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31. 发明授权

US08616380B2 Reverse osmosis composite membranes for boron removal 有权
标题翻译：反渗透复合膜去除硼
公开(公告)号：US08616380B2
公开(公告)日：2013-12-31
申请号：US13527640
申请日：2012-06-20
申请人： Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
发明人： Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
IPC分类号： B01D71/56 , B01D71/66
CPC分类号： C02F1/441 , C02F2101/108 , C02F2103/08 , Y02A20/131
摘要： Improved methods for reducing boron concentration in seawater or brackish water, while simultaneously maintaining or improving the salt rejection of membrane and flow performance of polyamide reverse osmosis (RO) membranes include contacting the water with a composite membrane comprising moieties derived from an aromatic sulfonyl halide, a heteroaromatic sulfonyl halide, a sulfinyl halide; a sulfenyl halide; a sulfuryl halide; a phosphoryl halide; a phosphonyl halide; a phosphinyl halide; a thiophosphoryl halide; a thiophosphonyl halide, an isocyanate, a urea, a cyanate, an aromatic carbonyl halide, an epoxide or a mixture thereof.
摘要翻译：改进的用于减少海水或微咸水中的硼浓度的方法，同时维持或改进膜的盐排斥和聚酰胺反渗透（RO）膜的流动性能包括使水与复合膜接触，所述复合膜包含衍生自芳族磺酰卤的部分，杂芳族磺酰卤，亚硫酰卤; 硫基卤化物; 硫酰卤; 磷酰卤; 膦酰卤; 卤化膦硫代磷酰卤; 硫代膦酰卤，异氰酸酯，脲，氰酸酯，芳族羰基卤化物，环氧化物或其混合物。

32. 发明授权

US08467083B2 Framework for processing the content of a digital image of a microscope sample 有权
标题翻译：用于处理显微镜样品的数字图像的内容的框架
公开(公告)号：US08467083B2
公开(公告)日：2013-06-18
申请号：US13494715
申请日：2012-06-12
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K15/00 , G06F3/12
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images. In an embodiment, identifications of one or more algorithms and one or more digital slide images are received over a network. In addition, one or more parameter data are received that constrain the execution of the algorithm(s) to defined sub-region(s) of the digital slide image(s). The digital slide image(s) are retrieved, and the identified algorithm(s) are executed to analyze the defined sub-region(s) of the digital slide image(s).
摘要翻译：一种用于处理和分析虚拟显微镜数字图像的系统和方法。在一个实施例中，通过网络接收一个或多个算法和一个或多个数字幻灯片图像的标识。另外，接收一个或多个参数数据，这些参数数据将算法的执行限制到数字幻灯片图像的定义的子区域。检索数字幻灯片图像，并且执行识别的算法来分析数字幻灯片图像的确定的子区域。

33. 发明申请

US20120255909A1 REVERSE OSMOSIS COMPOSITE MEMBRANES FOR BORON REMOVAL 有权
标题翻译：反向复合膜用于去除硼
公开(公告)号：US20120255909A1
公开(公告)日：2012-10-11
申请号：US13527640
申请日：2012-06-20
申请人： Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
发明人： Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
IPC分类号： C02F1/44 , B01D71/56 , C02F101/10
CPC分类号： C02F1/441 , C02F2101/108 , C02F2103/08 , Y02A20/131
摘要： Improved methods for reducing boron concentration in seawater or brackish water, while simultaneously maintaining or improving the salt rejection of membrane and flow performance of polyamide reverse osmosis (RO) membranes include contacting the water with a composite membrane comprising moieties derived from an aromatic sulfonyl halide, a heteroaromatic sulfonyl halide, a sulfinyl halide; a sulfenyl halide; a sulfuryl halide; a phosphoryl halide; a phosphonyl halide; a phosphinyl halide; a thiophosphoryl halide; a thiophosphonyl halide, an isocyanate, a urea, a cyanate, an aromatic carbonyl halide, an epoxide or a mixture thereof.
摘要翻译：改进的用于减少海水或微咸水中的硼浓度的方法，同时维持或改进膜的盐排斥和聚酰胺反渗透（RO）膜的流动性能包括使水与复合膜接触，所述复合膜包含衍生自芳族磺酰卤的部分，杂芳族磺酰卤，亚硫酰卤; 硫基卤化物; 硫酰卤; 磷酰卤; 膦酰卤; 卤化膦硫代磷酰卤; 硫代膦酰卤，异氰酸酯，脲，氰酸酯，芳族羰基卤化物，环氧化物或其混合物。

