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31. 发明授权

US5760266A Method for the cyclotrimerization of alkynes in aqueous solutions 失效
标题翻译：炔烃在水溶液中环状三聚化的方法
公开(公告)号：US5760266A
公开(公告)日：1998-06-02
申请号：US816588
申请日：1997-03-13
申请人： Bruce Eaton , Matthew S. Sigman
发明人： Bruce Eaton , Matthew S. Sigman
IPC分类号： B01J31/22 , C07B61/00 , C07C2/48 , C07C15/02 , C07C29/44 , C07C33/26 , C07C41/30 , C07C43/164 , C07C45/59 , C07C45/72 , C07C45/73 , C07C49/213 , C07C49/76 , C07C67/347 , C07C69/78 , C07C209/68 , C07C211/27 , C08F4/60 , C07F17/02 , C07F15/00
CPC分类号： B01J31/2291 , B01J31/2295 , C07C209/68 , C07C29/44 , C07C45/59 , C07C45/73 , C07C67/347 , B01J2231/328 , B01J2531/822 , B01J2531/827 , B01J2531/845 , B01J2531/96 , C07C2101/16 , Y10S526/943
摘要： This invention discloses an improved method for the �2+2+2! cyclotrimerization reaction in aqueous solutions using a water soluble transition metal catalyst.
摘要翻译：本发明公开了一种使用水溶性过渡金属催化剂在水溶液中进行[2 + 2 + 2]环三聚反应的改进方法。

32. 发明授权

US5705337A Systematic evolution of ligands by exponential enrichment: chemi-SELEX 失效
公开(公告)号：US5705337A
公开(公告)日：1998-01-06
申请号：US400440
申请日：1995-03-08
申请人： Larry Gold , Bruce Eaton , Drew Smith , Matthew Wecker , Kirk Jensen
发明人： Larry Gold , Bruce Eaton , Drew Smith , Matthew Wecker , Kirk Jensen
IPC分类号： G01N33/58 , C07B61/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/00 , C12N9/12 , C12N15/09 , C12N15/10 , C12N15/115 , C12Q1/37 , C12Q1/68 , C12Q1/70 , F02B75/02 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/569 , G01N33/68 , G01N33/76 , C12P19/34
CPC分类号： A61K47/48076 , A61K47/48092 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N15/1048 , C12N15/115 , C12N9/1276 , C12Q1/37 , C12Q1/6811 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C40B40/00 , F02B2075/027 , G01N2333/163 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976
摘要： This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including its associated functional unit, and its target.

33. 发明授权

US5659069A Method for the cyclotrimerization of alkynes in aqueous solutions 失效
标题翻译：炔烃在水溶液中环状三聚化的方法
公开(公告)号：US5659069A
公开(公告)日：1997-08-19
申请号：US619228
申请日：1996-03-20
申请人： Bruce Eaton , Matthew S. Sigman
发明人： Bruce Eaton , Matthew S. Sigman
IPC分类号： B01J31/22 , C07B61/00 , C07C2/48 , C07C15/02 , C07C29/44 , C07C33/26 , C07C41/30 , C07C43/164 , C07C45/59 , C07C45/72 , C07C45/73 , C07C49/213 , C07C49/76 , C07C67/347 , C07C69/78 , C07C209/68 , C07C211/27 , C08F4/60 , C07C69/76
CPC分类号： B01J31/2291 , B01J31/2295 , C07C209/68 , C07C29/44 , C07C45/59 , C07C45/73 , C07C67/347 , B01J2231/328 , B01J2531/822 , B01J2531/827 , B01J2531/845 , B01J2531/96 , C07C2101/16 , Y10S526/943
摘要： This invention discloses an improved method for the [2+2+2] cyclotrimerization reaction in aqueous solutions using a water soluble transition metal catalyst.
摘要翻译：本发明公开了一种使用水溶性过渡金属催化剂在水溶液中进行[2 + 2 + 2]环三聚反应的改进方法。

34. 发明授权

US07964356B2 Method for generating aptamers with improved off-rates 有权
标题翻译：用于产生具有改善的脱离率的适配体的方法
公开(公告)号：US07964356B2
公开(公告)日：2011-06-21
申请号：US12499967
申请日：2009-07-09
申请人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12N15/1048 , C12Q1/6811 , C12Q2525/205
摘要： The present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. This invention relates to the field of diagnostic histology, cytology, histopathology, and cytopathology methods and reagents for the detection of various disease states. More specifically, the invention relates to the use of aptamers in histologic, cytologic, histopathic, and/or cytopathic diagnostic methods. Aptamers may be provided that react with specific target molecules contained within a histological or cytological sample. Aptamers may be used to assess localization, relative density, and presence or absence of one or more target. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. Aptamers may be used to introduce target specific signal moieties. Antigen retrieval methods may be applied to the sample prior to reaction with the specific aptamer/s to improve interaction of the aptamer and target within the sample. Or aptamers may be developed for the specific target that eliminates the need for the antigen retrieval process. In addition to target identification, aptamers may be used to amplify signal generation through a variety of methods.
摘要翻译：本公开描述了用于产生具有比使用先前的SELEX和photoSELEX方法获得的解离速率常数更慢的适体和光催化剂的方法。本公开进一步描述了具有比使用现有方法获得的那些更快的解离速率常数的适体和光致抗体。本发明涉及用于检测各种疾病状态的诊断组织学，细胞学，组织病理学和细胞病理学方法和试剂领域。更具体地，本发明涉及适配体在组织学，细胞学，组织病理学和/或细胞病变诊断方法中的用途。可以提供与包含在组织学或细胞学样品中的特定靶分子反应的适配子。可以使用适配器来评估定位，相对密度以及一个或多个靶的存在或不存在。可以选择对于样品收集的给定疾病状态的特异性和诊断性的靶标。适配子可用于引入目标特异性信号部分。抗原检索方法可以在与特异性适体反应之前应用于样品，以改善样品中适体和靶标的相互作用。或者可以针对特定靶标开发适配体，从而消除对抗原检索过程的需要。除目标识别之外，适体可用于通过各种方法放大信号产生。

