专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US11795191B2 Method of preparation of nanopore and uses thereof 有权
公开(公告)号：US11795191B2
公开(公告)日：2023-10-24
申请号：US16371646
申请日：2019-04-01
申请人： Jingyue Ju , Shiv Kumar , Chuanjuan Tao , Minchen Chien , James J. Russo , John J. Kasianowicz , Joseph W. F. Robertson
发明人： Jingyue Ju , Shiv Kumar , Chuanjuan Tao , Minchen Chien , James J. Russo , John J. Kasianowicz , Joseph W. F. Robertson
IPC分类号： C12Q1/68 , C07H19/00 , C12Q1/42 , C12Q1/48 , C12Q1/6869 , C07H19/06 , C07H19/16 , G01N33/487 , C12Q1/6883 , B82Y5/00
CPC分类号： C07H19/00 , C07H19/06 , C07H19/16 , C12Q1/42 , C12Q1/48 , C12Q1/6869 , C12Q1/6883 , G01N33/48721 , B82Y5/00 , C12Q2600/158 , G01N2333/9125 , C12Q1/6869 , C12Q2521/525 , C12Q2521/543 , C12Q2537/157 , C12Q2565/631 , C12Q1/6869 , C12Q2521/525 , C12Q2521/543 , C12Q2535/107 , C12Q2565/631 , C12Q1/6869 , C12Q2565/631
摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

22. 发明公开

US20230172961A1 THERAPEUTICS FOR COVID-19 审中-公开
公开(公告)号：US20230172961A1
公开(公告)日：2023-06-08
申请号：US17796629
申请日：2021-01-29
申请人： Jingyue JU , Steffen JOCKUSCH , Chuanjuan TAO , Minchen CHIEN , James J. RUSSO , Shiv KUMAR , Xiaoxu LI , Xuanting WANG
发明人： Jingyue Ju , Steffen Jockusch , Chuanjuan Tao , Minchen Chien , James J. Russo , Shiv Kumar , Xiaoxu Li , Xuanting Wang
IPC分类号： A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7068 , A61K45/06
CPC分类号： A61K31/7072 , A61K31/708 , A61K31/7068 , A61K31/7076 , A61K45/06
摘要： This invention relates to the use of nucleoside, nucleotide and other compounds which are inhibitors or terminators of viral RNA dependent RNA polymerases or inhibitors of exonucleases as antiviral agents. These antiviral agents can be used alone or in combination with other polymerase or exonuclease inhibitors, helicase inhibitors, HCV NS5A inhibitors, HIV integrase inhibitors and HCV NS3-4A and other protease inhibitors to treat viral infections such as SARS-CoV-2, the causative agent of the COVID-19 infection.

23. 发明申请

US20220213542A1 SEQUENCING BY SYNTHESIS WITH ENERGY TRANSFER DYE PAIRS 有权
公开(公告)号：US20220213542A1
公开(公告)日：2022-07-07
申请号：US17600593
申请日：2020-04-02
申请人： Jingyue Ju , Shiv Kumar , James Russo , Xiaoxu Li , Steffen Jockusch , Minchen Chien , Chuanjuan Tao
发明人： Jingyue Ju , Shiv Kumar , James Russo , Xiaoxu Li , Steffen Jockusch , Minchen Chien , Chuanjuan Tao
IPC分类号： C12Q1/6869 , C12Q1/6848
摘要： The invention provides nucleotide analogues and methods of use thereof for sequencing by synthesis using energy transfer dye pairs.

24. 发明申请

US20210285041A1 3'-O-MODIFIED NUCLEOTIDE ANALOGUES WITH DIFFERENT CLEAVABLE LINKERS FOR ATTACHING FLUORESCENT LABELS TO THE BASE FOR DNA SEQUENCING BY SYNTHESIS 有权
公开(公告)号：US20210285041A1
公开(公告)日：2021-09-16
申请号：US16498132
申请日：2018-03-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Shiv Kumar , James Russo , Minchen Chien
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Shiv Kumar , James Russo , Minchen Chien
IPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20
摘要： Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

25. 发明授权

US10732183B2 Method for detecting multiple predetermined compounds in a sample 有权
公开(公告)号：US10732183B2
公开(公告)日：2020-08-04
申请号：US14776461
申请日：2014-03-14
申请人： Jingyue Ju , Shiv Kumar , Chuanjuan Tao , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Shiv Kumar , Chuanjuan Tao , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H21/00 , G01N33/68 , G01N33/487 , C08G65/48
摘要： This invention provides methods for detecting the presence of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention also provides methods for determining the quantity of each of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention further provides methods for detecting interaction of at least two predetermined compounds using at least one tag moiety and at least one nanopore.

