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21. 发明申请

US20170196809A1 METHOD OF ENCAPSULATING A NUCLEIC ACID IN A LIPID NANOPARTICLE HOST 审中-公开
公开(公告)号：US20170196809A1
公开(公告)日：2017-07-13
申请号：US15326291
申请日：2015-07-10
申请人： Keith A. BOWMAN , Noah GARDNER , Travis JEANNOTTE , Chandra VARGEESE
发明人： Keith A. BOWMAN , Noah GARDNER , Travis JEANNOTTE , Chandra VARGEESE
IPC分类号： A61K9/127 , A61K48/00 , C12N15/113
CPC分类号： A61K9/1277 , A61K9/1272 , A61K31/7105 , A61K31/713 , A61K48/0008 , A61K48/0091 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

22. 发明申请

US20170172921A1 POLYPHENOLIC COMPOUNDS ENCAPSUALATED IN LONG CIRCULATING LIPOSOMES AND USE THEREOF 审中-公开
公开(公告)号：US20170172921A1
公开(公告)日：2017-06-22
申请号：US15378091
申请日：2016-12-14
申请人： Mahmoud Reza Jaafari , Fatemeh Gheybi , Seyed Mahdi Rezayat Sorkhabadi
发明人： Mahmoud Reza Jaafari , Fatemeh Gheybi , Seyed Mahdi Rezayat Sorkhabadi
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1271 , A61K9/1277
摘要： A method for preparing a liposome composition for delivering polyphenolic compounds to the target organs may include preparing a complex that contains at least one polyphenolic compound. Then, encapsulating the polyphenolic compound into a liposome composition by admixing the prepared complex with the liposome ingredients.

23. 发明授权

US09668974B2 Depot formulations of a local anesthetic and methods for preparation thereof 有权
公开(公告)号：US09668974B2
公开(公告)日：2017-06-06
申请号：US14399815
申请日：2013-05-09
申请人： PAINREFORM LTD.
发明人： Shimon Amselem , Michael Naveh
IPC分类号： A61K9/127 , A61K47/10 , A61K9/00 , A61K47/44 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/20 , A61K47/24
CPC分类号： A61K9/1277 , A61K9/0024 , A61K9/127 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/20 , A61K47/24 , A61K47/44
摘要： The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a local anesthetic in the form of a clear oily solution and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.

24. 发明授权

US09603800B2 Methods of treating inflammatory and autoimmune diseases and disorders using nanolipogels 有权
公开(公告)号：US09603800B2
公开(公告)日：2017-03-28
申请号：US14394147
申请日：2013-04-12
申请人： Yale University
发明人： Tarek M. Fahmy , Michael Look , Joseph Craft
IPC分类号： A61K9/127 , A61K47/24 , A61K47/40 , A61K47/48 , B82Y5/00 , A61K38/18 , A61K38/20 , A61K31/343
CPC分类号： A61K38/1841 , A61K9/0019 , A61K9/1271 , A61K9/1273 , A61K9/1277 , A61K9/5153 , A61K31/343 , A61K38/2013 , A61K47/24 , A61K47/40 , A61K47/58 , A61K47/6849 , A61K47/6937 , A61K47/6951 , B82Y5/00
摘要： Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder. The nanolipogel includes a lipid bilayer surrounding a hydrogel core, which may optionally include a host molecule, for example, an absorbent such as a cyclodextrin or ion-exchange resin. In preferred embodiments at least one of active agents is an immunosuppressant.

25. 发明申请

US20170079912A1 Liposomes Useful for Drug Delivery 审中-公开
公开(公告)号：US20170079912A1
公开(公告)日：2017-03-23
申请号：US15363923
申请日：2016-11-29
申请人： Merrimack Pharmaceuticals, Inc.
发明人： Keelung Hong , Daryl C. Drummond , Dmitri Kirpotin
IPC分类号： A61K9/127 , A61K31/4745
CPC分类号： A61K31/4745 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/1278 , A61K31/337 , A61K31/4375 , A61K31/475 , A61K31/704 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/60 , A61K47/6913 , C07H13/12 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.

