专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20080269074A1 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation 失效
公开(公告)号：US20080269074A1
公开(公告)日：2008-10-30
申请号：US11616059
申请日：2006-12-26
申请人： James M. Coull , Mark J. Fiandaca , Mark D. Kristjanson , Jens J. Hyldig-Nielsen , Theresa S. Creasey
发明人： James M. Coull , Mark J. Fiandaca , Mark D. Kristjanson , Jens J. Hyldig-Nielsen , Theresa S. Creasey
IPC分类号： C40B50/06 , C12P19/34
CPC分类号： C12Q1/6816 , C07B2200/11 , C40B20/04 , C40B30/04 , C40B40/00 , C40B40/06 , Y10S435/81 , C12Q2565/137 , C12Q2525/107 , C12Q2531/113
摘要： This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.

22. 发明授权

US5612458A Antibody to PNA/nucleic acid complexes 失效
标题翻译： PNA /核酸复合物的抗体
公开(公告)号：US5612458A
公开(公告)日：1997-03-18
申请号：US361643
申请日：1994-12-22
申请人： Jens J. Hyldig-Nielsen , Karl-Johan Pluzek
发明人： Jens J. Hyldig-Nielsen , Karl-Johan Pluzek
IPC分类号： G01N33/53 , C07K16/44 , C12N15/09 , A61K39/00 , A61K51/10
CPC分类号： C07K16/44
摘要： This invention relates to antibodies to complexes formed between PNA (Peptide Nucleic Acid) and nucleic acids, particularly antibodies to PNA/DNA or PNA/RNA complexes. The preferred antibodies are polyclonal, monoclonal and recombinant antibodies that binds to PNA/DNA or PNA/RNA complexes, but not to single-stranded PNA, double-stranded nucleic acid or single-stranded nucleic acid. Peptide Nucleic Acids (PNA) are newly developed, not naturally occurring compounds comprising a polyamide backbone bearing a plurality of ligands such as naturally occuring nucleobases attached to a polyamide backbone through a suitable linker. PNA oligomers with a backbone of N-(2-aminoethyl)glycin units have a surprising high affinity for complementary nucleic acid forming very stable and specific complexes. This property makes PNA oligomers suitable as hybridization probes for detection of nucleic acids. The usability of PNA as hybridization probes is greatly increased by the present antibodies. The antibodies according to the invention are useful in the capture, recognition, detection, identification or quantitation of nucleic acids in biological samples, via their ability to react with PNA-nucleic acid complexes.
摘要翻译：本发明涉及在PNA（肽核酸）和核酸之间形成的复合物的抗体，特别是针对PNA / DNA或PNA / RNA复合物的抗体。优选的抗体是结合PNA / DNA或PNA / RNA复合物但不与单链PNA，双链核酸或单链核酸结合的多克隆，单克隆和重组抗体。肽核酸（PNA）是新开发的，而不是天然存在的化合物，其包含具有多个配体的聚酰胺主链，例如通过合适的接头天然存在连接到聚酰胺主链的核碱基。具有N-（2-氨基乙基）甘氨酸单元骨架的PNA寡聚体对形成非常稳定和特异性复合物的互补核酸具有惊人的高亲和力。该性质使得PNA低聚物适合作为检测核酸的杂交探针。通过本发明的抗体，PNA作为杂交探针的可用性大大提高。根据本发明的抗体可用于通过其与PNA-核酸复合物反应的能力捕获，识别，鉴定或定量生物样品中的核酸。

