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21. 发明授权

US06453195B1 Closed loop drug delivery system and remote management thereof 有权
标题翻译：闭环药物输送系统及其远程管理
公开(公告)号：US06453195B1
公开(公告)日：2002-09-17
申请号：US09811685
申请日：2001-03-19
申请人： David L. Thompson
发明人： David L. Thompson
IPC分类号： A61N1362
CPC分类号： A61N1/30 , A61N1/3956
摘要： A transdermal drug delivery device in communication with at least one IMD is externally mounted to deliver pain analgesics and/or threshold reduction medications prior to or contemporaneous with a shock associated with a pacer, a defibrillator and similar therapy device. The drug delivery device includes an attachable strip with a storage for medications and is epidermally mounted. The medications are released into the bloodstream in response to an indication that the IMD is about to deliver a shock. The drug delivery device is adapted for use with various drugs. Further, the delivery of drugs could be controlled by the patient to provide a semi-automatic use and/or to terminate delay shock. The transdermal drug delivery device and the IMD include system status indicators to provide real-time operational data of the drug delivery device and the IMD individually and in combination. The drug delivery device is also implemented with a CHF monitor to treat CHF patients.
摘要翻译：与至少一个IMD通信的透皮药物递送装置被外部安装以在与起搏器，除颤器和类似治疗装置相关的冲击之前或同时发生疼痛镇痛药和/或阈值减少药物。药物递送装置包括具有用于药物的储存器的可附接条带并且被表皮地安装。药物被释放到血液中，以反映IMD即将发生冲击的迹象。药物输送装置适用于各种药物。此外，药物的输送可以由患者控制以提供半自动使用和/或终止延迟休克。透皮药物递送装置和IMD包括系统状态指示器，以单独和组合地提供药物递送装置和IMD的实时操作数据。药物输送装置还用CHF监测器来治疗CHF患者。

22. 发明授权

US06438422B1 Power dissipation reduction in medical devices using adiabatic logic 失效
标题翻译：使用绝热逻辑的医疗设备功耗降低
公开(公告)号：US06438422B1
公开(公告)日：2002-08-20
申请号：US09467288
申请日：1999-12-20
申请人： Carl A. Schu , Daniel R. Greeninger , David L. Thompson
发明人： Carl A. Schu , Daniel R. Greeninger , David L. Thompson
IPC分类号： A61N1362
CPC分类号： G06F1/324 , A61N1/025 , A61N1/3605 , A61N1/362 , A61N1/378 , G06F1/3203 , G06F1/3296 , H03K19/0019 , Y02D10/126 , Y02D10/172
摘要： A system for minimizing power dissipation within an implantable medical device through use of adiabatic logic is disclosed. The system includes a first and a second sub-circuit of the implantable medical device. An electrical connection interconnects the first and the second sub-circuits, the electrical connection including a capacitive element. Circuitry, which charges the capacitive element of the electrical connection to generate a ramp logic signal, is connected to the capacitive element. The ramp logic signal includes a frequency of less than 500 kilohertz, thereby creating a low frequency, low power system which reduces energy dissipation to the surrounding environment.
摘要翻译：公开了一种通过使用绝热逻辑来最小化可植入医疗装置内的功率耗散的系统。该系统包括可植入医疗装置的第一和第二子电路。电连接将第一和第二子电路互连，电连接包括电容元件。将电连接的电容元件充电以产生斜坡逻辑信号的电路连接到电容元件。斜坡逻辑信号包括小于500千赫的频率，从而产生低频，低功率系统，从而减少对周围环境的能量耗散。

