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21. 发明申请

US20110028398A1 METHODS FOR TREATING AND LIMITING FIBROTIC DISORDERS AND KELOIDS 审中-公开
标题翻译：治疗和限制纤维性疾病和恐惧症的方法
公开(公告)号：US20110028398A1
公开(公告)日：2011-02-03
申请号：US12305885
申请日：2007-07-10
申请人： Luciana Biagini Lopes , Elizabeth J. Furnish , Charles Robert Flynn , Padmini Komalavilas , Alyssa Panitch , Colleen M. Brophy
发明人： Luciana Biagini Lopes , Elizabeth J. Furnish , Charles Robert Flynn , Padmini Komalavilas , Alyssa Panitch , Colleen M. Brophy
IPC分类号： A61K38/16 , A61P9/04 , A61P17/02 , A61P27/02 , A61K38/10 , A61P13/12 , A61P1/16 , A61P19/04
CPC分类号： A61K38/1709 , A61K38/10 , C07K14/47
摘要： The present invention provides methods for treating and/or limiting fibrotic disorders and/or treating or limiting scars selected from the group consisting of keloids and hypertrophic scars comprising administering to an individual in need thereof an amount effective to treat and/or limit scars selected from the group consisting of keloids and hypertrophic scars of a polypeptide comprising an HSP20-related polypeptide.
摘要翻译：本发明提供了治疗和/或限制纤维化病症和/或治疗或限制选自瘢痕疙瘩和肥大性瘢痕的瘢痕的方法，其包括向有需要的个体施用有效治疗和/或限制选自以下的瘢痕的量：由包含HSP20相关多肽的多肽的瘢痕疙瘩和肥厚性瘢痕组成的组。

22. 发明申请

US20100268055A1 Self-Anchoring MEMS Intrafascicular Neural Electrode 审中-公开
标题翻译：自锚式MEMS内部神经电极
公开(公告)号：US20100268055A1
公开(公告)日：2010-10-21
申请号：US12669761
申请日：2008-07-21
申请人： Ranu Jung , Stephen M. Phillips , James J. Abbas
发明人： Ranu Jung , Stephen M. Phillips , James J. Abbas
IPC分类号： A61B5/04 , C12N13/00 , H01R43/00 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/4064 , A61B5/4076 , A61B5/6882 , A61B2562/028 , A61B2562/125 , A61N1/0558
摘要： The present invention provides a self anchoring electrode for recording, measuring and/or stimulating nerve activity in nerves and/or nerve fascicles of the peripheral nervous system, and methods for using such a self anchoring electrode.
摘要翻译：本发明提供一种用于记录，测量和/或刺激周围神经系统的神经和/或神经分支中的神经活动的自身锚定电极，以及使用这种自身锚定电极的方法。

23. 发明申请

US20100267085A1 NOVEL PSEUDOCHLOROCOCCUM SPECIES AND USES THEREFOR 审中-公开
标题翻译：新型PSEUDOCHOCOCCUM物种及其用途
公开(公告)号：US20100267085A1
公开(公告)日：2010-10-21
申请号：US12667220
申请日：2007-06-29
申请人： Qiang Hu , Danzxiang Han , Milton Summerfeld
发明人： Qiang Hu , Danzxiang Han , Milton Summerfeld
IPC分类号： C12P21/06 , C12N1/13 , C12M1/00 , C12P7/64 , C02F3/32
CPC分类号： C12N1/12 , Y02W10/37
摘要： The present invention relates to algal species and compositions, methods for identifying algae that produce high lipid content and possess CO2 tolerance, and methods for using such algae for lipid isolation, wastewater remediation, waste gas remediation, and/or biomass production.
摘要翻译：本发明涉及藻类物种和组合物，用于鉴定产生高脂质含量并具有CO 2耐受性的藻类的方法，以及使用这种藻类进行脂质分离，废水处理，废气修复和/或生物质生产的方法。

