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1. 发明授权

US07807183B2 Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof 有权
标题翻译：用于穿过血脑屏障和脑癌细胞的运输剂及其使用方法
公开(公告)号：US07807183B2
公开(公告)日：2010-10-05
申请号：US11488695
申请日：2006-07-19
申请人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： A61K39/095 , A61K39/02 , A61K39/00
CPC分类号： C07K14/22 , A61K9/0085 , A61K38/00 , A61K38/164 , A61K45/06 , A61K47/64 , A61K47/66 , A61K49/0002 , A61K49/001 , A61K49/0041 , A61K49/0056 , A61K49/04 , A61K49/085 , A61K49/14 , A61K49/221 , B82Y5/00 , C07K7/06 , C07K14/47 , C12N15/625 , G01N33/5091
摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP (SEQ ID NO: 25). The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particularly brain cancer.
摘要翻译：本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。本发明还提供由五肽AAEAP（SEQ ID NO：25）组成的合成转运肽。本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。此外，本发明提供了成像和诊断癌症，特别是脑癌的方法。

2. 发明授权

US07556810B2 Compositions and methods to control angiogenesis with cupredoxins 有权
标题翻译：用氧氟沙星控制血管生成的组合物和方法
公开(公告)号：US07556810B2
公开(公告)日：2009-07-07
申请号：US11488693
申请日：2006-07-19
申请人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02
CPC分类号： A61K38/164 , A01K67/0271 , A01K2207/15 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K45/06 , C07K14/21 , G01N33/6893
摘要： The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.
摘要翻译：本发明涉及包含铜氧还蛋白的组合物及其用于抑制哺乳动物细胞，组织和动物中的血管生成，特别是伴随肿瘤发展，特别是人类的血管生成。具体地说，本发明涉及包含铜氧还蛋白的组合物，和/或作为氧还蛋白的变体，衍生物或结构等同物的肽，其保留抑制哺乳动物细胞，组织或动物中血管生成的能力。这些组合物可以是肽或药物组合物等。本发明的组合物可用于治疗作为症状或引起不适当的血管发生以及与肿瘤发展相关的特别不合适的血管生成的任何病理状况。

3. 发明申请

US20080182782A1 Cytotoxic factors for modulating cell death 审中-公开
标题翻译：调节细胞死亡的细胞毒性因子
公开(公告)号：US20080182782A1
公开(公告)日：2008-07-31
申请号：US11509682
申请日：2006-08-25
申请人： Ananda M. Chakrabarty , Tapas K. Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
发明人： Ananda M. Chakrabarty , Tapas K. Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
IPC分类号： A61K38/00 , C07K16/00
摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
摘要翻译：公开了用于调节细胞死亡的细胞毒性因子及其在治疗坏死或凋亡相关病症的方法中的用途。本发明还涉及用于鉴定可用于治疗与细胞死亡或不受控生长相关的病症的活性剂的方法。本发明人发现，不同的微生物产生具有抗癌活性的不同的细胞毒性因子。基本上纯的细胞毒性因子可用于治疗感染性疾病或癌症的方法。

4. 发明申请

US20130004431A1 TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS AND METHODS OF USE THEREOF 有权
标题翻译：用于交叉血脑屏障和脑癌细胞的运输代理及其使用方法
公开(公告)号：US20130004431A1
公开(公告)日：2013-01-03
申请号：US13481018
申请日：2012-05-25
申请人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： C07K14/22 , A61K38/16 , C12N5/071 , C12N5/09 , C12N5/079 , A61P35/00 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/22 , C12Q1/02 , C07H21/04 , A61P25/00 , C07K19/00 , B82Y5/00
CPC分类号： C07K14/22 , A61K9/0085 , A61K38/00 , A61K38/164 , A61K45/06 , A61K47/64 , A61K47/66 , A61K49/0002 , A61K49/001 , A61K49/0041 , A61K49/0056 , A61K49/04 , A61K49/085 , A61K49/14 , A61K49/221 , B82Y5/00 , C07K7/06 , C07K14/47 , C12N15/625 , G01N33/5091
摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.
摘要翻译：本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。本发明还提供了由五肽AAEAP组成的合成转运肽。本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。此外，本发明提供了成像和诊断癌症，特定脑癌的方法。

