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21. 发明授权

US06177544B1 Collagen-based auxiliary agent for ophthalmic surgery 失效
标题翻译：胶原基辅助剂用于眼科手术
公开(公告)号：US06177544B1
公开(公告)日：2001-01-23
申请号：US09284648
申请日：1999-04-16
申请人： Atsushi Kanai , Teruo Miyata , Hiroshi Itoh , Akiko Tanaka
发明人： Atsushi Kanai , Teruo Miyata , Hiroshi Itoh , Akiko Tanaka
IPC分类号： A61K3817
CPC分类号： A61L31/044 , Y10S128/08
摘要： An auxiliary agent for ophthalmic surgery is based on collagen and, after the completion of surgery, undergoes a lowering in viscosity, and thus can be easily removed. This agent is a neutral solution of collagen which is transparent at a neutral pH and has a denaturation temperature below the intraocular temperature, or a derivative thereof. The agent has a visual light transmission at 400 nm of at least 90% of that before the denaturation, when solution is heated to cause denaturation.
摘要翻译：用于眼科手术的辅助剂基于胶原蛋白，并且在手术完成后，粘度降低，因此可以容易地去除。该试剂是在中性pH下透明并具有低于眼内温度的变性温度的胶原的中性溶液或其衍生物。该试剂在400nm处具有在变性之前至少90％的视觉光透射，当溶液被加热以引起变性时。

22. 发明授权

US5387236A Vascular prosthesis, manufacturing method of the same, and substrate for vascular prosthesis 失效
标题翻译：血管假体，其制造方法和血管假体的底物
公开(公告)号：US5387236A
公开(公告)日：1995-02-07
申请号：US988777
申请日：1992-12-10
申请人： Yasuhara Noishiki , Teruo Miyata
发明人： Yasuhara Noishiki , Teruo Miyata
IPC分类号： A61F2/06 , A61L27/50
CPC分类号： A61L27/507 , A61F2/062 , Y10S623/901 , Y10S623/921
摘要： The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.
摘要翻译：本发明涉及一种血管假体，其中沉积并俘获诸如血管组织，结缔组织，脂肪组织和构成血管壁的肌肉组织和/或细胞如血管内皮细胞，平滑肌细胞和成纤维细胞的生物组织的片段血管假体基底的壁; 一种制造方法，包括以下步骤：将血管假体底物浸入诸如血管组织，结缔组织，脂肪组织和肌肉组织和/或组成血管壁的细胞如血管内皮细胞，平滑肌细胞的分散溶液中和成纤维细胞，并且通过在血管假体基底壁的一侧到另一侧通过在外部和外侧之间的压力差来沉积和捕获血管假体的内壁和内壁内的细胞和/或组织碎片血管假体底物内; 以及适于制造具有多孔膜的血管假体的基底，其具有能够捕获组织碎片的孔，或具有这种膜的层压结构和具有不足以穿过细胞或组织碎片的孔的另一多孔膜。

23. 发明授权

US4833200A Antithrombogenic medical material and method of preparing same 失效
标题翻译：抗凝血药物及其制备方法
公开(公告)号：US4833200A
公开(公告)日：1989-05-23
申请号：US889654
申请日：1986-07-25
申请人： Yasuharu Noishiki , Teruo Miyata
发明人： Yasuharu Noishiki , Teruo Miyata
IPC分类号： A61K38/16 , A61K38/17 , A61L33/00 , C08L5/10
CPC分类号： A61L33/0029 , C08L5/10 , Y10S514/801 , Y10S514/822
摘要： An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a synthetic polymer material is provided. And a method of preparing an antithrombogenic medical material is provided, wherein a synthetic polymer material is subjected to a coating or impregnating treatment with a collagen-containing solution, followed by heparinization of the collagen, and the heparinized collagen is fixed to the synthetic polymer material. This method allows manufacturing of antithrombogenic medical material with ease.
摘要翻译：本发明提供具有抗凝血性能和组织相容性以及通过将肝素化胶原固定在合成高分子材料上形成的充分体力的抗血栓形成的医用材料。提供一种制备抗血栓形成的医药材料的方法，其中合成聚合物材料用含胶原的溶液进行包衣或浸渍处理，然后将胶原蛋白肝素化，并将肝素化胶原蛋白固定在合成聚合物材料。该方法容易制造抗血栓形成的医用材料。

24. 发明授权

US4806595A Method of preparing antithrombogenic medical materials 失效
标题翻译：制备抗凝血药物的方法
公开(公告)号：US4806595A
公开(公告)日：1989-02-21
申请号：US891915
申请日：1986-08-01
申请人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata
发明人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata
IPC分类号： A61L33/10 , A61L33/00 , C08L5/10 , A61F2/04
CPC分类号： C08L5/10 , A61L33/0029 , Y10S514/822 , Y10S623/917
摘要： In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.
摘要翻译：在制备具有肝素化胶原蛋白作为抗血栓形成成分的抗血栓形成医学材料的方法中，提供了一种方法，其包括以下步骤：通过聚环氧化合物将鱼精蛋白固定在胶原蛋白上，并通过将肝素固定在鱼精蛋白上来使胶原蛋白肝素化。

