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21. 发明申请

US20080069737A1 APPARATUS FOR RECEIVING BIOLOGICAL SPECIMENS AND METHOD FOR LASER DISSECTION OF BIOLOGICAL SPECIMENS 有权
标题翻译：用于接收生物样本的装置和用于激光去除生物样本的方法
公开(公告)号：US20080069737A1
公开(公告)日：2008-03-20
申请号：US11532841
申请日：2006-09-18
申请人： Robert Fasulka
发明人： Robert Fasulka
IPC分类号： B01L3/00
CPC分类号： G01N1/2813 , B01L3/5025 , B01L2300/04 , B01L2300/0654 , B01L2300/0819 , B01L2300/18 , B01L2400/0457 , G01N2001/2886 , G02B21/34
摘要： An apparatus for receiving biological specimens, the apparatus being introducible into a laser microdissection device for laser microdissection of a biological specimen, includes a first element having a first opening extending from a first side to a second side of the first element. A second element is provided having a second opening extending from a third side to a fourth side of the second element. The second opening is closed at the third side. The second element is disposed relative to the first element so that the first opening is aligned with the second opening. A layer is disposed between the first and second elements, the layer being designed to receive the biological specimen thereon and being capable of being cut through by laser light in a laser microdissection operation so that a portion of the biological specimen is received in the second opening so as to remain inside the apparatus.
摘要翻译：一种用于接收生物样本的装置，该装置被引入用于生物样本的激光显微切割的激光显微切割装置中，包括具有从第一元件的第一侧延伸到第二侧的第一开口的第一元件。提供了第二元件，其具有从第二元件的第三侧延伸到第四侧的第二开口。第二个开口在第三侧关闭。第二元件相对于第一元件设置，使得第一开口与第二开口对准。一层设置在第一和第二元件之间，该层被设计成在其上接收生物样本，并且能够在激光显微切割操作中通过激光切割，使得生物样本的一部分被容纳在第二开口以便保持在设备内部。

22. 发明授权

US07152616B2 Devices and methods for programmable microscale manipulation of fluids 有权
标题翻译：流体可编程微尺度操作的装置和方法
公开(公告)号：US07152616B2
公开(公告)日：2006-12-26
申请号：US10491299
申请日：2003-12-04
申请人： Piero Zucchelli , Bart Van de Vyver
发明人： Piero Zucchelli , Bart Van de Vyver
IPC分类号： F16K31/02 , G01N35/00 , B01L3/00
CPC分类号： F16K99/0001 , B01F11/0002 , B01F13/0059 , B01F13/0809 , B01F15/0205 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F16K99/003 , F16K99/0034 , F16K99/004 , F16K2099/0073 , F16K2099/008 , F16K2099/0084 , G01N21/01 , G01N35/00069 , G01N2001/2886 , G01N2035/00247 , Y10T137/1624 , Y10T137/1632 , Y10T436/2575
摘要： The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar position of a pickup in the reference frame of a rotating device.
摘要翻译：本发明一般涉及以可编程方式控制中尺度流体组分中的流体流动的装置和方法。具体而言，本发明涉及一种用于将两个微流体组分置于流体连通中的任意位置和时间的装置和方法，两者都是外部限定的。本发明的装置使用电磁辐射穿透具有选定吸附性质的材料层。材料层的穿孔允许微流体组分之间的流体连通。本发明的其它方面包括对流体进行体积定量的装置和方法，用于编程一组输入毛细管和一组输出毛细管之间的任意连接的装置，以及将向心装置中的流体从较大传送到半径较小此外，本发明还涉及一种确定旋转装置的参考系中拾取器的径向和极位置的方法。

23. 发明申请

US20060087643A1 Laser microdissection apparatus and method 有权
标题翻译：激光显微解剖设备及方法
公开(公告)号：US20060087643A1
公开(公告)日：2006-04-27
申请号：US11222281
申请日：2005-09-08
申请人： Brian Donovan , Thomas Baer
发明人： Brian Donovan , Thomas Baer
IPC分类号： G01N1/00
CPC分类号： G01N1/28 , G01N1/2813 , G01N1/286 , G01N1/30 , G01N1/44 , G01N2001/2826 , G01N2001/2833 , G01N2001/284 , G01N2001/2886 , Y10T156/10 , Y10T156/1054
摘要： Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a polymer membrane which is then placed onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the biological material. In yet another variation, a sample of biological material is mounted onto a polymer membrane which is then inverted onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the polymer membrane. Then, an UV laser cuts along a cut path around the targeted portions of biological material in a closed cut path or a substantially closed cut path defining an interior and an exterior portion of the tissue sample. In a substantially closed cut path, bridges are left spanning the interior of the cut path and the exterior of the cut path. An IR laser activates at least a portion of the transfer film such that the transfer film in the vicinity of targeted portion adheres to the biological material interior to the cut path. The transfer film is then removed separating the targeted portions of biological material which are adhered to the transfer film from the remaining portion of the tissue sample.
摘要翻译：公开了用于自动激光显微切割的系统和方法。在一个变型中，手动或自动选择目标生物材料，并且将转移膜并排放置在切割路径的内部的位置。在另一个变体中，将生物材料样品安装在聚合物膜上，然后将其放置在基底上。手动或自动选择靶向生物材料，并将转移膜与生物材料侧面上的靶向生物材料并置放置。在另一个变体中，将生物材料样品安装在聚合物膜上，然后将其反转到基底上。手动或自动选择目标生物材料，并将转移膜与聚合物膜侧面上的目标生物材料并置放置。然后，UV激光沿着围绕生物材料的目标部分的切割路径沿封闭的切割路径或限定组织样本的内部和外部部分的基本封闭的切割路径切割。在基本封闭的切割路径中，跨越切割路径的内部和切割路径的外部。红外激光激活转印膜的至少一部分，使得目标部分附近的转印膜附着在生物材料内部至切割路径。然后除去转移膜，从生物材料的目标部分分离出粘附到转移膜上的剩余部分的组织样品。