23. 发明授权

US06438418B1 Method and apparatus for reduction of pain from electric shock therapies 有权
标题翻译：减轻电击治疗疼痛的方法和装置
公开(公告)号：US06438418B1
公开(公告)日：2002-08-20
申请号：US09568237
申请日：2000-05-05
申请人： Charles D. Swerdlow , Neal R. Swerdlow , James E. Brewer
发明人： Charles D. Swerdlow , Neal R. Swerdlow , James E. Brewer
IPC分类号： A61N1362
CPC分类号： A61N1/395 , A61N1/36021 , A61N1/36071 , A61N1/39 , A61N1/3906 , A61N1/3956
摘要： A method and apparatus for pretreating a patient prior to a therapeutic painful stimulus, comprising the application of pain inhibiting stimuli to a patient prior to an application of the therapeutic painful stimulus. Applying pain inhibiting stimuli comprises the steps of sensing a need for the therapeutic painful stimulus, preparing to deliver the pain inhibiting stimuli to the patient prior to applying the therapeutic painful stimulus, and delivering the pain inhibiting stimuli to the patient prior to applying the therapeutic painful stimulus. The method and apparatus are embodied in modern, fully automatic, fully implantable, single or dual chamber atrial or ventricular cardioverter-defibrillators. The pain inhibiting prepulse method is intended primarily for use in conscious patients but may also be used in sleeping patients.
摘要翻译：一种用于在治疗性疼痛刺激之前预处理患者的方法和装置，包括在施用治疗性疼痛刺激之前向患者施用疼痛抑制刺激物。应用疼痛抑制刺激包括以下步骤：感觉需要治疗性疼痛刺激，准备在施用治疗性疼痛刺激之前将疼痛抑制刺激递送给患者，以及在施用治疗性疼痛之前将疼痛抑制刺激递送给患者刺激。该方法和装置体现在现代，全自动，完全可植入，单室或双室心房或心室心律转复除颤器中。疼痛抑制前脉冲法主要用于有意识的患者，但也可用于睡眠患者。

24. 发明授权

US06415180B1 Device and method for ventricular tracking and pacing 有权
公开(公告)号：US06415180B1
公开(公告)日：2002-07-02
申请号：US09420679
申请日：1999-10-19
申请人： Andrew P. Kramer , Albert Maarse , Jeffrey E. Stahmann , Rene H. Wentkowski
发明人： Andrew P. Kramer , Albert Maarse , Jeffrey E. Stahmann , Rene H. Wentkowski
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/368
摘要： A device and method for multi chamber pacing a patient's heart having heart failure and intrinsic conduction, wherein ventricular tracking is used to pace the ventricle when the sinus rate exceeds a preset atrial maximum tracking rate. The ventricular tracking pacemaker increases the range of pacing the ventricle. The ventricular tracking minimizes the loss of ventricular pacing caused by intrinsic conduction when the sinus rate is below an atrial maximum tracking rate, and it induces a new ventricular pacing behavior for sinus rates above the atrial maximum tracking rate without any significant pacing hysteresis as the sinus rate returns towards the lower rate limit.

25. 发明授权

US06353759B1 Cardiac rhythm management system promoting a trial pacing 有权
标题翻译：心律管理系统促进心房起搏
公开(公告)号：US06353759B1
公开(公告)日：2002-03-05
申请号：US09693402
申请日：2000-10-20
申请人： Jesse W. Hartley , Andrew P. Kramer , Jeffrey E. Stahmann , David B. Krig
发明人： Jesse W. Hartley , Andrew P. Kramer , Jeffrey E. Stahmann , David B. Krig
IPC分类号： A61N1362
CPC分类号： A61N1/3621 , A61N1/3627 , A61N1/3682 , A61N1/395 , A61N1/3962 , A61N1/3987
摘要： A cardiac rhythm management system includes an atrial pacing preference (APP) filter for promoting atrial pacing. The APP filter includes an infinite impulse response (IIR) or other filter that controls the timing of delivery of atrial pacing pulses. The atrial pacing pulses are delivered at an APP-indicated pacing rate that is typically at a small amount above the intrinsic atrial heart rate. For sensed beats, the APP indicated rate is increased until it becomes slightly faster than the intrinsic atrial heart rate. The APP-indicated pacing rate is then gradually decreased to search for the underlying intrinsic atrial heart rate. Then, after a sensed atrial beat, the APP filter again increases the pacing rate until it becomes faster than the intrinsic atrial rate by a small amount. As a result, most atrial heart beats are paced, rather than sensed. This decreases the likelihood of the occurrence of an atrial tachyarrhythima, such as atrial fibrillation. The decreased likelihood of atrial tachyarrhythmia, in turn, decreases the likelihood of inducing a ventricular arrhythmia, either as a result of the atrial tachyarrhythmia, or as the result of delivering a defibrillation shock to treat the atrial tachyarrhythmia.
摘要翻译：心律管理系统包括用于促进心房起搏的心房起搏偏好（APP）滤波器。 APP滤波器包括无限脉冲响应（IIR）或其他滤波器，其控制心房起搏脉冲的递送时间。心房起搏脉冲以APP指示的起搏速率递送，其通常在固有心房心率以上的小量起搏。对于检测到的心跳，APP指示的速率增加，直到其变得比内在的心房心率稍快。然后APP指示的起搏率逐渐降低，以寻找潜在的固有心房心率。然后，在感觉到的心房搏动之后，APP滤波器再次增加起搏速率，直到其变得比固有心房率小得多。因此，大多数心房心脏跳动起搏，而不是感觉到。这降低了房性快速性心律失常发生的可能性，例如房颤。房性心律失常的可能性降低反过来也降低了引起室性心律失常的可能性，由于房性快速性心律失常，或作为递送除颤休克以治疗房性快速性心律失常的结果。