34. 发明申请

US20120114204A1 Optimizing Virtual Slide Image Quality 有权
标题翻译：优化虚拟幻灯片图像质量
公开(公告)号：US20120114204A1
公开(公告)日：2012-05-10
申请号：US13355245
申请日：2012-01-20
申请人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
发明人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
IPC分类号： G06K9/40
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether any of multiple virtual slide images has an out of focus area and is therefore a candidate for manual inspection or rescanning, various focus points used to scan each virtual slide image are used to calculate a best fit surface for each virtual slide image. The best fit surface is then used to determine whether any of the various focus points are outliers. If it is determined that a virtual slide image is associated with outlying focus points, it is identified as a candidate for manual inspection or rescanning.
摘要翻译：提供了评估和优化虚拟显微镜载玻片图像质量的系统和方法。为了确定多个虚拟幻灯片图像中的任何一个是否具有失焦区域，因此是用于手动检查或重新扫描的候选者，用于扫描每个虚拟幻灯片图像的各种对焦点用于为每个虚拟幻灯片计算最佳拟合曲面图片。然后使用最佳拟合曲面来确定各个焦点中是否有异常值。如果确定虚拟幻灯片图像与外围焦点相关联，则将其识别为手动检查或重新扫描的候选者。

35. 发明申请

US20120014576A1 Signal to Noise Ratio in Digital Pathology Image Analysis 有权
标题翻译：数字病理图像分析中的信噪比
公开(公告)号：US20120014576A1
公开(公告)日：2012-01-19
申请号：US13259562
申请日：2010-12-10
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

36. 发明申请

US20100297429A1 COMPOSITE MEMBRANE AND METHOD OF MAKING 有权
标题翻译：复合膜及其制备方法
公开(公告)号：US20100297429A1
公开(公告)日：2010-11-25
申请号：US12470606
申请日：2009-05-22
申请人： Hua Wang , Su Lu , Hua Li , Steven Thomas Rice , Joseph Anthony Suriano , Bing Zhang , Chen Wang , Lawrence Charles Costa , Steven John Harrold , David Allen Olson , Wenqing Peng
发明人： Hua Wang , Su Lu , Hua Li , Steven Thomas Rice , Joseph Anthony Suriano , Bing Zhang , Chen Wang , Lawrence Charles Costa , Steven John Harrold , David Allen Olson , Wenqing Peng
IPC分类号： B32B27/34 , C08J9/00
CPC分类号： B01D69/125 , B01D67/0006 , B01D71/56 , B01D2323/40 , Y10T428/249991
摘要： The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C3-C8 cyclic carbonyl compound and a C1-C8 amide compound, said amide compound comprising at least one N—H moiety. In addition the present invention provides a method of preparing a composite membrane comprising contacting under interfacial polymerization conditions an organic solution comprising a polyacid halide with an aqueous solution comprising a polyamine, said contacting being carried out on a surface of a porous base membrane, said organic solution further comprising a C3-C8 cyclic carbonyl compound, said aqueous solution comprising a C1-C8 amide compound, said amide compound comprising at least one N—H moiety.
摘要翻译：本发明提供一种复合膜，其包含多孔基膜和设置在所述多孔基膜上的聚酰胺涂层，所述聚酰胺涂层包含C3-C8环状羰基化合物和C1-C8酰胺化合物，所述酰胺化合物包含至少一个N -H部分。另外本发明提供一种制备复合膜的方法，包括在界面聚合条件下使包含多酰卤的有机溶液与包含多胺的水溶液接触，所述接触在多孔基膜的表面上进行，所述有机所述溶液还包含C 3 -C 8环状羰基化合物，所述水溶液包含C 1 -C 8酰胺化合物，所述酰胺化合物包含至少一个N-H部分。

