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21. 发明申请

US20050186695A1 Method for manufacturing solid-state imaging device 审中-公开
标题翻译：固态成像装置的制造方法
公开(公告)号：US20050186695A1
公开(公告)日：2005-08-25
申请号：US11049029
申请日：2005-02-01
申请人： Tohru Yamada
发明人： Tohru Yamada
IPC分类号： H01L27/14 , H01L27/148 , H01L29/768
CPC分类号： H01L27/14689 , H01L27/14687 , H01L27/14806 , H01L31/03529
摘要： First, a first gate insulating film is formed in a region where a charge transfer portion is to be formed on a semiconductor substrate, and a protective film is formed on the first gate insulating film. A photoresist for transfer channel formation is formed on the protective film, and then a part of the photoresist for the transfer channel formation is removed by patterning. Next, an impurity is ion-implanted using the photoresist for the transfer channel formation as a mask, so as to form a transfer channel below the first gate insulating film. Subsequently, the photoresist for the transfer channel formation is removed, and the second gate insulating film is formed on the protective film. Thereafter, a transfer electrode is formed.
摘要翻译：首先，在半导体衬底上形成电荷转移部分的区域中形成第一栅极绝缘膜，并在第一栅极绝缘膜上形成保护膜。在保护膜上形成用于转移通道形成的光致抗蚀剂，然后通过图案化去除用于转移通道形成的光致抗蚀剂的一部分。接下来，使用用于传输沟道形成的光致抗蚀剂离子注入杂质作为掩模，以在第一栅极绝缘膜下方形成传输沟道。随后，去除用于转移通道形成的光致抗蚀剂，并且在保护膜上形成第二栅极绝缘膜。之后，形成转印电极。

22. 发明授权

US06252285B1 Efficient inspection of light-gathering rate of microlens in solid state imaging device 失效
标题翻译：有效检查固态成像装置中微透镜的聚光率
公开(公告)号：US06252285B1
公开(公告)日：2001-06-26
申请号：US09288299
申请日：1999-04-08
申请人： Masayuki Furumiya , Yasutaka Nakashiba , Tohru Yamada , Katsumi Yamamoto , Keiichi Hara
发明人： Masayuki Furumiya , Yasutaka Nakashiba , Tohru Yamada , Katsumi Yamamoto , Keiichi Hara
IPC分类号： H01L27148
CPC分类号： H01L27/14627 , H01L27/14806
摘要： A solid state imaging device includes a plurality of photoelectric conversion elements arranged in an imaging area of a semiconductor substrate. Above each of the photoelectric conversion elements, a light-gathering microlens for gathering light on the photoelectric conversion element is disposed. Further, a microlens for shape inspection having the same shape as that of the light-gathering microlens is disposed outside the imaging area. A base pattern for inspection is disposed below the microlens for shape inspection. The shape of the microlens for shape inspection is inspected through observing an image of the base pattern through the microlens for shape inspection. A result of this inspection applies as it is to the light-gathering microlenses.
摘要翻译：固态成像装置包括布置在半导体衬底的成像区域中的多个光电转换元件。在每个光电转换元件上方，设置用于在光电转换元件上聚集光的聚光微透镜。此外，具有与聚光微透镜相同形状的形状检查用微透镜设置在摄像区域的外侧。用于检查的基本图案被放置在微透镜的下面用于形状检查。用于形状检查的微透镜的形状通过观察通过微透镜的基底图案的图像进行检查。这种检查的结果适用于聚光微透镜。

23. 发明授权

US5847489A Piezoelectric device and a package 失效
公开(公告)号：US5847489A
公开(公告)日：1998-12-08
申请号：US708918
申请日：1996-09-06
申请人： Yuki Satoh , Toshio Ishizaki , Tsuyoshi Sakaue , Koji Hashimoto , Tohru Yamada , Tomoki Uwano
发明人： Yuki Satoh , Toshio Ishizaki , Tsuyoshi Sakaue , Koji Hashimoto , Tohru Yamada , Tomoki Uwano
IPC分类号： H01C1/02 , H01L23/08 , H01L41/053 , H03H3/007 , H03H9/02 , H03H9/05 , H03H9/10 , H03H9/13 , H03H9/17 , H03H9/25 , H03H9/56 , H05K5/06 , H01L41/08
CPC分类号： H03H9/1071 , H03H9/1035
摘要： A piezoelectric device includes a piezoelectric plate provided with at least one electrode at almost a central portion of each face; a first plate made of an ionic material having a recessed portion to cover the at least one electrode at one face to face the piezoelectric plate; and a second plate made of an ionic material having a recessed portion to cover the at least one electrode at one face to face the piezoelectric plate. Each of the at least one electrode is packaged by direct bonding the piezoelectric plate with the first plate and the second plate so as to be sandwiched therebetween. A package includes a body member made of an ionic material provided with a recessed portion or an opening, having a flat face around the recessed portion or the opening; and a covering member made of an ionic material having a flat face to cover the body member. The flat face of the body member and the flat face of the covering member are cleaned and attached to each other so as to be direct bonded with each other using hydrogen bonds generated between the ionic materials, thereby packaging the recessed portion or the opening.