26. 发明授权

US06332096B1 Augmentation of electrical conduction and contractility by biphasic cardiac pacing 有权
标题翻译：通过双相心脏起搏增强电传导和收缩
公开(公告)号：US06332096B1
公开(公告)日：2001-12-18
申请号：US09504710
申请日：2000-02-16
申请人： Morton M. Mower
发明人： Morton M. Mower
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/368
摘要： Augmentation of electrical conduction and contractility by biphasic cardiac pacing. A first stimulation phase is administered to the muscle tissue. This first stimulation phase has a predefined polarity, amplitude and duration. A second stimulation phase is then administered to the muscle tissue. This second phase also has a predefined polarity, amplitude and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is first applied and followed by cathodal stimulation. In this fashion, pulse conduction through the cardiac muscle is improved together with the increase in contractility. The technique can also be applied to large muscle tissue stimulation other than cardiac muscle.
摘要翻译：通过双相心脏起搏增强电传导和收缩。向肌肉组织施用第一刺激阶段。该第一刺激阶段具有预定义的极性，幅度和持续时间。然后将第二刺激期施用于肌肉组织。该第二阶段也具有预定义的极性，幅度和持续时间。顺序应用两个阶段。与目前的想法相反，首先应用阳极刺激，然后进行阴极刺激。以这种方式，通过心肌的脉冲传导随着收缩性的增加而提高。该技术也可应用于心肌以外的大肌肉组织刺激。

27. 再颁专利

USRE37454E1 Cardiac pacemaker with hystersis behavior 失效
标题翻译：心脏起搏器与hystersis行为
公开(公告)号：USRE37454E1
公开(公告)日：2001-11-27
申请号：US08547350
申请日：1995-10-24
申请人： Richard Sutton , Ivan Bourgeois
发明人： Richard Sutton , Ivan Bourgeois
IPC分类号： A61N1362
CPC分类号： A61N1/365
摘要： A pacemaker having a hysteresis feature which permits intrinsic heart activity, controlled by the sinus node to resume optimally after pacing. The pacemaker has a programmable lower rate and upper rate, a programmable lower hysteresis rate (LRH) corresponding to a lower rate hysteresis interval (LRHI), and a programmable rate (IR) intermediate an upper pacing rate (UR) and a lower pacing rate (LR). A microprocessor measures the average rate of change MAVG in the intervals between consecutive ventricular depolarizations, and compares the last intrinsic escape interval RRN to the lower rate hysteresis interval (LRHI). If the last intrinsic escape interval RRN is longer than the lower rate hysteresis interval (LRHI), and if the value of MAVG is greater than a first preselected value SL1 but less than a second preselected value SL2, the pacemaker stimulates at the lower rate hysteresis (LRH) and thereafter gradually increases the pacing rate up to the intermediate rate (IR). A time counter maintains a continuous pacing at the intermediate rate (IR) for a predefined period of time, and the pacing rate is gradually decreased toward the lower pacing rate (LR).
摘要翻译：具有滞后特征的起搏器，其允许内部心脏活动，由起搏节点控制，以便在起搏之后恢复最佳。起搏器具有可编程的较低速率和较高速率，对应于较低速率滞后间隔（LRHI）的可编程较低滞后速率（LRH）和中间起搏速率（UR）和较低起搏速率的可编程速率（IR）（LR）。微处理器测量连续心室去极化之间间隔的平均变化率MAVG，并将最后的内在逃逸间隔RRN与较低速率滞后间隔（LRHI）进行比较。如果最后一个内在逃逸间隔RRN大于较低速率滞后间隔（LRHI），并且如果MAVG的值大于第一预选值SL1但小于第二预选值SL2，起搏器以较低的速率滞后（LRH）刺激，然后逐渐增加起搏速率直到中间速率（IR）。时间计数器以预定的时间段维持中间速率（IR）的连续起搏，并且起搏速率朝向较低的起搏速率（LR）逐渐降低。

