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1. 发明申请

US20150219614A1 METHODS OF DETERMINING CRUDE OIL STABILITY 有权
标题翻译：确定原油稳定性的方法
公开(公告)号：US20150219614A1
公开(公告)日：2015-08-06
申请号：US14690012
申请日：2015-04-17
申请人： Baker Hughes Incorporated
发明人： Marco Respini , Giuseppe Della Sala , Gavin M. Medine , Corina L. Sandu
IPC分类号： G01N33/28 , G01N21/41 , C10G31/08
CPC分类号： G01N33/2823 , C10G31/08 , C10G33/04 , C10G75/00 , C10G2300/206 , G01N21/41 , G01N21/552 , G01N21/83 , G01N21/8507 , G01N2021/8416 , Y10T137/0324
摘要： The stability of an oil-based fluid crude oil fluid may be determined by measuring a first RI value of the crude oil that does not comprise a solvent where the first RI value is used to determine a first solubility parameter therefrom. A second RI value may be taken from the crude oil at a point of asphaltene flocculation during a turbidimetric flocculation titration. The second RI value may be used to determine a second solubility parameter. A process for refining the crude oil may be controlled by maintaining the process or implementing a change to the process based on a ratio of the first solubility parameter to the second solubility parameter.
摘要翻译：油基流体原油流体的稳定性可以通过测量不含溶剂的原油的第一RI值来确定，其中第一RI值用于确定第一溶解度参数。在比浊絮凝滴定过程中，沥青质絮凝点可以从原油获取第二个RI值。第二RI值可用于确定第二溶解度参数。可以通过维持该方法或基于第一溶解度参数与第二溶解度参数的比率来实现该方法的改变来控制精制粗油的方法。

2. 发明授权

US06827478B2 Method and device for carrying out the automated preparation and characterization of liquid multi-constituent systems 失效
公开(公告)号：US06827478B2
公开(公告)日：2004-12-07
申请号：US10332843
申请日：2003-01-14
申请人： Dietmar Becker , Georg Beck , Stefan Bentz , Wolfgang Best , Peter Erk , Günter Etzrodt , Martin Könemann , Reinhold Rieger , Klaus Unterforsthuber
发明人： Dietmar Becker , Georg Beck , Stefan Bentz , Wolfgang Best , Peter Erk , Günter Etzrodt , Martin Könemann , Reinhold Rieger , Klaus Unterforsthuber
IPC分类号： B01F1100
CPC分类号： G01N35/0099 , B01F11/02 , B01F13/1055 , B01F15/00207 , B01F15/00214 , B01F15/0441 , B01F2215/005 , G01N21/25 , G01N21/83 , G01N35/028 , G01N35/10 , G01N2035/00188 , G01N2035/00217 , G01N2035/00752 , Y10S366/605
摘要： A method of automated preparation and characterization of liquid multicomponent systems comprising at least two, preferably three components comprises the automated preparation of a mixture by combining at least two, preferably three components in a vessel, at least one component being metered in an automated fashion into the vessel, and the automated homogenization of the mixture with subsequent automated measuring and evaluation. The apparatus for conducting this method comprises at least one metering station, one closing station, one homogenizing station, one measuring station for determining formulation properties, and one evaluation unit.

3. 发明申请

US20040017728A1 Method and device for carrying out the automated preparation and characterization of liquid multi-constituent systems 失效
标题翻译：用于进行液体多组分体系的自动化制备和表征的方法和装置
公开(公告)号：US20040017728A1
公开(公告)日：2004-01-29
申请号：US10332843
申请日：2003-01-14
发明人： Dietmar Becker , Georg Beck , Stefan Bentz , Wolfgang Best , Peter Erk , Gunter Etzrodt , Martin Konemann , Reinhold Rieger , Klaus Unterforsthuber
IPC分类号： B01F015/04
CPC分类号： G01N35/0099 , B01F11/02 , B01F13/1055 , B01F15/00207 , B01F15/00214 , B01F15/0441 , B01F2215/005 , G01N21/25 , G01N21/83 , G01N35/028 , G01N35/10 , G01N2035/00188 , G01N2035/00217 , G01N2035/00752 , Y10S366/605
摘要： A method of automated preparation and characterization of liquid multicomponent systems comprising at least two, preferably three components comprises the automated preparation of a mixture by combining at least two, preferably three components in a vessel, at least one component being metered in an automated fashion into the vessel, and the automated homogenization of the mixture with subsequent automated measuring and evaluation. The apparatus for conducting this method comprises at least one metering station, one closing station, one homogenizing station, one measuring station for determining formulation properties, and one evaluation unit.
摘要翻译：包含至少两个，优选三个组分的液体多组分体系的自动化制备和表征的方法包括通过将至少两种，优选三种组分在容器中组合的至少一种组分以自动方式计量加入该容器和混合物的自动均质化随后进行自动测量和评价。用于执行该方法的装置包括至少一个计量站，一个关闭站，一个均质站，用于确定配方属性的一个测量站和一个评估单元。

