over a predetermined history time. The relative influence of the activity sensing and minute ventilation sensing on rate determination is periodically scaled or balanced based upon comparison of the histogram data with predetermined desired response data.
摘要翻译：身体植入式速率响应心脏起搏器被提供有用于感测已知指示患者对增加的心输出量的代谢需求的多个生理参数的电路。在一个实施例中，速率响应起搏器设置有用于检测患者的身体活动水平的活动传感器，并且还设置有阻抗感测电路，用于通过监测心脏阻抗来检测患者的分钟通气水平。由起搏器的控制电路实现的速率响应传递函数周期性地计算速率响应起搏速率作为来自生理感测电路的输出的函数。起搏器的起搏速率在由预定（可编程）上限和下限限定的速率范围内是可变的。在优选实施例中，活动感测和分钟通气参数的影响根据当前起搏速率而变化。特别是，根据速率响应函数的速率测定中的活动检测的影响大于分钟通气量，对于较慢的起搏速率，而微动通气检测的影响比活动检测的影响高于起搏率。以预定历史时间存储的直方图数据的形式记录所公开的系统的速率响应操作。基于直方图数据与预定的期望响应数据的比较，活动感测和分钟通气感测对速率确定的相对影响被周期地缩放或平衡。

35. 发明授权

US08688225B2 Posture state detection using selectable system control parameters 有权
标题翻译：姿态检测采用可选择的系统控制参数
公开(公告)号：US08688225B2
公开(公告)日：2014-04-01
申请号：US12433029
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61N1/00
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques for detecting and classifying a posture state of a patient are disclosed, wherein a posture state includes at least one of a posture and/or an activity state related to motion. In one embodiment, one or more signals indicative of at least one of posture and activity state of the patient may be sensed by a sensor. Control logic may be provided to process the one or more sensed signals in a selectable manner. This selectable manner may be based on current posture state data describing a posture state in which the patient has previously been classified. Alternatively or additionally, this current posture state data may describe a posture state transition previously undergone by the patient. The one or more signals that are so processed may then be used to classify a posture state of the patient.
摘要翻译：公开了用于检测和分类患者的姿势状态的技术，其中姿势状态包括与运动相关的姿势和/或活动状态中的至少一个。在一个实施例中，可以由传感器感测指示患者的姿势和活动状态中的至少一个的一个或多个信号。可以提供控制逻辑以以可选择的方式处理一个或多个感测信号。该可选择方式可以基于描述患者以前被分类的姿势状态的当前姿势状态数据。或者或另外，该当前姿势状态数据可以描述先前由患者进行的姿势状态转换。然后可以将如此处理的一个或多个信号用于对患者的姿势状态进行分类。

36. 发明授权

US08565864B2 Techniques for data retention upon detection of an event in an implantable medical device 有权
标题翻译：检测植入式医疗设备中的事件时的数据保留技术
公开(公告)号：US08565864B2
公开(公告)日：2013-10-22
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录，其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。

37. 发明授权

US08515549B2 Associating therapy adjustments with intended patient posture states 有权
标题翻译：将治疗调整与预期的患者姿势状态相关联
公开(公告)号：US08515549B2
公开(公告)日：2013-08-20
申请号：US12433756
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61B5/00 , A61B5/02 , A61B5/103 , A61B5/11 , A61N1/00 , A61N1/05 , A61N1/372
CPC分类号： A61B5/1116 , A61B5/103 , A61B5/686 , A61B2560/0219 , A61B2562/0219 , A61N1/36071 , A61N1/36139 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： The disclosure described techniques for associating therapy adjustments with intended patient posture states. The techniques may include receiving a patient therapy adjustment to a parameter of a therapy program that defines electrical stimulation therapy delivered to the patient, identifying a posture state of the patient, and associating the patient therapy adjustment with the posture state when the patient therapy adjustment is within a range determined based on stored adjustment information for the identified posture state.
摘要翻译：本公开描述了将治疗调整与预期患者姿势状态相关联的技术。这些技术可以包括接收患者治疗调整，该治疗程序的参数限定递送给患者的电刺激治疗，识别患者的姿势状态，以及当患者治疗调整为在基于所识别的姿势状态的存储的调整信息确定的范围内。

38. 发明授权

US08380314B2 Patient directed therapy control 有权
公开(公告)号：US08380314B2
公开(公告)日：2013-02-19
申请号：US11974931
申请日：2007-10-16
申请人： Eric J. Panken , Timothy J. Denison , Gregory F. Molnar
发明人： Eric J. Panken , Timothy J. Denison , Gregory F. Molnar
IPC分类号： A61N1/18
CPC分类号： A61N1/36139 , A61B5/048 , A61B5/4082 , A61B5/7475 , A61M5/14276 , A61M5/1723 , A61M2210/0693 , A61N1/36014 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/3605 , A61N1/3606 , A61N1/36071 , A61N1/36082 , A61N1/37252 , G06F3/015
摘要： A patient controls the delivery of therapy through volitional inputs that are detected by a biosignal within the brain. The volitional patient input may be directed towards performing a specific physical or mental activity, such as moving a muscle or performing a mathematical calculation. In one embodiment, a biosignal detection module monitors an electroencephalogram (EEG) signal from within the brain of the patient and determines whether the EEG signal includes the biosignal. In one embodiment, the biosignal detection module analyzes one or more frequency components of the EEG signal. In this manner, the patient may adjust therapy delivery by providing a volitional input that is detected by brain signals, wherein the volitional input may not require the interaction with another device, thereby eliminating the need for an external programmer to adjust therapy delivery. Example therapies include electrical stimulation, drug delivery, and delivery of sensory cues.

39. 发明授权

US08209019B2 System and method for utilizing brain state information to modulate cardiac therapy 有权
标题翻译：利用脑状态信息调制心脏治疗的系统和方法
公开(公告)号：US08209019B2
公开(公告)日：2012-06-26
申请号：US11796577
申请日：2007-04-27
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/00 , A61B5/02
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0476 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3621 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/37288 , A61N1/3962
摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.
摘要翻译：使用脑状态信息调节或调节心脏治疗的系统。调节可以包括在一段时间内抑制标准的，规定的心脏治疗，或者可以涉及调节递送的心脏治疗的类型。在另一个实施例中，提供了一种用于确定心脏事件是否被分类为神经学匹配的系统，如果是调节心脏的治疗输出。

40. 发明授权

US08108033B2 Techniques for data retention upon detection of an event in an implantable medical device 有权
标题翻译：检测植入式医疗设备中的事件时的数据保留技术
公开(公告)号：US08108033B2
公开(公告)日：2012-01-31
申请号：US11264974
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. Upon detection of a possible occurrence of a physiological event by one group of monitoring elements, an implanted device records data received from another group of monitoring elements. The implanted device obtains and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。在通过一组监测元件检测到生理事件的可能发生时，植入装置记录从另一组监测元件接收的数据。植入装置以基于年龄的第一数据结构获得并存储在数据记录中的数据。在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。

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