24. 发明申请

US20100243753A1 Gas Dynamic Virtual Nozzle for Generation of Microscopic Droplet Streams 有权
标题翻译：用于产生微观液滴流的气体动态虚拟喷嘴
公开(公告)号：US20100243753A1
公开(公告)日：2010-09-30
申请号：US12664437
申请日：2008-06-20
申请人： Robert Bruce Doak , John C.H. Spence , Uwe Weierstall , Daniel DePonte , Dmitri Starodub , Jared Scott Warner
发明人： Robert Bruce Doak , John C.H. Spence , Uwe Weierstall , Daniel DePonte , Dmitri Starodub , Jared Scott Warner
IPC分类号： B05B17/04 , B05B7/00
CPC分类号： B05B7/0475 , B05B1/02
摘要： A nozzle for producing a single-file stream of droplets of a fluid, methods using the nozzle, and an injector, comprising the nozzle of the invention, for providing the single-file stream of droplets of a fluid to a high-vacuum system are described. The nozzle comprises two concentric tubes wherein the outer tube comprises a smoothly converging-diverging exit channel and the outlet end of the first tube is positioned within the converging section of the exit channel.
摘要翻译：用于产生流体液滴单液流的喷嘴，使用喷嘴的方法和喷射器，其包括本发明的喷嘴，用于向高真空系统提供流体的单液滴流。描述。喷嘴包括两个同心管，其中外管包括平稳会聚的发散出口通道，并且第一管的出口端位于出口通道的会聚部分内。

25. 发明申请

US20090035751A1 Single Molecule Detection Using Molecular Motors 有权
标题翻译：使用分子电机的单分子检测
公开(公告)号：US20090035751A1
公开(公告)日：2009-02-05
申请号：US10582820
申请日：2004-12-17
申请人： Lyian He , Wayne Frasch
发明人： Lyian He , Wayne Frasch
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6834 , C12Q2565/619 , C12Q2531/137 , C12Q2533/107 , C12Q2565/601 , C12Q2565/629 , C12Q2563/125
摘要： The present invention provides methods and compositions for highly sensitive nucleic acid detection, down to the single nucleic acid molecule level. In one aspect, the present invention provides methods for detecting a target nucleic acid comprising: (a) providing first and second target-specific nucleic acids, wherein the first and second target-specific nucleic acids each comprise sequences complementary to the target nucleic acid; wherein the first target specific nucleic acid is bound to a first affinity tag and the second target-specific nucleic acid is bound to a second affinity tag, wherein the first affinity tag is capable of binding to a molecular motor, and wherein the second affinity tag is capable of binding to a detection probe; (b) contacting the first and second target-specific nucleic acids to a sample under conditions whereby the first and second target-specific nucleic acids will hybridize to the target nucleic acid if the target nucleic acid is present in the sample, wherein upon hybridization to the target nucleic acid the first and second target-specific nucleic acids are directly adjacent to each other; (c) ligating the first and second target-specific nucleic acids together; (d) binding the molecular motor t˜ the first affinity tag and the detection probe to the second affinity tag; (e) inducing movement of the molecular motor; and (f) detecting movement of the molecular motor through the detection probe, wherein the movement of the molecular motor serves to detect the target nucleic acid in the sample.
摘要翻译：本发明提供用于高度敏感的核酸检测的方法和组合物，直到单个核酸分子水平。一方面，本发明提供了用于检测靶核酸的方法，包括：（a）提供第一和第二靶特异性核酸，其中第一和第二靶特异性核酸各自包含与靶核酸互补的序列; 其中所述第一靶特异性核酸与第一亲和标签结合，并且所述第二靶特异性核酸与第二亲和标签结合，其中所述第一亲和标签能够结合分子马达，并且其中所述第二亲和标签能够结合检测探针; （b）在条件下使第一和第二靶特异性核酸与样品接触，其中如果靶核酸存在于样品中，则第一和第二靶特异性核酸将与靶核酸杂交，其中在与靶核酸第一和第二靶特异性核酸彼此直接相邻; （c）将第一和第二靶特异性核酸连接在一起; （d）将第一亲和标签和检测探针的分子马达结合到第二亲和标签上; （e）诱导分子马达的运动; 和（f）检测分子马达通过检测探针的运动，其中分子马达的移动用于检测样品中的靶核酸。

26. 发明申请

US20080277647A1 Materials and Optical Devices Based on Group IV Quantum Wells Grown on Si-Ge-Sn Buffered Silicon 失效
标题翻译：基于Si-Ge-Sn缓冲硅上生长的IV族量子阱的材料和光学器件
公开(公告)号：US20080277647A1
公开(公告)日：2008-11-13
申请号：US11663024
申请日：2005-09-16
申请人： John Kouvetakis , Jose Menendez , John Tolle , Ling Liao , Dean Samara-Rubio
发明人： John Kouvetakis , Jose Menendez , John Tolle , Ling Liao , Dean Samara-Rubio
IPC分类号： H01L31/0264
CPC分类号： G02F1/017 , B82Y20/00 , G02F1/01708 , G02F2001/0157 , G02F2203/11 , H01L21/02381 , H01L21/0245 , H01L21/02452 , H01L21/02532 , H01L21/02535 , H01L21/0262 , H01L31/028 , H01L31/035254 , H01L31/109 , Y02E10/547
摘要： A semiconductor structure including a single quantum well Ge1−x1−ySix1Sn/Ge1−x2Six2 heterostructure grown strain-free on Si(100) via a Sn1−xGex buffer layer is shown.
摘要翻译：包括单量子阱的半导体结构Ge 1-x1-y Si 1 Sn 1 / x 1 x 2 Si x 2 x 2 示出了在Si（100）上通过Sn 1-x N Ge x S x缓冲层生长无应变的异质结构。

