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31. 发明授权

US07620062B2 Method of real time optimizing multimedia packet transmission rate 失效
标题翻译：实时优化多媒体分组传输速率的方法
公开(公告)号：US07620062B2
公开(公告)日：2009-11-17
申请号：US10726440
申请日：2003-12-02
申请人： Osamu Kobayashi
发明人： Osamu Kobayashi
IPC分类号： H04J3/17
CPC分类号： G06F3/14 , G09G5/006 , G09G2370/04 , H04L1/0002 , H04L5/1415 , H04L5/1446 , H04L25/4904 , H04N11/042 , Y02D50/10
摘要： A method and apparatus of optimizing transmission (both real time and continuous) of a number of multimedia data packets between a multimedia source device and a multimedia display device is disclosed. In the described embodiment, the multimedia source device and the display device are coupled by way of a unidirectional main link arranged to carry the multimedia data packets from the multimedia source device and the multimedia display device and a bi-directional auxiliary channel arranged to transfer information between the multimedia source device and the multimedia display device. The method can be carried out by following at least the following operations. Providing a test pattern by the multimedia source device on the main link, determining a transmission quality factor of the main link based upon the test pattern, and optimizing the transmission of the multimedia data packets based upon the transmission quality factor.
摘要翻译：公开了一种在多媒体源设备和多媒体显示设备之间优化多个多媒体数据分组的传输（包括实时和连续的）的方法和装置。在所描述的实施例中，多媒体源设备和显示设备通过布置成承载来自多媒体源设备和多媒体显示设备的多媒体数据分组的单向主链路和布置成传送信息的双向辅助信道在多媒体源设备和多媒体显示设备之间。该方法可以通过以下操作进行至少以下操作。通过主链路上的多媒体源设备提供测试模式，基于测试模式确定主链路的传输质量因子，并且基于传输质量因子优化多媒体数据分组的传输。

32. 发明授权

US07614135B2 Method for making reservoir-based sensor device 有权
标题翻译：制作储层传感器装置的方法
公开(公告)号：US07614135B2
公开(公告)日：2009-11-10
申请号：US11927156
申请日：2007-10-29
申请人： John T. Santini, Jr. , Norman F. Sheppard, Jr. , Robert S. Langer , Chung Chang Young
发明人： John T. Santini, Jr. , Norman F. Sheppard, Jr. , Robert S. Langer , Chung Chang Young
IPC分类号： H01R3/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Methods are provided for making a reservoir-based sensor device. The method may include fabricating a first substrate portion which comprises an upper surface, an opposed lower surface, a plurality of through holes defining reservoirs between said upper surface and said lower surface, and a plurality of reservoir caps closing off one end of said through holes at said upper surface; fabricating a plurality of sensors on an upper surface of a second substrate portion; aligning the first and second substrate portions such that each of said plurality of sensors is in alignment with each of said plurality of reservoirs; and bonding together the lower surface of said first substrate portion and the upper surface of said second substrate portion to seal each of said sensors inside the reservoir with which it is aligned.
摘要翻译：提供了制备基于储液器的传感器装置的方法。该方法可以包括制造第一衬底部分，其包括上表面，相对的下表面，在所述上表面和所述下表面之间限定储存器的多个通孔，以及封闭所述通孔的一端的多个贮存器盖在所述上表面; 在第二基板部分的上表面上制造多个传感器; 对准所述第一和第二基板部分，使得所述多个传感器中的每一个与所述多个储存器中的每一个对齐; 以及将所述第一基板部分的下表面和所述第二基板部分的上表面接合在一起，以密封与所述第二基板部分对准的所述储存器内的每个所述传感器。

33. 发明授权

US07582080B2 Implantable, tissue conforming drug delivery device 失效
标题翻译：可植入，组织贴合药物输送装置
公开(公告)号：US07582080B2
公开(公告)日：2009-09-01
申请号：US11291973
申请日：2005-12-01
申请人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Stephen J. Herman
发明人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Stephen J. Herman
IPC分类号： A61K9/22
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A drug delivery device for implantation into a patient is provided that includes at least one device element that includes a substrate having a plurality of discrete reservoirs disposed therein, the reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.
摘要翻译：提供了用于植入患者体内的药物递送装置，其包括至少一个装置元件，其包括具有设置在其中的多个分立储存器的基底，所述储存器包含药物分子和可降解基质材料，其控制药物分子的体内释放其中所述药物递送装置适于符合弯曲的骨组织表面。在一个实施例中，基底是柔性的并且符合骨组织表面。在另一个实施例中，该装置具有两个或更多个装置元件，其连接到柔性支撑层或与柔性支撑层成一体。

