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21. 发明授权

US08172994B2 Biomaterial measuring device and manufacturing method thereof 有权
标题翻译：生物材料测量装置及其制造方法
公开(公告)号：US08172994B2
公开(公告)日：2012-05-08
申请号：US10582529
申请日：2004-12-10
申请人： Jin-Woo Lee
发明人： Jin-Woo Lee
IPC分类号： G01N27/26 , G01N31/00 , G01N33/50 , G01N33/487 , C12Q1/00 , C12M1/34 , C12M3/00 , H01R43/20
CPC分类号： G01N33/5438 , G01N21/253 , G01N21/78 , G01N27/3272 , G01N2021/7783 , Y10T29/49208
摘要： A method of producing a biomaterial measuring device is disclosed. The method includes forming a plurality of reactions elements, to which an assay reagent is applied, on a first substrate, cutting the resulting first substrate in a unit of individual reaction element, and attaching a first substrate piece, which is formed by cutting the resulting first substrate in the unit of individual reaction element, to a predetermined portion of a second substrate. In the biomaterial measuring device, since a material cost in minimized and it is easy to automate production, it is possible to reduce a production, it is possible to reduce a production cost.
摘要翻译：公开了一种制造生物材料测量装置的方法。该方法包括在第一基板上形成多个反应元件，将测定试剂施加到其上，以单个反应元件为单位切割得到的第一基板，并且通过切割所形成的第一基板单个反应元件单元中的第一衬底到第二衬底的预定部分。在生物材料测量装置中，由于最小化材料成本并且易于自动化生产，因此可以减少生产，可以降低生产成本。

22. 发明申请

US20120013911A1 DEVICE AND METHOD FOR OPTICAL SENSING OF SUBSTANCES OR ENVIRONMENTAL CONDITIONS 有权
标题翻译：物质或环境条件的光学感测装置和方法
公开(公告)号：US20120013911A1
公开(公告)日：2012-01-19
申请号：US13233158
申请日：2011-09-15
申请人： Shlomo RUSCHIN , Tanya HUTTER
发明人： Shlomo RUSCHIN , Tanya HUTTER
IPC分类号： G01J3/45
CPC分类号： G01N21/77 , G01N33/0054 , G01N2021/7723 , G01N2021/773 , G01N2021/7773 , G01N2021/7783 , G01N2021/7793 , G01N2021/7796 , Y02A50/246
摘要： A device for optical sensing of substances or environmental conditions in a fluid includes a number of non-overlapping adjacent sensing elements, each having a layered optical element for generating a wavelength-specific interference effect and being treated so as to respond to the presence of a predefined substance or a predefined environmental condition to cause an optically detectable change. The sensing elements are distinct from each other both in their wavelength-specific interference effect and in the corresponding optically detectable change. As a result, when the device is illuminated by a common illumination beam of multi-wavelength illumination, spectral analysis performed on the reflected or transmitted illumination enables simultaneous sensing of a plurality of substances or environmental conditions. In certain preferred implementations, the layered optical element includes at least one layer of porous silicon.
摘要翻译：用于光学感测流体中的物质或环境条件的装置包括多个不重叠的相邻感测元件，每个感测元件具有用于产生波长特异性干扰效应的分层光学元件，并被处理以响应于预定义物质或预定的环境条件以引起光学上可检测的变化。感测元件在其波长特异性干扰效应和相应的可光学检测变化中彼此不同。结果，当通过多波长照明的公共照明光束照射该装置时，对反射或透射照明执行的光谱分析能够同时检测多种物质或环境条件。在某些优选实施方案中，层状光学元件包括至少一层多孔硅。