26. 发明申请

US20170065614A1 PROLIPOSOMAL TESTOSTERONE FORMULATIONS 有权
标题翻译：孕激素配方
公开(公告)号：US20170065614A1
公开(公告)日：2017-03-09
申请号：US15268917
申请日：2016-09-19
申请人： WESTERN UNIVERSITY OF HEALTH SCIENCES , TESORX PHARMA, LLC
发明人： Guru V. BETAGERI , Ramachandran THIRUCOTE , Veeran Gowda KADAJJI
IPC分类号： A61K31/568 , A61K9/48 , A61K9/00 , A61K9/127
CPC分类号： A61K31/568 , A61K9/0053 , A61K9/10 , A61K9/127 , A61K9/1277 , A61K9/145 , A61K9/19 , A61K9/2013 , A61K9/2846 , A61K9/4858 , A61K9/4866 , A61K9/4891 , A61K31/575
摘要： Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/cholesterol system to produce a proliposomal powder dispersion. The proliposomal powder dispersions of the invention may be formulated with phamarceutically acceptable excipients to form pharmaceutical compositions. Enterically coated oral dosage forms are disclosed as are methods of treatment for testosterone replacement therapy.
摘要翻译：公开了新的睾丸酮制剂，其中将睾酮并入磷脂/胆固醇系统中以产生脱脂体粉末分散体。本发明的前体脂质体粉末分散体可以配合有可溶性赋形剂以形成药物组合物。公开了肠溶包衣的口服剂型作为治疗睾酮替代疗法的方法。

27. 发明授权

US09579261B2 Method and apparatus for preparing novel liposome 有权
标题翻译：制备新型脂质体的方法和装置
公开(公告)号：US09579261B2
公开(公告)日：2017-02-28
申请号：US13580236
申请日：2011-02-24
申请人： Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
发明人： Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
IPC分类号： A61J3/07 , A61K9/127 , A61K9/19 , A61K31/70 , B01D11/04
CPC分类号： A61J3/07 , A61K9/127 , A61K9/1277 , A61K9/19 , A61K31/70 , B01D11/0411
摘要： Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.
摘要翻译：公开了一种制备脂质体制剂的方法。在所公开的方法中，将脂质部分溶解在有机溶剂中。将包含生物活性成分和脂质部分的溶液与载体一起放入反应容器中，并向其中引入超临界流体，以制备涂覆有生物活性成分 - 脂质的颗粒。通过压缩将超临界流体排出以获得催乳素体颗粒，然后通过包含水的水溶液使前体脂质颗粒水合以形成脂质体溶液。优选地，制剂可以包括一种或多种生物活性成分。根据需要，脂质体制剂可以通过诸如粒径减小，去除有机溶剂和冷冻干燥的方法进一步加工。该制备方法可以在实验室规模下轻松进行。此外，相同的方法可以在批量生产或商业规模的脂质体制剂制备中使用。

28. 发明申请

US20170014793A1 Single Use, Low Dead Volume Apparatus For Liposome Sizing or Extrusion 审中-公开
标题翻译：用于脂质体定型或挤出的单次使用，低死体积装置
公开(公告)号：US20170014793A1
公开(公告)日：2017-01-19
申请号：US15209193
申请日：2016-07-13
申请人： Graham Jeffrey Taylor , Nima Tamaddoni Jahromi
发明人： Graham Jeffrey Taylor , Nima Tamaddoni Jahromi
IPC分类号： B01J13/04 , A61K9/127
CPC分类号： B01J13/04 , A61K9/1277
摘要： A single-use, extrusion apparatus and method of using the apparatus. The apparatus includes a first housing member having a first port dimensioned to receive a first needle-tipped syringe, and a first needle path dimensioned to receive a first needle, wherein the first needle path extends from the first port through the first housing member; a second housing member having a second port dimensioned to receive a second needle-tipped syringe, and a second needle path, dimensioned to receive a second needle, wherein the second needle path extends from the second port through the second housing member and is collinear with the first needle path extending through the first housing member; and a membrane filter disposed between the first and second housing members, wherein a total dead-volume of the apparatus, not including the first and second needle paths is less than or equal to about 50 microliters.
摘要翻译：使用该设备的一次性挤出设备和方法。该设备包括第一壳体构件，其具有第一端口，该第一端口的尺寸被设计成容纳第一针尖注射器，以及第一针通路，其尺寸设置成容纳第一针，其中第一针路径从第一端口延伸穿过第一壳体构件; 第二壳体构件，具有尺寸适于接收第二针尖注射器的第二端口和尺寸适于接收第二针的第二针通路，其中第二针通路从第二端口延伸穿过第二壳体构件并与所述第一针通路延伸穿过所述第一壳体构件; 以及设置在第一和第二壳体构件之间的膜过滤器，其中不包括第一和第二针通路的设备的总死体积小于或等于约50微升。