25. 发明授权

US4695281A Medical material 失效
标题翻译：医疗材料
公开(公告)号：US4695281A
公开(公告)日：1987-09-22
申请号：US478773
申请日：1983-03-25
申请人： Teruo Miyata , Yasuharu Noishiki
发明人： Teruo Miyata , Yasuharu Noishiki
IPC分类号： A61F2/00 , A61L27/24 , A61L27/36 , A61L33/00 , C08H1/06 , A61F2/02 , A61F2/06
CPC分类号： C08H1/06 , A61L27/24 , A61L27/36 , A61L33/0082 , A61F2310/00365 , Y10S623/917
摘要： The medical material according to this invention contains collagen, which as been chemically modified by saccinylation of thermal --NH.sub.2 groups of said chains attached to poly peptide chains of the collagen so that the --NH.sub.2 groups are converted into groups having --COOH groups. This succinylation can be carried out by reacting succinic anhydride with the --NH.sub.2 groups of the collagen. Since the above medical material has excellent compatibility with living bodies, especially, with blood, it is suitable to use it as a replacement material for tissues and/or organs which are kept in contact with blood at their surfaces, namely, is suitable for use in artificial blood vessels, artificial valves, some parts of artificial hearts which are kept in contact with blood at said parts, etc. and as a patching material for hearts.
摘要翻译：根据本发明的医疗材料包含胶原蛋白，其通过连接到胶原的多肽链的所述链的热-NH 2基团的凝血化而被化学修饰，使得-NH 2基团转化为具有-COOH基团的基团。该琥珀酰化可以通过使琥珀酸酐与胶原的-NH 2基团反应来进行。由于上述医用材料与生物体，特别是血液具有良好的相容性，因此适合用作与其表面保持与血液接触的组织和/或器官的替代材料，即适合使用在人造血管，人造瓣膜，与所述部分血液保持接触的人造心脏的一些部分等，以及作为心脏的修补材料。

26. 发明授权

US4565580A Substrate consisting of regenerated collagen fibrils and method of manufacturing same 失效
标题翻译：由再生胶原纤维组成的基质及其制造方法
公开(公告)号：US4565580A
公开(公告)日：1986-01-21
申请号：US586944
申请日：1984-03-07
申请人： Teruo Miyata , Shinichi Namiki
发明人： Teruo Miyata , Shinichi Namiki
IPC分类号： A61K9/16 , A61K35/36 , A61K38/17 , C12N5/00 , C12N5/02 , C12N5/06 , C12N11/08 , C12R1/91 , G01N33/86 , C08L89/00
CPC分类号： A61K9/1658 , C12N5/0075 , G01N33/86 , C12N2533/54 , G01N2333/78
摘要： A substrate consisting essentially of regenerated collagen fibrils is provided which is in the form of a bead, or microsphere and comprises irregularly entangled regenerated collagen fibrils each having a diameter of 10-1000 m.mu. and an aqueous solution existing between the regenerated collagen fibrils, the content of the regenerated collagen fibrils being 20-0.01 wt. %. The substrate can be used for cell culture or for measuring adhesion activity of blood platelet.According to one method of manufacturing the collagen beads, an acidic aqueous collagen solution is dispersed in a water-immiscible organic solvent in the form of numerous droplets to form an emulsion, and the droplets are then coagulated by addition of a water-miscible organic solvent and an alkali to the emulsion.According to another method of manufacturing the collagen beads or microspheres, a neutral collagen solution is dispersed in a water-immiscible organic solvent in the form of numerous droplets to form an emulsion, and the droplets are then coagulated by raising the temperature of the emulsion to 30.degree. C.-40.degree. C. The collagen beads or microspheres prepared by the methods described above may be cross-linked by hexamethylenediisocyanate or glutaraldehyde.
摘要翻译：提供了基本上由再生的胶原纤维组成的底物，其为珠粒或微球的形式，并且包含直径为10-1000μm的不规则缠结的再生胶原原纤维和存在于再生的胶原纤维之间的水溶液，再生胶原原纤维的含量为20〜0.01wt。％。底物可用于细胞培养或测量血小板的粘附活性。根据制造胶原珠粒的一种方法，将酸性胶原水溶液以许多液滴的形式分散在与水不混溶的有机溶剂中以形成乳液，然后通过加入水混溶性有机溶剂使液滴凝结并向该乳液提供碱。根据制造胶原珠粒或微球体的另一种方法，将中性胶原溶液以许多液滴的形式分散在与水不混溶的有机溶剂中以形成乳液，然后通过将乳液的温度升高至通过上述方法制备的胶原珠粒或微球体可以通过六亚甲基二异氰酸酯或戊二醛交联。

