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1. 发明申请

US20130069261A1 METHOD AND APPARATUS FOR PREPARING NOVEL LIPOSOME 有权
标题翻译：制备新型脂质体的方法和装置
公开(公告)号：US20130069261A1
公开(公告)日：2013-03-21
申请号：US13580236
申请日：2011-02-24
申请人： Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
发明人： Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
IPC分类号： A61J3/07
CPC分类号： A61J3/07 , A61K9/127 , A61K9/1277 , A61K9/19 , A61K31/70 , B01D11/0411
摘要： Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.
摘要翻译：公开了一种制备脂质体制剂的方法。在所公开的方法中，将脂质部分溶解在有机溶剂中。将包含生物活性成分和脂质部分的溶液与载体一起放入反应容器中，并向其中引入超临界流体，以制备涂覆有生物活性成分 - 脂质的颗粒。通过压缩将超临界流体排出以获得催乳素体颗粒，然后通过包含水的水溶液使前体脂质颗粒水合以形成脂质体溶液。优选地，制剂可以包括一种或多种生物活性成分。根据需要，脂质体制剂可以通过诸如粒径减小，去除有机溶剂和冷冻干燥的方法进一步加工。该制备方法可以在实验室规模下轻松进行。此外，相同的方法可以在批量生产或商业规模的脂质体制剂制备中使用。

2. 发明授权

US09579261B2 Method and apparatus for preparing novel liposome 有权
标题翻译：制备新型脂质体的方法和装置
公开(公告)号：US09579261B2
公开(公告)日：2017-02-28
申请号：US13580236
申请日：2011-02-24
申请人： Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
发明人： Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
IPC分类号： A61J3/07 , A61K9/127 , A61K9/19 , A61K31/70 , B01D11/04
CPC分类号： A61J3/07 , A61K9/127 , A61K9/1277 , A61K9/19 , A61K31/70 , B01D11/0411
摘要： Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.
摘要翻译：公开了一种制备脂质体制剂的方法。在所公开的方法中，将脂质部分溶解在有机溶剂中。将包含生物活性成分和脂质部分的溶液与载体一起放入反应容器中，并向其中引入超临界流体，以制备涂覆有生物活性成分 - 脂质的颗粒。通过压缩将超临界流体排出以获得催乳素体颗粒，然后通过包含水的水溶液使前体脂质颗粒水合以形成脂质体溶液。优选地，制剂可以包括一种或多种生物活性成分。根据需要，脂质体制剂可以通过诸如粒径减小，去除有机溶剂和冷冻干燥的方法进一步加工。该制备方法可以在实验室规模下轻松进行。此外，相同的方法可以在批量生产或商业规模的脂质体制剂制备中使用。

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