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    • 5. 发明授权
    • Man-made skin composed of two layers: collagen and a poly-alpha-amino
acid
    • 人造皮肤由两层组成:胶原蛋白和聚-α-氨基酸
    • US4642118A
    • 1987-02-10
    • US741835
    • 1985-06-06
    • Yoshimitsu KuroyanagiTeruo MiyataManabu Seno
    • Yoshimitsu KuroyanagiTeruo MiyataManabu Seno
    • A61L27/00A61F2/10A61L27/34A61L27/60
    • A61L27/60A61L27/34
    • This invention concerns a double-layered man-made skin which is prepared by laminating a collagen sponge sheet and a poly-.alpha.-amino acid membrane that has a good affinity with tissue cells and an appropriate permeability for moisture. When the man-made skin is applied on burns, cuts or wounds, the fibroblasts proliferate in the collagen sponge sheet forming a three-dimensional structure, while the epidermal cells proliferate in the region between the poly-.alpha.-amino acid membrane and a collagen sponge sheet. The poly-.alpha.-amino acid membrane plays a role in protecting affected part and in providing an optimum condition for the proliferation of fibroblasts and epidermal cells, and then it falls off as the epidermis completely regenerates. On the other hand, the collagen sponge sheet assimilates in the living tissue after having played a general role of the dermis.
    • 本发明涉及一种双层人造皮肤,其通过层叠胶原海绵片和与组织细胞具有良好亲和性并具有适当的渗透性的聚-α-氨基酸膜制备。 当人造皮肤应用于烧伤,切口或伤口时,成纤维细胞在形成三维结构的胶原海绵片中增殖,而表皮细胞在聚-α-氨基酸膜和胶原之间的区域中增殖 海绵片。 聚-α-氨基酸膜在保护受影响部位和为成纤维细胞和表皮细胞增殖提供最佳条件方面发挥作用,随着表皮完全再生,其脱落。 另一方面,在发挥真皮的一般作用后,胶原蛋白海绵片在活组织中被吸收。