28. 发明授权

US06321115B1 Noise detection system and method for use in an implantable medical device 有权
标题翻译：用于可植入医疗装置的噪声检测系统和方法
公开(公告)号：US06321115B1
公开(公告)日：2001-11-20
申请号：US09453654
申请日：1999-12-03
申请人： Gabriel A. Mouchawar , James D. Causey, III , Wayne A. Morgan , Mae-Mae Shieh , Curtis A. Knight
发明人： Gabriel A. Mouchawar , James D. Causey, III , Wayne A. Morgan , Mae-Mae Shieh , Curtis A. Knight
IPC分类号： A61N1362
CPC分类号： A61N1/37 , A61N1/3718
摘要： An implantable cardiac stimulation device includes a system for detecting noise in an electrogram signal. The system for detecting noise generates an event signal when the electrogram signal exceeds a threshold. A timer times a refractory time period responsive to an event signal. During the refractory time period, a zero crossing detector generates a zero crossing signal when the electrogram signal transitions between positive and negative values. A counter counts the zero crossing signals during the time period and a comparator determines if the counter reached a predetermined count during the time period. If the counter exceeds a programmable count, a noise detection flag is set and the controller is alerted to the presence of noise in its input signal.
摘要翻译：可植入心脏刺激装置包括用于检测电描记图信号中的噪声的系统。当电图信号超过阈值时，用于检测噪声的系统产生事件信号。响应于事件信号，定时器响应不期望时间。在不耐时间期间，当电图信号在正值和负值之间转换时，过零检测器产生过零信号。计数器在该时间周期期间对过零信号进行计数，并且比较器确定在该时间段期间计数器是否达到预定计数。如果计数器超过可编程计数，则设置噪声检测标志，并且在其输入信号中警告控制器存在噪声。

29. 发明授权

US06292693B1 Contractility enhancement using excitable tissue control and multi-site pacing 有权
标题翻译：使用可兴奋的组织控制和多部位起搏进行收缩性增强
公开(公告)号：US06292693B1
公开(公告)日：2001-09-18
申请号：US09260769
申请日：1999-03-02
申请人： Nissim Darvish , Itzhak Shemer
发明人： Nissim Darvish , Itzhak Shemer
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/362 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： A method and apparatus for stimulating cardiac tissue. Pacing pulses are applied to the heart at multiple sites in at least two different chambers of the heart; and an Excitable Tissue Control (ETC) signal is applied in a vicinity of one or more of the pacing sites following application of the pacing pulse at the site.
摘要翻译：一种刺激心脏组织的方法和装置。起搏脉冲在心脏的至少两个不同室中的多个部位施加于心脏; 并且在现场施加起搏脉冲之后，在一个或多个起搏部位的附近施加可激励组织控制（ETC）信号。

30. 发明授权

US06285909B1 Preserving patient specific data in implantable pulse generator systems 有权
标题翻译：在植入式脉冲发生器系统中保存患者特定数据
公开(公告)号：US06285909B1
公开(公告)日：2001-09-04
申请号：US09321254
申请日：1999-05-27
申请人： Robert J. Sweeney , Brian Brandell , Bruce H. KenKnight
发明人： Robert J. Sweeney , Brian Brandell , Bruce H. KenKnight
IPC分类号： A61N1362
CPC分类号： A61N1/37252 , A61N1/37288
摘要： A method and a system for preserving patient specific data in implantable pulse generator systems. A communication link is established with a first implantable pulse generator. Electronic cardiac data contained within the first implantable pulse generator is retrieved through the communication link. The electronic cardiac data is then electronically downloaded to a second implantable pulse generator. Prior to downloading, the electronic cardiac data can be formatted into a format compatible with the second implantable pulse generator.
摘要翻译：一种用于在植入式脉冲发生器系统中保存患者特定数据的方法和系统。建立与第一可植入脉冲发生器的通信链路。通过通信链路检索包含在第一可植入脉冲发生器内的电子心脏数据。然后将电子心脏数据电子下载到第二可植入脉冲发生器。在下载之前，电子心脏数据可以被格式化成与第二可植入脉冲发生器兼容的格式。

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