24. 发明授权

US5053164A Substituted naphthalene compounds and liquid crystal compositions containing same 失效
标题翻译：取代的萘甲酸酯化合物和含有相同的液晶组合物
公开(公告)号：US5053164A
公开(公告)日：1991-10-01
申请号：US496033
申请日：1990-03-20
申请人： Shinichi Nishiyama , Hideo Yamaoka , Tooru Yamanaka , Tohru Yamada
发明人： Shinichi Nishiyama , Hideo Yamaoka , Tooru Yamanaka , Tohru Yamada
IPC分类号： C09K19/32
CPC分类号： C09K19/322
摘要： In accordance with the present invention, there is provided substituted naphthalene compounds represented by the following formula [I]. ##STR1## wherein R.sup.1 represents alkyl of 1-18 carbon atoms, R.sup.2 represents alkyl of 1-18 carbon atoms, X is a group represented by --OCH.sub.2 -- or --CH.sub.2 CH.sub.2 --, and n is 0 or 1.In accordance with the invention, moreover, there is provided liquid crystal compositions containing the substituted naphthalene compounds represented by the above-mentioned formula [I].

25. 发明授权

US4943651A Novel substitued naphthalene compounds and liquid crystal compositions containing same 失效
标题翻译：新型取代的萘化合物和含有它们的液晶组合物
公开(公告)号：US4943651A
公开(公告)日：1990-07-24
申请号：US318560
申请日：1989-03-03
申请人： Shinichi Nishiyama , Hideo Yamaoka , Tooru Yamanaka , Tohru Yamada
发明人： Shinichi Nishiyama , Hideo Yamaoka , Tooru Yamanaka , Tohru Yamada
IPC分类号： C09K19/32
CPC分类号： C09K19/322
摘要： In accordance with the present invention, there is provided substituted naphthalene compounds represented by the following formula [I]. ##STR1## wherein R.sup.1 represents alkyl of 1-18 carbon atoms, R.sup.2 represents alkyl of 1-18 carbon atoms, X is a group represented by --OCH.sub.2 -- or --CH.sub.2 CH.sub.2 --, and n is 0 or 1.In accordance with the invention, moreover, there is provided liquid crystal compositions containing the substituted naphthalene compounds represented by the above-mentioned formula [I].

26. 发明授权

US10266868B2 Compositions for treating HIV infection with cupredoxin and cytochrome C 有权
公开(公告)号：US10266868B2
公开(公告)日：2019-04-23
申请号：US12880682
申请日：2010-09-13
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
IPC分类号： C07K14/195 , C12Q1/18
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.

27. 发明授权

US09968685B2 Methods to treat cancer with cupredoxins 有权
公开(公告)号：US09968685B2
公开(公告)日：2018-05-15
申请号：US12338480
申请日：2008-12-18
申请人： Brad N. Taylor , Rajeshwari Mehta , Tohru Yamada , Craig Beattie , Tapas Das Gupta
发明人： Brad N. Taylor , Rajeshwari Mehta , Tohru Yamada , Craig Beattie , Tapas Das Gupta
IPC分类号： A61K38/03 , C07K14/195 , C07K14/21 , C07K14/35 , A61K47/48 , A61K49/00 , C07K14/415 , C12N9/02 , G01N33/50 , G01N33/569 , A61K38/00
CPC分类号： A61K47/6455 , A61K38/00 , A61K38/03 , A61K47/64 , A61K49/0002 , A61K49/0032 , A61K49/0056 , C07K14/195 , C07K14/21 , C07K14/35 , C07K14/415 , C12N9/0004 , G01N33/5011 , G01N33/569 , G01N2510/00
摘要： The present invention discloses methods and materials for killing and/or inhibiting the growth of a cancer cell via preferential entry of a cytotoxic compound. Preferential entry of the cytotoxic compound is accomplished by the use of protein transduction domains derived from cupredoxins, including the p18 and p28 truncations of azurin.