23. 发明申请

US20110318230A1 Chemical Sensor with an Indicator Dye 审中-公开
标题翻译：带有指示剂染料的化学传感器
公开(公告)号：US20110318230A1
公开(公告)日：2011-12-29
申请号：US12954871
申请日：2010-11-27
申请人： Sergey Sarkisov , Wiaczeslaw Mazuruk
发明人： Sergey Sarkisov , Wiaczeslaw Mazuruk
IPC分类号： G01N21/78 , B82Y15/00
CPC分类号： G01N21/77 , C08K3/08 , G01N21/274 , G01N21/783 , G01N21/80 , G01N2021/7726 , G01N2021/773 , G01N2021/7783 , G01N2201/0696
摘要： A chemical sensor based on an indicator dye wherein a light transmissive element containing the indicator dye is made of a hygroscopic polymer. The polymer may be, for example, a polyimide or PMMA or other polymer. In an alternative embodiment the light transmissive element is doped with metal nanocolloidal particles. One embodiment may include a reference photodiode and differential amplifier to compensate for the fluctuations of the intensity of the light source. The light source may be pulse modulated. The sensor may include calibration means comprising a reference sample of the chemical to be detected and a precision delivery means. A method of fabricating the polymer and metal nanocolloid is disclosed wherein the nanocolloid is produced by generating a pulsed laser plasma in a suspension of metal particles and an organic solvent and adding the resulting solvent colloid to a solution containing the polymer.
摘要翻译：一种基于指示剂染料的化学传感器，其中含有指示剂染料的透光元件由吸湿性聚合物制成。聚合物可以是例如聚酰亚胺或PMMA或其它聚合物。在替代实施例中，透光元件掺杂有金属纳米胶体颗粒。一个实施例可以包括参考光电二极管和差分放大器以补偿光源的强度的波动。光源可以被脉冲调制。传感器可以包括校准装置，其包括待检测的化学物质的参考样品和精密传送装置。公开了一种制造聚合物和金属纳米胶体的方法，其中纳米胶体通过在金属颗粒和有机溶剂的悬浮液中产生脉冲激光等离子体并将所得溶剂胶体加入到含有聚合物的溶液中来制备。

24. 发明申请

US20100323382A1 METHOD FOR ASSAYING BILIRUBIN AND ASSAY INSTRUMENT USED IN BILIRUBIN ASSAY 有权
标题翻译：用于测定胆红素测定的方法和测定用于胆红素测定的仪器
公开(公告)号：US20100323382A1
公开(公告)日：2010-12-23
申请号：US12526214
申请日：2008-04-17
申请人： Toshio Takama
发明人： Toshio Takama
IPC分类号： C12Q1/26 , C12M1/34
CPC分类号： G01N33/728 , C12Q1/26 , G01N21/78 , G01N33/523 , G01N2021/0325 , G01N2021/7773 , G01N2021/7783 , G01N2800/085
摘要： A method for assaying bilirubin in which a dry reagent is used, which is capable of accelerating the reaction of bilirubin oxidase, and an assay instrument to be used in the method for assaying bilirubin, are provided. The method for assaying bilirubin is characterized in that a biological sample and a bilirubin oxidase-containing dry reagent are mixed first, and then the mixture obtained and a surfactant-containing dry reagent are mixed. An assay instrument (1) to be used in bilirubin assay is characterized in that a bilirubin oxidase and a surfactant are arranged in any of a sample supply part (11), passages (12, 13, 14), and a detection part (15) in a manner such that the bilirubin oxidase is positioned closer to the sample supply part (11) than the surfactant is.
摘要翻译：本发明提供了能够加速胆红素氧化酶的反应的使用干试剂的胆红素的测定方法和用于测定胆红素的方法中使用的测定仪器。用于测定胆红素的方法的特征在于首先混合生物样品和含有胆红素氧化酶的干试剂，然后将得到的混合物和含表面活性剂的干试剂混合。用于胆红素测定的测定仪器（1）的特征在于，将胆红素氧化酶和表面活性剂配置在样品供给部（11），通路（12,13,14）和检测部（15 ），使得胆红素氧化酶比表面活性剂更靠近样品供给部（11）。

25. 发明申请

US20100231899A1 SENSOR FOR THIOL ANALYTES 失效
标题翻译： THIOL分析仪传感器
公开(公告)号：US20100231899A1
公开(公告)日：2010-09-16
申请号：US12574511
申请日：2009-10-06
申请人： Michael HULKO , Ingeborg HOSPACH , Gabriele NELLES , Jens ULMER
发明人： Michael HULKO , Ingeborg HOSPACH , Gabriele NELLES , Jens ULMER
IPC分类号： G01J1/42
CPC分类号： G01N21/77 , C12Q1/005 , G01N21/783 , G01N2021/7773 , G01N2021/7776 , G01N2021/7783 , G01N2021/7786
摘要： The present invention relates to a sensor for thiol analytes, to a sensor array and to a method of detecting thiol analytes using said sensor.
摘要翻译：本发明涉及用于硫醇分析物的传感器，传感器阵列和使用所述传感器检测硫醇分析物的方法。