23. 发明授权

US08912312B2 PNA probes, probe sets, methods and kits pertaining to the detection of Candida 有权
标题翻译： PNA探针，探针组，与念珠菌检测有关的方法和试剂盒
公开(公告)号：US08912312B2
公开(公告)日：2014-12-16
申请号：US13207283
申请日：2011-08-10
申请人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
发明人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
IPC分类号： C12Q1/68 , C07K14/00
CPC分类号： C12Q1/6895 , C07K14/003 , C12Q1/689 , C12Q2525/107
摘要： This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be selected from the group consisting of: AGA-GAG-CAG-CAT-GCA (Seq. Id. No. 1), AGA-GAG-CAA-CAT-GCA (Seq. Id. No. 2), ACA-GCA-GAA-GCC-GTG (Seq. Id. No. 3), CAT-AAA-TGG-CTA-CCA-GA (Seq. Id. No. 4), CAT-AAA-TGG-CTA-CCC-AG (Seq. Id. No. 5), ACT-TGG-AGT-CGA-TAG (Seq. Id. No. 6), CCA-AGG-CTT-ATA-CTC-GC (Seq. Id. No. 7), CCC-CTG-AAT-CGG-GAT (Seq. Id. No. 8), GAC-GCC-AAA-GAC-GCC (Seq. Id. No. 9), ATC-GTC-AGA-GGC-TAT-AA (Seq. Id. No. 10), TAG-CCA-GAA-GAA-AGG (Seq. Id. No. 11), CAT-AAA-TGG-CTA-GCC-AG (Seq. Id. No. 12), CTC-CGA-TGT-GAC-TGC-G (Seq. Id. No. 13), TCC-CAG-ACT-GCT-CGG (Seq. Id. No. 14), TCC-AAG-AGG-TCG-AGA (Seq. Id. No. 15), GCC-AAG-CCA-CAA-GGA (Seq. Id. No. 16), GCC-GCC-AAG-CCA-CA (Seq. Id. No. 17), GGA-CTT-GGG-GTT-AG (Seq. Id. No. 18), CCG-GGT-GCA-TTC-CA (Seq. Id. No. 19), ATG-TAG-AAC-GGA-ACT-A (Seq. Id. No. 20), GAT-TCT-CGG-CCC-CAT-G (Seq. Id. No. 21), CTG-GTT-CGC-CAA-AAA-G (Seq. Id. No. 22) and AGT-ACG-CAT-CAG-AAA (Seq. Id. No. 23).
摘要翻译：本发明涉及与一种或多种念珠菌酵母的检测有关的新型PNA探针，探针组，方法和试剂盒。可用于本发明探针的探测核碱基序列的非限制性实例可以选自：AGA-GAG-CAG-CAT-GCA（Seq.Id。No.1），AGA-GAG- CAA-CAT-GCA（序列号2），ACA-GCA-GAA-GCC-GTG（序列号3），CAT-AAA-TGG-CTA-CCA-GA（Seq.Id。第4号），CAT-AAA-TGG-CTA-CCC-AG（Seq.Id。No.5），ACT-TGG-AGT-CGA-TAG（Seq.Id。No.6），CCA-AGG-CTT -ATA-CTC-GC（Seq.Id。No.7），CCC-CTG-AAT-CGG-GAT（Seq.Id。No.8），GAC-GCC-AAA-GAC-GCC（Seq.Id.No ATC-GTC-AGA-GGC-TAT-AA（序列号10），TAG-CCA-GAA-GAA-AGG（序列号11），CAT-AAA-TGG- CTA-GCC-AG（序列号12），CTC-CGA-TGT-GAC-TGC-G（序列号13），TCC-CAG-ACT-GCT-CGG（Seq.Id。第14号），TCC-AAG-AGG-TCG-AGA（序列号15），GCC-AAG-CCA-CAA-GGA（序列号16），GCC-GCC-AAG-CCA -CA（Seq.Id。No.17），GGA-CTT-GGG-GTT-AG（Seq.Id.18），CCG-GGT-GCA-TTC-CA（Seq.Id.No.19） ATG-TAG-AAC-GGA-ACT-A（序列号20），GAT-TCT-CGG-CCC-CAT-G（序列号21），CTG-GTT-CGC-CAA- AAA-G （Seq。 ID。 No.22）和AGT-ACG-CAT-CAG-AAA（Seq.Id。No.23）。

24. 发明授权

US08754191B2 Methods, kits and compositions pertaining to the suppression of the detectable probe binding to randomly distributed repeat sequences genomic nucleic acid 有权
标题翻译：与抑制可检测探针结合随机分布的重复序列基因组核酸有关的方法，试剂盒和组合物
公开(公告)号：US08754191B2
公开(公告)日：2014-06-17
申请号：US13368732
申请日：2012-02-08
申请人： Kirsten Vang Nielsen , Jens J. Hyldig-Nielsen , Brett F. Williams
发明人： Kirsten Vang Nielsen , Jens J. Hyldig-Nielsen , Brett F. Williams
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6837 , C12Q1/6876 , C12Q2600/156 , C12Q2537/162 , C12Q2525/186 , C12Q2525/107 , C12Q2525/151
摘要： This invention is directed to methods, kits, non-nucleotide probes as well as other compositions pertaining to the suppression of binding of detectable nucleic acid probes to undesired nucleotide sequences of genomic nucleic acid in assays designed to determine target genomic nucleic acid.
摘要翻译：本发明涉及方法，试剂盒，非核苷酸探针以及其它有关抑制可检测的核酸探针与设计用于确定靶基因组核酸的测定中的基因组核酸的不需要的核苷酸序列结合有关的组合物。