34. 发明申请

US20090163895A1 IMPLANTABLE DEVICE FOR CONTROLLED, EXTENDED DELIVERY OF PARATHYROID HORMONE 有权
标题翻译：用于控制，延伸的PARATHYROID HORMONE的可植入装置
公开(公告)号：US20090163895A1
公开(公告)日：2009-06-25
申请号：US12358850
申请日：2009-01-23
申请人： Dennis Ausiello , John T. Santini, JR. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
发明人： Dennis Ausiello , John T. Santini, JR. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
IPC分类号： A61M37/00
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/0036 , A61K9/0097 , A61K38/29 , A61K2300/00
摘要： Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
摘要翻译：提供了将甲状旁腺激素延伸和控制递送给患者的方法和装置。所述方法包括将医疗装置植入患者体内，所述医疗装置包括衬底，衬底中的多个储存器，每个储存器中包含的释放系统，其中所述释放系统包括甲状旁腺激素; 并且可控地从储存器释放药学有效量的甲状旁腺激素。间歇性地释放甲状旁腺激素，例如每天一次（例如两个月，十个月或更长时间）释放。该装置还可以包括含有骨吸收抑制剂或其它用于释放的药物的储存器。该装置可用于输送PTH以治疗和预防骨丢失，例如与骨质疏松症有关。

35. 发明申请

US20090142386A1 CONTROL OF DRUG RELEASE BY TRANSIENT MODIFICATION OF LOCAL MICROENVIRONMENTS 审中-公开
标题翻译：通过瞬时修改局部微环境控制药物释放
公开(公告)号：US20090142386A1
公开(公告)日：2009-06-04
申请号：US12367900
申请日：2009-02-09
申请人： James H. Prescott , Timothy Krieger , Elizabeth R. Proos
发明人： James H. Prescott , Timothy Krieger , Elizabeth R. Proos
IPC分类号： A61K38/22 , A61F2/00 , A61K38/02 , A61K38/29
CPC分类号： A61K38/29 , A61F2/82 , A61F2250/0068 , A61K9/0024 , A61K9/0097 , A61K47/12
摘要： Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.
摘要翻译：提供了用于增强从医疗装置输送药物的方法，制剂和装置。提供该方法用于增加从可植入药物递送装置释放的药物制剂的速率或数量，该方法包括以有效抑制作用的方式在可植入药物递送装置内或附近提供释放调节剂的步骤药物制剂的凝胶化，聚集或沉淀从装置中释放出来。药物制剂和释放调节剂可以一起储存在可植入药物递送装置中的至少一个储存器中。或者，释放 - 调节剂可以存储在与药物制剂分离的一个或多个储存器中。

36. 发明授权

US07510551B2 Controlled release device and method using electrothermal ablation 有权
标题翻译：控制释放装置和使用电热消融的方法
公开(公告)号：US07510551B2
公开(公告)日：2009-03-31
申请号：US10641507
申请日：2003-08-15
申请人： Scott A. Uhland , Benjamin F. Polito , John M. Maloney , Norman F. Sheppard, Jr. , Stephen J. Herman , Barry Y. Yomtov
发明人： Scott A. Uhland , Benjamin F. Polito , John M. Maloney , Norman F. Sheppard, Jr. , Stephen J. Herman , Barry Y. Yomtov
IPC分类号： A61K9/22
CPC分类号： A61M25/0082 , A61B5/0215 , A61B5/042 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61M5/14276 , A61M25/0069 , A61M37/00 , A61M2005/1726 , A61M2205/0244 , A61M2205/123 , A61M2205/3653 , A61N1/32 , Y10T436/25
摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.
摘要翻译：提供了用于控制释放或暴露储存器内容物的装置和方法。该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。在一个实施方案中，将控制释放系统结合到可植入药物递送装置中。

37. 发明授权

US07497855B2 Method and device for the controlled delivery of parathyroid hormone 有权
标题翻译：用于甲状旁腺激素受控递送的方法和装置
公开(公告)号：US07497855B2
公开(公告)日：2009-03-03
申请号：US10654761
申请日：2003-09-04
申请人： Dennis Ausiello , John T. Santini, Jr. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
发明人： Dennis Ausiello , John T. Santini, Jr. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/0036 , A61K9/0097 , A61K38/29 , A61K2300/00
摘要： Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
摘要翻译：提供了将甲状旁腺激素延伸和控制递送给患者的方法和装置。所述方法包括将医疗装置植入患者体内，所述医疗装置包括衬底，衬底中的多个储存器，每个储存器中包含的释放系统，其中所述释放系统包括甲状旁腺激素; 并且可控地从储存器释放药学有效量的甲状旁腺激素。间歇性地释放甲状旁腺激素，例如每天一次（例如两个月，十个月或更长时间）释放。该装置还可以包括含有骨吸收抑制剂或其它用于释放的药物的储存器。该装置可用于输送PTH以治疗和预防骨丢失，例如与骨质疏松症有关。

