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1. 发明申请

US20070095393A1 Devices and methods for programmable microscale manipulation of fluids 审中-公开
标题翻译：流体可编程微尺度操作的装置和方法
公开(公告)号：US20070095393A1
公开(公告)日：2007-05-03
申请号：US11633745
申请日：2006-12-05
申请人： Piero Zucchelli , Bart Van de Vyver
发明人： Piero Zucchelli , Bart Van de Vyver
IPC分类号： F16K17/40
CPC分类号： B01L3/502738 , B01L3/50273 , B01L7/52 , B01L2200/0605 , B01L2200/147 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/003 , F16K99/004 , F16K2099/0076 , F16K2099/0078 , F16K2099/0084 , G01N35/00069 , G01N35/1097 , Y10T137/0324 , Y10T137/0329 , Y10T137/1632
摘要： The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar position of a pickup in the reference frame of a rotating device.
摘要翻译：本发明一般涉及以可编程方式控制中尺度流体组分中的流体流动的装置和方法。具体而言，本发明涉及一种用于将两个微流体组分置于流体连通中的任意位置和时间的装置和方法，两者都是外部限定的。本发明的装置使用电磁辐射穿透具有选定吸附性质的材料层。材料层的穿孔允许微流体组分之间的流体连通。本发明的其它方面包括对流体进行体积定量的装置和方法，用于编程一组输入毛细管和一组输出毛细管之间的任意连接的装置，以及将向心装置中的流体从较大传送到半径较小此外，本发明还涉及一种确定旋转装置的参考系中拾取器的径向和极位置的方法。

2. 发明申请

US20090039000A1 DOSIMETER FOR PROGRAMMABLE MICROSCALE MANIPULATION OF FLUIDS 失效
标题翻译：用于可编程微流控液体的剂量计
公开(公告)号：US20090039000A1
公开(公告)日：2009-02-12
申请号：US11915805
申请日：2006-06-05
申请人： Piero Zucchelli , Bart Van de Vyver
发明人： Piero Zucchelli , Bart Van de Vyver
IPC分类号： B01D17/12 , B01D21/30 , B01D15/04 , B01D35/14 , B29C45/16 , B01D21/26
CPC分类号： B01L3/50273 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2300/0806 , B01L2300/0887 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , G01N35/00069 , Y10T137/1632 , Y10T137/1812 , Y10T137/2224 , Y10T436/111666 , Y10T436/2575
摘要： The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components allowing volumetric quantitation of fluids. Using the perforation of the material functionality such as metering and multiplexing are achieved on a microscale. This functionality is achieved through basic operations, like dosimeters filling, dosimeters purging, dosimeters extraction, dosimeters ventilation and channels routing. Accordingly, these operations are performed in microfluidic platforms and are characterized extensively, allowing the realization of complex assays in a miniaturized format, where dilutions of proteins and assay readout can be performed in an extremely small footprint.
摘要翻译：本发明一般涉及以可编程方式控制中尺度流体组分中的流体流动的装置和方法。具体而言，本发明涉及一种用于将两个微流体组分置于流体连通中的任意位置和时间的装置和方法，两者都是外部限定的。本发明的装置使用电磁辐射穿透具有选定吸附性质的材料层。材料层的穿孔允许微流体组分之间的流体连通允许流体的体积定量。使用诸如计量和多路复用的材料功能的穿孔是在微尺度上实现的。此功能通过基本操作实现，例如剂量计填充，剂量计清洗，剂量计提取，剂量计通气和通道路由。因此，这些操作在微流体平台中进行并且被广泛表征，允许以小型化形式实现复杂测定，其中蛋白质的稀释度和测定读数可以在极小的占地面积中进行。