26. 发明授权

US10246479B2 Method of preparation of nanopore and uses thereof 有权
公开(公告)号：US10246479B2
公开(公告)日：2019-04-02
申请号：US14391320
申请日：2013-04-08
申请人： Jingyue Ju , Shiv Kumar , Chuanjuan Tao , Minchen Chien , James J. Russo , John J. Kasianowicz , Joseph W. F. Robertson
发明人： Jingyue Ju , Shiv Kumar , Chuanjuan Tao , Minchen Chien , James J. Russo , John J. Kasianowicz , Joseph W. F. Robertson
IPC分类号： C07H19/00 , C12Q1/42 , C12Q1/48 , C12Q1/6869 , C07H19/06 , C07H19/16 , C12Q1/6883 , G01N33/487 , C12Q1/68 , B82Y5/00
摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

27. 发明授权

US10240195B2 Chemical methods for producing tagged nucleotides 有权
公开(公告)号：US10240195B2
公开(公告)日：2019-03-26
申请号：US14666124
申请日：2015-03-23
申请人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
发明人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/20 , C12Q1/6874 , C07H17/02 , C12Q1/6806
摘要： This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

28. 发明申请

US20180274024A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开
公开(公告)号：US20180274024A1
公开(公告)日：2018-09-27
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/20 , C07H19/10 , C07H19/14
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q2525/117 , C12Q2563/107
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

29. 发明申请

US20120208223A1 FLUORESCENCE RESONANCE ENERGY TRANSFER ENZYME SUBSTRATES 审中-公开
标题翻译：荧光共振能量转移酶基质
公开(公告)号：US20120208223A1
公开(公告)日：2012-08-16
申请号：US13183518
申请日：2011-07-15
申请人： Shiv Kumar , Anup Sood
发明人： Shiv Kumar , Anup Sood
IPC分类号： G01N21/64 , C07H21/00 , C07K2/00
CPC分类号： G01N33/542 , C12Q1/34
摘要： Disclosed are compounds of formula (I) wherein D1 is a first dye moiety whose fluorescence properties may be modulated so as to be suitable as a donor or an acceptor in an energy transfer arrangement; D2 is a second dye moiety suitable as an acceptor or a donor in an energy transfer arrangement with said first dye; L is a linking group comprises 2-200 linked atoms, wherein said linking group optionally includes an enzyme cleavage site; and M is an enzyme cleavable group chosen to modulate the fluorescence properties of D1. The compounds of formula (I) may be used as reporter molecules for detecting biochemical cleavage events in assays that employ fluorescence resonance energy transfer.
摘要翻译：公开了式（I）的化合物，其中D1是可以调节其荧光性质以适合作为能量转移装置中的给体或受体的第一染料部分; D2是第二染料部分，其适于作为与所述第一染料的能量转移装置中的受体或供体; L是包含2-200个连接原子的连接基团，其中所述连接基团任选地包括酶切割位点; M是选择调节D1荧光性质的酶切割基团。式（I）的化合物可以用作用于检测采用荧光共振能量转移的测定中生化裂解事件的报道分子。

30. 发明申请

US20120081860A1 PRE-TREATMENT OF MEMORY CARDS FOR INK JET PRINTING 审中-公开
标题翻译：用于墨水印刷的记忆卡预处理
公开(公告)号：US20120081860A1
公开(公告)日：2012-04-05
申请号：US13129510
申请日：2010-10-04
申请人： Itzhak Pomerantz , Shiv Kumar , Robert Miller , Chin-Tien Chiu , Peng Fu , Cheeman Yu , Hem Takiar , Chih Chiang Tung , Kaiyou Qian
发明人： Itzhak Pomerantz , Shiv Kumar , Robert Miller , Chin-Tien Chiu , Peng Fu , Cheeman Yu , Hem Takiar , Chih Chiang Tung , Kaiyou Qian
IPC分类号： H05K1/14 , B32B3/10 , B32B3/02 , H05K7/00 , B32B3/30
CPC分类号： H05K5/0252 , G06K19/07 , Y10T428/239 , Y10T428/24479 , Y10T428/2457 , Y10T428/24802
摘要： A memory device is disclosed including at least one surface pre-treated to roughen the surface for better adhesion of ink on the surface. The surface of the memory device may be pre-treated by scoring lines in the surface with a laser or by forming discrete deformations with a particle blaster. The surface may also be roughened by providing a roughened pattern on a mold plate during an encapsulation process. In further examples, the surface may be chemically pre-treated to roughen the surface and/or increase the adhesion energy of the surface.
摘要翻译：公开了一种记录装置，其包括至少一个预处理表面的表面，以便更好地粘附在表面上的墨。存储器件的表面可以通过用激光在表面上刻划线或者通过用粒子喷射器形成离散的变形来预处理。在封装过程中，通过在模板上提供粗糙图案也可以使表面粗糙化。在另外的实施例中，表面可以被化学预处理以使表面粗糙化和/或增加表面的粘附能。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式