27. 发明授权

US4215200A Chemically and enzymatically modified collagen hemostatic agent 失效
标题翻译：化学和酶改性胶原止血剂
公开(公告)号：US4215200A
公开(公告)日：1980-07-29
申请号：US948003
申请日：1978-10-02
申请人： Teruo Miyata , Kurt H. Stenzel , Albert L. Rubin
发明人： Teruo Miyata , Kurt H. Stenzel , Albert L. Rubin
IPC分类号： A61K38/00 , A61L15/32 , C07K14/78 , C07G7/00 , C08L89/06
CPC分类号： A61L15/325 , C07K14/78 , A61K38/00 , A61L2400/04 , Y10S128/08
摘要： Polymers of quaternary-structured collagen of minimum length, diameter and periodicity, and containing a relatively high positive electrostatic charge are claimed as hemostatic agents. Specific examples are guanidnated polymers of the type described, esterified polymers, and esterified-guanidinated polymers.
摘要翻译：要求具有最小长度，直径和周期性并且含有相对高的正静电荷的四元结构胶原的聚合物作为止血剂。具体实例是所述类型的官能聚合物，酯化聚合物和酯化 - 胍化聚合物。

28. 发明授权

US4164559A Collagen drug delivery device 失效
标题翻译：胶原药物输送装置
公开(公告)号：US4164559A
公开(公告)日：1979-08-14
申请号：US835302
申请日：1977-09-21
申请人： Teruo Miyata , Albert L. Rubin , Kurt H. Stenzel , Michael W. Dunn
发明人： Teruo Miyata , Albert L. Rubin , Kurt H. Stenzel , Michael W. Dunn
IPC分类号： A61K47/42 , A61K8/00 , A61K8/41 , A61K8/49 , A61K8/65 , A61K8/99 , A61K9/00 , A61Q1/00 , A61Q1/10 , A61Q17/04 , A61K37/12 , A61K47/00
CPC分类号： A61K9/0051
摘要： Chemically-modified collagen membrane prepared at physiologic pH and soluble thereat provides a carrier for ophthalmic medication leaving no removable material after drug release.
摘要翻译：化学修饰的胶原膜在生理pH和可溶性水溶液中制备，提供了一种用于眼科药物的载体，药物释放后不留下可去除的物质。

29. 发明授权

US06998268B2 Gene preparations 失效
标题翻译：基因制备
公开(公告)号：US06998268B2
公开(公告)日：2006-02-14
申请号：US10261618
申请日：2002-10-02
申请人： Masaaki Terada , Takahiro Ochiya , Teruo Miyata , Hiroshi Itoh
发明人： Masaaki Terada , Takahiro Ochiya , Teruo Miyata , Hiroshi Itoh
IPC分类号： C12N15/63 , C12N15/00 , A61K38/17 , C07H21/02 , A01N43/04
CPC分类号： C12N15/86 , A61K9/0019 , A61K9/1623 , A61K9/1652 , A61K9/2063 , A61K47/42 , A61K48/00 , A61K48/0025 , C12N2710/10343
摘要： The present invention relates to gene preparations comprising desired genes or vectors containing desired genes integrated there into and carriers for supporting the same. The carrier is preferably a soluble collagen such as atelocollagen and may further include an additive. The invention also encompasses methods for delivering genes to cells employing the gene preparation.
摘要翻译：本发明涉及包含所需基因的基因制品或含有整合在其中的所需基因的载体和用于支持其的载体。载体优选是可溶性胶原，例如胶原蛋白，并且还可以包括添加剂。本发明还包括使用基因制备将基因递送到细胞的方法。

30. 发明授权

US5314874A Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen 失效
标题翻译：用于植入高度浓缩的交联的胶原蛋白的体内注射组合物
公开(公告)号：US5314874A
公开(公告)日：1994-05-24
申请号：US872722
申请日：1992-04-15
申请人： Teruo Miyata , Tadatomo Kawai
发明人： Teruo Miyata , Tadatomo Kawai
IPC分类号： A61F2/00 , A61K38/39 , A61L24/10 , A61L27/24 , A61L33/00 , C07K15/20 , C08B37/10 , A61K7/12
CPC分类号： A61L27/24 , A61K38/39 , A61L24/102 , A61F2310/00365
摘要： The present invention provides an intracorporeally injectable non-toxic composition of atelocollagen having an excellent, long-lasting skin swelling effect due to its low viscosity, good fluidity, easy injectability and low antigenicity (without calcification) properties. The composition is prepared by treating an aqueous suspension of atelocollagen with a buffer for physiological conditions. The suspension can have atelocollagen content of 55 to 75 mg/ml, where approximately 20 to 100% by weight of atelocollagen is cross-linked with a polyepoxy compound.
摘要翻译：本发明提供一种体内可注射的无毒组合物，由于其粘度低，流动性好，易注射性和低抗原性（无钙化）性质，具有优异的持久的皮肤肿胀效果。通过用缓冲液处理含水悬浮液的生物学条件来制备组合物。悬浮液可以具有55至75mg / ml的胶原含量，其中约20至100重量％的胶原凝胶与聚环氧化合物交联。

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