27. 发明申请

US20080138801A1 Surface Plasmon Resonance Sensor for Detecting Changes in Polynucleotide Mass 审中-公开
标题翻译：用于检测多核苷酸质量变化的表面等离子体共振传感器
公开(公告)号：US20080138801A1
公开(公告)日：2008-06-12
申请号：US11578475
申请日：2005-05-27
申请人： Liyan He
发明人： Liyan He
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6837 , C12Q2565/628 , C12Q2565/607
摘要： The present invention provides methods for detecting nucleic acids by generating mass changes in a ligand on an SPR surface through target-dependent enzymatic reaction.
摘要翻译：本发明提供了通过靶依赖性酶反应在SPR表面上产生配体的质量变化来检测核酸的方法。

28. 发明授权

US5494893A Stylostatin 2 失效
公开(公告)号：US5494893A
公开(公告)日：1996-02-27
申请号：US338384
申请日：1994-11-14
申请人： George R. Pettit , Jayaram K. Srirangam
发明人： George R. Pettit , Jayaram K. Srirangam
IPC分类号： A61K38/00 , C07K7/64 , C07K5/12
CPC分类号： C07K7/64 , A61K38/00
摘要： The cytostatic cycloheptapeptide stylostatin 2 was isolated respectively, from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing high-field (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration was established by chiral gas chromatographic analytical technique. The cyclic heptapeptide backbone was found to include a .beta.-turn, type VIa, incorporating a cis peptide bond, at -Ser-Pro.
摘要翻译：分别从南太平洋和西太平洋海绵Stylotella sp。分离出细胞生长抑制性环庚沙门氏菌素2 和Phakellia costata。通过利用高场（500MHz）2D-NMR实验并通过X射线晶体结构测定证实提供赋形环（Pro-Leu-Ile-Phe-Ser-Pro-Ile）来进行结构测定。绝对配置是通过手性气相色谱分析技术建立的。在-Ser-Pro中发现环状七肽主链包含β-转角，VIa，并入顺式肽键。

29. 发明授权

US5045819A Multilayer-multiconductor microstrips for digital integrated circuits 失效
标题翻译：用于数字集成电路的多层多导体微带
公开(公告)号：US5045819A
公开(公告)日：1991-09-03
申请号：US533926
申请日：1990-06-06
申请人： Constantine A. Balanis , James P. K. Gilb
发明人： Constantine A. Balanis , James P. K. Gilb
IPC分类号： H01P3/08 , H05K1/00 , H05K1/02
CPC分类号： H01P3/082 , H05K1/0237 , H05K3/4676
摘要： A multilayer-multiconductor microstrip circuit having reduced dimensions and minimal pulse distortion and crosstalk for high-speed, high-density digital application is created utilizing a microstrip having a plurality of substrates, each having a preselected dielectric constant of a magnitude which, combined with the height of each substrate, produces effective dielectric constants of the independent propagating nodes which are substantially equal.
摘要翻译：利用具有多个基板的微带线产生具有尺寸减小和用于高速，高密度数字应用的最小脉冲失真和串扰的多层多导体微带电路，每个基板具有预选的介电常数，其大小与每个衬底的高度产生基本相等的独立传播节点的有效介电常数。

30. 发明授权

US10802026B2 Biomarkers for the early detection of breast cancer 有权
公开(公告)号：US10802026B2
公开(公告)日：2020-10-13
申请号：US15818975
申请日：2017-11-21
申请人： ARIZONA BOARD OF REGENTS, a body corporate acting for and on behalf of Arizona State University , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Joshua Labaer , Karen Sue Anderson , Garrick Wallstrom , Sahar Sibani , Niroshan Ramachandran
IPC分类号： G01N33/574 , C12Q1/6886
摘要： The present invention provides reagents and methods for breast cancer detection.

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