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31. 发明申请

US20140030694A1 OXYGEN DEPLETION DEVICES AND METHODS FOR REMOVING OXYGEN FROM RED BLOOD CELLS 有权
标题翻译：氧气去除装置和从红细胞中除去氧气的方法
公开(公告)号：US20140030694A1
公开(公告)日：2014-01-30
申请号：US14038001
申请日：2013-09-26
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , New Health Sciences, Inc.
发明人： William J. FEDERSPIEL , Brian J. FRANKOWSKI , Tatsuro YOSHIDA , Paul J. VERNUCCI
IPC分类号： C12N5/078
CPC分类号： C12N5/0641 , A01N1/0236 , A61M1/0272 , A61M2202/0208 , A61M2202/0429
摘要： An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.
摘要翻译：氧耗尽装置。设备有一个墨盒; 多个中空纤维，其在所述药筒内从入口到出口延伸; 一定量的氧清除剂，其被包装在筒内并与多个中空纤维相邻并且在其间。中空纤维适于接收和输送红细胞。还有一种氧还原装置和从红细胞中除氧的方法。

32. 发明授权

US08535421B2 Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities 有权
公开(公告)号：US08535421B2
公开(公告)日：2013-09-17
申请号：US12901350
申请日：2010-10-08
申请人： Tatsuro Yoshida , Paul J. Vernucci
发明人： Tatsuro Yoshida , Paul J. Vernucci
IPC分类号： B01D53/22 , B01D19/00 , A61J1/10 , A61J1/14
CPC分类号： C12N5/0641 , A01N1/0221 , A01N1/0226 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/0272 , A61M1/342 , A61M2202/0208 , A61M2202/0225 , B01D19/0031 , B01D53/22
摘要： A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.

33. 发明申请

US20130004937A1 SYSTEM FOR EXTENDED STORAGE OF RED BLOOD CELLS AND METHODS OF USE 有权
标题翻译：红血细胞扩增储存系统及其使用方法
公开(公告)号：US20130004937A1
公开(公告)日：2013-01-03
申请号：US13541554
申请日：2012-07-03
申请人： Tatsuro YOSHIDA , Paul VERNUCCI
发明人： Tatsuro YOSHIDA , Paul VERNUCCI
IPC分类号： C12N5/078 , A61M1/32
CPC分类号： A61M1/0209 , A01N1/021 , A01N1/0226 , A01N1/0263 , A01N1/0294 , A61M1/0231 , A61M1/0272 , A61M2202/0208 , A61M2202/0225 , B01D19/0031
摘要： A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.
摘要翻译：描述了用于保存红细胞的系统和方法，其中红细胞是氧或氧，并且二氧化碳被耗尽，处理并储存在厌氧环境中以优化用于输血的准备。更具体地说，描述了在输血前优化红细胞的红细胞从收集到输血的延长储存的系统和方法。

34. 发明申请

US20120024156A1 BLOOD STORAGE BAG SYSTEM AND DEPLETION DEVICES WITH OXYGEN AND CARBON DIOXIDE DEPLETION CAPABILITIES 有权
标题翻译：血液储存袋系统和具有氧气和二氧化碳排泄能力的装置
公开(公告)号：US20120024156A1
公开(公告)日：2012-02-02
申请号：US12901350
申请日：2010-10-08
申请人： Tatsura Yoshida , Paul J. Vernucci
发明人： Tatsura Yoshida , Paul J. Vernucci
IPC分类号： A61J1/14 , A61J1/10 , B65D85/00 , B01D19/00
CPC分类号： C12N5/0641 , A01N1/0221 , A01N1/0226 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/0272 , A61M1/342 , A61M2202/0208 , A61M2202/0225 , B01D19/0031 , B01D53/22
摘要： A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.
摘要翻译：血液储存系统。该系统具有红细胞收集袋; 氧/二氧化碳消耗装置; 红血球储存袋; 以及将收集袋连接到耗尽装置和将耗尽装置连接到存储袋的管道。耗尽装置包括固体材料的容器，其具有适于接收和排出冲洗气体的入口和出口; 多个中空纤维或气体可渗透膜，在容器内从入口到出口延伸。中空纤维或透气膜适于接收和输送红细胞。

35. 发明申请

US20070016046A1 Systems and methods for using dynamic vascular assessment to distinguish among vascular states and for investigating intracranial pressure 审中-公开
标题翻译：使用动态血管评估来区分血管状态和调查颅内压的系统和方法
公开(公告)号：US20070016046A1
公开(公告)日：2007-01-18
申请号：US11387049
申请日：2006-03-23
申请人： B. Mozayeni , Kevin Crutchfield
发明人： B. Mozayeni , Kevin Crutchfield
IPC分类号： A61B8/00
CPC分类号： A61B8/06 , A61B8/0808
摘要： The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.
摘要翻译：本发明涉及用于评估单个或多个血管和节段中的血流的系统和方法，用于评估血管健康，进行临床试验，筛选治疗干预效果，评估风险因素，评估颅内压和分析结果以定义的方式。本发明能够直接监测血管，特别是脑血管系统的治疗，物质和装置。相关血流参数包括平均流速，收缩期加速度和搏动指数。这些参数的测量和分析以及其他参数提供了有关个体和多个血管的血管健康状况的细节，以及对个体血管总体健康状况的全面分析。本发明可以追踪经历颅内压升高的个体的发作，进展和治疗效果，或者可以帮助将血管系统的潜在的脆弱性识别为与肝硬化或痴呆相关并表现为正常压力的正常压力。

