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1. 发明申请

US20230010193A1 CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES 有权
公开(公告)号：US20230010193A1
公开(公告)日：2023-01-12
申请号：US17856923
申请日：2022-07-01
申请人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
发明人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
IPC分类号： C12Q1/6874 , C07H19/10 , C07H19/20 , C07H17/02 , C12Q1/6806
摘要： This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

2. 发明申请

US20150368710A1 CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES 审中-公开
标题翻译：用于生产标记核酸的化学方法
公开(公告)号：US20150368710A1
公开(公告)日：2015-12-24
申请号：US14666124
申请日：2015-03-23
申请人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
发明人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
IPC分类号： C12Q1/68 , C07H17/02
CPC分类号： C12Q1/6874 , C07H17/02 , C07H19/10 , C07H19/20 , C12Q1/6806
摘要： This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.
摘要翻译：本公开提供了将纳米孔可检测标签附着于核苷酸的系统和方法。本公开还提供了使用公开的标记核苷酸对核酸进行测序的方法。

3. 发明授权

US10240195B2 Chemical methods for producing tagged nucleotides 有权
公开(公告)号：US10240195B2
公开(公告)日：2019-03-26
申请号：US14666124
申请日：2015-03-23
申请人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
发明人： Carl W. Fuller , Shiv Kumar , Jingyue Ju , Randall Davis , Roger Chen
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/20 , C12Q1/6874 , C07H17/02 , C12Q1/6806
摘要： This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

4. 发明授权

US11608523B2 Nucleic acid sequencing by nanopore detection of tag molecules 有权
公开(公告)号：US11608523B2
公开(公告)日：2023-03-21
申请号：US15712763
申请日：2017-09-22
申请人： Jingyue Ju , Randall Davis , Roger Chen
发明人： Jingyue Ju , Randall Davis , Roger Chen
IPC分类号： C12Q1/6869 , G01N33/487
摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to compositions, methods, and systems for sequencing nucleic acids using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

5. 发明申请

US20150119259A1 NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION OF TAG MOLECULES 审中-公开
标题翻译：通过纳米检测标签分子的核酸序列
公开(公告)号：US20150119259A1
公开(公告)日：2015-04-30
申请号：US14391337
申请日：2013-04-08
申请人： Jingyue JU , Randall DAVIS , Roger CHEN , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , GENIA TECHNOLOGIES, INC.
发明人： Jingyue Ju , Randall Davis , Roger Chen
IPC分类号： C12Q1/68
摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
摘要翻译：本公开提供了使用核苷酸类似物对核酸进行测序的系统和方法，以及通过纳米孔从掺入的核苷酸类似物转移标签。在一些方面，本公开涉及使用标签分子对核酸进行测序的组合物，方法和系统，以及通过从分子掺入释放的标记的纳米孔的易位检测。

6. 发明申请

US20180223351A1 Nanopore Based Molecular Detection and Sequencing 审中-公开
公开(公告)号：US20180223351A1
公开(公告)日：2018-08-09
申请号：US15703909
申请日：2017-09-13
申请人： Randall Davis , Roger Chen
发明人： Randall Davis , Roger Chen
IPC分类号： C12Q1/6869 , C12Q1/6874 , G01N33/487
摘要： This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.

7. 发明申请

US20140034497A1 CHIP SET-UP AND HIGH-ACCURACY NUCLEIC ACID SEQUENCING 有权
标题翻译：芯片设置和高精度核酸序列
公开(公告)号：US20140034497A1
公开(公告)日：2014-02-06
申请号：US13918626
申请日：2013-06-14
申请人： Randall Davis , Roger Chen , Arkadiusz Bibillo , Kevin Deierling
发明人： Randall Davis , Roger Chen , Arkadiusz Bibillo , Kevin Deierling
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , C12Q1/6869 , G01N33/48721 , C12Q2565/631
摘要： The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. Nucleic acid molecules can be sequenced with a high accuracy (e.g., greater than 97% in a single pass) using a chip comprising an array of independently addressable nanopore sensors at a density of at least about 500 sites per 1 mm2. An individual nanopore sensor can include a nanopore in a membrane that is adjacent or in proximity to a sensing electrode.
摘要翻译：本公开提供了用于测序核酸分子的装置，系统和方法。使用包含独立可寻址的纳米孔传感器阵列的芯片，密度为每1mm 2至少约500个位点，核酸分子可以以高精度（例如，单次通过中大于97％）进行测序。单个纳米孔传感器可以包括邻近或接近检测电极的膜中的纳米孔。