24. 发明授权

US06841788B1 Transmission electron microscope sample preparation 有权
标题翻译：透射电子显微镜样品制备
公开(公告)号：US06841788B1
公开(公告)日：2005-01-11
申请号：US09920715
申请日：2001-08-03
申请人： Joseph Robinson , Kenneth H. Church
发明人： Joseph Robinson , Kenneth H. Church
IPC分类号： G01N1/32 , G01N23/225 , G21K7/00 , H01J37/31 , B23K26/38
CPC分类号： G01N1/32 , G01N23/225 , G01N2001/2886 , H01J2237/2817 , H01J2237/3174
摘要： Sample preparation apparatus and method includes a wafer stage platform with an optical microscope and integrated pattern recognition to automatically address specific locations on the wafer sample of interest. A laser attaches to the optical microscope to mill a set pattern around the area of interest. A precision micro-manipulator engages the sample support structure, extracts the structure, and places the structure in a TEM holder or holder tip. The holder or holder tip can then be placed inside a FIB for final thinning, followed by direct transfer into the TEM.
摘要翻译：样品制备装置和方法包括具有光学显微镜和集成模式识别的晶片台平台，以自动寻址感兴趣的晶片样品上的特定位置。激光器附着在光学显微镜上以研磨围绕感兴趣区域的设定图案。精密微操作器与样品支撑结构接合，提取结构，并将结构放置在TEM支架或支架尖端。然后可以将保持器或保持器尖端放置在FIB内用于最终变薄，然后直接转移到TEM中。

25. 发明申请

US20040245466A1 Transmission electron microscope sample preparation 有权
标题翻译：透射电子显微镜样品制备
公开(公告)号：US20040245466A1
公开(公告)日：2004-12-09
申请号：US10886201
申请日：2004-07-06
发明人： Joseph Robinson , Kenneth H. Church
IPC分类号： G01N023/00 , G21K007/00
CPC分类号： G01N1/32 , G01N23/225 , G01N2001/2886 , H01J2237/2817 , H01J2237/3174
摘要： Sample preparation apparatus and method includes a wafer stage platform with an optical microscope and integrated pattern recognition to automatically address specific locations on the wafer sample of interest. A laser attaches to the optical microscope to mill a set pattern around the area of interest. A precision micro-manipulator engages the sample support structure, extracts the structure, and places the structure in a TEM holder or holder tip. The holder or holder tip can then be placed inside a FIB for final thinning, followed by direct transfer into the TEM.
摘要翻译：样品制备装置和方法包括具有光学显微镜和集成模式识别的晶片台平台，以自动寻址感兴趣的晶片样品上的特定位置。激光器附着在光学显微镜上以研磨围绕感兴趣区域的设定图案。精密微操作器与样品支撑结构接合，提取结构，并将结构放置在TEM支架或支架尖端。然后可以将保持器或保持器尖端放置在FIB内用于最终变薄，然后直接转移到TEM中。

26. 发明授权

US06813008B2 Microdissection optical system 有权
标题翻译：显微解剖光学系统
公开(公告)号：US06813008B2
公开(公告)日：2004-11-02
申请号：US10165929
申请日：2002-06-10
申请人： Howard Fein , Andrew G. Cartlidge
发明人： Howard Fein , Andrew G. Cartlidge
IPC分类号： G01N100
CPC分类号： G02B21/365 , G01N1/2813 , G01N2001/2886 , G02B21/32
摘要： Improved laser capture microdissection systems and related methods are provided by using an imaging system for imaging the tissue sample from which a cell sample is to be obtained, the imaging system comprising a sensor having one or more receptors, and an image transfer medium to scale the one or more receptors to an object field of view.
摘要翻译：通过使用成像系统来提供改进的激光捕获显微解剖系统和相关方法，所述成像系统用于对要从其获得细胞样品的组织样本进行成像，所述成像系统包括具有一个或多个受体的传感器，以及图像转印介质，一个或多个受体到物体视场。

