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21. 发明申请

US20110054518A1 BURR HOLE SEALING DEVICE FOR PREVENTING BRAIN SHIFT 有权
标题翻译：用于预防脑移位的双孔密封装置
公开(公告)号：US20110054518A1
公开(公告)日：2011-03-03
申请号：US12549174
申请日：2009-08-27
申请人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
发明人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
IPC分类号： A61B17/08 , A61M5/00
CPC分类号： A61N1/0539 , A61B17/3415 , A61B90/14 , A61B2017/3419 , A61B2090/103 , A61M2039/025 , A61M2039/0276 , A61M2039/0282
摘要： A burr hole sealing device for preventing brain shift during a stimulation lead implantation procedure is provided. The device includes a suction cup ring and a self-sealing membrane positioned within the aperture of the ring. The sealing device is attached adjacent to a burr hole and over a dura layer that is exposed in the bottom of the burr hole. The stimulation lead is disposed through the burr hole, through the membrane, through the dura layer and into brain tissue. The membrane is configured to allow the lead to pass therethrough while maintaining a tight seal around the diameter of the lead, thereby hindering leakage of cerebrospinal fluid out of the cranial cavity and maintaining a substantially fixed intracranial pressure. In one embodiment, the sealing device includes a syringe for adding fluid to, or removing fluid from, the cranial cavity in response to a detected change in intracranial pressure.
摘要翻译：提供了一种用于在刺激引线植入程序期间防止脑移位的钻孔密封装置。该装置包括吸盘环和位于环的孔内的自密封膜。密封装置邻近毛刺孔并暴露在钻孔底部的硬脑膜层上。刺激引线通过毛刺孔穿过膜，穿过硬脑膜层并进入脑组织。膜被配置为允许引线通过，同时保持围绕铅直径的紧密密封，从而阻止脑脊液从脑腔中泄漏并保持基本上固定的颅内压。在一个实施例中，密封装置包括用于响应于检测到的颅内压变化而将流体添加到颅腔或从头颅腔移除流体的注射器。

22. 发明申请

US20110009920A1 SKULL-MOUNTED ELECTRICAL STIMULATION SYSTEM AND METHOD FOR TREATING PATIENTS 审中-公开
标题翻译：滑动电刺激系统和治疗患者的方法
公开(公告)号：US20110009920A1
公开(公告)日：2011-01-13
申请号：US12835680
申请日：2010-07-13
申请人： Todd K. Whitehurst , Rafael Carbunaru
发明人： Todd K. Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61M2205/52 , A61M2205/8243 , A61N1/0526 , A61N1/0529 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36114 , A61N1/37211 , A61N1/37229
摘要： A system and method for applying electrical stimulation or drug infusion to nervous tissue of a patient to treat epilepsy, movement disorders, and other indications uses at least one implantable system control unit (SCU) (110), including an implantable signal/pulse generator (IPG) and one or more electrodes (152, 152). The IPG is implanted in the mastoid area (143) of the skull (140) and communicates with at least one external appliance (230), such as a Behind-the-Ear (BTE) unit (100). In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：用于对患者的神经组织施加电刺激或药物输注以治疗癫痫，运动障碍和其它指征的系统和方法使用至少一个可植入系统控制单元（SCU）（110），包括可植入信号/脉冲发生器 IPG）和一个或多个电极（152,152）。将IPG植入颅骨（140）的乳突区域（143）中并与至少一个外部设备（230）（例如，耳后（BTE）单元）进行通信。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。