4. 发明授权

US5181082A On-line titration using colorimetric end point detection 失效
标题翻译：使用比色终点检测进行在线滴定
公开(公告)号：US5181082A
公开(公告)日：1993-01-19
申请号：US514061
申请日：1990-04-24
申请人： Anthony C. Jeannotte , Anthony C. Gilby , M. Charles Cheney , Barry J. Meneghelli
发明人： Anthony C. Jeannotte , Anthony C. Gilby , M. Charles Cheney , Barry J. Meneghelli
IPC分类号： G01N21/27 , G01N21/05 , G01N21/77 , G01N21/83 , G01N21/85 , G01N31/16
CPC分类号： G01N21/83 , G01N21/8507 , G01N2021/054 , G01N2021/1744 , G01N2201/064 , G01N2201/0642 , G01N2201/08 , G01N2201/084
摘要： Radiant energy is transmitted to a probe element including an interior conical reflecting surface and a fluid sample chamber. Portions of the light which have been transmitted, partially attenuated, or scattered by a fluid sample in the sample chamber are directed by at least a portion of the interior conical reflecting surface to means for collecting the transmitted, partially attenuated, or scattered light. A stilling valve incorporated into the probe element enables elimination of entrained gas bubbles from the chamber. A specific application of the probe is disclosed in which a titration analyzer is combined with electro-optic signal conversion and processing circuits and a probe according to the invention to provide titration colorimetric endpoint determination in measuring the free fatty acid content of a fluid such as a edible oil or fat.
摘要翻译：辐射能量传递到包括内部锥形反射表面和流体样品室的探针元件。通过样品室中的流体样品透射，部分衰减或散射的光的部分由内部锥形反射表面的至少一部分引导到用于收集透射的，部分衰减的或散射的光的装置。结合到探针元件中的静止阀能够消除来自腔室的夹带的气泡。公开了探针的具体应用，其中滴定分析仪与电光信号转换和处理电路组合，根据本发明的探针结合以提供滴定比色终点测定，以测量流体的游离脂肪酸含量，例如食用油或脂肪。

5. 发明授权

US4801550A Method for separating and analyzing nucleic acids 失效
标题翻译：分离和分析核酸的方法
公开(公告)号：US4801550A
公开(公告)日：1989-01-31
申请号：US613156
申请日：1984-05-23
申请人： Jan Kapuscinski , Zbigniew Darzynkiewicz
发明人： Jan Kapuscinski , Zbigniew Darzynkiewicz
IPC分类号： C12Q1/68 , G01N21/83 , G01N33/53 , G01N31/02 , G01N33/50
CPC分类号： G01N33/5308 , C12Q1/6806 , C12Q1/6816 , G01N21/83 , Y10T436/143333 , Y10T436/255
摘要： The primary and/or secondary structure of nucleic acid as well as its content and molecular weight can be analyzed in solutions by light scatter or fluorescence measurements after treatment with 3 or 4 ring aromatic cations which bind to single-stranded nucleic acids by cooperative association and induce their condensation (collapse). Preparative separation of nucleic acids of different types from the mixtures in the solution is also accomplished by the same principle and techniques wherein each condensed acid is removed from solution and the condensation reversed.
摘要翻译：核酸的主要和/或二级结构以及其含量和分子量可以在用3或4环芳族阳离子处理之后通过光散射或荧光测量在溶液中进行分析，所述环芳族阳离子通过协同缔合结合单链核酸，引起它们的凝结（崩溃）。不同类型的核酸与溶液中的混合物的制备性分离也通过相同的原理和技术来实现，其中每个冷凝的酸从溶液中除去并且凝结反转。

