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1. 发明申请

US20100256514A1 Analyzer for Nitric Oxide in Exhaled Breath with Multiple-Use Sensor 有权
标题翻译：多用途传感器呼气呼吸中一氧化氮分析仪
公开(公告)号：US20100256514A1
公开(公告)日：2010-10-07
申请号：US12416760
申请日：2009-04-01
申请人： David J. Chazan , Bhairavi R. Parikh , Bryan P. Flaherty , David J. Anvar , Brian A. Awabdy
发明人： David J. Chazan , Bhairavi R. Parikh , Bryan P. Flaherty , David J. Anvar , Brian A. Awabdy
IPC分类号： A61B5/08
CPC分类号： G01N33/0037 , G01N21/783 , G01N33/497 , Y02A50/245
摘要： A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NOx-free air in a controlled manner, preferably in pulses separated by equilibration periods.
摘要翻译：呼吸密度高达200 ppb或以下的一氧化氮高灵敏度分析仪，含有细胞色素C的传感器可以多种用途，无需为每次使用安装新的传感器。该功能通过在每次使用后通过以受控方式吹扫传感器和周围区域以无NOx的空气，优选地以平衡周期分开的脉冲来再生分析器来实现。

2. 发明授权

US08206311B2 Analyzer for nitric oxide in exhaled breath with multiple-use sensor 有权
标题翻译：多用途传感器呼气中一氧化氮分析仪
公开(公告)号：US08206311B2
公开(公告)日：2012-06-26
申请号：US12416760
申请日：2009-04-01
申请人： David J. Chazan , Bhairavi R. Parikh , Bryan P. Flaherty , David J. Anvar , Brian A. Awabdy
发明人： David J. Chazan , Bhairavi R. Parikh , Bryan P. Flaherty , David J. Anvar , Brian A. Awabdy
IPC分类号： A61B5/08 , G01N33/497
CPC分类号： G01N33/0037 , G01N21/783 , G01N33/497 , Y02A50/245
摘要： A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NOx-free air in a controlled manner, preferably in pulses separated by equilibration periods.
摘要翻译：呼吸密度高达200 ppb或以下的一氧化氮高灵敏度分析仪，含有细胞色素C的传感器具有多种用途，无需为每次使用安装新的传感器。该功能通过在每次使用后通过以受控方式吹扫传感器和周围区域以无NOx的空气，优选地以平衡周期分开的脉冲来再生分析器来实现。

3. 发明授权

US07611671B2 Reduction of carbon monoxide interference in gaseous analyte detectors 有权
标题翻译：降低气态分析物检测器中的一氧化碳干扰
公开(公告)号：US07611671B2
公开(公告)日：2009-11-03
申请号：US11250958
申请日：2005-10-14
申请人： David J. Anvar , David J. Chazan , Bryan P. Flaherty , Bhairavi R. Parikh
发明人： David J. Anvar , David J. Chazan , Bryan P. Flaherty , Bhairavi R. Parikh
IPC分类号： G01N33/497
CPC分类号： G01N21/783 , G01N21/76 , G01N33/0037 , G01N33/0059 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y02A50/245 , Y10T436/177692 , Y10T436/179228
摘要： Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.
摘要翻译：通过将一氧化碳清除剂并入装置的内部或在装置包装中，用于检测气态样品中一氧化氮和/或其它气态分析物的高灵敏度装置得到改善。通过用于建筑外壳中的塑料或释放一氧化碳的装置内的任何物质，在装置的壳体内释放一氧化碳导致由于一氧化碳和一氧化氮之间的竞争导致的结合的灵敏度损失设备传感器上的站点。清除剂通过催化一氧化碳氧化成竞争力较低的二氧化碳或通过亲和型或共价结合固定一氧化碳来纠正这一点。对一氧化氮以外的分析物也能达到类似的效果，但同样遇到一氧化碳与传感器结合的干扰。