29. 发明授权

US09522114B1 Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin 有权
标题翻译：通过壳聚糖水凝胶和氯毒素增强靶向药物递送系统
公开(公告)号：US09522114B1
公开(公告)日：2016-12-20
申请号：US14671439
申请日：2015-03-27
申请人： Norma A. Alcantar , Rana Falahat , Marzenna Wiranowska , Ryan G. Toomey
发明人： Norma A. Alcantar , Rana Falahat , Marzenna Wiranowska , Ryan G. Toomey
IPC分类号： A61K38/00 , A61K9/127 , A61K31/337 , A61K47/36 , A61K38/17 , A61K9/06 , A61K47/24
CPC分类号： A61K47/24 , A61K9/0024 , A61K9/06 , A61K9/1272 , A61K9/1277 , A61K31/337 , A61K38/1767 , A61K47/36
摘要： Specific drug delivery to tumor cells without affecting normal cells is a major challenge in cancer treatment. The present invention incorporates embedding nonionic surfactant vesicles (niosomes) containing an anti-cancer therapeutic agent with chlorotoxin into a thermosensitive chitosan hydrogel network. Chitosan has mucoadhesive property which can be used in the targeting of the tumor cells with the mucin over expression. Chlorotoxin is a 36 amino acid peptide obtained from Leiurus quinquestriatus scorpion venom which binds preferentially to tumor cells of neuroectodermal origin but not to normal cells. The incorporation of chlorotoxin along with niosomes in the chitosan hydrogel is used as the second targeting strategy to further improve the specific delivery of drugs to tumor cells such as glioma.
摘要翻译：不影响正常细胞的肿瘤细胞的特异性药物递送是癌症治疗中的主要挑战。本发明将含有抗癌治疗剂的非离子型表面活性剂囊泡（niosomes）与氯毒素嵌入热敏壳聚糖水凝胶网络中。壳聚糖具有粘膜粘附性，可用于靶向肿瘤细胞与粘蛋白过度表达。蝎毒素是一种从Leiurus quinquestriatus蝎子毒液获得的36个氨基酸肽，其优先结合神经外胚层起源但不与正常细胞的肿瘤细胞结合。将氯毒素与壳聚糖水凝胶中的niosomes结合用作第二靶向策略，以进一步改善药物对肿瘤细胞如胶质瘤的特异性递送。

30. 发明授权

US09504651B2 Lipid compositions for nucleic acid delivery 有权
标题翻译：用于核酸递送的脂质组合物
公开(公告)号：US09504651B2
公开(公告)日：2016-11-29
申请号：US14304578
申请日：2014-06-13
申请人： PROTIVA BIOTHERAPEUTICS, INC.
发明人： Ian MacLachlan , Lloyd Jeffs , Lorne R. Palmer , Cory Giesbrecht
IPC分类号： A61K47/10 , A61K47/24 , B01J13/04 , A61K9/127 , A61K47/48 , A61K31/7084 , A61K31/7088 , A61K47/44
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
摘要翻译：本发明提供了用于生产脂质体的装置和方法。通过在第一储存器中提供缓冲溶液，并将第二储存器中的脂质溶液连续地稀释在混合室中的缓冲溶液中的脂质溶液产生脂质体。脂溶液优选包含有机溶剂，例如低级链烷醇。

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