25. 发明授权

US08026051B2 PNA probes, probe sets, methods and kits pertaining to the detection of Candida 有权
标题翻译： PNA探针，探针组，与念珠菌检测有关的方法和试剂盒
公开(公告)号：US08026051B2
公开(公告)日：2011-09-27
申请号：US10150045
申请日：2002-05-17
申请人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
发明人： Jens J. Hyldig-Nielsen , Henrik Stender , Kenneth M. Oliveira , Susan Rigby
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6895 , C07K14/003 , C12Q1/689 , C12Q2525/107
摘要： This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be selected from the group consisting of: AGA-GAG-CAG-CAT-GCA (Seq. Id. No. 1), AGA-GAG-CAA-CAT-GCA (Seq. Id. No. 2), ACA-GCA-GAA-GCC-GTG (Seq. Id. No. 3), CAT-AAA-TGG-CTA-CCA-GA (Seq. Id. No. 4), CAT-AAA-TGG-CTA-CCC-AG (Seq. Id. No. 5), ACT-TGG-AGT-CGA-TAG (Seq. Id. No. 6), CCA-AGG-CTT-ATA-CTC-GC (Seq. Id. No. 7), CCC-CTG-AAT-CGG-GAT (Seq. Id. No. 8), GAC-GCC-AAA-GAC-GCC (Seq. Id. No. 9), ATC-GTC-AGA-GGC-TAT-AA (Seq. Id. No. 10), TAG-CCA-GAA-GAA-AGG (Seq. Id. No. 11), CAT-AAA-TGG-CTA-GCC-AG (Seq. Id. No. 12), CTC-CGA-TGT-GAC-TGC-G (Seq. Id. No. 13), TCC-CAG-ACT-GCT-CGG (Seq. Id. No. 14), TCC-AAG-AGG-TCG-AGA (Seq. Id. No. 15), GCC-AAG-CCA-CAA-GGA (Seq. Id. No. 16), GCC-GCC-AAG-CCA-CA (Seq. Id. No. 17), GGA-CTT-GGG-GTT-AG (Seq. Id. No. 18), CCG-GGT-GCA-TTC-CA (Seq. Id. No. 19), ATG-TAG-AAC-GGA-ACT-A (Seq. Id. No. 20), GAT-TCT-CGG-CCC-CAT-G (Seq. Id. No. 21), CTG-GTT-CGC-CAA-AAA-G (Seq. Id. No. 22) and AGT-ACG-CAT-CAG-AAA (Seq. Id. No. 23).
摘要翻译：本发明涉及与一种或多种念珠菌酵母的检测有关的新型PNA探针，探针组，方法和试剂盒。可用于本发明探针的探测核碱基序列的非限制性实例可以选自：AGA-GAG-CAG-CAT-GCA（Seq.Id。No.1），AGA-GAG- CAA-CAT-GCA（序列号2），ACA-GCA-GAA-GCC-GTG（序列号3），CAT-AAA-TGG-CTA-CCA-GA（Seq.Id。第4号），CAT-AAA-TGG-CTA-CCC-AG（Seq.Id。No.5），ACT-TGG-AGT-CGA-TAG（Seq.Id。No.6），CCA-AGG-CTT -ATA-CTC-GC（Seq.Id。No.7），CCC-CTG-AAT-CGG-GAT（Seq.Id。No.8），GAC-GCC-AAA-GAC-GCC（Seq.Id.No ATC-GTC-AGA-GGC-TAT-AA（序列号10），TAG-CCA-GAA-GAA-AGG（序列号11），CAT-AAA-TGG- CTA-GCC-AG（序列号12），CTC-CGA-TGT-GAC-TGC-G（序列号13），TCC-CAG-ACT-GCT-CGG（Seq.Id。第14号），TCC-AAG-AGG-TCG-AGA（序列号15），GCC-AAG-CCA-CAA-GGA（序列号16），GCC-GCC-AAG-CCA -CA（Seq.Id。No.17），GGA-CTT-GGG-GTT-AG（Seq.Id.18），CCG-GGT-GCA-TTC-CA（Seq.Id.No.19） ATG-TAG-AAC-GGA-ACT-A（序列号20），GAT-TCT-CGG-CCC-CAT-G（序列号21），CTG-GTT-CGC-CAA- AAA-G （Seq。 ID。 No.22）和AGT-ACG-CAT-CAG-AAA（Seq.Id。No.23）。