4. 发明授权

US08932230B2 Controlling flow of exhaled breath during analysis 有权
标题翻译：在分析期间控制呼气的流量
公开(公告)号：US08932230B2
公开(公告)日：2015-01-13
申请号：US11348943
申请日：2006-02-06
申请人： Kevin Nason , Jonathan Fay , Bryan P. Flaherty , Bhairavi R. Parikh
发明人： Kevin Nason , Jonathan Fay , Bryan P. Flaherty , Bhairavi R. Parikh
IPC分类号： A61B5/08 , G01N33/497
CPC分类号： A61M16/085 , A61B5/0803 , A61B5/082 , A61B5/097 , A61M16/0003 , A61M16/0057 , A61M16/06 , A61M16/208 , A61M2016/0027 , A61M2205/3331 , G01N33/497
摘要： The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.
摘要翻译：通过分析装置的呼出气体的气体样品的流量由泵控制，并且在某些实施例中由两个泵控制。将分析物传感器放置在通过装置从主流分支的二次流中，进一步控制与传感器接触的呼吸的方式，持续时间和数量。

5. 发明授权

US5791347A Motion insensitive pulse detector 失效
标题翻译：运动不敏感脉冲检测器
公开(公告)号：US5791347A
公开(公告)日：1998-08-11
申请号：US700647
申请日：1996-08-14
申请人： Bryan P. Flaherty , Mark H. Sher , Richard G. Caro
发明人： Bryan P. Flaherty , Mark H. Sher , Richard G. Caro
IPC分类号： A61B5/021 , A61B5/022 , A61B5/024 , A61B8/04 , A61B8/08 , A61B9/00 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/02133 , A61B5/022 , A61B5/024 , A61B5/7207 , A61B5/7228 , A61B8/04 , A61B8/488 , A61B5/02225 , A61B5/6824
摘要： A motion insensitive pulse detector for detecting a patient's pulse includes an exciter adapted to be positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient. A noninvasive sensor is adapted to be positioned over the blood vessel and configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a received exciter waveform. A processor is coupled to the noninvasive sensor and configured to process the noninvasive sensor signal to determine the patient's pulse. Advantages of the invention include the ability to detect a patient's pulse even when the patient is moving or being moved by medical personnel.
摘要翻译：用于检测患者脉搏的运动不敏感脉冲检测器包括适于定位在患者的血管上并被配置为将传输的激励器波形诱导到患者体内的激励器。非侵入性传感器适于被定位在血管上方并且被配置为感测血液参数并且产生代表包含接收到的激励器波形的分量的血液参数的非侵入性传感器信号。处理器耦合到无创传感器并且被配置为处理无创传感器信号以确定患者的脉搏。本发明的优点包括即使当患者正在由医务人员移动或移动时也能够检测患者的脉搏。

6. 发明授权

US07133715B1 Hearing evaluation device with noise detection and evaluation capability 有权
标题翻译：具有噪声检测和评估能力的听力评估装置
公开(公告)号：US07133715B1
公开(公告)日：2006-11-07
申请号：US09479548
申请日：2000-01-07
申请人： Matthijs P. Smits , Bryan P. Flaherty
发明人： Matthijs P. Smits , Bryan P. Flaherty
IPC分类号： A61B5/04 , H04R29/00
CPC分类号： A61B5/121 , A61B5/04845 , A61B5/7203
摘要： An apparatus and method for evaluation of hearing loss is disclosed. The apparatus and method use evoked Auditory Brainstem Responses (ABR) to determine if the subject is able to hear click stimuli that are repeatedly administered. In order to facilitate efficient differentiation of the ABR from the accompanying noise, normative data is used to detect test conditions where physiological, non-physiological, and ambient acoustic noise would interfere with the progression of test.
摘要翻译：公开了一种用于评价听力损失的装置和方法。该装置和方法使用诱发的听觉脑干反应（ABR）来确定受试者是否能够听到重复施用的点击刺激。为了促进ABR与伴随噪声的有效区分，使用规范数据来检测生理，非生理和环境声学噪声将干扰测试进展的测试条件。