23. 发明申请

US20100262210A1 Current Steering for an Implantable Stimulator Device Involving Fractionalized Stimulation Pulses 有权
标题翻译：用于涉及分数化刺激脉冲的可植入刺激装置的当前转向
公开(公告)号：US20100262210A1
公开(公告)日：2010-10-14
申请号：US12824663
申请日：2010-06-28
申请人： Jordi Parramon , Rafael Carbunaru , Matt I. Haller
发明人： Jordi Parramon , Rafael Carbunaru , Matt I. Haller
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36071 , A61N1/36125 , A61N1/36175 , A61N1/36178 , A61N1/37235
摘要： A method for configuring stimulation pulses in an implantable stimulator device having a plurality of electrodes is disclosed, which method is particularly useful in adjusting the electrodes by current steering during initialization of the device. In one aspect, a set of ideal pulses for patient therapy is determined, in which at least two of the ideal pulses are of the same polarity and are intended to be simultaneous applied to corresponding electrodes on the implantable stimulator device during an initial duration. These pulses are reconstructed into fractionalized pulses, each comprised of pulse portions. The fractionalized pulses are applied to the corresponding electrodes on the device during a final duration, but the pulse portions of the fractionalized pulses are not simultaneously applied during the final duration.
摘要翻译：公开了一种用于在具有多个电极的可植入刺激器装置中配置刺激脉冲的方法，该方法在装置的初始化期间通过电流转向来调节电极特别有用。在一个方面，确定用于患者治疗的一组理想脉冲，其中至少两个理想脉冲具有相同的极性并且旨在在初始持续时间期间同时施加到可植入刺激器装置上的对应电极。这些脉冲被重建成分数脉冲，每个脉冲包括脉冲部分。分数脉冲在最后的持续时间内施加到器件上的对应电极，但分数脉冲的脉冲部分在最后的持续时间内不被同时施加。

24. 发明申请

US20100030287A1 METHODS FOR TREATING AUTISM 审中-公开
标题翻译：治疗方法
公开(公告)号：US20100030287A1
公开(公告)日：2010-02-04
申请号：US12575974
申请日：2009-10-08
申请人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru , Allison M. Foster
发明人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru , Allison M. Foster
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61M5/14276 , A61M2210/0693 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Methods of treating autism include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. Systems for treating autism include a stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters.
摘要翻译：治疗自闭症的方法包括根据一个或多个刺激参数用植入的刺激器将至少一种刺激施加到患者脑内的刺激部位。用于治疗自闭症的系统包括刺激器，其被配置为根据一个或多个刺激参数将至少一个刺激应用于患者脑内的刺激部位。

25. 发明申请

US20090248095A1 ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权
标题翻译：可植入电刺激系统引导锚固单元及其制造和使用方法
公开(公告)号：US20090248095A1
公开(公告)日：2009-10-01
申请号：US12413081
申请日：2009-03-27
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/00 , A61N1/04
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

26. 发明申请

US20090192568A1 METHODS AND SYSTEMS FOR TREATING SEIZURES CAUSED BY BRAIN STIMULATION 失效
标题翻译：用于治疗由脑刺激引起的疾病的方法和系统
公开(公告)号：US20090192568A1
公开(公告)日：2009-07-30
申请号：US12339639
申请日：2008-12-19
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61N1/36064 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/37205 , A61N1/3756
摘要： Methods for treating seizures caused by brain stimulation include providing a stimulator, programming the stimulator with one or more stimulation parameters configured to treat a medical condition, applying at least one stimulus with the stimulator to a stimulation site within the brain of a patient in accordance with the one or more stimulation parameters, and monitoring the patient for a seizure caused by the at least one stimulus.
摘要翻译：用于治疗由脑刺激引起的癫痫发作的方法包括提供刺激器，用刺激器编程配置成治疗医疗状况的一个或多个刺激参数，使用刺激器施加至少一个刺激到患者脑内的刺激部位，一个或多个刺激参数，以及监测由至少一个刺激引起的癫痫发作的患者。