26. 发明授权

US08017758B2 PNA oligomers, oligomer sets, methods and kits pertaining to the detection of Bacillus anthracis 有权
标题翻译： PNA寡聚体，低聚物组，与炭疽芽孢杆菌检测有关的方法和试剂盒
公开(公告)号：US08017758B2
公开(公告)日：2011-09-13
申请号：US10393855
申请日：2003-03-21
申请人： Henrik Stender , Jens J. Hyldig-Nielsen
发明人： Henrik Stender , Jens J. Hyldig-Nielsen
IPC分类号： C07H21/04 , A61K31/70 , C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q2525/107
摘要： This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the determination of Bacillus anthracis.
摘要翻译：本发明涉及新型PNA探针，探针组，与炭疽芽孢杆菌测定有关的方法和试剂盒。

27. 发明申请

US20110111393A1 PNA Probes, Mixtures, Methods And Kits Pertaining To The Determination Of Mycoplasma and related Mollicutes 审中-公开
标题翻译： PNA探针，混合物，方法和试剂盒有关测定支原体和相关的细胞
公开(公告)号：US20110111393A1
公开(公告)日：2011-05-12
申请号：US12421927
申请日：2009-04-10
申请人： Jens J. Hyldig-Nielsen , Susan Rigby , Byron F. Brehm-Stecher , Ditte S. Lee , Michael Tanner
发明人： Jens J. Hyldig-Nielsen , Susan Rigby , Byron F. Brehm-Stecher , Ditte S. Lee , Michael Tanner
IPC分类号： C12Q1/68 , C07K7/08 , G01N33/50
CPC分类号： C12Q1/6816 , C12Q2525/313 , C12Q2525/107
摘要： This invention is related to PNA probes, probe sets, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes.
摘要翻译：本发明涉及与确定支原体和相关的Mollicutes有关的PNA探针，探针组，混合物，方法和试剂盒。

28. 发明申请

US20090136941A1 METHODS, KITS AND COMPOSITIONS PERTAINING TO LINEAR BEACONS 有权
标题翻译：方法，针对线性鸟类的套件和组合物
公开(公告)号：US20090136941A1
公开(公告)日：2009-05-28
申请号：US12206393
申请日：2008-09-08
申请人： Brian D. Gildea , James M. Coull , Jens J. Hyldig-Nielsen , Mark J. Fiandaca
发明人： Brian D. Gildea , James M. Coull , Jens J. Hyldig-Nielsen , Mark J. Fiandaca
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C07K14/003 , C12Q1/6837 , Y10T436/143333 , C12Q2565/1015 , C12Q2565/107 , C12Q2525/107
摘要： This invention is directed to methods for determining amplified nucleic acid using Linear Beacons
摘要翻译：本发明涉及使用线性信标确定扩增核酸的方法