27. 发明申请

US20020101654A1 Holder for positioning a specimen slide, and apparatus for laser cutting of specimens, and microscope 有权
标题翻译：用于定位试样滑块的支架，以及用于激光切割试样的装置和显微镜
公开(公告)号：US20020101654A1
公开(公告)日：2002-08-01
申请号：US10056584
申请日：2002-01-24
发明人： Gerhard Pfeifer
IPC分类号： G02B021/00 , G02B021/26
CPC分类号： G01N1/2813 , G01N2001/045 , G01N2001/2886 , G02B21/34
摘要： The invention concerns a holder (1) for positioning a specimen slide (2) on a microscope stage (7), having a baseplate (3), retainable on the microscope stage (7), in which is configured, for reception of the specimen slide (2), an opening (3a) comprising flat support surfaces (3b) and at least one abutment surface (3c), extending substantially perpendicular to the support surface (3b), for the specimen slide (2); and having at least one spring element (4) with which, by means of a compressive force (F) acting substantially horizontally, the specimen slide (2) arranged in the opening (3a) of the baseplate (3) can be pressed against the at least one abutment surface (3c) of the opening (3a).
摘要翻译：本发明涉及一种用于将样品载玻片（2）定位在显微镜台（7）上的支架（1），具有可保持在显微镜台（7）上的底板（3），其中构造成用于接收样品滑动件（2），包括平坦支撑表面（3b）的开口（3a）和基本上垂直于支撑表面（3b）延伸的至少一个邻接表面（3c），用于样品滑块（2）; 并且具有至少一个弹簧元件（4），通过所述至少一个弹簧元件（4）借助于基本上水平地施加的压缩力（F），布置在基板（3）的开口（3a）中的试样滑块（2）可被压靠在所述开口（3a）的至少一个邻接表面（3c）。

28. 发明申请

US20020056345A1 Method and apparatus for laser microdissection 失效
标题翻译：激光显微切割的方法和装置
公开(公告)号：US20020056345A1
公开(公告)日：2002-05-16
申请号：US09943093
申请日：2001-08-31
发明人： Michael Ganser , Albrecht Weiss , Joachim Wesner , Gerhard Johannsen
IPC分类号： G01N001/30 , G01N033/48
CPC分类号： B23K26/0736 , B23K2103/32 , B23K2103/50 , G01N1/2813 , G01N2001/045 , G01N2001/2886 , Y10S435/808 , Y10T83/04
摘要： A method and an apparatus for laser microdissection of specimen regions (23) of interest of a specimen (4) are described. In a first step, an incomplete cut line (25) enclosing the specimen region (23) of interest is generated by means of a laser beam (7). At the incomplete point of the cut line (25), there remains a web (26) which joins the specimen region (23) of interest to the surrounding specimen (4). In a second step, the web (26) is severed with a single laser pulse directed onto it, thereby completing the cut line. The specimen region (23) of interest is in that context detached from the specimen (4) and falls by the action of gravity into a collection vessel (19).
摘要翻译：描述了用于样本（4）的感兴趣的样本区域（23）的激光显微切割的方法和装置。在第一步骤中，通过激光束（7）产生包围感兴趣的样本区域（23）的不完整切割线（25）。在切割线（25）的不完整点处，存在将感兴趣的样品区域（23）连接到周围样品（4）的网（26）。在第二步骤中，用指向其上的单个激光脉冲切断网（26），从而完成切割线。感兴趣的样本区域（23）在该情况下与试样（4）分离，并且通过重力作用而落入收集容器（19）中。

29. 发明申请

US20180333806A1 SYSTEM FOR PROCESSING A DRIED FLUID SAMPLE SUBSTRATE AND METHOD THEREFOR 审中-公开
公开(公告)号：US20180333806A1
公开(公告)日：2018-11-22
申请号：US15982317
申请日：2018-05-17
申请人： Roche Molecular Systems, Inc.
发明人： Claudio Cherubini , Andreas Drechsler , Reto Huesser , Emad Sarofim
IPC分类号： B23K26/16 , B23K26/70
CPC分类号： B23K26/16 , G01N1/04 , G01N1/286 , G01N2001/2886
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.

30. 发明申请

US20180231438A1 Tissue Slicing Device and Apparatus Having Tissue Slicing Device 审中-公开
公开(公告)号：US20180231438A1
公开(公告)日：2018-08-16
申请号：US15475279
申请日：2017-03-31
申请人： SCL Biotech Ltd.
发明人： Hsin-Wu Mi , Ming-Cheng Lee
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , G01N1/286 , G01N2001/045 , G01N2001/2886
摘要： Provided is a tissue slicing device having a motor component, a filling component, a filter, a pipe, and a cutting component. The filling component includes a tube and a piston rod movably inserted through the tube. One end of the piston rod abuts against the motor component. The filter is located at an end of the tube opposite the motor component. The pipe is located at a common side of the motor component and the filling component, and includes a nozzle located at an end of the pipe and proximal to an end of the filter opposite the filling component. The cutting component is proximal to the filter. The guiding body is located at the end of the tube opposite the motor component. Provided is an apparatus having the tissue slicing device, such that manpower and time can be saved, and the tissue slicing degree can be unified.

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