28. 发明申请

US20130004431A1 TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS AND METHODS OF USE THEREOF 有权
标题翻译：用于交叉血脑屏障和脑癌细胞的运输代理及其使用方法
公开(公告)号：US20130004431A1
公开(公告)日：2013-01-03
申请号：US13481018
申请日：2012-05-25
申请人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： C07K14/22 , A61K38/16 , C12N5/071 , C12N5/09 , C12N5/079 , A61P35/00 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/22 , C12Q1/02 , C07H21/04 , A61P25/00 , C07K19/00 , B82Y5/00
CPC分类号： C07K14/22 , A61K9/0085 , A61K38/00 , A61K38/164 , A61K45/06 , A61K47/64 , A61K47/66 , A61K49/0002 , A61K49/001 , A61K49/0041 , A61K49/0056 , A61K49/04 , A61K49/085 , A61K49/14 , A61K49/221 , B82Y5/00 , C07K7/06 , C07K14/47 , C12N15/625 , G01N33/5091
摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.
摘要翻译：本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。本发明还提供了由五肽AAEAP组成的合成转运肽。本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。此外，本发明提供了成像和诊断癌症，特定脑癌的方法。

29. 发明申请

US20120196805A1 COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS 有权
标题翻译：用丙泊酚控制血管生成的组合物和方法
公开(公告)号：US20120196805A1
公开(公告)日：2012-08-02
申请号：US13405663
申请日：2012-02-27
申请人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： A61K38/16 , C07K14/21 , C07K14/225 , C07K14/235 , C07K14/22 , A61J1/06 , A61P35/00 , A61P37/02 , A61P17/06 , A61P29/00 , C12Q1/02 , C12N15/63 , C07K14/195 , C07K14/28
CPC分类号： A61K38/164 , A01K67/0271 , A01K2207/15 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K45/06 , C07K14/21 , G01N33/6893
摘要： The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.
摘要翻译：本发明涉及包含铜氧还蛋白的组合物及其用于抑制哺乳动物细胞，组织和动物中的血管生成，特别是伴随肿瘤发展，特别是人类的血管生成。具体地说，本发明涉及包含铜氧还蛋白的组合物，和/或作为氧还蛋白的变体，衍生物或结构等同物的肽，其保留抑制哺乳动物细胞，组织或动物中血管生成的能力。这些组合物可以是肽或药物组合物等。本发明的组合物可用于治疗作为症状或引起不适当的血管发生以及与肿瘤发展相关的特别不合适的血管生成的任何病理状况。

30. 发明授权

US07906824B2 Solid state imaging device and method of manufacturing the same 有权
标题翻译：固态成像装置及其制造方法
公开(公告)号：US07906824B2
公开(公告)日：2011-03-15
申请号：US12416506
申请日：2009-04-01
申请人： Ikuo Mizuno , Tohru Yamada
发明人： Ikuo Mizuno , Tohru Yamada
IPC分类号： H01L27/14
CPC分类号： H01L27/14818
摘要： A solid state imaging device has a plurality of photodetector parts 11 arranged in matrix, a plurality of vertical charge transfer electrodes 13 that read out signal charge from the photodetector parts and transfer the signal charge in the vertical direction, and a first light-shielding film 5 that shields the plural vertical charge transfer parts from incident light. Each of the vertical charge transfer electrodes includes: a transfer channel 12 provided along the vertical array of the plural photodetector parts, a plurality of first transfer electrodes 3a that are formed on the transfer channel so as to traverse the transfer channel and that is coupled in the horizontal direction in spacing between the photodetector parts; and second transfer electrodes 3b provided on the transfer channel and arranged between the first transfer electrodes. The first light-shielding film is formed continuously in the horizontal direction and has openings formed on the photodetector parts. Isolation regions having electroconductivity are formed between the photodetector parts and connected electrically to the second transfer electrode. Thereby, a shunt wiring structure capable of a high-speed transfer at a high sensitivity and with reduced smearing is obtained.
摘要翻译：固态成像装置具有多个以矩阵形式布置的光电检测器部分11，多个垂直电荷转移电极13，其从光电检测器部分读出信号电荷并在垂直方向上传送信号电荷;以及第一遮光膜 5从入射光屏蔽多个垂直电荷转移部分。每个垂直电荷转移电极包括：沿着多个光电检测器部分的垂直阵列设置的传输通道12，多个第一传输电极3a，其形成在传送通道上，以穿过传输通道并耦合在光电检测器部分之间的间隔的水平方向; 以及设置在传送通道上并布置在第一传输电极之间的第二传输电极3b。第一遮光膜在水平方向上连续地形成并且在光电检测器部分上形成有开口。在光检测器部分之间形成具有导电性的隔离区，并与第二转印电极电连接。由此，可以获得能够以高灵敏度高速转印并且减少拖尾的并联布线结构。

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