37. 发明授权

US06489850B2 Crosstalk suppression in differential AC coupled multichannel IC amplifiers 有权
标题翻译：差分交流耦合多通道IC放大器中的串扰抑制
公开(公告)号：US06489850B2
公开(公告)日：2002-12-03
申请号：US09810133
申请日：2001-03-16
申请人： Randolph B. Heineke , Scott Allen Olson , David John Orser
发明人： Randolph B. Heineke , Scott Allen Olson , David John Orser
IPC分类号： H03F314
CPC分类号： H01L27/0805 , H01L23/5222 , H01L2924/0002 , H01L2924/00
摘要： A multichannel parallel IC amplifier includes a plurality of amplifier circuits formed on an IC substrate. Each amplifier circuit is coupled to respective inputs via a pair of capacitors. The capacitors are configured so as to substantially equalize like sense and unlike sense coupling between adjacent channels, leading to cancellation of crosstalk signals.
摘要翻译：多通道并行IC放大器包括形成在IC基板上的多个放大电路。每个放大器电路经由一对电容器耦合到相应的输入端。这些电容器被配置成基本上相等于相邻通道之间的相似感测和不同的感测耦合，导致消除串扰信号。

38. 发明授权

US08805050B2 Optimizing virtual slide image quality 有权
标题翻译：优化虚拟幻灯片图像质量
公开(公告)号：US08805050B2
公开(公告)日：2014-08-12
申请号：US13355245
申请日：2012-01-20
申请人： Allen Olson , Dirk G. Soenksen , Kiran Saligrama
发明人： Allen Olson , Dirk G. Soenksen , Kiran Saligrama
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether any of multiple virtual slide images has an out of focus area and is therefore a candidate for manual inspection or rescanning, various focus points used to scan each virtual slide image are used to calculate a best fit surface for each virtual slide image. The best fit surface is then used to determine whether any of the various focus points are outliers. If it is determined that a virtual slide image is associated with outlying focus points, it is identified as a candidate for manual inspection or rescanning.
摘要翻译：提供了评估和优化虚拟显微镜载玻片图像质量的系统和方法。为了确定多个虚拟幻灯片图像中的任何一个是否具有失焦区域，因此是用于手动检查或重新扫描的候选者，用于扫描每个虚拟幻灯片图像的各种对焦点用于为每个虚拟幻灯片计算最佳拟合曲面图片。然后使用最佳拟合曲面来确定各个焦点中是否有异常值。如果确定虚拟幻灯片图像与外围焦点相关联，则将其识别为手动检查或重新扫描的候选者。

39. 发明申请

US20120269409A1 SIGNAL TO NOISE RATIO IN DIGITAL PATHOLOGY IMAGE ANALYSIS 有权
标题翻译：在数字病理学图像分析中的噪声比率信号
公开(公告)号：US20120269409A1
公开(公告)日：2012-10-25
申请号：US13370124
申请日：2012-02-09
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

40. 发明申请

US20120152839A1 MODIFIED SULFONAMIDE POLYMERIC MATRICES 审中-公开
标题翻译：改性磺酰胺聚合物基质
公开(公告)号：US20120152839A1
公开(公告)日：2012-06-21
申请号：US12973144
申请日：2010-12-20
申请人： David Allen Olson , Qingshan Jason Niu
发明人： David Allen Olson , Qingshan Jason Niu
IPC分类号： B01D71/56 , B05D3/10 , B01D61/02 , C08G75/00 , B01D61/10
CPC分类号： B01D71/66 , B01D61/025 , B01D61/027 , B01D67/0006 , B01D67/0093 , B01D69/125 , B01D2325/20
摘要： The present disclosure relates to a matrix comprising a modified sulfonamide polymer, processes for producing the same and uses thereof. In particular, the matrix comprises sulfonyl compound residues and aliphatic amine compound residues, and further comprises acyl compound residues and amine compound residues having at least two amine moieties, wherein the aliphatic amine compound residues and amine compound residues are different.
摘要翻译：本公开涉及包含改性磺酰胺聚合物的基质，其制备方法及其用途。特别地，基质包括磺酰化合物残基和脂族胺化合物残基，并且还包含具有至少两个胺部分的酰基化合物残基和胺化合物残基，其中脂族胺化合物残基和胺化合物残基不同。

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