3. 发明授权

US08226908B2 Dosimeter for programmable microscale manipulation of fluids 失效
标题翻译：用于流体可编程微尺度操作的剂量计
公开(公告)号：US08226908B2
公开(公告)日：2012-07-24
申请号：US11915805
申请日：2006-06-05
申请人： Piero Zucchelli , Bart Van de Vyver
发明人： Piero Zucchelli , Bart Van de Vyver
IPC分类号： F16K17/14 , G01N9/30
CPC分类号： B01L3/50273 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2300/0806 , B01L2300/0887 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , G01N35/00069 , Y10T137/1632 , Y10T137/1812 , Y10T137/2224 , Y10T436/111666 , Y10T436/2575
摘要： The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components allowing volumetric quantitation of fluids. Using the perforation of the material functionality such as metering and multiplexing are achieved on a microscale. This functionality is achieved through basic operations, like dosimeters filling, dosimeters purging, dosimeters extraction, dosimeters ventilation and channels routing. Accordingly, these operations are performed in microfluidic platforms and are characterized extensively, allowing the realization of complex assays in a miniaturized format, where dilutions of proteins and assay readout can be performed in an extremely small footprint.
摘要翻译：本发明一般涉及以可编程方式控制中尺度流体组分中的流体流动的装置和方法。具体而言，本发明涉及一种用于将两个微流体组分置于流体连通中的任意位置和时间的装置和方法，两者都是外部限定的。本发明的装置使用电磁辐射穿透具有选定吸附性质的材料层。材料层的穿孔允许微流体组分之间的流体连通允许流体的体积定量。使用诸如计量和多路复用的材料功能的穿孔是在微尺度上实现的。此功能通过基本操作实现，例如剂量计填充，剂量计清洗，剂量计提取，剂量计通气和通道路由。因此，这些操作在微流体平台中进行并且被广泛表征，允许以小型化形式实现复杂测定，其中蛋白质的稀释度和测定读数可以在极小的占地面积中进行。

4. 发明申请

US20080289692A1 DEVICES AND METHODS FOR PROGRAMMABLE MICROSCALE MANIPULATION OF FLUIDS 审中-公开
标题翻译：流体可编程微控制器的设备和方法
公开(公告)号：US20080289692A1
公开(公告)日：2008-11-27
申请号：US12125179
申请日：2008-05-22
申请人： Piero Zucchelli , Bart Van de Vyver
发明人： Piero Zucchelli , Bart Van de Vyver
IPC分类号： B01L3/00 , B81B1/00 , G01N9/30
CPC分类号： B01L3/502738 , B01L3/50273 , B01L7/52 , B01L2200/0605 , B01L2200/147 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/003 , F16K99/004 , F16K2099/0076 , F16K2099/0078 , F16K2099/0084 , G01N35/00069 , G01N35/1097 , Y10T137/0324 , Y10T137/0329 , Y10T137/1632
摘要： The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar position of a pickup in the reference frame of a rotating device.
摘要翻译：本发明一般涉及以可编程方式控制中尺度流体组分中的流体流动的装置和方法。具体而言，本发明涉及一种用于将两个微流体组分置于流体连通中的任意位置和时间的装置和方法，两者都是外部限定的。本发明的装置使用电磁辐射穿透具有选定吸附性质的材料层。材料层的穿孔允许微流体组分之间的流体连通。本发明的其它方面包括对流体进行体积定量的装置和方法，用于编程一组输入毛细管和一组输出毛细管之间的任意连接的装置，以及将向心装置中的流体从较大传送到半径较小此外，本发明还涉及一种确定旋转装置的参考系中拾取器的径向和极位置的方法。

5. 发明授权

US07152616B2 Devices and methods for programmable microscale manipulation of fluids 有权
标题翻译：流体可编程微尺度操作的装置和方法
公开(公告)号：US07152616B2
公开(公告)日：2006-12-26
申请号：US10491299
申请日：2003-12-04
申请人： Piero Zucchelli , Bart Van de Vyver
发明人： Piero Zucchelli , Bart Van de Vyver
IPC分类号： F16K31/02 , G01N35/00 , B01L3/00
CPC分类号： F16K99/0001 , B01F11/0002 , B01F13/0059 , B01F13/0809 , B01F15/0205 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F16K99/003 , F16K99/0034 , F16K99/004 , F16K2099/0073 , F16K2099/008 , F16K2099/0084 , G01N21/01 , G01N35/00069 , G01N2001/2886 , G01N2035/00247 , Y10T137/1624 , Y10T137/1632 , Y10T436/2575
摘要： The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar position of a pickup in the reference frame of a rotating device.
摘要翻译：本发明一般涉及以可编程方式控制中尺度流体组分中的流体流动的装置和方法。具体而言，本发明涉及一种用于将两个微流体组分置于流体连通中的任意位置和时间的装置和方法，两者都是外部限定的。本发明的装置使用电磁辐射穿透具有选定吸附性质的材料层。材料层的穿孔允许微流体组分之间的流体连通。本发明的其它方面包括对流体进行体积定量的装置和方法，用于编程一组输入毛细管和一组输出毛细管之间的任意连接的装置，以及将向心装置中的流体从较大传送到半径较小此外，本发明还涉及一种确定旋转装置的参考系中拾取器的径向和极位置的方法。

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