26. 发明申请

US20100129260A1 GELATION MEASURING APPARATUS AND SAMPLE CELL 审中-公开
标题翻译：凝胶测量装置和样品池
公开(公告)号：US20100129260A1
公开(公告)日：2010-05-27
申请号：US12451203
申请日：2007-01-05
申请人： Yoshiaki Shirasawa
发明人： Yoshiaki Shirasawa
IPC分类号： G01N21/00
CPC分类号： G01N21/5907 , G01N21/83 , G01N2021/7783 , G01N2400/50
摘要： It is an object of the present invention to allow rapid and accurate measurement of the concentration of substances such as endotoxins, β-D glucans and the like that is measured by gelation reactions. In a gelation-reaction measuring apparatus for measuring a target substance in a sample via a gelation reaction, a sample cell for housing a sample containing the target substance to be measured and a solution containing a reagent that gelates is irradiated with irradiation light from a light emitting diode 14. The solution in the sample cell 13 is stirred by a stir bar 25 to generate minute and uniform gel particles, through which the irradiation light passes. The light transmitted through the gel particles generated in the sample cell 13 is detected by a photodiode 22, and the detection output thereof is used to measure the concentration of the substance in the solution by a computer 21 on the basis of the lag time until the amount of transmitted light detected reaches or falls below a set level.
摘要翻译：本发明的目的是允许通过凝胶化反应测量的内毒素，β-葡聚糖等物质的浓度的快速和准确的测量。在通过凝胶化反应测定样品中的目标物质的凝胶化反应测定装置中，将含有待测物体的样品的容纳样品池和含有凝胶化试剂的溶液用来自光的照射光照射样品池13中的溶液被搅拌棒25搅拌以产生微小且均匀的凝胶颗粒，照射光通过该粒子。通过光电二极管22检测透过在样品池13中产生的凝胶颗粒的光，其检测输出用于通过计算机21基于滞后时间来测量溶液中物质的浓度，直到检测到的透射光的量达到或低于设定水平。

27. 发明授权

US07611671B2 Reduction of carbon monoxide interference in gaseous analyte detectors 有权
标题翻译：降低气态分析物检测器中的一氧化碳干扰
公开(公告)号：US07611671B2
公开(公告)日：2009-11-03
申请号：US11250958
申请日：2005-10-14
申请人： David J. Anvar , David J. Chazan , Bryan P. Flaherty , Bhairavi R. Parikh
发明人： David J. Anvar , David J. Chazan , Bryan P. Flaherty , Bhairavi R. Parikh
IPC分类号： G01N33/497
CPC分类号： G01N21/783 , G01N21/76 , G01N33/0037 , G01N33/0059 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y02A50/245 , Y10T436/177692 , Y10T436/179228
摘要： Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.
摘要翻译：通过将一氧化碳清除剂并入装置的内部或在装置包装中，用于检测气态样品中一氧化氮和/或其它气态分析物的高灵敏度装置得到改善。通过用于建筑外壳中的塑料或释放一氧化碳的装置内的任何物质，在装置的壳体内释放一氧化碳导致由于一氧化碳和一氧化氮之间的竞争导致的结合的灵敏度损失设备传感器上的站点。清除剂通过催化一氧化碳氧化成竞争力较低的二氧化碳或通过亲和型或共价结合固定一氧化碳来纠正这一点。对一氧化氮以外的分析物也能达到类似的效果，但同样遇到一氧化碳与传感器结合的干扰。