29. 发明授权

US07060432B1 Methods for the detection, identification, and/or enumeration of yeast, particularly in wine 有权
标题翻译：检测，鉴定和/或计数酵母，特别是葡萄酒的方法
公开(公告)号：US07060432B1
公开(公告)日：2006-06-13
申请号：US09593914
申请日：2000-06-14
申请人： Jens J. Hyldig-Nielsen , Heather P. O'Keefe , Henrik Stender
发明人： Jens J. Hyldig-Nielsen , Heather P. O'Keefe , Henrik Stender
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6895
摘要： This invention is related to novel probes, probe sets, methods and kits pertaining to the detection, identification and/or quantitation of yeasts and particularly Dekkera bruxellensis (a.k.a. Brettanomyces) an organism that spoils wine. Preferred probes for the detection of one or more species of the Dekkera/Brettanomyces genus comprise a probing nucleobase sequence, at least a portion of which is selected from the group consisting of: AGC-GGG-TCT-ATT-AGA (Seq. ID No. 1); CCA-GGT-GAG-GGT-CGC (Seq. ID No. 2); CGG-TTG-CCC-GAT-TTC (Seq. ID No. 3); TCG-CCT-TCC-TCC-TCT (Seq. ID No. 4); CGG-TCT-CCA-GCG-ATT (Seq. ID No. 5); CAC-AAG-ATG-TCC-GCG (Seq. ID No. 6); GCG-GGC-ACT-AAT-TGA (Seq. ID No. 7); CAT-CCA-CGA-GGA-ACG (Seq. ID No. 8); GTG-TAA-ACC-AGG-TGC (Seq. ID No. 9); ATG-GCT-CCC-AGA-ACC (Seq. ID No. 10) and GAC-AGA-ATC-GAA-GGG (Seq. ID No. 11). The probes, probe sets, methods and kits of this invention are particularly well suited for use in the analysis of yeast in wine, beer and liquor and in the monitoring of contamination of in-process product as well as the equipment and facilities used to manufacture product in wineries and breweries.
摘要翻译：本发明涉及关于酵母的特异性检测，鉴定和/或定量的新型探针，探针组，方法和试剂盒，尤其是破坏葡萄酒的生物的德克萨维酵母（A.k.a.Brettanomyces）。用于检测一种或多种Dekkera / Brettanomyces属的优选探针包括探测核碱基序列，其至少一部分选自：AGC-GGG-TCT-ATT-AGA（Seq.ID No 1）; CCA-GGT-GAG-GGT-CGC（Seq.ID No.2）; CGG-TTG-CCC-GAT-TTC（Seq.ID No.3）; TCG-CCT-TCC-TCC-TCT（Seq.ID No.4）; CGG-TCT-CCA-GCG-ATT（Seq.ID No.5）; CAC-AAG-ATG-TCC-GCG（Seq.ID No.6）; GCG-GGC-ACT-AAT-TGA（Seq.ID No.7）; CAT-CCA-CGA-GGA-ACG（Seq.ID No.8）; GTG-TAA-ACC-AGG-TGC（Seq.ID No.9）; ATG-GCT-CCC-AGA-ACC（Seq.ID No.10）和GAC-AGA-ATC-GAA-GGG（Seq.ID No.11）。本发明的探针，探针组，方法和试剂盒特别适合用于分析葡萄酒，啤酒和酒中的酵母，以及监测过程中产品的污染以及用于制造的设备和设备产品在酿酒厂和啤酒厂。

30. 发明授权

US06750039B1 Filtration apparatus and method for the separation of microscopic entities from a fluid 有权
标题翻译：用于将微观实体与流体分离的过滤装置和方法
公开(公告)号：US06750039B1
公开(公告)日：2004-06-15
申请号：US10101026
申请日：2002-03-19
申请人： Frederick G. Bargoot , Jens J. Hyldig-Nielsen , Donald B. Rising , Henrik Stender
发明人： Frederick G. Bargoot , Jens J. Hyldig-Nielsen , Donald B. Rising , Henrik Stender
IPC分类号： C12Q104
CPC分类号： G01N1/4077 , C12M47/02 , G01N1/2813
摘要： This invention relates to a filtration apparatus and method for the separation of microscopic entities from a fluid (liquid or gas) and subsequent visual or imaging microscopic analysis of the entities separated thereon either directly or after treatment of the entities whilst on the apparatus in order to enhance their subsequent visualization and/or imaging. Such treatment can comprise reaction with reagents contained in other solutions that can be made to imbibe and/or pass through the filtration apparatus and which can be washed with solutions that can be made to imbibe and/or pass through the filtration apparatus. An example of a specific area of application is in the microbiological testing of fluids in order to detect, identify and/or enumerate microorganisms contained in a fluid test sample.
摘要翻译：本发明涉及一种用于将微观实体与流体（液体或气体）分离的过滤装置和方法以及随后在实体上分离的实体的视觉或成像显微镜分析，其中在设备上直接或在处理实体之后，为了增强其随后的可视化和/或成像。这种处理可以包括与其它溶液中包含的试剂反应，其可以被吸收和/或通过过滤装置，并且可以用可以被吸收和/或通过过滤装置的溶液洗涤。特定应用领域的一个例子是流体的微生物测试，以便检测，识别和/或列举流体测试样品中所含的微生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式