27. 发明申请

US20070129780A1 Cuff electrode arrangement for nerve stimulation and methods of treating disorders 有权
标题翻译：用于神经刺激的袖带电极装置和治疗疾病的方法
公开(公告)号：US20070129780A1
公开(公告)日：2007-06-07
申请号：US11294283
申请日：2005-12-05
申请人： Todd Whitehurst , Kirsten Jaax , Rafael Carbunaru
发明人： Todd Whitehurst , Kirsten Jaax , Rafael Carbunaru
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/37205
摘要： One embodiment is a stimulator arrangement for a nerve. The stimulator arrangement includes a cuff for placement around the nerve and a plurality of electrodes disposed on the cuff. The cuff comprises a first edge and defines a plurality of indentations along the first edge of the cuff. The stimulator arrangement may also include a stimulator unit coupled to the electrodes of the cuff. The stimulator unit may also be implantable.
摘要翻译：一个实施例是用于神经的刺激器装置。刺激器装置包括用于放置在神经周围的袖带和设置在袖带上的多个电极。袖带包括第一边缘并且限定沿着袖带的第一边缘的多个凹痕。刺激器装置还可以包括耦合到袖带的电极的刺激器单元。刺激器单元也可以是可植入的。

28. 发明申请

US20070112403A1 Electrode contact configurations for an implantable stimulator 有权
标题翻译：用于植入式刺激器的电极接触配置
公开(公告)号：US20070112403A1
公开(公告)日：2007-05-17
申请号：US11280582
申请日：2005-11-16
申请人： Michael Moffitt , Rafael Carbunaru , Todd Whitehurst , Alfred Mann
发明人： Michael Moffitt , Rafael Carbunaru , Todd Whitehurst , Alfred Mann
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： An exemplary implantable stimulator includes at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. One or more of the electrode contacts disposed on the stimulator are configured to deliver monopolar stimulation and/or multipolar stimulation. Exemplary methods of stimulating a stimulation site within a patient include providing at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. The method further includes applying an electrical stimulation current to the stimulation site via one or more of the electrode contacts that are disposed on the stimulator.
摘要翻译：示例性可植入刺激器包括至少一个电极接触阵列和至少一个附加电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。设置在刺激器上的一个或多个电极接触器被配置成传递单极刺激和/或多极刺激。刺激患者内的刺激部位的示例性方法包括提供至少一个电极接触阵列和至少一个另外的电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。该方法还包括经由设置在刺激器上的一个或多个电极接触件向刺激部位施加电刺激电流。

29. 发明授权

US07203548B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US07203548B2
公开(公告)日：2007-04-10
申请号：US10176743
申请日：2002-06-20
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

30. 发明申请

US20070049988A1 Optimal electrode contact polarity configurations for implantable stimulation systems 审中-公开
标题翻译：可植入刺激系统的最佳电极接触极性配置
公开(公告)号：US20070049988A1
公开(公告)日：2007-03-01
申请号：US11322788
申请日：2005-12-30
申请人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
发明人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： Systems for treating a patient with a medical condition include a lead having an array of electrode contacts each being programmable to have either a first polarity or a second polarity and a programming device configured to test a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied. Methods of using an implantable stimulator system include implanting a lead having an array of programmable electrode contacts disposed thereon in communication with a stimulation site, testing a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied, selecting an optimal electrode contact polarity configuration out of the multiplicity of different electrode contact polarity configurations, and applying the stimulation current via the optimal electrode contact polarity configuration to the stimulation site in accordance with one or more stimulation parameters.
摘要翻译：用于治疗患有医疗状况的患者的系统包括具有每个可编程为具有第一极性或第二极性的电极接触阵列的引线和被配置为测试多个不同电极接触极性配置的编程设备，其中编程一个或多个电极触点的极性是变化的。使用可植入刺激器系统的方法包括植入具有与刺激部位连通的可编程电极触点阵列的引线，测试多个不同的电极接触极性配置，其中一个或多个电极触点的编程极性为根据一个或多个刺激参数，通过不同电极接触极性配置的多重性选择最佳电极接触极性配置，并通过最佳电极接触极性配置将刺激电流施加到刺激部位。

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