28. 发明申请

US20090263071A1 Optical environmental sensor and method for the manufacturing of the sensor 有权
标题翻译：光学环境传感器和传感器制造方法
公开(公告)号：US20090263071A1
公开(公告)日：2009-10-22
申请号：US12384771
申请日：2009-04-08
申请人： Alexander Stuck , Harald Walter , Marc Schnieper
发明人： Alexander Stuck , Harald Walter , Marc Schnieper
IPC分类号： G02B6/00
CPC分类号： G01N21/7743 , G01N2021/7723 , G01N2021/7783
摘要： A sensor which reacts on influences from an environment. The sensor includes a zero-order diffractive color filter. The zero-order diffractive color filter includes a high-index waveguide layer, a zero-order diffractive grating structure and a layer of an reactive material, wherein the reactive material is in contact with the environment and wherein the reactive material changes its optical properties upon interaction with the environment. The reactive material is embedded in the waveguide layer and/or the reactive material is located at a maximum distance d from the waveguide layer. The distancing is effected by an intra layer having a low index of refraction.
摘要翻译：对环境影响作出反应的传感器。传感器包括零级衍射滤色器。零级衍射滤色器包括高折射率波导层，零级衍射光栅结构和反应性材料层，其中反应性材料与环境接触，并且其中反应性材料改变其光学性质与环境的互动。反应性材料嵌入在波导层中和/或反应性材料位于与波导层最大距离d处。距离由具有低折射率的内层实现。

29. 发明授权

US07580128B2 Linear optical loss probe 有权
标题翻译：线性光损耗探头
公开(公告)号：US07580128B2
公开(公告)日：2009-08-25
申请号：US11893033
申请日：2007-08-14
申请人： Mark Selker
发明人： Mark Selker
IPC分类号： G01N21/00
CPC分类号： G01N21/51 , G01N21/75 , G01N21/84 , G01N2021/4707 , G01N2021/4709 , G01N2021/7783
摘要： An optical loss probe utilized as a bioreactor process monitor manifesting a substantially linear response in optical loss vs. concentration of scatterers present in an aqueous medium in the range of between about 0 AU and about 4.0 AU, said probe comprising: i) a light source, ii) an optical detector, and iii) an optical gap between said light source and said optical detector, said optical detector having a receiving aperture configured such that the solid angle of acceptance of the light passing through said optical gap and impinging on said optical detector is less than π/50 radians.
摘要翻译：一种用作生物反应器过程监测器的光学损耗探针，其表现出在水介质中存在于约0A0至约4.0AU范围内的散射体的光学损耗与散射体的基本线性响应，所述探针包括：i）光源，ii）光学检测器，以及iii）所述光源和所述光学检测器之间的光学间隙，所述光学检测器具有接收孔，所述接收孔被配置为使得通过所述光学间隙的光的入射角接近所述光学检测器小于pi / 50弧度。

30. 发明申请

US20090035871A1 Method for measuring maturity degree of compost and measuring solution 有权
标题翻译：堆肥和测量溶液成熟度测定方法
公开(公告)号：US20090035871A1
公开(公告)日：2009-02-05
申请号：US11895193
申请日：2007-08-23
申请人： Shinya Shimizu , Tokuo Matsushima
发明人： Shinya Shimizu , Tokuo Matsushima
IPC分类号： G01N21/00
CPC分类号： G01N21/78 , G01N2021/7783
摘要： A method for measuring the maturity degree of a compost capable of determining the maturity degree of a compost purportedly of a product in a short period of time (10 to 30 minutes) by compost manufacturers, users and even those with insufficient expertise and experiences such as buyers in the distribution industry on site and also capable of determining it according to the maturity stage in an easy and cost-effective manner, and a measuring solution. A specific measuring solution is added to the compost to flocculate a compost extract containing humic-like substance and decomposed organic matter, and a liquid phase is acquired by precipitating the compost extract by the solid/liquid separation. Based on the correlation in which the absorbency of the liquid phase declines as the compost becomes more mature, the maturity degree of the compost is measured from the color contrasting density of the liquid phase.
摘要翻译：一种衡量堆肥成熟度的方法，该方法能够通过堆肥生产商，用户甚至具有不足的专业知识和经验的短时间（10至30分钟）来确定据称是产品的堆肥成熟度的成熟度现场分销行业的买家，也可以根据成熟阶段以简单，经济有效的方式进行确定，并提供测量解决方案。将特定的测量溶液加入到堆肥中以絮凝含有腐殖质和分解的有机物的堆肥提取物，并通过固/液分离沉淀堆肥提取物获得液相。基于堆肥变得越来越成熟的液相吸收率下降的相关性，堆肥的成熟度由液相的颜色对比密度测定。

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