6. 发明授权

US3731807A Apparatus for automatically determining the optimum amounts of reagents to be added to a liquid for its clarification 失效
标题翻译：用于自动确定要添加到液体中的试剂的最佳数量的装置进行澄清
公开(公告)号：US3731807A
公开(公告)日：1973-05-08
申请号：US3731807D
申请日：1970-07-07
申请人： DEGREMONT
发明人： LOUBOUTIN R , DAUDENARDE C
IPC分类号： C02F1/52 , G01N21/83 , G05D21/02 , B01D21/01
CPC分类号： G01N21/83 , C02F1/5209 , G05D21/02
摘要： Apparatus for automatically determining the optimum proportion of coagulant reagent to be added to a liquid in order to clarify same by coagulation of the substances in colloidal suspension therein, which comprises a plurality of mixing vessels into which predetermined quantities of liquid and reagent are introduced and in which these liquid and reagent are adapted to mix together, the resulting mixture being subsequently separated into a decanting fraction and a supernatant fraction, means for measuring the turbidity of said supernatant fraction, said means consisting advantageously of one or a plurality of turbidimeters, and other means such as computer for analyzing and comparing the measurements made in said turbidimeter or turbidimeters, and determining the optimum proportion of reagent to be added to the liquid.
摘要翻译：用于自动确定要添加到液体中的凝结剂的最佳比例的装置，以便通过其中胶体悬浮液中的物质的凝结来澄清它，其包括多个混合容器，其中引入了预定量的液体和试剂，将这些液体和试剂混合在一起，将所得混合物随后分离成倾析馏分和上清液部分，用于测量所述上清液部分的浊度的装置，所述装置有利地由一个或多个浊度计和其它用于分析和比较在所述浊度计或浊度计中进行的测量的计算机，以及确定待添加到液体中的试剂的最佳比例。

7. 发明申请

US20180251713A1 Field-deployable Multiplexed Sampling and Monitoring Device and Bacterial Contamination Measurement Method 审中-公开
公开(公告)号：US20180251713A1
公开(公告)日：2018-09-06
申请号：US15909523
申请日：2018-03-01
申请人： FLUIDION SAS
发明人： Dan E. Angelescu , Andreas Hausot
IPC分类号： C12M1/34 , G01N21/64 , G01N21/83 , C12M1/08 , C12M1/24 , C12M1/26 , C12M1/38 , C12M1/32
CPC分类号： C12M1/34 , C12M1/08 , C12M1/24 , C12M1/26 , C12M1/38 , C12M23/08 , C12M33/06 , C12M33/07 , C12M33/12 , G01N1/28 , G01N21/3151 , G01N21/645 , G01N21/6486 , G01N21/83
摘要： A system for processing samples from a body of fluid. The system includes one or more sample bottles for acquiring a sample from the body of fluid. Each sample bottle initially retains a pre-filling fluid. Each sample bottle includes a fluidic inlet port and a bottle outlet port. Each sample bottle has an inlet check valve coupled to the fluidic inlet port, the inlet check valve configured to allow fluid from the body of fluid into a sample bottle via the fluidic inlet port when the pressure difference between the body of fluid and fluid within the sample bottle reaches a threshold. The system further includes at least one pump, the bottle outlet port of each sample bottle selectively coupled to the at least one pump via a different control valve. The at least one pump is configured, in a first configuration, to remove prefilling fluid from each selected sample bottle such that, for each selected sample bottle, the pressure difference threshold is reached and a sample from the body of fluid is acquired.

8. 发明申请

US20170082539A1 METHOD FOR DETERMINING A SETTLING RATE OF AT LEAST ONE FOULANT IN OIL-BASED FLUIDS 审中-公开
公开(公告)号：US20170082539A1
公开(公告)日：2017-03-23
申请号：US14862740
申请日：2015-09-23
申请人： BAKER HUGHES INCORPORATED
发明人： MARCO RESPINI , Giuseppe Della Sala
IPC分类号： G01N21/59 , G01N33/28 , G01N15/04
CPC分类号： G01N21/59 , C10G75/00 , C10G2300/206 , G01N15/04 , G01N21/3577 , G01N21/359 , G01N21/552 , G01N21/83 , G01N33/28 , G01N2021/8416
摘要： A settling rate of at least one foulant in oil-based fluids may be determining a settling rate of an oil-based fluid by stirring the fluid during a turbidimetric flocculation titration, which includes solvent dosing and obtaining transmittance measurements of the oil-based fluid. The method may further include stopping the solvent dosing at the onset of flocculation of the foulant(s), stopping the stirring when at least two or more transmittance measurements are substantially similar, and measuring the transmittance of the oil-based fluid to determine a settling rate of the foulant(s). The settling rate may be proportional to an increase in transmittance or decrease in absorbance after the stirring has stopped.