5. 发明申请

US20120196805A1 COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS 有权
标题翻译：用丙泊酚控制血管生成的组合物和方法
公开(公告)号：US20120196805A1
公开(公告)日：2012-08-02
申请号：US13405663
申请日：2012-02-27
申请人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： A61K38/16 , C07K14/21 , C07K14/225 , C07K14/235 , C07K14/22 , A61J1/06 , A61P35/00 , A61P37/02 , A61P17/06 , A61P29/00 , C12Q1/02 , C12N15/63 , C07K14/195 , C07K14/28
CPC分类号： A61K38/164 , A01K67/0271 , A01K2207/15 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K45/06 , C07K14/21 , G01N33/6893
摘要： The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.
摘要翻译：本发明涉及包含铜氧还蛋白的组合物及其用于抑制哺乳动物细胞，组织和动物中的血管生成，特别是伴随肿瘤发展，特别是人类的血管生成。具体地说，本发明涉及包含铜氧还蛋白的组合物，和/或作为氧还蛋白的变体，衍生物或结构等同物的肽，其保留抑制哺乳动物细胞，组织或动物中血管生成的能力。这些组合物可以是肽或药物组合物等。本发明的组合物可用于治疗作为症状或引起不适当的血管发生以及与肿瘤发展相关的特别不合适的血管生成的任何病理状况。

6. 发明申请

US20110077387A1 TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS, AND METHODS OF USE THEREOF 有权
标题翻译：用于交叉血脑屏障和脑癌细胞的运输代理及其使用方法
公开(公告)号：US20110077387A1
公开(公告)日：2011-03-31
申请号：US12897298
申请日：2010-10-04
申请人： Chang Soo Hong , Tobru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Chang Soo Hong , Tobru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： C07H21/00
CPC分类号： C07K14/22 , A61K9/0085 , A61K38/00 , A61K38/164 , A61K45/06 , A61K47/64 , A61K47/66 , A61K49/0002 , A61K49/001 , A61K49/0041 , A61K49/0056 , A61K49/04 , A61K49/085 , A61K49/14 , A61K49/221 , B82Y5/00 , C07K7/06 , C07K14/47 , C12N15/625 , G01N33/5091
摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP (SEQ ID NO: 25). The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particularly brain cancer.
摘要翻译：本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。本发明还提供由五肽AAEAP（SEQ ID NO：25）组成的合成转运肽。本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。此外，本发明提供了成像和诊断癌症，特别是脑癌的方法。

7. 发明授权

US07491394B2 Cytotoxic factors for modulating cell death 有权
标题翻译：调节细胞死亡的细胞毒性因子
公开(公告)号：US07491394B2
公开(公告)日：2009-02-17
申请号：US10720603
申请日：2003-11-24
申请人： Ananda M. Chakrabarty , Tapas K. Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
发明人： Ananda M. Chakrabarty , Tapas K. Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
IPC分类号： A61K39/00 , A61K38/00 , C12Q1/00 , G01N33/53
CPC分类号： C07K14/80 , A61K38/164 , A61K38/168 , A61K38/415 , C07K14/195
摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
摘要翻译：公开了用于调节细胞死亡的细胞毒性因子及其在治疗坏死或凋亡相关病症的方法中的用途。本发明还涉及用于鉴定可用于治疗与细胞死亡或不受控生长相关的病症的活性剂的方法。本发明人发现，不同的微生物产生具有抗癌活性的不同的细胞毒性因子。基本上纯的细胞毒性因子可用于治疗感染性疾病或癌症的方法。

8. 发明申请

US20080213185A1 Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof 有权
标题翻译：用于穿过血脑屏障和脑癌细胞的运输剂及其使用方法
公开(公告)号：US20080213185A1
公开(公告)日：2008-09-04
申请号：US11488695
申请日：2006-07-19
申请人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Chang Soo Hong , Tohru Yamada , Arsenio M. Fialho , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： A61K49/06 , C07K14/00 , C07K1/00 , A61P35/00 , A61K49/22 , A61K38/00 , C07H21/04 , A61K49/04
CPC分类号： C07K14/22 , A61K9/0085 , A61K38/00 , A61K38/164 , A61K45/06 , A61K47/64 , A61K47/66 , A61K49/0002 , A61K49/001 , A61K49/0041 , A61K49/0056 , A61K49/04 , A61K49/085 , A61K49/14 , A61K49/221 , B82Y5/00 , C07K7/06 , C07K14/47 , C12N15/625 , G01N33/5091
摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.
摘要翻译：本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。本发明还提供了由五肽AAEAP组成的合成转运肽。本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。此外，本发明提供了成像和诊断癌症，特定脑癌的方法。