7. 发明授权

US5830131A Apparatus and method for measuring an induced perturbation to determine a physical condition of the human arterial system 失效
标题翻译：用于测量诱导的扰动以确定人类动脉系统的身体状况的装置和方法
公开(公告)号：US5830131A
公开(公告)日：1998-11-03
申请号：US561928
申请日：1995-11-22
申请人： Richard G. Caro , Mark H. Sher , Bryan P. Flaherty
发明人： Richard G. Caro , Mark H. Sher , Bryan P. Flaherty
IPC分类号： A61B5/022 , A61B5/00
CPC分类号： A61B5/02108 , A61B5/02133 , A61B5/022
摘要： A monitor for determining a patient's physical condition includes a calibration device configured to provide a calibration signal representative of a patient's physiological parameter. An exciter is positioned over a blood vessel of the patient for inducing a transmitted exciter waveform into the patient. A noninvasive sensor is positioned over the blood vessel, where the noninvasive sensor is configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a physiological parameter waveform and a component of a received exciter waveform. In this context, a hemoparameter is defined as any physiological parameter related to vessel blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position and other related parameters. A processor is configured to determine a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor is connected to receive the calibration signal and the noninvasive sensor signal, and the processor is configured to process the calibration signal and the noninvasive sensor signal to determine the physical condition. In an exemplary embodiment, the physical condition is arterial stiffness that represents cardiovascular disease, however, many additional physical conditions can be measured and determined such as arterial elasticity, arterial thickness, arterial wall compliance and other conditions. Also, in an exemplary embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters
摘要翻译：用于确定患者身体状况的监视器包括被配置为提供表示患者的生理参数的校准信号的校准装置。激励器位于患者的血管上方，用于将传输的激励器波形诱导到患者体内。无创传感器位于血管上方，其中无创传感器被配置为感测血液参数并且产生代表包含生理参数波形和接收的激励器波形的分量的成分的血液参数的无创传感器信号。在这种情况下，血液参数被定义为与血管血液相关的任何生理参数，例如压力，流量，体积，速度，血管壁运动，血管壁位置和其他相关参数。处理器被配置为确定所接收的激励器波形的特性与生理参数的特性之间的关系。处理器被连接以接收校准信号和无创传感器信号，并且处理器被配置为处理校准信号和非侵入式传感器信号以确定物理状况。在示例性实施例中，身体状况是代表心血管疾病的动脉硬度，然而，可以测量和确定许多额外的身体状况，例如动脉弹性，动脉厚度，动脉壁顺应性和其他状况。此外，在示例性实施例中，所测量的生理参数是血压，然而，本发明也可以用于分析和跟踪其他生理参数

8. 发明授权

US06544190B1 End tidal breath analyzer 失效
标题翻译：结束呼吸分析仪
公开(公告)号：US06544190B1
公开(公告)日：2003-04-08
申请号：US09922375
申请日：2001-08-03
申请人： Matthijs P. Smits , Bryan P. Flaherty
发明人： Matthijs P. Smits , Bryan P. Flaherty
IPC分类号： A61B508
CPC分类号： A61B5/0836
摘要： A noninvasive apparatus and method for measuring a subject's end tidal carbon monoxide concentration is disclosed, featuring the ability to (i) determine carbon monoxide concentration on a breath-by-breath basis, (ii) determine mean carbon monoxide concentration by averaging local carbon monoxide values, (iii) avoid the premature determination that an end tidal phase is over, and (iv) determine when breath variability or system variability will likely preclude accurate testing. The disclosed device and method allow for more robust determination of end tidal carbon monoxide concentration in subjects with turbulent or irregular breath patterns.
摘要翻译：公开了一种用于测量受试者末端潮气一氧化碳浓度的非侵入性装置和方法，其特征在于（i）基于呼吸基准确定一氧化碳浓度，（ii）通过平均局部一氧化碳来确定平均一氧化碳浓度值，（iii）避免过早确定结束潮汐阶段结束，以及（iv）确定何时呼吸变异性或系统变异性可能排除准确测试。所公开的装置和方法允许在具有湍动或不规则呼吸模式的受试者中更加鲁棒地确定末端潮汐一氧化碳浓度。