35. 发明授权

US07947447B2 Method for generating aptamers with improved off-rates 有权
标题翻译：用于产生具有改善的脱离率的适配体的方法
公开(公告)号：US07947447B2
公开(公告)日：2011-05-24
申请号：US12175434
申请日：2008-07-17
申请人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12N15/115 , C12N9/6429 , C12N15/1048 , C12N2310/16 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2330/31 , C12Q1/6811 , C12Q1/6816 , C12Q1/6832 , C12Q1/6834 , G01N33/5308 , G01N33/58 , C12Q2525/205 , C12Q2565/514 , C12Q2525/161 , C12Q2537/101 , C12Q2523/313
摘要： The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.
摘要翻译：本公开描述了用于产生能够结合靶分子的适配体的改进的SELEX方法，以及用于产生能够结合和共价交联靶分子的光反应性适体的改进的photoSELEX方法。具体地，本公开描述了用于生产具有比使用先前的SELEX和photoSELEX方法获得的解离速率常数更慢的适体和光致抗体的方法。本公开进一步描述了具有比使用现有方法获得的那些更快的解离速率常数的适体和光致抗体。此外，本公开描述了包括多种功能的适体构建体，包括可切割元件，检测元件和捕获或固定元件。

36. 发明申请

US20110105642A1 Drag reducing agent and method of use 有权
标题翻译：减阻剂和使用方法
公开(公告)号：US20110105642A1
公开(公告)日：2011-05-05
申请号：US12589818
申请日：2009-10-29
申请人： Gerald Bruce Eaton , Alan Kim Ebert
发明人： Gerald Bruce Eaton , Alan Kim Ebert
IPC分类号： B05D5/08
CPC分类号： F17D1/17
摘要： The present invention relates to a drag reducing agent, composition, compound, product, process and method of use for use in petroleum pipelines and the like. A preferred embodiment of the present invention provides a cryogenically-ground polyalphaolefin polymer at 15-25 wt. % of the commercial product formulation. The bulking agents comprise ethylene bis-stearamide alone or in combination with other polyethylene and/or polypropylene polymers at 2.0-5.0 wt. % of the commercial product formulation. In addition, diisobutyl ketone 20-60 wt. % of the commercial product formulation and propylene carbonate 2.8-8.4 wt. % of the commercial product formulation are used.
摘要翻译：本发明涉及用于石油管道等的减阻剂，组成物，化合物，产品，方法和使用方法。本发明的优选实施方案提供了15-25重量％的低温法研磨的聚α-烯烃聚合物。％的商业产品配方。填充剂单独使用乙烯双硬脂酰胺，或与其它聚乙烯和/或聚丙烯聚合物组合使用，2.0-5.0wt。％的商业产品配方。另外，二异丁酮20-60wt。％的市售产品配方和碳酸丙烯酯2.8-8.4wt。使用商业产品制剂的％。

37. 发明申请

US20070166740A1 MULTIPLEXED ANALYSES OF TEST SAMPLES 审中-公开
标题翻译：测试样本的多重分析
公开(公告)号：US20070166740A1
公开(公告)日：2007-07-19
申请号：US11623535
申请日：2007-01-16
申请人： James Heil , Daniel Schneider , Daniel Nieuwlandt , Sheri Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
发明人： James Heil , Daniel Schneider , Daniel Nieuwlandt , Sheri Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/5308 , C12N15/115 , C12N2310/16 , C12N2310/3519 , C12Q1/6816 , C12Q1/6832 , C12Q1/6834 , G01N33/58 , C12Q2565/514 , C12Q2525/205 , C12Q2525/161 , C12Q2537/101 , C12Q2523/313
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).
摘要翻译：本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。在一个实施方案中，将测试样品与包含标签的适体接触并对靶分子具有特异性亲和力。允许形成包含与其靶分子结合的适体的适体亲和复合体。如果测试样品含有目标分子，通常将在测试样品中形成适体亲和复合体。适体亲和复合物任选地转化为适体共价复合物，其包括与其靶分子共价结合的适体。然后可以使用本领域技术人员已知的各种方法中的任一种检测和/或定量适体亲和复合物（或任选的适体共价复合物），包括使用固体支持物，使用质谱法和使用定量聚合酶链反应（Q-PCR）。