36. 发明授权

US07104958B2 Systems and methods for investigating intracranial pressure 失效
标题翻译：用于调查颅内压的系统和方法
公开(公告)号：US07104958B2
公开(公告)日：2006-09-12
申请号：US10442194
申请日：2003-05-21
申请人： Kevin Crutchfield , B. Robert Mozayeni , John B. Davidson , Simon Fitall , Rakesh Lall
发明人： Kevin Crutchfield , B. Robert Mozayeni , John B. Davidson , Simon Fitall , Rakesh Lall
IPC分类号： A61B8/02
CPC分类号： A61B5/02007 , A61B5/0002 , A61B5/031 , A61B5/4088 , A61B5/411 , A61B5/7275 , A61B8/06 , A61B8/0808 , A61B8/56 , G01S15/8979 , G06F19/00
摘要： The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.
摘要翻译：本发明涉及用于评估单个或多个血管和节段中的血流的系统和方法，用于评估血管健康，进行临床试验，筛选治疗干预效果，评估风险因素，评估颅内压和分析结果以定义的方式。本发明能够直接监测血管，特别是脑血管系统的治疗，物质和装置。相关血流参数包括平均流速，收缩期加速度和搏动指数。这些参数的测量和分析以及其他参数提供了有关个体和多个血管的血管健康状况的细节，以及对个体血管总体健康状况的全面分析。本发明可以跟踪经历颅内压增加的个体的发作，进展和治疗功效，或者可以帮助将血管系统的潜在的脆弱性识别为与肝硬化或痴呆相关并表现为正常压力的正常压力。

37. 发明申请

US20200179446A1 METHODS AND TREATMENT OF TRAUMA 审中-公开
公开(公告)号：US20200179446A1
公开(公告)日：2020-06-11
申请号：US16614683
申请日：2018-05-18
申请人： New Health Sciences, Inc.
发明人： Andrew DUNHAM , Tatsuro YOSHIDA
IPC分类号： A61K35/14 , A61P7/04
摘要： Methods for the reversal of hemorrhagic shock or hemorrhagic trauma.

38. 发明申请

US20190230919A1 Oxygen Reduction Disposable Kits, Devices and Methods of Use Thereof 审中-公开
公开(公告)号：US20190230919A1
公开(公告)日：2019-08-01
申请号：US16375311
申请日：2019-04-04
申请人： Nerw Health Sciences, Inc.
发明人： Michael WOLF , Jancarlo SARITA , Jeffrey Karl SUTTON , Rafael CORDERO , Michael ZOCCHI , Philip KEEGAN , Narendran RENGANATHAN , Robert HARHEN
IPC分类号： A01N1/02 , A61J1/14 , A61M1/02
CPC分类号： A01N1/0263 , A01N1/021 , A61J1/10 , A61J1/1468 , A61K35/00 , A61M1/0272 , A61M2202/0208 , C12M23/14
摘要： The present disclosure relates to Oxygen Reduction Disposable kits (ORDKit), devices and methods for the improved preservation of whole blood and blood components. The improved devices and methods for the collection of blood and blood components provide for whole blood and blood components having reduced levels of oxygen. The devices and methods provide for the rapid preparation of deoxygenated blood and blood components for storage that improves the overall quality of the transfused blood and improves health outcomes in patients.

39. 发明申请

US20180306818A1 Capillary Network Devices and Methods of Use 审中-公开
公开(公告)号：US20180306818A1
公开(公告)日：2018-10-25
申请号：US15956447
申请日：2018-04-18
申请人： New Health Sciences, Inc. , The Administrators of the Tulane Educational Fund
发明人： Tatsuro YOSHIDA , Sergey S. SHEVKOPLYAS , Jennie M. BURNS
IPC分类号： G01N33/80 , B01L3/00
CPC分类号： G01N33/80 , B01L3/5027 , B01L3/502715 , B01L2300/0838 , B01L2300/0861 , B01L2300/0867
摘要： Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.

40. 发明授权

US09968718B2 Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly 有权
公开(公告)号：US09968718B2
公开(公告)日：2018-05-15
申请号：US14614045
申请日：2015-02-04
申请人： New Health Sciences, Inc.
发明人： Tatsuro Yoshida , Paul Vernucci
IPC分类号： A61M1/00 , A61M1/02 , A61M1/38
CPC分类号： A61M1/0272 , A61M1/0281 , A61M1/38 , A61M2202/0208 , A61M2202/0225 , A61M2202/0439
摘要： A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device, The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.

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