8. 发明申请

US20070108995A1 CURRENT TRANSFORMER TEST DEVICE AND METHOD 失效
标题翻译：电流互感器测试装置及方法
公开(公告)号：US20070108995A1
公开(公告)日：2007-05-17
申请号：US11513517
申请日：2006-08-30
申请人： John Cook , Randall Davis
发明人： John Cook , Randall Davis
IPC分类号： G01R29/20
CPC分类号： G01R35/02 , G01R31/027
摘要： A current transformer test method implemented using a test device, is useful to verify proper CT installation and operation, and does not rely on the generator (or other system) to be in a state of relatively high assembly. The test device allows a current transformer to be tested by supplying an alternating current (AC) signal to a primary winding of the current transformer to thereby induce an AC signal in a secondary winding of the current transformer. The test device is used to simultaneously monitor the phases of the supplied AC signal and the induced AC signal so that a determination can be made as to whether the current transformer secondary winding is properly installed relative to the current transformer primary winding, and to simultaneously monitor the current magnitudes of the supplied AC signal and the induced AC signal so that the turns ratio of the current transformer can be determined.
摘要翻译：使用测试装置实现的电流互感器测试方法对于验证正确的CT安装和操作是有用的，并且不依赖于发电机（或其他系统）处于相对高的组装状态。测试装置允许通过向电流互感器的初级绕组提供交流（AC）信号来测试电流互感器，从而在电流互感器的次级绕组中感应出交流信号。测试装置用于同时监视所提供的交流信号和感应的交流信号的相位，使得可以确定电流互感器次级绕组是否相对于电流互感器初级绕组正确安装，并同时监视提供的交流信号的电流幅度和感应的交流信号，从而可以确定电流互感器的匝数比。

9. 发明授权

US07176925B2 Formatting object for modifying the visual attributes of visual objects to reflect data values 有权
标题翻译：格式化对象以修改视觉对象的视觉属性以反映数据值
公开(公告)号：US07176925B2
公开(公告)日：2007-02-13
申请号：US10903280
申请日：2004-07-30
申请人： Randall Davis , Jeff Couckuyt , Paul Davies
发明人： Randall Davis , Jeff Couckuyt , Paul Davies
IPC分类号： G06T11/20
CPC分类号： G06F15/16
摘要： A formatting object according to the present invention conveys information to the reader of a document (such as a table or chart) by associating visual attributes (such as color, fill type, border width, line width, line style, font size, marker size and marker type) to characters or markers within the document. The formatting object may be used to emphasize data within a table or a chart by modifying the structural visual attributes of characters or markers within the table or chart according to pre-defined criteria. Similarly, the formatting object may be used to increase information density within a table or chart, and to elegantly represent the relationships between four or more interrelated variables in a two-dimensional chart. The formatting object accomplishes this by defining at least one format map that comprises one or more mapping segments. Each mapping segment includes a beginning boundary value, an ending boundary value, at least one beginning visual attribute corresponding to the beginning boundary value, and at least one ending visual attribute corresponding to the ending boundary value. The formatting object uses the information within the format maps, in combination with interpolation techniques, to determine one or more visual attributes that correspond to data points falling within the various mapping segments. The formatting object then expresses the data values by applying the appropriate visual attribute to a visual object displayed on a computer screen.
摘要翻译：根据本发明的格式化对象通过将视觉属性（诸如颜色，填充类型，边界宽度，线宽，线型，字体大小，标记尺寸等）相关联来向读者传达信息给读者（例如表或图表）和标记类型）到文档中的字符或标记。格式化对象可以用于通过根据预定义的标准修改表或图表中的字符或标记的结构视觉属性来强调表或图表中的数据。类似地，格式化对象可以用于增加表或图表中的信息密度，并且优雅地表示二维图中四个或更多个相关变量之间的关系。格式化对象通过定义至少一个包含一个或多个映射段的格式映射来实现。每个映射段包括开始边界值，结束边界值，对应于开始边界值的至少一个开始视觉属性，以及对应于结束边界值的至少一个结束视觉属性。格式化对象使用格式图中的信息结合插值技术来确定对应于落在各种映射段内的数据点的一个或多个视觉属性。然后，格式化对象通过将适当的视觉属性应用于显示在计算机屏幕上的可视对象来表达数据值。

10. 发明申请

US20050285603A1 A/C generator rotor test apparatus 失效
标题翻译： A / C发电机转子试验装置
公开(公告)号：US20050285603A1
公开(公告)日：2005-12-29
申请号：US10880694
申请日：2004-06-29
申请人： Randall Davis , Phillip Hudson
发明人： Randall Davis , Phillip Hudson
IPC分类号： G01R31/06 , G01R31/34
CPC分类号： G01R31/34 , G01R31/346
摘要： An assembly is provided for testing a circuit of a rotor of an AC generator. The assembly includes a base, a rack, a coil housing, one or more coils, and a rotor stand. The rack is coupled to the base and the coil housing is coupled to the rack. The one or more coils are disposed within the coil housing and are adapted to receive electrical power and configured, in response to receiving the power, to generate a magnetic field. The rotor stand is coupled to the base and configured to mount the rotor therein to position the rotor proximate the coil housing.
摘要翻译：提供用于测试AC发电机的转子的电路的组件。组件包括基座，机架，线圈壳体，一个或多个线圈和转子架。机架联接到基座，线圈壳体联接到机架。一个或多个线圈设置在线圈壳体内并且适于接收电力并且被配置为响应于接收到功率而产生磁场。转子架联接到基座并且构造成将转子安装在其中以将转子定位在线圈壳体附近。

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