38. 发明申请

US20060088877A1 Systematic evolution of ligands by exponential enrichment: Chemi-SELEX 审中-公开
标题翻译：配体通过指数富集的系统演化：Chemi-SELEX
公开(公告)号：US20060088877A1
公开(公告)日：2006-04-27
申请号：US11296832
申请日：2005-12-06
申请人： Larry Gold , Bruce Eaton , Drew Smith , Matthew Wecker , Kirk Jensen
发明人： Larry Gold , Bruce Eaton , Drew Smith , Matthew Wecker , Kirk Jensen
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12N15/115 , A61K47/547 , A61K47/549 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12P19/34 , C12Q1/37 , C12Q1/6804 , C12Q1/6811 , C12Q1/6876 , C12Q1/70 , C40B40/00 , F02B2075/027 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , G01N2333/163 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12Q2541/101 , C12Q2525/101 , C12Q2525/179 , C12Q2525/155 , C12Q2521/101
摘要： This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including its associated functional unit, and its target.
摘要翻译：该应用提供了用于鉴定能够与感兴趣的靶标共价相互作用的核酸配体的方法。核酸可以与各种功能单元相关联。该方法还允许鉴定具有促进活性的核酸，其通过其促进在包括其相关功能单位的核酸与其靶标之间形成共价键的能力来测量。

39. 发明授权

US06914138B2 Urea nucleosides as therapeutic and diagnostic agents 失效
标题翻译：尿素核苷作为治疗和诊断剂
公开(公告)号：US06914138B2
公开(公告)日：2005-07-05
申请号：US10216553
申请日：2002-08-09
申请人： Gary Kirschenheuter , Bruce Eaton
发明人： Gary Kirschenheuter , Bruce Eaton
IPC分类号： C07H11/02 , C07H19/06 , C07H19/16 , C07H19/00 , C07H19/22
CPC分类号： C07H11/02 , C07H19/06 , C07H19/16
摘要： Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at one or more of the carbon atoms in the purine or pyrimidine ring, with a vinylstannane, carbon monoxide, and a palladium catalyst to provide 1-ene-3-one intermediates. These intermediates are then reacted with suitably functionalized primary or secondary amines via a Michael reaction. When the intermediate is a 5-position modified pyrimidine ring, and the amine contains a second hydrogen, it can do a second Michael reaction with the ene-one or the ene-imine in the pyrimidine ring. Appropriate modification of the amine reactant can yield products with various bioactivities. The nucleosides can be used therapeutically as anti-cancer, anti-bacterial or anti-viral drugs. The nucleosides can also be used for diagnostic applications, for example, by incorporating a radiolabel or fluorescent label into the molecule. The nucleosides can be used to prepare oligonucleotides for use in various applications, either alone or in combination with other modified nucleosides and/or naturally occurring nucleosides.
摘要翻译：公开了修饰的核苷和制备和使用核苷的方法。可以通过使含有嘌呤或嘧啶环中的一个或多个碳原子上的合适的离去基团的核苷起始原料与乙烯基苯烷，一氧化碳和钯催化剂反应来制备化合物，以提供1-烯-3-醇，一个中间体。然后通过迈克尔反应将这些中间体与适当官能化的伯胺或仲胺反应。当中间体是5-位修饰的嘧啶环，并且胺含有第二个氢时，它可以与嘧啶环中的一个或烯 - 亚胺进行第二个迈克尔反应。胺反应物的适当改性可产生具有各种生物活性的产物。核苷可以用作治疗性的抗癌，抗细菌或抗病毒药物。核苷也可用于诊断应用，例如通过在分子中掺入放射性标记或荧光标记。核苷可用于制备用于各种应用的寡核苷酸，单独使用或与其它修饰的核苷和/或天然存在的核苷组合。

40. 发明申请

US20050136439A1 Novel methods of inorganic compound discovery and synthesis 审中-公开
标题翻译：无机化合物发现与合成的新方法
公开(公告)号：US20050136439A1
公开(公告)日：2005-06-23
申请号：US10937524
申请日：2004-09-09
申请人： Bruce Eaton , Daniel Feldheim , Magda Dolska , Lina Gugliotti
发明人： Bruce Eaton , Daniel Feldheim , Magda Dolska , Lina Gugliotti
IPC分类号： C12N15/10 , C12Q1/68 , C12P19/34
CPC分类号： B82Y30/00 , C12N15/1048
摘要： The present invention provides methods for the synthesis and/or discovery of inorganic compounds, including organometallic compounds. Also provided are functional nucleic acids for synthesis of inorganic compounds and methods of identifying the same. As another aspect, the invention provides compounds made according to the inventive methods, including palladium plates and cobalt-iron oxides spheres, cubes, fibers and nanotubes.
摘要翻译：本发明提供了合成和/或发现包括有机金属化合物在内的无机化合物的方法。还提供了用于合成无机化合物的功能性核酸及其鉴定方法。另一方面，本发明提供根据本发明方法制备的化合物，包括钯板和钴 - 铁氧化物球体，立方体，纤维和纳米管。

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