9. 发明授权

US06475163B1 Hearing evaluation device with patient connection evaluation capabilities 失效
标题翻译：具有患者连接评估功能的听力评估装置
公开(公告)号：US06475163B1
公开(公告)日：2002-11-05
申请号：US09479559
申请日：2000-01-07
申请人： Matthijs P. Smits , Vineet Bansal , Abraham J. Totah , Bryan P. Flaherty , Alfred Christian Walton
发明人： Matthijs P. Smits , Vineet Bansal , Abraham J. Totah , Bryan P. Flaherty , Alfred Christian Walton
IPC分类号： A61B500
CPC分类号： A61B5/121 , A61B5/04845 , A61B5/7203
摘要： An apparatus and method for evaluation of hearing loss is disclosed. The apparatus and method use evoked Auditory Brainstem Responses (ABR) to determine if the subject is able to hear iteratively administered click stimuli. The present invention evaluates the sufficiency of the patient connections, namely earphones and electrodes, to the evaluation device. More particularly, the present invention determines if the earphones are detached or deformed, if the electrodes have been reversed, or if the electrodes have become detached.
摘要翻译：公开了一种用于评价听力损失的装置和方法。该装置和方法使用诱发听觉脑干反应（ABR）来确定受试者是否能够听到迭代施用的点击刺激。本发明评价患者连接（即耳机和电极）对评估装置的充分性。更具体地说，本发明确定耳机是否脱离或变形，如果电极已被反转，或者电极已经脱离。

10. 发明授权

US6045509A Apparatus and method for measuring an induced perturbation to determine a physiological parameter 失效
标题翻译：用于测量诱导扰动以确定生理参数的装置和方法
公开(公告)号：US6045509A
公开(公告)日：2000-04-04
申请号：US26048
申请日：1998-02-19
申请人： Richard G. Caro , Mark H. Sher , Bryan P. Flaherty
发明人： Richard G. Caro , Mark H. Sher , Bryan P. Flaherty
IPC分类号： A61B5/022 , A61B5/00
CPC分类号： A61B5/022 , A61B5/02133
摘要： A monitor for determining a patient's physiological parameter includes a calibration device configured to provide a calibration signal representative of the patient's physiological parameter. An exciter is positioned over a blood vessel of the patient for inducing a transmitted exciter waveform into the patient. A noninvasive sensor is positioned over the blood vessel, where the noninvasive sensor is configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a physiological parameter waveform and a component of a received exciter waveform. In this context, a hemoparameter is defined as any physiological parameter related to vessel blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position and other related parameters. A processor is configured to determine a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor is connected to receive the calibration signal and the noninvasive sensor signal, and the processor is configured to process the calibration signal and the noninvasive sensor signal to determine the physiological parameter. In the preferred embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters such as vascular wall compliance, strength of ventricular contractions, vascular resistance, fluid volume, cardiac output, myocardial contractility and other related parameters.
摘要翻译：用于确定患者生理参数的监测器包括被配置为提供表示患者生理参数的校准信号的校准装置。激励器位于患者的血管上方，用于将传输的激励器波形诱导到患者体内。无创传感器位于血管上方，其中无创传感器被配置为感测血液参数并且产生代表包含生理参数波形和接收的激励器波形的分量的成分的血液参数的无创传感器信号。在这种情况下，血液参数被定义为与血管血液相关的任何生理参数，例如压力，流量，体积，速度，血管壁运动，血管壁位置和其他相关参数。处理器被配置为确定所接收的激励器波形的特性与生理参数的特性之间的关系。处理器被连接以接收校准信号和无创传感器信号，并且处理器被配置为处理校准信号和非侵入式传感器信号以确定生理参数。在优选实施例中，测量的生理参数是血压，然而，本发明也可用于分析和跟踪其他生理参数，例如血管壁顺应性，心室收缩强度，血管阻力，流体体积，心输出量，心肌收缩性等相关参数。

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