9. 发明申请

US20170045441A1 SAMPLE ANALYSIS METHODS 审中-公开
标题翻译：样本分析方法
公开(公告)号：US20170045441A1
公开(公告)日：2017-02-16
申请号：US15340615
申请日：2016-11-01
申请人： ARCHIMEJ TECHNOLOGY
发明人： Mejdi Nciri
IPC分类号： G01N21/31
CPC分类号： G01N21/31 , G01J3/0208 , G01J3/10 , G01J3/14 , G01J3/42 , G01J3/4406 , G01J2003/1282 , G01N21/6458 , G01N21/83 , G01N33/49 , G01N2021/3129 , G01N2021/3196 , G01N2021/6417 , G02B27/1006
摘要： The invention generally relates to methods for determining a concentration of at least one target analyte in a heterogeneous sample and methods for detecting a condition. In certain aspects, the inventions provides methods that involve illuminating a heterogeneous sample, such as a biological sample, including at least one target analyte with polychromatic light, receiving luminous data of the heterogeneous sample and the at least one target analyte with a detector without splitting the polychromatic light into individual wavelengths and generating spectral data therefrom. The spectral data is then converted into a concentration of the at least one target analyte in the biological sample by comparing the spectral data to a database comprising known spectra already associated with concentration levels.
摘要翻译：本发明一般涉及用于确定异质样品中至少一种目标分析物的浓度的方法和用于检测病症的方法。在某些方面，本发明提供了涉及照射诸如生物样品的异质样品（包括至少一种具有多色光的目标分析物）的方法，使用检测器接收异质样品和至少一种目标分析物的发光数据而不分裂将多色光转换为单个波长并从其产生光谱数据。然后通过将光谱数据与包括已经与浓度水平相关联的已知光谱的数据库进行比较，将光谱数据转换成生物样品中至少一种目标分析物的浓度。

10. 发明申请

US20160195522A1 METHOD OF AGGLUTINATION IMMUNOASSAY 审中-公开
标题翻译：免疫免疫法的方法
公开(公告)号：US20160195522A1
公开(公告)日：2016-07-07
申请号：US14894207
申请日：2014-06-02
申请人： SEKISUI MEDICAL CO., LTD.
发明人： Hiroshi TAKAHASHI , Tadaaki YOSHIDA , Yoshimasa BANBA , Yuki TAKAHASHI
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , G01N21/31 , G01N21/47 , G01N21/59 , G01N21/83 , G01N2021/1734 , G01N2333/705
摘要： The present invention provides a particle enhanced agglutination immunoassay including the steps of: mixing a sample solution containing an analyte with a solution containing insoluble carrier particles carrying a binding partner or binding partners for the analyte to prepare a mixed solution; determining a variation (i) in intensity of light scattered from the mixed solution based on a difference in intensity of scattered light between first and second time points; determining a variation (ii) in absorbance of the mixed solution based on a difference in absorbance between third and fourth time points; and correlating the determined variation (i) in intensity of scattered light and the determined variation (ii) in absorbance with an amount of the analyte present in the sample using a calibration curve plotted based on the variation in intensity of scattered light and a calibration curve plotted based on the variation in absorbance. The present invention employs measurements of the intensity of scattered light and the absorbance in combination for a single assay, and thus provides a particle enhanced agglutination immunoassay which achieves higher sensitivity and a wider dynamic range than conventional assays.
摘要翻译：本发明提供一种增强粒细胞的凝集免疫测定法，其包括以下步骤：将含有分析物的样品溶液与含有不溶性载体颗粒的溶液混合，所述溶液携带用于分析物的结合配偶体或结合配偶体以制备混合溶液; 基于第一和第二时间点之间的散射光的强度差，确定从混合溶液散射的光的强度的变化（i）; 基于第三和第四时间点之间的吸光度差，确定混合溶液的吸光度的变化（ii）; 并使用基于散射光的强度和校正曲线的变化绘制的校准曲线将确定的散射光强度和所确定的吸光度变化（ii）与样品中存在的分析物的量相关联基于吸光度的变化绘制。本发明采用单一测定结合测量散射光的强度和吸光度，从而提供与常规测定相比更高的灵敏度和更广的动态范围的增强粒子的凝集免疫测定。

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