38. 发明申请

US20080221557A1 METHOD OF OPENING RESERVOIR OF CONTAINMENT DEVICE 有权
标题翻译：打开储存装置储存的方法
公开(公告)号：US20080221557A1
公开(公告)日：2008-09-11
申请号：US11925466
申请日：2007-10-26
申请人： John T. Santini , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard
发明人： John T. Santini , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard
IPC分类号： B23K26/36 , A61K9/22
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to said reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor.
摘要翻译：提供了一种用于选择性地打开容纳储存器的方法。该方法包括提供一种装置，其包括基板，其中至少一个储存器定位并被储存器盖覆盖; 并将激光引导到所述储存器盖以使储存器盖分解或变得可渗透。该装置可以是可植入医疗装置。储存器可以含有用于控制释放的药物或生物传感器。

39. 发明申请

US20080071252A1 METHOD OF ACTUATING IMPLANTED MEDICAL DEVICE 有权
标题翻译：实施植入式医疗装置的方法
公开(公告)号：US20080071252A1
公开(公告)日：2008-03-20
申请号：US11925507
申请日：2007-10-26
申请人： John Santini , Michael Cima , Robert Langer , Dennis Ausiello , Norman Sheppard
发明人： John Santini , Michael Cima , Robert Langer , Dennis Ausiello , Norman Sheppard
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor located in the reservoir, and (iii) control circuitry and a power source for disintegrating or permeabilizing the reservoir cap, and (iv) an external interface to receive incident light energy; and directing focused light to the external interface of the implanted device to actuate disintegration or permeabilization of the reservoir cap to release the drug or expose the sensor. The device may implanted onto or into the sclera or other tissue surface of the eye of the patient. The focused light may be laser light which may be used to transmit power or data to the device.
摘要翻译：提供了用于治疗或诊断患者的方法。该方法包括向患者植入一种装置，该装置包括：（i）至少一个储存器定位并被第一储存器盖覆盖的基底，（ii）位于储存器中的药物或传感器，以及（iii）控制电路以及用于使储存器盖分解或渗透的电源，以及（iv）外部接口以接收入射光能; 并将聚焦的光引导到植入装置的外部界面以致驱动贮存器盖的分解或透化以释放药物或暴露传感器。该装置可植入患者眼睛的巩膜或其他组织表面上或其中。聚焦光可以是可以用于将功率或数据传输到设备的激光。

40. 发明申请

US20070275035A1 Minimally Invasive Medical Implant Devices for Controlled Drug Delivery 审中-公开
标题翻译：用于控制药物递送的微创医学植入装置
公开(公告)号：US20070275035A1
公开(公告)日：2007-11-29
申请号：US11753330
申请日：2007-05-24
申请人： Stephen J. Herman , John T. Santini , Mark A. Staples
发明人： Stephen J. Herman , John T. Santini , Mark A. Staples
IPC分类号： A61K9/14 , A61M31/00
CPC分类号： A61K9/0097 , A61K9/0024 , A61M31/002
摘要： Implantable medical devices and methods of use are provided for controlled drug delivery. The devices may include an elongated body dimensioned to facilitate minimally invasive and complete implantation into a patient, wherein the elongated body portion comprises a first, closed end portion, a second closed end portion and an intermediate portion disposed between and connected to the first closed end portion and the second closed end portion; two or more discrete reservoirs disposed in the elongated body portion, each reservoir having one or more openings; a drug formulation, which comprises at least one drug, disposed in the two more discrete reservoirs; and reservoir caps closing off the one or more openings of each reservoir, wherein release of the drug in vivo is controlled at least in part by the in vivo disintegration or permeabilization of the discrete reservoir caps.
摘要翻译：为可控制的药物输送提供可植入的医疗装置和使用方法。所述装置可以包括细长的主体，其尺寸适于促进对患者的微创和完全植入，其中所述细长主体部分包括第一封闭端部，第二封闭端部和设置在所述第一闭合端之间并连接到所述第一闭合端部分和第二封闭端部; 设置在细长主体部分中的两个或更多个离散储存器，每个储存器具有一个或多个开口; 一种药物制剂，其包含设置在两个更离散的储存器中的至少一种药物; 并且储存器盖封闭每个储存器的一个或多个开口，其中药物在体内的释放至少部分地通过离散储器盖的体内分解或透化来控制。

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