9. 发明授权

US4259444A Microorganisms having multiple compatible degradative energy-generating plasmids and preparation thereof 失效
标题翻译：具有多种相容的降解产生质粒的微生物及其制备
公开(公告)号：US4259444A
公开(公告)日：1981-03-31
申请号：US260563
申请日：1972-06-07
申请人： Ananda M. Chakrabarty
发明人： Ananda M. Chakrabarty
IPC分类号： C02F3/34 , C12N1/20 , C12N15/00
CPC分类号： C12N15/00 , Y10S423/17 , Y10S435/82 , Y10S435/875 , Y10S435/877
摘要： Unique microorganisms have been developed by the application of genetic engineering techniques. These microorganisms contain at least two stable (compatible) energy-generating plasmids, these plasmids specifying separate degradative pathways. The techniques for preparing such multi-plasmid strains from bacteria of the genus Pseudomonas are described. Living cultures of two strains of Pseudomonas (P. aeruginosa [NRRL B-5472] and P. putida [NRRL B-5473]) have been deposited with the United States Department of Agriculture, Agricultural Research Service, Northern Marketing and Nutrient Research Division, Peoria, Ill. The P. aeruginosa NRRL B-5472 was derived from Pseudomonas aeruginosa strain 1c by the genetic transfer thereto, and containment therein, of camphor, octane, salicylate and naphthalene degradative pathways in the form of plasmids. The P. putida NRRL B-5473 was derived from Pseudomonas putida strain PpG1 by genetic transfer thereto, and containment therein, of camphor, salicylate and naphthalene degradative pathways and drug resistance factor RP-1, all in the form of plasmids.
摘要翻译：通过应用遗传工程技术开发出独特的微生物。这些微生物含有至少两种稳定的（相容的）能量产生质粒，这些质粒指定分开的降解途径。描述了从假单胞菌属细菌制备这种多质粒株的技术。两种假单胞菌（铜绿假单胞菌[NRRL B-5472]和恶臭假单胞菌[NRRL B-5473]）的生活培养物已经存放在美国农业部农业研究服务部，北方营销与营养研究部门，绿脓杆菌NRRL B-5472通过遗传转移来源于铜绿假单胞菌菌株1c，其中含有以质粒形式的樟脑，辛烷，水杨酸酯和萘降解途径。恶臭假单胞菌NRRL B-5473通过遗传转移来源于恶臭假单胞菌PpG1，其中含有樟脑，水杨酸盐和萘降解途径和药物抗性因子RP-1，均以质粒的形式存在。

10. 发明申请

US20090137468A1 CYTOTOXIC FACTORS FOR MODULATING CELL DEATH 审中-公开
标题翻译：用于调节细胞死亡的细胞因子
公开(公告)号：US20090137468A1
公开(公告)日：2009-05-28
申请号：US12123131
申请日：2008-05-19
申请人： Ananda M. Chakrabarty , Tapas K. Das Gupta , Vas Punj , Olga Zaborina
发明人： Ananda M. Chakrabarty , Tapas K. Das Gupta , Vas Punj , Olga Zaborina
IPC分类号： A61K38/16 , C07K14/00 , A61P35/00
CPC分类号： C07K14/35 , A61K38/00 , C07K14/195 , G01N33/5011 , G01N33/569 , G01N2510/00
摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
摘要翻译：公开了用于调节细胞死亡的细胞毒性因子及其在治疗坏死或凋亡相关病症的方法中的用途。本发明还涉及用于鉴定可用于治疗与细胞死亡相关的病症的活性剂的方法。本发明人发现不同的病原体产生具有抗癌活性的不同的细胞毒性因子。基本上纯的细胞毒性因子可用于治疗感染性疾病或癌症的方法。

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